- Our Work
- Get Involved
Dengue and chikungunya co-infection associated with more severe clinical disease than mono-infection
International Journal of Healthcare and Biomedical Research
Background: Dengue and chikungunya infections appear to be increasing in India. While Aedies aegypti is the transmitting vector for both viruses and co-infection occurs in the same communities, studies on the clinical significance of co-infection are limited.
Materials and Methods: We conducted a retrospective case-control analysis of consecutive hospitalized patients presenting with febrile illness to the Sassoon General Hospital/BJ Medical College in Pune, India, who were screened for serologic evidence of dengue and chikungunya infection. Fischer’s Exact test and Mann-Whitney test were used to compare mortality and morbidity between patients with dual and mono-infection. Morbidity outcomes included lowest blood pressure (in first 5 days of admission), requirement for intensive care and mechanical ventilation, blood product transfusion requirement, as well as complete blood count.
Gandhi BS, Kulkarni K, Godbole M, Dole SS, Kapur S, Satpathy P, Khatri AM, Deshpande PS, Azad F, Gupte N, Bharadwaj R, Bollinger RC, Gupta A. Dengue and chikungunya co-infection associated with more severe clinical disease than mono-infection. International J. of Healthcare and Biomedical Research. 2015 Apr;3(3).