Isoniazid hair concentrations in children with tuberculosis: a proof of concept study

Post Date: 
2016-06-01
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Publication: 
International Journal of Tuberculosis and Lung Disease
Summary: 

Assessing treatment adherence and quantifying exposure to anti-tuberculosis drugs among children is challenging. We undertook a 'proof of concept' study to assess the drug concentrations of isoniazid (INH) in hair as a therapeutic drug monitoring tool. Children aged <12 years initiated on a thrice-weekly treatment regimen including INH (10 mg/kg) for newly diagnosed tuberculosis were enrolled. INH concentrations in hair were measured using liquid chromatography-tandem mass spectrometry at 1, 2, 4 and 6 months after initiating anti-tuberculosis treatment. We found that INH hair concentrations in all children on thrice-weekly INH were detectable and displayed variability across a dynamic range.

Citation: 
Mave V, Chandanwale A, Kinikar A, Khadse S, Kagal A, Gupte N, Suryavanshi N, Nimkar S, Koli H, Khwaja S, Bharadwaj R, Joshi S, Horng H, Benet LZ, Ramachandran G, Dooley KE, Gupta A, Gandhi M. Isoniazid hair concentrations in children with tuberculosis: a proof of concept study. International Journal of Tuberculosis and Lung Disease. 2016 Jun;20(6):844-7. doi: 10.5588/ijtld.15.0882
Collaborators: 

BJGMC, Pune, India


NIRT, Pune, India


University of California, San Francisco, CA


National Institute of Research in Tuberculosis, Chennai, India