25-Hydroxyvitamin D insufficiency and deficiency is associated with HIV disease progression and virological failure post-antiretroviral therapy initiation in diverse multinational settings

Post Date: 
2014-07-15
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Clinical Sites: 
Publication: 
The Journal of Infectious Diseases
Summary: 
Background: Low 25-hydroxyvitamin D (25(OH)D) has been associated with increased HIV mortality, but prospective studies assessing treatment outcomes after combination antiretroviral therapy (cART) initiation in resource-limited settings are lacking.
 
Methods: A case-cohort study (N = 411) was nested within a randomized cART trial of 1571 cART-naive adults in 8 resource-limited settings and the United States. The primary outcome (WHO stage 3/4 disease or death within 96 weeks of cART initiation) was met by 192 cases, and 152 and 29 cases met secondary outcomes of virologic and immunologic failure. We studied prevalence and risk factors for baseline low 25(OH)D (<32 ng/mL) and examined associated outcomes using proportional hazard models.
Citation: 
Havers F, Smeaton L, Gupte N, Detrick B, Bollinger RC, Hakim J, Kumarasamy N, Andrade A, Christian P, Lama JR, Campbell TB, Gupta A; ACTG PEARLS; NWCS 319 Study Teams. 25-Hydroxyvitamin D insufficiency and deficiency is associated with HIV disease progression and virological failure post-antiretroviral therapy initiation in diverse multinational settings. J Infect Dis. 2014 Jul 15;210(2):244-53. doi: 10.1093/infdis/jiu259. Epub 2014 May 5. PMID: 24799602
Collaborators: 
  • Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD
  • Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland HIV Clinical Trials Unit, B.J. Medical College, Pune, India
  • Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD
  • Department of Medicine, University of Zimbabwe, Harare, Zimbabwe
  • YRGCARE Medical Centre, Chennai, India
  • IMPACTA PERU Clinical Trials Unit, Asociacion Civil Impacta Salud y Educacion, Lima, Peru
  • Division of Infectious Diseases, University of Colorado Denver, Aurora, CO