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Healthcare-Associated Sepsis in the Neonatal Intensive Care Unit in Pune, India
This study is part of CDC's Safe Healthcare, Epidemiology, and Prevention Research Development (SHEPheRD) Program under Domain 7: International HAI and Other Adverse Healthcare Event Prevention. Johns Hopkins neonatologist Dr. Julia Johnson is lead investigator for a systematic study of the epidemiology of neonatal sepsis in the Neonatal Intensive Care Unit in tertiary care facilities in India. The Principal Investigators for this study are pediatric infectious disease specialist Aaron Milstone, MD, MPH; and infectious disease specialists Amita Gupta, MD, MHS, and Yuka Manabe, MD.
This study is providing important baseline data to serve as the basis for future interventional studies to reduce the incidence of sepsis. It will also help inform antibiotic selection in neonates in whom sepsis is suspected by providing a systematic analysis of the epidemiology of sepsis, including antimicrobial resistance patterns. Additionally, it will be used to help guide local infection control guidelines.
To describe the incidence of bacterial culture-confirmed sepsis in neonates admitted to the Neonatal Intensive Care Unit
To ascertain risk factors for neonatal sepsis among neonates admitted to the Neonatal Intensive Care Unit
To describe patterns of antimicrobial resistance for pathogens isolated in neonates with sepsis