Akshay Gupte, PhD, MBBS, MSPH

Role:

Scholar

Junior Investigator

Akshay Gupte, PhD, MBBS, MSPH

Akshay Gupte is a junior investigator trained in medicine, clinical research, and global health. He recently completed his doctoral training in the Department of International Health at the Johns Hopkins Bloomberg School of Public Health (JHSPH). His research interests include exploring approaches to host directed adjuvant therapies in tuberculosis (TB) and studying the impact of TB and HIV on lung health of populations.

Akshay is leading an Indo-US collaborative study aimed at exploring the impact of TB disease; alone and in combination with smoking, air pollution, HIV and diabetes mellitus; on respiratory impairment and risk of chronic obstructive pulmonary disease in India. He is also a co-investigator on the CTRIUMPH study—a multi-center cohort study aimed at addressing key knowledge gaps in the epidemiology of TB and informing effective preventive and treatment strategies—which is part of the RePORT-India consortium. Additionally, Akshay is a co-investigator on a multi-site study in India, Brazil, and South Africa evaluating molecular signatures of the TB and diabetes interaction.

Akshay is a 2017 Fogarty Fellow and a 2017 recipient of the Arthur M. Dannenberg, Jr., Award. He completed his medical training in India, received his MSPH and PhD degrees from Johns Hopkins Bloomberg School of Public Health, and has worked as a medical officer in rural and urban settings.

Faculty Mentor(s):

Bob Bollinger, MD, MPH

Jonathan Golub, MPH, PhD

Amita Gupta, MD, MHS

Vidya Mave, MD, MPH

Studies/Projects
Publications
Presentations
Scholars
News

Impact of Diabetes on TB Treatment Outcomes: Nested Study: Lipid Mediators of Inflammation in TB and TB-Diabetes

Post Date:

2017-10-02

Studies have shown that individuals with Tuberculosis (TB) and diabetes (TB-DM) have a distinct immune profile compared to individuals with TB alone. Individuals with TB-DM have higher inflammation, a higher bacillary load, increased Th1 immune responses and a defective neutrophil and macrophage...

TB and Pregnancy Impact of Immune Changes of HIV and Stages of Pregnancy on Tuberculosis: Nested Study on Investigating Maternal Antibodies to Modify Infant Tuberculosis Acquisition

Post Date:

2017-08-29

Country:

New study in Pune, India, aims to identify the profile of TB antibodies between mothers and infants, and to see if the presence of antibodies lowers risk of infant infection.

RePORT: C-TRIUMPH: Nested Study on Association of Lipid Mediators of Inflammation with TB Treatment Outcomes

Post Date:

2017-08-03

Country:

Purpose: Recent studies have shown the significant role that host lipids play in modulating immunity and disease outcomes. Prostaglandins and leukotrienes are lipids that have a pro-inflammatory role in the fight against infectious agents while Specialized Pro-resolving lipid Mediators (SPMs)...

RePORT: C-TRIUMPH: Substudy on Residual Respiratory Impairment Following Pulmonary Tuberculosis

Post Date:

2015-09-13

Country:

Many TB patients have residual respiratory impairment despite treatment. Such individuals may be at increased risk of chronic lung diseases and disability in the future. Using respiratory questionnaires and lung function tests, the Lung Health Sub-study will evaluate 400 adult TB patients enrolled...

RePORT: C-TRIUMPH: Cohort for Tuberculosis Research by the Indo-US Medical Partnership

Post Date:

2013-09-28

Country:

Collaboratively funded by the US NIH, India’s Department of Biotechnology [DBT], and Indian Council of Medical Research, the Cohort for TB Research by the Indo-US Medical Partnership (C-TRIUMPH) is an Indo-US research consortium that is part of RePORT India, a countrywide consortium for TB research...

BWI CTU: Baltimore-Washington-India Clinical Trials Unit

Post Date:

2007-02-02

Country:

Comprising clinical trial sites at Johns Hopkins Medicine in Baltimore, Whitman Walker Health in Washington, DC, and the BJGMC-CCGHE collaboration in Pune, India, the Baltimore-Washington-India Clinical Trials Unit (BWI-CTU) is one of only 25 international HIV/TB clinical trial sites funded by the...

Diabetes and pre-diabetes among household contacts of tuberculosis patients in India: is it time to screen them all?

Post Date:

2018-05-22

Publication:

The International Journal of Tuberculosis and Lung Disease

Country:

Authors find that screening contacts of TB patients for pre-DM/DM and linking them to care may mitigate the risk of developing tuberculosis and improve management of diabetes.

Prevalence of dysglycemia and clinical presentation of pulmonary tuberculosis in Western India

Post Date:

2017-12-01

Publication:

International Journal of Tuberculosis and Lung Disease

Country:

Objectives: To estimate the prevalence and risk factors of pre-diabetes mellitus (DM) and DM, and its associations with the clinical presentation of tuberculosis (TB). Design: Screening for DM was conducted among adults (age  18 years) with confirmed TB between December 2013 and January 2017. We...

Novel interferon-gamma assays for diagnosing tuberculosis in young children in India

Post Date:

2017-04-01

Publication:

International Journal of Tuberculosis and Lung Disease

Country:

Setting: The tuberculin skin test (TST) and interferon-gamma release assays (IGRAs) are used as supportive evidence to diagnose active tuberculosis (TB). Novel IGRAs could improve diagnosis, but data are lacking in young children. Design: Children (age 5 years or younger) with suspected TB were...

Cohort for Tuberculosis Research by the Indo-US Medical Partnership (C-TRIUMPH): protocol for a multicentric prospective observational study

Post Date:

2016-02-25

Publication:

BMJ Open

Country:

Introduction: Tuberculosis disease (TB) remains an important global health threat. An evidence-based response, tailored to local disease epidemiology in high-burden countries, is key to controlling the global TB epidemic. Reliable surrogate biomarkers that predict key active disease and latent TB...

Low Vitamin-D levels combined with PKP3-SIGIRR-TMEM16J host variants is strongly associated with tuberculosis and death in HIV-infected and -exposed infants

Post Date:

2016-02-12

Publication:

PLOS One

Country:

Background: This study examined the associations of 25-hydroxyvitamin D and specific host genetic variants that affect vitamin D levels or its effects on immune function, with the risk of TB or mortality in children. Methods: A case-cohort sample of 466 South African infants enrolled in P1041 trial...

Incidence of Tuberculosis Disease among Household Contacts of Adult Pulmonary TB Patients in India-A Multi Centric Cohort Study

Post Date:

2018-02-21

Presentation Location:

New Delhi, India

Country:

Event & Convener:

5th Global Forum on TB Vaccines

Presentation. Selvaraju S , Thiruvenkadam K, Paradkar M, Marinaik SB, Bharadwaj R, Rajagopalan S, Gaikwad S, Pattabiraman S, Kinikar A, Sivaramakrishnan GN, Meshram S, Hanna LE, Lokhande R, Dhanasekaran K, Gupte A, John S, Gupte N, Thomas B, Kukarni V, Ayyanu S, Kohli R, Shivakumar SVBY,...

Infection Free “Resistors” among Household Contacts of Culture-Confirmed Adult Pulmonary TB Cases

Post Date:

2018-02-21

Presentation Location:

New Delhi, India

Country:

Event & Convener:

5th Global Forum on TB Vaccines

Presentation. Mave V , Chandrasekaran P, Paradkar M, Gupte A, Pradhan N, Kannan GN, Shivakumar SVBY, Kulkarni V, Dhanasekaran K, Subramanyam B, Selvaraju S, Murali L, Bharadwaj R, Gaikwad S, Meshram S, Kinikar A, Hanna LE, Swaminathan S, Gupte N, Gupta A.

TB Infection Among Household Contacts: Preventive Therapy for All?

Post Date:

2018-02-21

Presentation Location:

New Delhi, India

Country:

Event & Convener:

5th Global Forum on TB Vaccines

Presentation. Dolla CK, Paradkar M, Gupte A, Thiruvenkadam K, Gupte N, Kulkarni A, Balasubranian U, Hanna LE, Dhanasekaran K, Bharadwaj R, Shivakumar SVBY, Gaikwad S, Meshram S, Kohli R, Lokhande R, Thomas B, Kinikar A, Swaminathan S, Mave V, Gupta A, Chandrasekaran P

Risk Factors Associated with Unfavorable Outcomes in a Cohort of Pulmonary TB Patients

Post Date:

2018-02-15

Presentation Location:

New Delhi, India

Country:

Event & Convener:

RePORT India Annual Meeting

Oral Presentation. Dhanasekaran K, Chandrasekaran P, Paradkar M, Marinaik SB, Gupte A, Dolla CK, Joseph B, Subramanyam B, Sivaramakrishnan GR, Thiruvengadam K, Gupte N, Rajagopal S, Pradhan N, Selvaraju S, Kulkarni V, Hannah LE, Nayakam R, Suryavanshi N, Shivakumar SVBY, Mave V, Thomas B, Bharadwaj...

Incidence of Mycobacterium tuberculosis Infection among Household Contacts of Adult Pulmonary Tuberculosis Cases in India

Post Date:

2018-02-15

Presentation Location:

New Delhi, India

Country:

Event & Convener:

CTRIUMPh Study Team, RePORT India Annual Meeting

Paradkar M, Dhanasekaran K, Kinikar A, Kulkarni R, Bharadwaj R, Gaikwad S, Lokhande R, Meshram S, Dolla CK, Selvaraju S, Murali L, Thiruvengadam K, Jain D, Rajagopal S, Kulkarni V, Pradhan N, John S, Kohli R, Nayagam R, Shivakumar SVBY, Suryavanshi N, Cox S, Gupte A, Chandrasekaran P, Mave V, Gupta...

Interleukin-6, Interleukin-13 and Interferon-γ as Potential Biomarkers for Treatment Failure in Pulmonary Tuberculosis

Post Date:

2018-02-15

Presentation Location:

New Delhi, India

Country:

Event & Convener:

RePORT India Annual Meeting

Gupte A, Andrade B, Kumar P, Selvaraju S, Lokhande R, Kulkarni V, Paradkar M, Kohli R, Thiru K, Shivakumar SVBY, Gupte N, Babu S, Golub J, Mave V, Chandrasekaran P, Gupta A.

Trends in Glycated Hemoglobin Levels and Implications for Diabetes Screening among Pulmonary Tuberculosis Cases Undergoing Treatment in India

Post Date:

2017-09-13

Presentation Location:

Rio de Janiero, Brazil

Country:

Event & Convener:

3rd Annual RePORT International Meeting, RICC

Poster Presentation. Gupte AN , Mave V, Meshram S, Lokhande R, Kadam D, Dharmshale S, Bharadwaj R, Kagal A, Pradhan N, Deshmukh S, Atre S, Sahasrabudhe T, Barthwal M, Meshram S, Kakrani A, Kulkarni V, Raskar S, Suryavanshi S, Shivakoti R, Chon S, Selvin E, Gupte N, Gupta A, Golub JE

High Burden of Diabetes and Prediabetes among Adult Household Contacts of India

Post Date:

2017-09-13

Presentation Location:

Rio De Janiero, Brazil

Country:

Event & Convener:

RePORT International Conference, RICC

Poster Presentation. Shivakumar SVBY , Chandrasekaran P, Kumar AJMV, Paradkar M, Dhanasekaran K, Suryavanshi N, Thomas B, Kohli R, Thiruvengadam K, Kulkarni V, Hannah LE, Sivaramakrishnan GN, Pradhan N, Dolla C, Gupte A, Ramachandran G, DeLuca A, Meshram S, Bhardawaj R, Bollinger RC, Golub J,...

Factors Associated with Pulmonary Impairment in HIV-infected South African Adults

Post Date:

2017-02-14

Presentation Location:

Seattle, Washington

Country:

Event & Convener:

CROI 2017

Poster Presentation. Gupte A , Wong M, Msandiwa R, Barnes G, Golub J, Chaisson R, Hoffmann C, Martinson N

Alcohol Use Among Adult Pulmonary and Extra-pulmonary TB Cases in the C-TRIUMPH India Cohort

Post Date:

2017-02-03

Presentation Location:

Hyderabad, India

Country:

Event & Convener:

6th Annual Regional Prospective Observational Research for Tuberculosis (RePORT) India Joint Leadership Meeting

Poster presentation. John S , DeLuca A, Paradkar M, Nayagam R, Shivakumar SVBY, Gupte A, Gupte N, Thomas B, Suryavanshi N, Kolhi R, Golub J, Kulkarni V, Pradhan N, Mave V, Chandrasekaran P, Gupta A

Host Factors Associated with Poor Respiratory Health-Related Quality of Life in Pulmonary Tuberculosis

Post Date:

2017-02-03

Presentation Location:

Hyderabad, India

Country:

Event & Convener:

6th Annual Regional Prospective Observational Research for Tuberculosis (RePORT) India Joint Leadership Meeting

Poster presentation. Gupte A , Meshram S, Selvaraju S, Gupte N, Shivakumar SVBY, Paradkar M, Kohli R, Theruvengadam K, Suryavanshi N, Chandrasekaran P, Mave V, Swaminathan S, Salvi S, Checkley, W, Golub J, Gupta A

Descriptive Baseline Characteristics, Treatment Outcomes and Biorepository of Pediatric TB Cases in CTRIUMPh-RePORT India Prospective Cohort

Post Date:

2017-02-03

Presentation Location:

Hyderabad, India

Country:

Event & Convener:

6th Annual Regional Prospective Observational Research for Tuberculosis (RePORT) India Joint Leadership Meeting

Poster presentation. Paradkar M , Kavitha D, Shiva Kumar SVBY, Khadse S, Khwaja S, Hari K, Rani N, Thiruvengadam K, Gupte N, Raskar S, Jain D, Suryavanshi S, Kohli R, Kulkarni V, Pradhan N, Sathyamurthi B, Tornheim J, Gupte A, DeLuca A, Mave V, Chandrasekaran P, Gupta A for the CTRIUMPH Study Team

Household Contact Tracing of Adult Pulmonary TB Patients in India: Prevalence of TB Disease and Infection

Post Date:

2017-02-03

Presentation Location:

Hyderabad, India

Country:

Event & Convener:

6th Annual Regional Prospective Observational Research for Tuberculosis (RePORT) India Joint Leadership Meeting

Poster presentation. Chandrasekaran P , Thiruvengadam K, Gupte N, Luck EH, Mave M, Gupte A, Gupta A, Swaminathan S

Household Contact Tracing of Adult Pulmonary TB Patients in India: Prevalence of TB Disease and Infection

Post Date:

2016-10-27

Presentation Location:

New Orleans, LA

Country:

Event & Convener:

ID Week 2016

Poster Abstract Session: Tuberculosis Epidemiology and Diagnosis. Chandrasekaran P , Thiruvengadam K, Gupte N, Luck EH, Mave M, Gupte A, Gupta A, Swaminathan S

Host Factors Associated with Poor Respiratory Health-Related Quality of Life in Pulmonary Tuberculosis

Post Date:

2016-10-27

Presentation Location:

New Orleans, LA

Country:

Event & Convener:

ID Week 2016

Poster Abstract Session: Tuberculosis Treatment and Outcome. Gupte A , Meshram S, Selvaraju S, Gupte N, Shivakumar SVBY, Paradkar M, Kohli R, Theruvengadam K, Suryavanshi N, Chandrasekaran P, Mave V, Swaminathan S, Salvi S, Checkley, W, Golub J, Gupta A

TB Infection Prevalence, Incidence and Risk Factors among Child and Adult Household Contacts of Adult TB Cases in India

Post Date:

2016-10-27

Presentation Location:

New Orleans, LA

Country:

Event & Convener:

ID Week 2016

Poster presentation. Shivakumar SVBY , Chandrasekaran P, Thiruvengadam K, Gupte N, Mave V, Hannah LE, Kulkarni V, Gupte A, Deluca A, Gomathy NS, Sathyamurthi P, Paradkar M, Kohli R, Meshram S, Kagal A, Suryavanshi N, Ramachandran G, Thomas B, Dolla CK, Subramanyam B, Golub J, Swaminathan S, Gupta A.

Host Factors Associated with Poor Respiratory Health-related Quality of Life in Pulmonary Tuberculosis

Post Date:

2016-07-17

Presentation Location:

Durban, South Africa

Event & Convener:

21st Annual International AIDS Conference (AIDS 2016)

RePORT International Oral Abstract Presentation. Gupte A , Meshram S, Selvaraju S, Gupte N, Shivakumar SVBY, Paradkar M, Kohli R, Theruvengadam K, Suryavanshi N, Chandrasekaran P, Mave V, Swaminathan S, Salvi S, Checkley, W, Golub J, Gupta A

Host Factors Associated with Poor Respiratory Health-Related Quality of Life in Pulmonary TB

Post Date:

2016-06-21

Presentation Location:

Baltimore, MD

Event & Convener:

2016 Annual Meeting. Johns Hopkins Center for Tuberculosis Research

Presentation

Abhilash Suresh

Baltimore, Maryland

Abhilash Suresh is a BS candidate in biomedical engineering at Johns Hopkins Whiting School of Engineering (2018), who worked with Drs. Akshay Gupte and Shri Vijay Bala Yogendra Shivakumar on the C-TRIUMPH substudy on Residual Respiratory Impairment Following Pulmonary Tuberculosis. During May and June 2016 he conducted a field placement in Chennai, India, at the National Institute for Research in Tuberculosis where he worked under Dr. Shivakumar. Awards 2016 Global Health Established Field Placement Grant From Mr. Suresh's Field Report: This placement opened my eyes to how healthcare works...

Celebrating Johns Hopkins Medicine's impact in India

Post Date:

2017-12-13

Source:

The Campaign for Johns Hopkins Medicine

In 4 years, the CCGHE has tripled its capacity for conducting research on grave health threats, thanks to strong philanthropic support.

Amita Gupta and colleagues discuss female leadership in academic global health

Post Date:

2017-05-04

Drs. Gupta, Manabe, Mathad discuss need for more women in global health leadership at CUGH's annual meeting.

Advancing Global TB Research through RePORT

Post Date:

2016-02-29

Regional Prospective Observational Research for Tuberculosis (RePORT) International is a large, international tuberculosis research effort being undertaken by 4 regional consortia: RePORT Brazil, RePORT South Africa, RePORT Indonesia, and RePORT India. While each region collects and maintains its...