Quantitative IFN-y,IL-2 response and latent tuberculosis test discordance in HIV-infected pregnant women

Post Date: 
2016-06-15
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Publication: 
American Journal of Respiratory and Critical Care Medicine
Summary: 
Rationale: Pregnant women with latent tuberculosis infection (LTBI) are at high risk for development of TB, especially if infected with HIV.
 
Objectives: To assess the performance of LTBI tests in pregnant and postpartum women infected with HIV, investigate the immunology behind discordance in pregnancy, and explore the implications for the development of postpartum TB.>
 
Methods: We screened pregnant women in their second/third trimester and at delivery for LTBI using the tuberculin skin test (TST) and IFN-γ release assay (IGRA) (QuantiFERON Gold). A subset of antepartum women had longitudinal testing, with repeat testing at delivery and postpartum and additional cytokines measured from the IGRA supernatant. The kappa statistic and Wilcoxon rank sum test were used to determine agreement and comparison of cytokine concentrations, respectively.
Citation: 
Mathad J, Bhosale R, Balasubramanian U, Kanade S, Mave V, Suryavanshi N, Gupte N, Joshi S, Chandanwale A, Dupnik K, Kulkarni V, Deshpande P, Fitzgerald D, Gupta A. Quantitative IFN-γ,IL-2 response and latent tuberculosis test discordance in HIV-infected pregnant women. Am J Respir Crit Care Med. 2016 Jun 15;193(12):1421-8. doi: 10.1164/rccm.201508-1595OC.
Collaborators: 
  • Weill Cornell Medical College, New York, NY
  • Byramjee Jeejeebhoy Government Medical College/Sassoon General Hospital, Pune, India
  • Byramjee Jeejeebhoy Government Medical College-Johns Hopkins Clinical Trials Unit, Pune, India