Maternal pneumococcal capsular IgG antibodies and transplacental transfer are lower in South Asian HIV-infected mother-infant pairs

Post Date: 
2014-03-14
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Publication: 
Vaccine
Summary: 

Background: Our understanding of the mother-to-child transfer of serotype-specific pneumococcal antibodies is limited in non-immunized, HIV-positive women.



 



Methods: We compared geometric mean antibody concentrations (GMCs), geometric mean transplacental cord:maternal ratios (GMRs) and proportions of samples with protective antibody concentration (≥0.35μg/ml) to serotypes 1, 4, 5, 6B, 9V, 14, 18C, 19F, 23F between 74 HIV-infected and 98 HIV-uninfected mother-infant pairs who had not received pneumococcal immunization in South Asia. Multivariable analysis was performed to assess the influence of HIV on protective antibody concentrations.

Citation: 
Gupta A, Mathad JS, Yang W-T, Singh HK, Gupte N, Mave V, Bharadwaj R, Zaman K, Roy E, Bollinger RC, Bhosale R, Steinhoff MC, for the SWEN India Study Team. Maternal pneumococcal capsular IgG antibodies and transplacental transfer are lower in South Asian HIV-infected mother-infant pairs. Vaccine. 2014;32(13):1466-72. PMID: 24486350; PMC3975143.
Collaborators: 


  • Johns Hopkins Bloomberg School of Public Health, Baltimore, MD

  • BJGMC, Pune, India

  • Weill Cornell Medical College, New York, NY

  • International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh

  • Cincinnati Children's Hospital, Cincinnati, OH