Impact of patient-selected care buddies on adherence to HIV care, disease progression and conduct of daily life among pre-antiretroviral HIV-infected patients in Rakai, Uganda: a randomized controlled trial

Post Date: 
2015-06-01
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Countries: 
Publication: 
Journal of Acquired Immune Deficiency Syndromes
Summary: 
Background: Data are limited on effects of household or community support persons ("care buddies") on enrollment into and adherence to pre-antiretroviral HIV care. We assessed the impact of care buddies on adherence to HIV clinic appointments, HIV progression, and conduct of daily life among pre-antiretroviral therapy (pre-ART) HIV-infected individuals in Rakai, Uganda.
 
Methods: A total of 1209 HIV-infected pre-ART patients aged ≥15 years were randomized to standard of care (SOC) (n = 604) or patient-selected care buddy (PSCB) (n = 605) and followed at 6 and 12 months. Outcomes were adherence to clinic visits, HIV disease progression, and self-reported conduct of daily life. Incidence and prevalence rate ratios and 95% confidence intervals (CIs) were used to assess outcomes in the intent-to-treat and as-treated analyses.
Citation: 
Nakigozi G, Makumbi FE, Bwanika JB, Atuyambe L, Reynolds SJ, Kigozi G, Nalugoda F, Chang LW, Kiggundu V, Serwadda D, Wawer MJ, Gray RH, Kamya MR. Impact of patient-selected care buddies on adherence to HIV care, disease progression and conduct of daily life among pre-antiretroviral HIV-infected patients in Rakai, Uganda: a randomized controlled trial. J Acquir Immune Defic Syndr. 2015;Jun 1.
Collaborators: 
  • Rakai Health Sciences Program, Kalisizo, Uganda
  • School of Public Health, Makerere University College of Health Sciences, Kampala, Uganda
  • NIH/NIAID, Bethesda, MD
  • Johns Hopkins Bloomberg School of Public Health, Baltimore, MD
  • Makerere University College of Health Sciences, Kampala, Uganda