BJGMC

Byramjee Jeejeebhoy Government Medical College (BJGMC), and Sassoon General Hospitals (SGH)
Jai Prakash Narayan Road, Near Pune Railway Station
Pune, India 411001
www.bjmcpune.org    

 

About:

  • Among the top 10 medical schools in India
  • 200 medical students, 130 residents per year; 50 nursing students per year
  • SGH: State-funded 1500-bed tertiary-care public hospital, 21 outpatient clinics, and links to multiple NGOs in the community
  • CCGHE partnership established in 1999 for HIV studies; now investigates other infectious diseases, noncommunicable diseases, and comorbidities 
  • In 2011, JHU field office established at BJGMC Clinical Research Site: 3 full time Hopkins faculty and 20 staff; 150 BJGMC clinical research staff.
  • Clinical research as well as leadership and oversight for clinical rotations and field studies

 

Field Study Administrators:

Mental Health Outcomes among Health Care Professionals Involved in the Treatment and Care of COVID 19 Patients in India

Post Date: 
2020-06-01
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Drs. Nikhil Gupta and Nishi Suryavanshi are leading this survey project. This study is investigating the immediate impact of the COVID-19 pandemic on mental health outcomes and overall quality of life and what are the factors associated with it among Indian Health care workers. Among health care...

Prevalence of Risk Factors for Lung Cancer and Facilitators and Barriers for Tobacco Cessation among People Living with HIV

Post Date: 
2020-04-01
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India has the world’s third largest HIV epidemic, with 2.1 million people currently living with HIV and an additional 90,000 new infections each year.[29] At the same time, expansion of the HIV response under India’s premier governmental agency - the National AIDS Control Organization (NACO), has...

The Sentinel Research Network of IeDEA: A Prospective Cohort among People Living with HIV

Post Date: 
2020-03-12
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This study is nested within the TREAT Asia HIV Observational Database initiative. The global scale up of antiretroviral therapy (ART) has significantly improved the immune recovery and life expectancy of people living with HIV (PLHIV). However, PLHIV on long-term ART now face health challenges...

Hybrid Trial for Alcohol Reduction among People with TB and HIV in India

Post Date: 
2020-02-12
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The highest incidence of tuberculosis disease (TB) in the world is in India, accounting for 27% of all new cases globally, with approximately 86,000 among persons with HIV (PWH). Unhealthy alcohol use triples the risk of TB in the general population, increasing susceptibility to primary infection...

Pregnancy Associated Immune Responses to Tuberculosis and HIV in India and South Africa (PARTHISA)

Post Date: 
2020-01-14
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Dr. Jyoti Mathad is Co-PI of this study. Purpose: Tuberculosis (TB) is a leading cause of maternal mortality, especially among HIV-infected women. Women are most likely to develop active TB during and immediately after pregnancy. The immunologic conditions responsible for this phenomenon are not...

Increasing Market and Public Health Outcomes Through Scaling Up Affordable Access Models of Short Course Preventive Therapy for TB (IMPAACT4TB)

Post Date: 
2019-12-17
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Primary Objective: This study is being conducted in Brazil, Cambodia, China, Ethiopia, Ghana, Haiti, India, Indonesia, Kenya, Malawi, Mozambique, South Africa, Tanzania, and Zimbabwe. The overall goal is to reduce TB incidence among (1) people living with HIV who are on antiretroviral therapy, and...

Markers of Lung Impairment in HIV-TB Coinfected Indian Adults

Post Date: 
2019-12-11
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Objectives/Aims We will compare the degree of lung impairment between HIV-TB co-infected adults (HIV-TB group) and TB cases without HIV co-infection (TB group) who successfully complete TB therapy. We hypothesize that the HIV-TB group will have a greater degree of lung impairment compared to the TB...

T Cell Biomarkers and T-regulatory Responses to Pediatric TB

Post Date: 
2019-11-21
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The goals of this study are to: Validate host T cell biomarkers for diagnosis of pediatric TB Investigate the phenotype and functions of T-regulatory cells in pediatric TB We will use cryopreserved PBMC samples from CTRIUMPH cohorts: Pediatric unconfirmed TB, confirmed TB, latest Tb, and no TB...

Inflammasome Genetics and Tuberculosis Treatment Outcomes

Post Date: 
2019-11-07
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Dr. Amita Gupta is a Co-PI on this study. STUDY DESIGN We will conduct a retrospective case-cohort study nested within the CTRIUMPH and EDOTS cohorts to address our study objectives. This will enable us to measure the association of polymorphisms with multiple clinical outcomes simultaneously and...

A Phase 2a, Double-Blind, Placebo-Controlled, Randomized Clinical Trial to Evaluate the Safety and Immunogenicity of ID93 + GLA-SE Vaccine Administered to HIV-Negative Patients at 3 Time Points During Multidrug Therapy for Drug Susceptible Pulmonary TB

Post Date: 
2019-10-28
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This study was terminated in April 2020. Vidya Mave was PI of this HIV vaccine trial. BACKGOUND: Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis (Mtb). TB is one of the leading causes of morbidity and mortality around the world with an estimated 10...

Evaluation of a Urinary Biomarker Assay for Diagnosis and Test of Cure for Tuberculosis

Post Date: 
2019-09-09
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Dr. Jeff Tornheim is PI of this study. METHODS This study will make use of biorepository samples from the Cohort for TB Research by the Indo-US Medical Partnership (CTRIUMPh). CTRIUMPh, funded by the US NIH and Indian Department of Biotechnology, is an academic collaboration between Johns Hopkins...

A5300B/I2003B: Protecting Households On Exposure to Newly Diagnosed Index Multidrug-Resistant Tuberculosis Patients (PHOENIx)

Post Date: 
2019-08-19
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Dr. Amita Gupta is Protocol Co-chair for this multinational clinical trial. BACKGROUND The World Health Organization (WHO) estimates that there were 480,000 incident cases of MDR-TB globally in 2015. MDR-TB has been shown to be almost twice as common in TB patients living with HIV compared with TB...

A5300B/I2003B: Protecting Households On Exposure to Newly Diagnosed Index Multidrug-Resistant Tuberculosis Patients (PHOENIx)

Post Date: 
2019-08-19
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Dr. Amita Gupta is Protocol Co-chair for this multinational clinical trial. BACKGROUND The World Health Organization (WHO) estimates that there were 480,000 incident cases of MDR-TB globally in 2015. MDR-TB has been shown to be almost twice as common in TB patients living with HIV compared with TB...

Visual Field Loss in HIV-Positive Patients of Non-Infectious HIV Retinopathy

Post Date: 
2019-06-02
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New study will assess HIV+ patients and determine the prevalence of visual field loss due to noninfectious HIV retinopathy

P2010: Phase III Study of the Virologic Efficacy and Safety of Dolutegravir-Containing versus Efavirenz-Containing Antiretroviral Therapy Regimens in HIV-1-Infected Pregnant Women and their Infants “VESTED”

Post Date: 
2019-02-06
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Full Title: P2010: Phase III Study of the Virologic Efficacy and Safety of Dolutegravir-Containing versus Efavirenz-Containing Antiretroviral Therapy Regimens in HIV-1-Infected Pregnant Women and their Infants “VESTED”: V irologic E fficacy and S afety of ART Combinations with T AF/TDF, E FV, and D...

Prevalence of Tuberculosis in Severely Malnourished Indian Children

Post Date: 
2018-12-18
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This study is funded and conducted under the U.S. National Institutes of Health, Fogarty International Center. PIs are Robert Bollinger, MD, MPH; Dr. Muralidhar Tambe, BJGMC Severely malnourished children are vulnerable population for communicable and non-communicable disease. Diagnosis of TB among...

Characterization of Genomics and Metabolomics among Individuals Highly-Exposed, but Resistant to MTB Infection

Post Date: 
2018-12-13
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New study launched in India & South Africa to identify functional relationships between genomics & metabolomics, & to characterize fundamental biological systems underlying resistance to Mtb infection.

Host RNA Expression for Diagnosis and Monitoring of Pediatric TB in Africa and India

Post Date: 
2018-12-13
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We are leveraging the RePORT platform by including a cohort of Indian children together with South African children in a large validation study to study on changes in gene expression profiles during treatment for TB

Immune Responses and Effect of Disulfiram on MTB Infected PBMCs as a Potential Host Directed Therapy

Post Date: 
2018-11-26
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Dr. Mandar Paradkar is lead investigator for this study that is assessing the immune responses of adult pulmonary TB patients enrolled in the CTRIUMPh study, using PBMC samples of those with harmful use of alcohol assessed by AUDIT scores ≥ 8 compared to non-alcoholics (AUDIT < 8). Aim 1: To...

Characterization of TB-specific T Cell Responses in Highly-exposed, but Uninfected Health Care Workers in India

Post Date: 
2018-10-25
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This study is funded and conducted under the U.S. National Institutes of Health, Fogarty International Center. PIs are Robert Bollinger, MD, MPH; Jyothi Rengarajan, MD, Emory University. Primary Research Question Do health care workers who remain TST negative, despite high-exposure to TB,...

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High prevalence of late presentation of ART-naïve perinatally infected children for care in Pune, India

Post Date: 
2020-02-19
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AIDS Care
AIDS Care : There is an urgent need to identify strategies that improve linkage of perinatally infected ART-naïve children to care, and earlier than what is currently observed.

Assessment of the Xpert assay among new pulmonary tuberculosis suspects with and without diabetes mellitus

Post Date: 
2020-01-01
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International Journal of Tuberculosis and Lung Disease
IJTLD: Deshmukh and colleagues: High sensitivity and specificity of Xpert underscores need for rapid scale up for early detection of TB in settings with a high dual burden of TB and DM

Transcriptomic profiles of confirmed pediatric tuberculosis patients and household contacts identifies active tuberculosis, infection, and treatment response among Indian children

Post Date: 
2019-12-04
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Publication: 
Journal of Infectious Diseases
Journal of Infectious Diseases: Gene expression profiles among Indian children with confirmed TB were distinct from those of adults, highlighting the importance of including distinct populations in differential gene expression models

MAL adaptor (TIRAP) S180L polymorphism and severity of disease among tuberculosis patients

Post Date: 
2019-10-31
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Infection, Genetics, and Evolution
Infection, Genetics, and Evolution : We investigated the association of TIRAP variants with severity of TB disease and IP-10 production in humans, which may be useful in predicting poor clinical outcome

Incidence of tuberculosis in HIV-infected adults on first- and second-line antiretroviral therapy in India

Post Date: 
2019-10-29
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BMC Infectious Diseases
In this study among people living with HIV, Akshay Gupte and colleagues found that the risk of acquiring tuberculosis was higher in those receiving first-line antiretrovial therapy versus those receiving second-line medications.

Isoniazid preventive therapy in HIV-infected pregnant and postpartum women

Post Date: 
2019-10-03
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Publication: 
New England Journal of Medicine
New England Journal of Medicine: Dr. Amita Gupta and colleagues found that the current standard of care given to HIV+ pregnant women to prevent TB should wait until 12 weeks after delivery. The study underscores the need to include pregnant women in clinical trials.

Challenges in conducting trials for pediatric tuberculosis meningitis: lessons learned in the field

Post Date: 
2019-10-01
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International Journal of Tuberculosis and Lung Disease
International Journal of Tuberculosis and Lung Disease: Researchers describe the challenges associated with conducting the first randomized clinical trial of antimicrobial agents in pediatric tuberculosis meningitis.

Inclusion of key populations in clinical trials of new antituberculosis treatments: Current barriers and recommendations for pregnant and lactating women, children, and HIV-infected persons

Post Date: 
2019-08-15
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PLOS Medicine
PLOS Medicine: Dr. Amita Gupta and colleagues discuss the scientific and ethical basis for including pregnant and lactation women, children, and HIV+ patients in tuberculosis therapeutic clinical trials.

Smoking, alcohol use disorder and tuberculosis treatment outcomes: A dual co-morbidity burden that cannot be ignored

Post Date: 
2019-07-31
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PLoS One
BACKGROUND: More than 20% of tuberculosis (TB) disease worldwide may be attributable to smoking and alcohol abuse. India is the second largest consumer of tobacco products, a major consumer of alcohol particularly among males, and has the highest burden of TB globally. The impact of...

Third-line antiretroviral therapy in low-income and middle-income countries (ACTG A5288): a prospective strategy study

Post Date: 
2019-07-29
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Lancet HIV
BACKGROUND: Antiretroviral therapy (ART) management is challenging for individuals in resource-limited settings presenting for third-line treatment because of complex resistance patterns, partly due to reduced access to viral load monitoring. We aimed to evaluate use of newer...

Infection free "resisters" among household contacts of adult pulmonary tuberculosis

Post Date: 
2019-07-18
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PLoS One
Despite substantial exposure to infectious pulmonary tuberculosis (TB) cases, some household contacts (HHC) never acquire latent TB infection (LTBI). Characterizing these "resisters" can inform who to study immunologically for the development of TB vaccines. We enrolled HHCs of culture-...

High risk for latent tuberculosis infection among medical residents and nursing students in India

Post Date: 
2019-07-08
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PLoS One
PLoS ONE: Self-reported TB exposure is underreported, and uptake of LTBI prevention therapy remains low

Mobile phone access and comfort: implications for HIV and tuberculosis care in India and South Africa.

Post Date: 
2019-07-01
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Publication: 
International Journal of Tuberculosis and Lung Disease
SETTING: India and South Africa shoulder the greatest burden of tuberculosis (TB) and human immunodeficiency virus (HIV) infection respectively, but care retention is suboptimal. OBJECTIVE: We conducted a study in Pune, India, and Matlosana, South Africa ...

Elevated highly sensitive C-reactive protein and d-dimer levels are associated with food insecurity among people living with HIV in Pune, India

Post Date: 
2019-03-04
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Public Health Nutrition
Abstract OBJECTIVE: To assess the prevalence and determinants of food insecurity among people living with HIV (PLWH) in Pune, India and its association with biomarkers known to confer increased risks of morbidity and mortality in this population. DESIGN:...

Female global health leadership: Data-driven approaches to close the gender gap

Post Date: 
2019-02-09
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The Lancet
Lancet article investigates gender-based challenges of female health trainees and professionals and identifies interventions

HIV testing uptake among the household contacts of multidrug-resistant tuberculosis index cases in eight countries

Post Date: 
2019-01-07
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International Journal of Tuberculosis and Lung Disease
International Journal of Tuberculosis and Lung Disease : The Indo-JHU Clinical Research Parentership participated in this multinational study to determine if it's feasible to provide HIV testing for household contacts of MDR-TB cases.

Is there a connection between gestational diabetes, human immunodeficiency virus infection, and tuberculosis?

Post Date: 
2019-01-01
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International Journal of Tuberculosis and Lung Disease
IJTLD article reviews the epidemiology and immunology of gestational diabetes and finds there's a lot we don't know about interactions between diabetes, pregnancy, and tuberculosis in both HIV+/- women

Drug-resistant Enterobacteriaceae colonization is associated with healthcare utilization and antimicrobial use among inpatients in Pune, India

Post Date: 
2018-10-04
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BMC Infectious Diseases
BACKGROUND: Healthcare exposure may increase drug-resistant Enterobacteriaceae colonization risk. Nascent antimicrobial stewardship efforts in low- and middle-income countries require setting-specific data. We aimed to evaluate risk factors for inpatient drug resistant...

Barriers to screening and isoniazid preventive therapy for child contacts of tuberculosis patients

Post Date: 
2018-10-01
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Publication: 
International Journal of Tuberculosis and Lung Disease
Universal, timely TB screening and IPT for exposed children are urgently needed to reduce pediatric TB in India

Inflammation and micronutrient biomarkers predict clinical HIV treatment failure and incident active TB in HIV-infected adults: a case-control study

Post Date: 
2018-09-24
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BMC Medicine
Factors identified through exploratory factor analysis were associated with adverse outcomes in HIV-infected individuals.

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Factors associated with gestational diabetes in HIV+ and HIV- women in Pune, India

Post Date: 
2020-03-09
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Chebrolu P , Alexander M, Bhosale R, Naik S, Patil N, Gupta A, Mathad J. Factors associated with gestational diabetes in HIV+ and HIV- women in Pune, India. Presented at: CROI 2020. Boston, Massachusetts. March 8-11, 2020.

Geographic and Individual Risk Factors for TB or Death in the Brief-TB Trial (A5279)

Post Date: 
2020-03-09
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Riviere C , Juste MAJ, Ramchandani R, Gupta A, Benson CA, Masheto G, Supparatpinyo K, Mohapi L, da Silva Escada RO, Mngqibisa R, Kanyama C, Langat D, Swindells S, Chaisson RE, for the A5279/BRIEF TB Study Team. Geographic and Individual Risk Factors for TB or Death in the Brief-TB Trial (A5279)...

Adjusted analysis of effect of IPT on adverse pregnancy outcomes in women with HIV

Post Date: 
2020-03-09
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Theron G , Chakhtoura N, Montepiedra G, Aaron L, Jean-Phillipe P, Weinberg A, McCarthy K, Nematadzira T, Masheto G, Chipato T, Onyango-Makumbi C, Gupta A, the IMPAACTP1078 Team. Adjusted analysis of effect of IPT on adverse pregnancy outcomes in women with HIV. Presented at: CROI 2020. Boston,...

Tuberculosis preventive therapy should be considered for all household contacts of pulmonary TB patients in India

Post Date: 
2020-02-07
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Paradkar M, Chandrasekara P, Jain D, Shivakumar SVBY, Thiruvengadan K, Gupte AN, Thomas B, Kinikar A, Sekar K, Bharadwaj R, Dolla CK, Gaikwad S, Elilarasi S, Lokhande R, Reddy D, Murali L, Kulkarni V, Pradhan N, Hanna LE, Pattabiraman S, Kohli R, Nayagam R, Suryavanshi N, Shrinivasa BM, Cox SR,...

Female tuberculosis (TB) patients with stigma are at increased risk of persistent depression: time to integrate mental health screening into TB care

Post Date: 
2019-11-20
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Suryavanshi N . Female tuberculosis (TB) patients with stigma are at increased risk of persistent depression: time to integrate mental health screening into TB care. Poster presentation. 50th Union World Conference on Lung Health. Hyderabad, India. October 30-November 2, 2019.

The crisis in maternal TB: a case-based discussion of research gaps

Post Date: 
2019-11-02
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Naik SN . The crisis in maternal TB: a case-based discussion of research gaps. Speaker. Confronting the crisis: emerging research in maternal-child TB Symposium. 50th Union World Conference on Lung Health. Hyderabad, India. October 30-November 2, 2019.

Is there a connection between gestational diabetes and TB?

Post Date: 
2019-11-02
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Alexander M . Is there a connection between gestational diabetes and TB? Speaker. Confronting the crisis: emerging research in maternal-child TB Symposium.50th Union World Conference on Lung Health. Hyderabad, India. October 30-November 2, 2019.

Performance of QuantiFERON-TB Gold in Tube (QFT-GIT) and QuantiFERON-TB Gold Plus (QFT-Plus) for detection of Mycobacterium tuberculosis infection in pregnant women in India

Post Date: 
2019-11-01
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Kulkarni V , Bhosale R, Jain D, Deshpande P, Naik N, Alexander M, Patil N, Gupte N, Gupta A, Mathad J. Performance of QuantiFERON-TB Gold in Tube (QFT-GIT) and QuantiFERON-TB Gold Plus (QFT-Plus) for detection of Mycobacterium tuberculosis infection in pregnant women in India. Poster presentation...

Six-week culture conversion predicts tuberculosis treatment outcomes

Post Date: 
2019-11-01
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Pradhan N , Kagal A, Gupte N, Gaikwad S, Barthwa M, Gupta A, Golub JE, Mave V. Six-week culture conversion predicts tuberculosis treatment outcomes. Poster presentation. 50th Union World Conference on Lung Health. Hyderabad, India. October 30-November 2, 2019.

Association of latent TB infection in pregnancy with perinatal health outcomes in an Indian cohort

Post Date: 
2019-11-01
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Graham H , Bhosale R, Alexander M, Kinikar A, Khwaja S, Patil N, Mathad J, Shivakoti S, Gupta A. Association of latent TB infection in pregnancy with perinatal health outcomes in an Indian cohort. Poster presentation. 50th Union World Conference on Lung Health. Hyderabad, India. October 30-November...

Inappropriate postpartum weight loss may predict development of active TB: Findings from a cohort study in Pune, India

Post Date: 
2019-11-01
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Alexander M , Bhosale R, Naik S, Gupte N, Jain D, Patil N, Pradhan N, Mave V, Gupta A, Mathad J. Inappropriate postpartum weight loss may predict development of active TB: Findings from a cohort study in Pune, India. Poster presentation. 50th Union World Conference on Lung Health. Hyderabad, India...

Does treatment of infertile women with probable genital tuberculosis improve fertility outcome?

Post Date: 
2019-11-01
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Naik SN , Chandanwale A, Kadam D, Sambarey PW, Dhumal G, DeLuca A, Jain D, Gupta A, Bollinger R, Mave V. Does treatment of infertile women with probable genital tuberculosis improve fertility outcome? Poster presentation. 50th Union World Conference on Lung Health. Hyderabad, India. October 30-...

Tuberculosis infection and inflammation among HIV-infected adults in India

Post Date: 
2019-10-31
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Kulkarni V . Tuberculosis infection and inflammation among HIV-infected adults in India. Oral Presentation. 50th Union World Conference on Lung Health. Hyderabad, India. October 30-November 2, 2019.

Resistance to Mycobacterium tuberculosis infection among household contacts of MDR TB patients

Post Date: 
2019-10-31
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Baliashvili D , Gandhi NR, Kim S, Gupta A, Churchyard G, Swindells S, Hesseling A, Hughes M, Shah S for the ACTG 5300/IMPAACT I2003 PHOENIx Feasibility Study Team. Resistance to Mycobacterium tuberculosis infection among household contacts of MDR TB patients. Poster presentation. 50th Union World...

High prevalence of tuberculosis infection in children living in households of MDR-TB patients

Post Date: 
2019-10-31
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Kim S , Wu X, Hughes M, Mendoza-Ticona A, Churchyard G, Swindells S, Shah NS, Gupta A, Hesseling A for the A5300/I2003 PHOENIx Feasibility Study Team. High prevalence of tuberculosis infection in children living in households of MDR-TB patients. Short oral presentation. 50th Union World Conference...

Assessing TB-related knowledge and stigma and associated risk factors among pregnant women in low-resource settings of Pune, India

Post Date: 
2019-10-30
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Mehta S , Murrill M, Suryavanshi N, Bhosale R, Naik S, Patil N, Gupta A, Mathad J, Shivakoti R, Alexander M. Assessing TB-related knowledge and stigma and associated risk factors among pregnant women in low-resource settings of Pune, India. Poster presentation. 50th Union World Conference on Lung...

Association of latent TB infection in pregnancy with perinatal health outcomes in an Indian cohort

Post Date: 
2019-10-30
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Countries: 
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Bhosale R , Graham H, Alexander M, Kinikar A, Khwaja S, Patil N, Gupta A, Mathad J, Shivakoti R. Association of latent TB infection in pregnancy with perinatal health outcomes in an Indian cohort. Poster presentation. 50th Union World Conference on Lung Health. Hyderabad, India. October 30-November...

Pitfalls in Chest X-ray Scoring of Patients Receiving Treatment for Active Tuberculosis in Pune, India

Post Date: 
2019-03-28
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Orsini E , Gupte A, Paradkar M, Jain D, Raskar S, Lokhande R, Mave V, Gupta A. Pitfalls in Chest X-ray Scoring of Patients Receiving Treatment for Active Tuberculosis in Pune, India. Johns Hopkins Global Health Day 2019. Baltimore, MD. March 28, 2019.

The prevalence of perinatal depression and associated birth outcomes in Pune, India

Post Date: 
2019-02-11
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Grossman TB , Mathad JS, Suryavanshi N, Alexander M, Mave V, Bhosale R, Gupta A. The prevalence of perinatal depression and associated birth outcomes in Pune, India. Society for Maternal-Fetal Medicine 39th Annual Pregnancy Meeting. Las Vegas, NV. February 11-16, 2019.

Host Lipidomic Profile Associated with Adverse Tuberculosis Treatment Outcomes

Post Date: 
2019-02-04
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Shivakoti R , Chandrasekaran P, Hannah LE, Thiruvengadam K, Saravanan N, Karunaianatham R, Gupta A, Mave V, Gupte N, Kulkarni V, Pradhan N, Gupte A, Paradkar M, Shivakumar SVBY, Bharadwaj, Kagal A, Gaikwad S, Sangle S, Borkowski K, Newman J, Fiehn O. Host Lipidomic Profile Associated with Adverse...

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