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HIV transmitted drug resistance in adult and pediatric populations in Panama
Revista Panamerica de Salud Publica--Pan American Journal of Public Health
Objective: To investigate the prevalence of transmitted drug-resistant HIV among adults in Panama by using a modified World Health Organization Threshold Survey (WHO-TS) and to investigate rates of initial resistance among HIV-positive infants in Panama.
Methods: At the Gorgas Memorial Institute, 47 HIV-positive adults were genotyped for mutations associated with transmitted drug resistance(TDR) in the reverse transcriptase and protease genes of HIV-1, according to WHO-TS guidelines, modified to include patients ≤ 26 years old. Prevalence rates for drug-resistance mutations against three classes of antiretroviral drugs-nucleoside analog reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs), and protease inhibitors-were calculated as low (< 5.0%), moderate (5.0%-15.0%), and high (> 15.0%). Twenty-five infant patients were also geno-typed and prevalence rates for drug-resistance mutations were calculated.
Castillo J, Arteaga G, Mendoza Y, Martínez AA, Samaniego R, Estripeaut D, Page KR, Smith RE, Sosa N, Pascale JM. HIV Transmitted drug resistance in adult and pediatric populations in Panama. Rev Panam Salud Publica (6). 2011 Dec;30(6):649-56