Antiretroviral regimens for patients with HIV who fail first-line antiretroviral therapy

Post Date: 
2010-06-16
Publication: 
Cochrane Database of Systematic Reviews
Summary: 

Background: Highly active antiretroviral therapy has reduced the morbidity and mortality of patients with HIV/AIDS. A common first-line ART regimen in low-resource settings includes a non-nucleoside reverse transcriptase inhibitor (NNRTI) and two nucleoside reverse transcriptase inhibitors (NRTIs). If treatment failure occurs, a change to second-line therapy is necessary.


 


Objectives: This systematic review aimed to assess the optimum antiretroviral regimen for patients with HIV who fail first-line therapy (ART-naive) with a recommended World Health Organization (WHO) first-line regimen.

Citation: 
Humphreys EH, Chang LW, Harris J. Antiretroviral regimens for patients with HIV who fail first-line antiretroviral therapy. Cochrane Database Syst Rev. 2010 June 16(6):CD006517. doi: 10.1002/14651858.CD006517.pub3.
Collaborators: 


Global Health Sciences, University of California, San Francisco, CA