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Impact of maternal HIV co-infection on the vertical transmission of Hepatitis C virus: a meta-analysis.
Clinical Infectious Diseases
Background: Observational studies suggest that maternal human immunodeficiency virus (HIV)-hepatitis C virus (HCV) coinfection is associated with increased odds of vertical HCV transmission. We performed a meta-analysis to summarize current evidence.
Methods: We systematically searched for relevant articles published during the period from January 1992 through July 2006 and independently abstracted articles that met our inclusion criteria. Under a random effects model, we calculated the pooled odds ratio for vertical HCV transmission according to maternal HIV-HCV coinfection status and performed sensitivity analyses.
Polis C, Shah S, Johnson K, Gupta A. Impact of maternal HIV co-infection on the vertical transmission of Hepatitis C virus: a meta-analysis. Clin Infect Dis. 2007 Apr 15; 44(8) 1123-31. doi: 10.1086/512815.