Publications - United States

Cell phone utilization among foreign-born latinos: a promising tool for dissemination of health and HIV information

Post Date: 
2014-08-01
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Publication: 
Journal of Immigrant and Minority Health
Latinos in the U.S. are disproportionately affected by HIV and are at risk for late presentation to care. Between June 2011 and January 2012, we conducted a cross-sectional survey of 209 Baltimore Latinos at community-based venues to evaluate the feasibility of using communication technology (ICT)-...

25-Hydroxyvitamin D insufficiency and deficiency is associated with HIV disease progression and virological failure post-antiretroviral therapy initiation in diverse multinational settings

Post Date: 
2014-07-15
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Publication: 
The Journal of Infectious Diseases
Background: Low 25-hydroxyvitamin D (25(OH)D) has been associated with increased HIV mortality, but prospective studies assessing treatment outcomes after combination antiretroviral therapy (cART) initiation in resource-limited settings are lacking. Methods: A case-cohort study (N = 411) was nested...

Change in Vitamin D levels occurs early after antiretroviral therapy initiation and depends on treatment regimen in resource-limited settings

Post Date: 
2014-04-21
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Publication: 
PLOS One
Background: Vitamin D has wide-ranging effects on the immune system, and studies suggest that low serum vitamin D levels are associated with worse clinical outcomes in HIV. Recent studies have identified an interaction between antiretrovirals used to treat HIV and reduced serum vitamin D levels,...

The Exposure Assessment in current time (EXACT) study: implementation, feasibility and acceptability of real-time data collection in a community cohort of illicit drug users

Post Date: 
2013-11-06
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Publication: 
AIDS Research and Treatment
Objective: We describe the study design and evaluate the implementation, feasibility, and acceptability of an ecological momentary assessment (EMA) study of illicit drug users. Design. Four sequential field trials targeting observation of 30 individuals followed for a four week period. Participants...

Cost-effectiveness of Xpert MTB/RIF for diagnosing pulmonary Tuberculosis in the United States

Post Date: 
2013-10-15
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Publication: 
International Journal of Tuberculosis and Lung Disease
Setting : Conventional approaches to tuberculosis (TB) diagnosis and resistance testing are slow. The Xpert® MTB/RIF assay is an emerging molecular diagnostic assay for rapid TB diagnosis, offering results within 2 hours. However, the cost-effectiveness of implementing Xpert in settings with low TB...

Intensified case-finding of latent tuberculosis infection among the Baltimore City Hispanic population

Post Date: 
2013-08-15
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Publication: 
Journal of Immigrant and Minority Health
Foreign-born immigrants are at high risk for latent TB infection (LTBI). In conjunction with the Baltimore City Health Department (BCHD), student volunteers conducted intensified LTBI case-finding (ICF) using tuberculin skin testing (TST) in the Hispanic community from 2006-2010. We sought to...

Assessing the evolving definition of underrepresented minority and its application in academic medicine

Post Date: 
2013-01-15
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Publication: 
Academic Medicine
Purpose: To assess how U.S. academic health centers (AHCs) define the term underrepresented minority (URM) and apply it to their diversity programs, following the 2003 revision of the Association of American Medical Colleges' (AAMC's) definition of URM. Method: In 2010, the authors developed and...

QuantiFERON-TB gold in-tube implementation for latent tuberculosis diagnosis in a public health clinic: a cost-effectiveness analysis

Post Date: 
2012-12-19
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Publication: 
BMC Infectious Diseases
Background : The tuberculin skin test (TST) has limitations for latent tuberculosis infection (LTBI) diagnosis in low-prevalence settings. Previously, all TST-positive individuals referred from the community to Baltimore City Health Department (BCHD) were offered LTBI treatment, after active TB was...

HIV testing behaviors among Latinos in Baltimore City

Post Date: 
2012-08-14
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Publication: 
Journal of Immigrant and Minority Health
In the US, HIV disproportionately affects Latinos who often present late in the disease. Baltimore has seen a recent rapid growth in its Latino population paralleled by an increasing impact of HIV/AIDS among Latinos. From 2009 to 2010, we performed a cross-sectional survey of Latinos accessing the...

Detection of microbial translocation in HIV and SIV infection using the limulus amebocyte lysate assay is masked by serum and plasma

Post Date: 
2012-08-01
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Publication: 
PLOS One
Objective: Microbial translocation (MT) is thought to be a major contributor to the pathogenesis of HIV-related immune activation, and circulating lipopolysaccharide (LPS) from Gram-negative bacteria is the principle measurement of this process. However, related research has been impeded by...

Programmatic impact of QuantiFERON-TB Gold In-Tube implementation on latent tuberculosis diagnosis and treatment in a public health clinic

Post Date: 
2012-05-07
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Publication: 
PLoS One
Background : QuantiFERON-TB Gold In-Tube (QFT-GIT) is considered an alternative to the tuberculin skin test (TST) for the diagnosis of tuberculosis (TB) infection, but the programmatic impact of QFT-GIT implementation is largely unknown. In March, 2010, the Baltimore City Health Department (BCHD)...

Safety, tolerability, and pharmacokinetic interactions between single-dose TMC207 and steady-state efavirenz in healthy volunteers: AIDS Clinical Trials Group (ACTG) Study.

Post Date: 
2012-04-15
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Publication: 
Journal of Acquired Immune Deficiency Syndromes
Background: Drug-drug interactions complicate management of coinfection with HIV-1 and Mycobacterium tuberculosis. Bedaquiline (formerly TMC207), an investigational agent for the treatment of tuberculosis, is metabolized by cytochrome P450 (CYP) 3A which may be induced by the antiretroviral drug...

Peer Health Workers and AIDS Care in Rakai, Uganda: A mixed methods operations research evaluation of a cluster-randomized trial

Post Date: 
2011-12-15
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Publication: 
AIDS Patient Care and STDs
Settings with limited health care workers are challenging environments for delivery of antiretroviral therapy. One strategy to address this human resource crisis is to task shift through training selected patients as peer health workers (PHWs) to provide care to other individuals receiving...

Faculty diversity programs in U.S. medical schools and characteristics associated with higher faculty diversity.

Post Date: 
2011-10-15
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Publication: 
Academic Medicine
Purpose: To describe diversity programs for racial and ethnic minority faculty in U.S. medical schools and identify characteristics associated with higher faculty diversity. Method: The authors conducted a cross-sectional survey study of leaders of diversity programs at 106 U.S. MD-granting medical...

Increased gonorrhea and chlamydia testing did not increase case detection in an HIV clinical cohort 1999 - 2007

Post Date: 
2011-10-15
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Publication: 
Sexually Transmitted Infections
Objectives: Since 2003, U.S. organizations have recommended universal screening, rather than targeted screening, of HIV-infected persons for gonorrhea (NG) and Chlamydia (CT). Our objective was to determine whether wider testing resulting from these guidelines would produce an increase in NG/CT...

Prevention of HIV-1 infection with early antiretroviral therapy

Publication: 
New England Journal of Medicine
Background: Antiretroviral therapy that reduces viral replication could limit the transmission of human immunodeficiency virus type 1 (HIV-1) in serodiscordant couples. Methods: In nine countries, we enrolled 1763 couples in which one partner was HIV-1–positive and the other was HIV-1–negative; 54...

Predictors of HIV testing among Latinos in Baltimore City

Post Date: 
2010-12-15
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Countries: 
Publication: 
Journal of Immigrant and Minority Health
To better understand access to HIV testing and prevention services experienced by Latinos, we evaluated data compiled through Baltimore City Health Department HIV outreach efforts in 2008. Of 6,443 clients served, Latinos were more likely male, young, and less-educated than non-Latinos. A greater...

Gonorrhoea and chlamydia testing rates of HIV-infected men: low despute guidelines

Post Date: 
2010-11-15
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Publication: 
Sexually Transmitted Infections
Objectives: Screening HIV-infected men for gonorrhea (GC) and Chlamydia (CT) may decrease HIV transmission and reduce the incidence of pelvic inflammatory disease in female partners. This study determined GC/CT testing rates in a clinical HIV cohort before and after 2003 when the U.S. Centers for...

Unique aspects of the care of HIV-positive Latino patients living in the United States

Post Date: 
2010-08-15
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Countries: 
Publication: 
Current HIV/AIDS Reports
Latinos are disproportionately affected by HIV, with a higher risk of infection and a delayed presentation to care as compared to non-Hispanic whites. Over the last decade many Latinos, especially foreign-born migrants, have settled in regions of the country with historically low Latino...

Sexually transmitted infection prevalence and behavioral risk factors among Latino and non-Latino patients attending the Baltimore City STD clinics

Post Date: 
2010-03-15
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Publication: 
Sexually Transmitted Diseases
Background: Many studies have evaluated factors influencing STD/HIV disparities between African-American and white populations, but fewer have explicitly included Latinos for comparison. Methods: We analyzed demographic and behavioral data captured in electronic medical records of patients first...

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