Determinants of default from tuberculosis treatment among patients with drug-susceptible tuberculosis in Karachi, Pakistan: a mixed methods study

Post Date: 
2015-11-12
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Countries: 
Publication: 
PLOS One
Summary: 

Purpose: Non-adherence to tuberculosis therapy can lead to drug resistance, prolonged infectiousness, and death; therefore, understanding what causes treatment default is important. Pakistan has one of the highest burdens of tuberculosis in the world, yet there have been no qualitative studies in Pakistan that have specifically examined why default occurs. We conducted a mixed methods study at a tuberculosis clinic in Karachi to understand why patients with drug-susceptible tuberculosis default from treatment, and to identify factors associated with default. Patients attending this clinic pick up medications weekly and undergo family-supported directly observed therapy.

Citation: 
Chida N, Ansari Z, Hussain H, Jaswal M, Symes S, Khan AJ, Mohammed S. Determinants of default from tuberculosis treatment among patients with drug-susceptible tuberculosis in Karachi, Pakistan: a mixed methods study. PLOS One. 2015 Nov 12.
Collaborators: 

Jay Weiss Institute for Health Equity, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL


Interactive Research and Development, Karachi, Sindh, Pakistan.


Indus Hospital Research Center, Indus Hospital, Karachi, Sindh, Pakistan.