Guidelines for improving entry into and retention in care and antiretroviral adherence for persons with HIV: evidence-based recommendations from an International Association of Physicians in AIDS Care panel

Post Date: 
2012-06-05
Publication: 
Annals of Internal Medicine
Summary: 
Description: After HIV diagnosis, timely entry into HIV medical care and retention in that care are essential to the provision of effective antiretroviral therapy (ART). ART adherence is among the key determinants of successful HIV treatment outcome and is essential to minimize the emergence of drug resistance. The International Association of Physicians in AIDS Care convened a panel to develop evidence-based recommendations to optimize entry into and retention in care and ART adherence for people with HIV.
 
Methods: A systematic literature search was conducted to produce an evidence base restricted to randomized, controlled trials and observational studies with comparators that had at least 1 measured biological or behavioral end point. A total of 325 studies met the criteria. Two reviewers independently extracted and coded data from each study using a standardized data extraction form. Panel members drafted recommendations based on the body of evidence for each method or intervention and then graded the overall quality of the body of evidence and the strength for each recommendation.
Citation: 
Thompson MA, Mugavero MJ, Amico KR, Cargill VA, Chang LW, Gross R, Orrell C, Altice FL, Bangsberg DR, Bartlett JG, Beckwith CG, Dowshen N, Gordon CM, Horn T, Kumar P, Scott JD, Stirratt MJ, Remien RH, Simoni JM, Nachega JB. Guidelines for improving entry into and retention in care and antiretroviral adherence for persons with HIV: evidence-based recommendations from an International Association of Physicians in AIDS Care panel. Ann Intern Med. 2012 Jun 5;156(11):817-33. doi: 10.7326/0003-4819-156-11-201206050-00419.
Collaborators: 
AIDS Research Consortium of Atlanta, Atlanta, GA
University of Alabama, Birmingham, AL
University of Connecticut, Storrs, CT
NIH/NIMH, Bethesda, MD
Johns Hopkins University/Stellenbosch University, Baltimore, MD
University of Pennsylvania and The Children's Hospital of Philadelphia, Philadelphia, PA
University of Cape Town, Cape Town, South Africa
Yale University, New Haven, CT
Harvard Medical School, Cambridge, MA
Warren Alpert Medical School of Brown University and The Miriam Hospital, Providence, RI
AIDSmeds.com and Columbia University, New York, NY
Georgetown University, Washington, DC
Western University of Health Sciences, Pomona, CA
University of Washington, Seattle, WA