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Presence of Human Hepegivirus-1 in a Cohort of People Who Inject Drugs

ID Fellow Matt Robinson and colleagues looked at sensitivity and accuracy of next-generation metagenomic sequencing in plasma virome of HIV-HCV positive IV drug users.

Background:
Next-generation metagenomic sequencing (NGMS) has opened new frontiers in microbial discovery but has been clinically characterized in only a few settings.

Objective:
To explore the plasma virome of persons who inject drugs and to characterize the sensitivity and accuracy of NGMS compared with quantitative clinical standards.

Design:
Longitudinal and cross-sectional studies.

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