NIRT

National Institute for Research in Tuberculosis
No.1, Mayor Sathiyamoorthy Road
Chetpet, Chennai 
600 031, India
91-44-2836 9500 
www.nirt.res.in 

  • Established in 1956 as India’s Tuberculosis Research Centre
  • Internationally renowned TB research institution, Supranatural Reference Laboratory, and WHO Collaborating Centre for TB Research and Training
  • CCGHE research partnership looking at:
    • Lasting pulmonary effects and respiratory impairment following recovery from TB
    • Hair concentrations of anti-tuberculosis drugs among HIV-infected and uninfected children
    • Improving TBM treatment outcomes in children ages 6 months to 12 years
    • Assessing dosage levels of rifampicin and evaluating safety of TBM treatment
    • Relationship between diet and inflammation during pregnancy
    • Immune changes that happen during pregnancy and how they affect different methods for latent TB screening among pregnant women
    • Host and microbial factors associated with 1) poor response to TB treatment, 2) progression to active TB disease and 3) TB transmission/acquisition

C-TRIUMPH: Validating a Novel Functional Correlate of Immune Protection of Tuberculosis

Post Date: 
2018-10-03
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This is a longitudinal assessment of PBMC samples of progressors and non-progressors among adult household contacts of active TB patients. The purpose of the study is to probe the functional diversity of T cell responses to several of the antigens encoded by Mtb simultaneously in subjects covering...

Molecular Signatures of Tuberculosis-Diabetes Interaction: Metabolomics Study

Post Date: 
2018-06-15
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Type 2 diabetes mellitus (DM) is an acquired host factor that increases the risk for and severity of pulmonary tuberculosis (PTB). A report published in 2007 estimated that, in India, DM accounted for 14.8% (range 7.1% to 23.8%) of PTB and 20.2% (8.3% to 41.9%) of smear-positive PTB. Emerging data...

Molecular Signatures of Tuberculosis-Diabetes Interaction: Transcriptomics Study

Post Date: 
2018-06-15
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Type 2 diabetes is an acquired host factor that increases the risk for and severity of pulmonary tuberculosis. A report published in 2007 estimated that, in India, diabetes accounted for 14.8% (range 7.1% to 23.8%) of pulmonary tuberculosis and 20.2% (8.3% to 41.9%) of smear-positive cases...

Predictors of Resistance Emergence Evaluation in Multidrug Resistant-Tuberculosis Patients on Treatment (PREEMPT Pilot Study)

Post Date: 
2018-03-20
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Indo-JHU Clinical Resarch Partnership is participating with Brazilian colleagues in a 3-year effort led by Boston University to identify what contributes to TB drug resistance.

A Multicenter Phase II/II Double-Blind, Randomized, Placebo Controlled Study to Evaluate the Efficacy and Safety of VPM1002 in the Prevention of Tuberculosis (TB) Recurrence in Pulmonary TB Patients After Successful TB Treatment in India

Post Date: 
2018-01-23
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Dr. Vidya Mave is leading this clinical trial evaluating the safety and efficacy of a new recombinant BCG vaccine.

RePORT: C-TRIUMPH: Nested Study on Association of Lipid Mediators of Inflammation with TB Treatment Outcomes

Post Date: 
2017-08-03
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Recent studies have shown the significant role that host lipids play in modulating immunity and disease outcomes. Prostaglandins and leukotrienes are lipids that have a pro-inflammatory role in the fight against infectious agents while Specialized Pro-resolving lipid Mediators (SPMs) including...

Optimizing Treatment to Improve TBM Outcomes in Children: Substudy on Clinical Profile and CSF Biorepository of the Pediatric Suspected Meningitis Cases

Post Date: 
2017-07-18
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This sub-study is being led by PIs Dr. Kelly Dooley and Dr. Chhaya Valvi. Meningoencephalitis is associated with significant morbidity and mortality. Several viruses, bacteria, and fungal pathogens including Neisseria meningitidis, Streptococcus pneumoniae, Mycobacterium tuberculosis, Herpes...

RePORT: C-TRIUMPH: Biomarkers for Tuberculosis Diagnosis and Treatment Response

Post Date: 
2017-03-24
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Aims: To develop non-sputum, blood-based tools for TB diagnosis and treatment, we urgently need biomarkers that identify active TB (ATB) cases and accurately distinguish them from latent TB infection (LTBI). Such biomarkers, when validated in diverse populations, can be developed into improved...

Impact of HIV and Diabetes Mellitus on TB Drug Resistance and Recurrence

Post Date: 
2017-03-02
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Tuberculosis (TB) is the leading cause of mortality globally. With increasing burden of HIV and diabetes mellitus (DM), there is a critical need to understand the microbial response and ensuing disease dynamics of TB in the HIV-infected and diabetic host to optimally control TB globally. Among...

Measuring TB Drugs in Hair as a Tool to Monitor Adherence, Exposure and Response in Patients with HIV

Post Date: 
2016-08-16
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Our study will examine whether hair levels of two key first line tuberculosis drugs will be useful markers to identify individuals at highest risk of treatment failure in active tuberculosis. Our study aims to provide a lowcost clinical tool using hair that can be noninvasively collected to monitor...

TB and Pregnancy Impact of Immune Changes of HIV and Stages of Pregnancy on Tuberculosis: Nested Study on Temporal Dynamics of Gut Microbiota in HIV Infected Pregnant Women

Post Date: 
2016-07-05
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This is a nested prospective longitudinal cohort study of 35 HIV-infected and 35 HIV-noninfected pregnant women who are part of the parent study “Impact of Immune Changes of HIV and Stages of Pregnancy on Tuberculosis." The objectives are to: Determine the association of gestational age with...

RePORT: C-TRIUMPH: Substudy on Comparison of Available Purified-protein Derivative (PPD) Tuberculin Skin Test (TST) Antigen Solutions in Detecting Latent Tuberculosis Infection in India

Post Date: 
2016-04-21
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Given the worldwide shortage of PPD TST antigen solutions, it is important to establish the sensitivity of the commercially available SPAN diagnostic TST when compared products used in international settings. This study aims to establish whether the SPAN diagnostic product is bioequivalent to PPDs...

RePORT: C-TRIUMPH: Substudy on Residual Respiratory Impairment Following Pulmonary Tuberculosis

Post Date: 
2015-09-13
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Many TB patients have residual respiratory impairment despite treatment. Such individuals may be at increased risk of chronic lung diseases and disability in the future. Using respiratory questionnaires and lung function tests, the Lung Health Sub-study will evaluate 400 adult TB patients enrolled...

Diagnosis of Tuberculosis Infection and Th1 Immune Response in Pregnant Women in India

Post Date: 
2014-09-01
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This study was terminated April 16, 2018. Tuberculosis (TB) disease is a major cause of mortality among Indian women of reproductive age; approximately 20-50% of women in India are latently infected with Mycobacterium tuberculosis (MTB). Due to immune changes of pregnancy, women are particularly at...

TB and Pregnancy Impact of Immune Changes of HIV and Stages of Pregnancy on Tuberculosis

Post Date: 
2014-09-01
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This is a cross sectional observational study known as PRACHITi (PRegnancy And CHanges In Tuberculosis), Purpose: TB is a leading cause of maternal mortality, especially among HIV-infected women. Women are most likely to develop active TB during and immediately after pregnancy. The immunologic...

Optimizing Treatment to Improve TBM Outcomes in Children

Post Date: 
2014-05-01
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This study, known as TBM Kids, is being conducted in India and Malawi. Primary Objectives To characterize the pharmacokinetics (PK) (plasma and cerebrospinal fluid (CSF)) of rifampicin given at model-derived optimal daily doses and levofloxacin in children ages 6 months to 12 years of age with TBM...

Tuberculosis Noon Conference

Post Date: 
2013-10-24
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This effort ended in 2015. As part of the BJGMC-Johns Hopkins India Fogarty Training Program, from 2013-2015 CCGHE hosted the live Tuberculosis Noon Conference webcast. Led by Drs. Maunank Shah, Jonathan Golub, and Richard Chaisson, these webcast meetings brought together Johns Hopkins TB...

RePORT: C-TRIUMPH: Cohort for Tuberculosis Research by the Indo-US Medical Partnership

Post Date: 
2013-09-28
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Collaboratively funded by the US NIH, India’s Department of Biotechnology [DBT], and Indian Council of Medical Research, the Cohort for TB Research by the Indo-US Medical Partnership (C-TRIUMPH) is an Indo-US research consortium that is part of RePORT India, a countrywide consortium for TB research...

RePORT India

Post Date: 
2012-06-30
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RePORT India is a joint venture between the Indian and US governments. The Indo-US Vaccine Action Program, a collaboration between the Indian Department of Biotechnology (DBT), the Indian Council of Medical Research (ICMR), and the US NIH, is co-funding six teams of India- and US-based...

The effect of diabetes mellitus on the pharmacokinetics and pharmacodynamics of tuberculosis treatment

Post Date: 
2018-08-20
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Antimicrobial Agents and Chemotherapy
DM and higher HbA1c increased the risk of not achieving therapeutic targets for pyrazinamide, but higher pyrazinamide concentrations were asociated with worse microbiologic and clinical outcomes

Intestinal barrier dysfunction and microbial translocation in HIV-infected pregnant women is associated with preterm birth

Post Date: 
2018-03-24
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Clinical Infectious Diseases
Our results show select immune markers can identify women at higher risk for PTB in HIV-1-infected populations and suggest modulating gut barrier integrity and microbial translocation may affect PTB.

Isoniazid concentrations in hair and plasma area-under-the-curve exposure among children with tuberculosis

Post Date: 
2017-12-07
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PLOS One
PLOS One: Mave and colleagues compared TB drug exposure in plasma and hair samples among a small cohort of children.

Suboptimal anti-tuberculosis drug concentrations and outcomes in small and HIV coinfected children in India: recommendations for dose modifications

Post Date: 
2017-12-01
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Clinical Pharmacology and Therapeutics
This work aimed to evaluate the once-daily anti-tuberculosis treatment as recommended by the new Indian pediatric guidelines. Isoniazid, rifampin and pyrazinamide concentration-time profiles and treatment outcome were obtained from 161 Indian children with drug-sensitive tuberculosis undergoing...

Vitamin A and D deficiencies associated with incident tuberculosis in HIV-infected patients initiating antiretroviral therapy in multinational case-cohort study

Post Date: 
2017-07-01
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Journal of Acquired Immune Deficiency Syndromes
Introduction: Numerous micronutrients have immunomodulatory roles that may influence risk of tuberculosis (TB), but the association between baseline micronutrient deficiencies and incident TB after antiretroviral therapy (ART) initiation in HIV-infected individuals is not well characterized...

Isoniazid hair concentrations in children with tuberculosis: a proof of concept study

Post Date: 
2016-06-01
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International Journal of Tuberculosis and Lung Disease
Assessing treatment adherence and quantifying exposure to anti-tuberculosis drugs among children is challenging. We undertook a 'proof of concept' study to assess the drug concentrations of isoniazid (INH) in hair as a therapeutic drug monitoring tool. Children aged <12 years initiated on...

Cohort for Tuberculosis Research by the Indo-US Medical Partnership (C-TRIUMPH): protocol for a multicentric prospective observational study

Post Date: 
2016-02-25
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BMJ Open
Introduction: Tuberculosis disease (TB) remains an important global health threat. An evidence-based response, tailored to local disease epidemiology in high-burden countries, is key to controlling the global TB epidemic. Reliable surrogate biomarkers that predict key active disease and...

RePORT International: advancing tuberculosis biomarker research through global collaboration

Post Date: 
2015-10-15
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Clinical Infectious Diseases
Progress in tuberculosis clinical research is hampered by a lack of reliable biomarkers that predict progression from latent to active tuberculosis, and subsequent cure, relapse, or failure. Regional Prospective Observational Research for Tuberculosis (RePORT) International represents a consortium...

Pre-cART elevation of CRP and CD4+ T-cell immune activation associated with HIV clinical progression in a multinational case-cohort study

Post Date: 
2015-10-01
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Publication: 
Journal of Acquired Immune Deficiency Syndromes
Background: Despite the success of combination antiretroviral therapy (cART), a subset of HIV-infected patients who initiate cART develop early clinical progression to AIDS; therefore, some cART initiators are not fully benefitted by cART. Immune activation pre-cART may predict clinical progression...

TB Infection Among Household Contacts: Preventive Therapy for All?

Post Date: 
2018-02-21
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Dolla CK, Paradkar M, Gupte A, Thiruvenkadam K, Gupte N, Kulkarni A, Balasubranian U, Hanna LE, Dhanasekaran K, Bharadwaj R, Shivakumar SVBY, Gaikwad S, Meshram S, Kohli R, Lokhande R, Thomas B, Kinikar A, Swaminathan S, Mave V, Gupta A, Chandrasekaran P. TB Infection Among Household Contacts:...

Incidence of Mycobacterium tuberculosis Infection among Household Contacts of Adult Pulmonary Tuberculosis Cases in India

Post Date: 
2018-02-20
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Selvaraju S, Thiruvenkadam K, Paradkar M , Marinaik SB, Bharadwaj R, Rajagopalan S, Gaikwad S, Pattabiraman S, Kinikar A, Sivaramakrishnan GN, Meshram S, Hanna LE, Lokhande R, Dhanasekaran K, Gupte A, John S, Gupte N, Thomas B, Kukarni V, Ayyanu S, Kohli R, Shivakumar SVBY, Swaminathan S, Mave V,...

High Burden of Diabetes and Prediabetes among Adult Household Contacts of India

Post Date: 
2017-09-13
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Shivakumar SVBY , Chandrasekaran P, Kumar AJMV, Paradkar M, Dhanasekaran K, Suryavanshi N, Thomas B, Kohli R, Thiruvengadam K, Kulkarni V, Hannah LE, Sivaramakrishnan GN, Pradhan N, Dolla C, Gupte A, Ramachandran G, DeLuca A, Meshram S, Bhardawaj R, Bollinger RC, Golub J, Selvaraj K, Gupte N,...

CTRIUMPh Pediatric Biomarker Substudy

Post Date: 
2017-05-30
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Tornheim J . Paradkar M. CTRIUMPh Pediatric Biomarker Substudy. 2017 IMPAACT Annual Meeting. Washington, DC. 2017.

Host Factors Associated with Poor Respiratory Health-Related Quality of Life in Pulmonary Tuberculosis

Post Date: 
2017-02-03
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Gupte A , Meshram S, Selvaraju S, Gupte N, Shivakumar SVBY, Paradkar M, Kohli R, Theruvengadam K, Suryavanshi N, Chandrasekaran P, Mave V, Swaminathan S, Salvi S, Checkley, W, Golub J, Gupta A. Host Factors Associated with Poor Respiratory Health-Related Quality of Life in Pulmonary Tuberculosis...

Household Contact Tracing of Adult Pulmonary TB Patients in India: Prevalence of TB Disease and Infection

Post Date: 
2017-02-03
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Chandrasekaran P , Thiruvengadam K, Gupte N, Luck EH, Mave M, Gupte A, Gupta A, Swaminathan S. Household Contact Tracing of Adult Pulmonary TB Patients in India: Prevalence of TB Disease and Infection. 6th Annual Regional Prospective Observational Research for Tuberculosis (RePORT) India Joint...

Household Contact Tracing of Adult Pulmonary TB Patients in India: Prevalence of TB Disease and Infection

Post Date: 
2016-10-27
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Chandrasekaran P , Thiruvengadam K, Gupte N, Luck EH, Mave M, Gupte A, Gupta A, Swaminathan S. Household Contact Tracing of Adult Pulmonary TB Patients in India: Prevalence of TB Disease and Infection. ID Week 2016. New Orleans, LA. 2016.

Host Factors Associated with Poor Respiratory Health-Related Quality of Life in Pulmonary Tuberculosis

Post Date: 
2016-10-27
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Gupte A , Meshram S, Selvaraju S, Gupte N, Shivakumar SVBY, Paradkar M, Kohli R, Theruvengadam K, Suryavanshi N, Chandrasekaran P, Mave V, Swaminathan S, Salvi S, Checkley, W, Golub J, Gupta A. Host Factors Associated with Poor Respiratory Health-Related Quality of Life in Pulmonary Tuberculosis...

Sub-Therapeutic Concentrations of Anti-Tuberculosis Drugs in Children when Treated According to Indian Dosing Recommendation

Post Date: 
2016-10-24
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Guiastrennec B, Ramachandran G, Karlsson MO, Kumar H, Bhavani PK, Gangadevi NP, Swaminathan S, Gupta A, Dooley KE, Savic RM. Sub-Therapeutic Concentrations of Anti-Tuberculosis Drugs in Children when Treated According to Indian Dosing Recommendation. 9th Annual International Workshop on Clinical...

Host Factors Associated with Poor Respiratory Health-related Quality of Life in Pulmonary Tuberculosis

Post Date: 
2016-07-17
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Gupte A , Meshram S, Selvaraju S, Gupte N, Shivakumar SVBY, Paradkar M, Kohli R, Theruvengadam K, Suryavanshi N, Chandrasekaran P, Mave V, Swaminathan S, Salvi S, Checkley, W, Golub J, Gupta A. Host Factors Associated with Poor Respiratory Health-related Quality of Life in Pulmonary Tuberculosis...

Host Factors Associated with Poor Respiratory Health-Related Quality of Life in Pulmonary TB

Post Date: 
2016-06-21
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Gupte, A. Host Factors Associated with Poor Respiratory Health-Related Quality of Life in Pulmonary TB. 2016 Annual Meeting. Johns Hopkins Center for Tuberculosis Research. Baltimore, MD. 2016.

Therapeutic Drug Monitoring (TDM) of TB in Young Children: The Role of Hair Assays

Post Date: 
2015-06-17
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Mave, V. Therapeutic Drug Monitoring (TDM) of TB in Young Children: The Role of Hair Assays. IMPAACT Annual Meeting. Washington, DC.
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