Sandesh Patil, MBBS, DGO, MPH

Pune, India

Role:

Staff

Clinical Coordinator

Dr. Sandesh Patil is a Clinical Coordinator with John Hopkins Center for Clinical Global Health Education (CCGHE) and the BJGMC-CRS, based in Pune, India. He has more than 12 years of experience in clinical research and has worked in different capacities including as Research Officer and Study Clinician in NIH-funded ACTG and IMPAACT network clinical trials.

He was actively involved in the SWEN India trial which helped WHO to reform PMTCT guidelines among breastfed infants. He has a post graduate degree in Obstetrics and Gynecology and has pursued Clinical Research as a career and interest. He has more than 10 publications and presentations on women’s health related topics. He has served as a member of Women’s Health Internetwork Scientific Committee for the 4 years. In addition, he has >10 years of experience in collaborating with different NGOs, different departments, Community health facilities, Institutes and Medical colleges where women’s health issues are discussed to prioritize the clinical research agenda.

Studies/Projects
Publications
Presentations
News

Vaginal Microbiota in HIV Infected and Uninfected Pregnant Women (Stand Alone)

Post Date:

2018-10-16

Countries:

India

Clinical Sites:

BJGMC

NIRT

Amita Gupta, MD, MHS, and Shilpa Naik, MD, are PIs for this study; Rupak Shivakoti, PhD, MSPH, is Co-Investigator The makeup of vaginal microbiota is dynamic and may play a role in the birth outcomes of pregnant women. While HIV and pregnancy both uniquely impact vaginal microbiota, the impact of...

Vaginal Microbiota in HIV Infected Pregnant Women

Post Date:

2017-07-14

Countries:

India

Clinical Sites:

BJGMC

This study is conducted under CCGHE’s PRACHITI (PRegnancy And CHanges In TuberculosIs) effort, supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development at the U.S. National Institutes of Health. Led by Dr. Rupak Shivakoti, this is a nested cross-sectional...

A5332: Randomized Trial to Prevent Vascular Events in HIV – REPRIEVE

Post Date:

2017-06-09

Countries:

India

Clinical Sites:

BJGMC

This study is conducted under the AIDS Clinical Trials Group (ACTG) and funded by the U.S. National Institutes of Health. This is a prospective, double-blind, randomized, placebo-controlled, multicenter efficacy study in 6500 subjects, with individual subjects to be followed for up to 72 months...

TB and Pregnancy Impact of Immune Changes of HIV and Stages of Pregnancy on Tuberculosis: Nested Study on Temporal Dynamics of Gut Microbiota in HIV Infected Pregnant Women

Post Date:

2016-07-05

Countries:

India

Clinical Sites:

BJGMC

NIRT

This is a nested prospective longitudinal cohort study of 35 HIV-infected and 35 HIV-noninfected pregnant women who are part of the parent study “Impact of Immune Changes of HIV and Stages of Pregnancy on Tuberculosis." The objectives are to: Determine the association of gestational age with...

P1077BF: Breastfeeding Version of the PROMISE Study (Promoting Maternal and Infant Survival Everywhere)

Post Date:

2010-02-02

Countries:

India

This trial was terminated November 6, 2019. This multi-country trial is being conducted in India, Malawi, South Africa, Tanzania, Uganda, Zambia, and Zimbabwe, conducted under the International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) Network and funded by the U.S. National...

BWI CTU: Baltimore-Washington-India Clinical Trials Unit

Post Date:

2007-02-02

Countries:

India

United States

Clinical Sites:

BJGMC

Comprising clinical trial sites at Johns Hopkins Medicine in Baltimore, Whitman Walker Health in Washington, DC, and the BJGMC-CCGHE collaboration in Pune, India, the Baltimore-Washington-India Clinical Trials Unit (BWI-CTU) is one of only 25 international HIV/TB clinical trial sites funded by the...

A5207: Maintaining Options for Mothers Study (MOMS): A Phase II Randomized Comparison of Three Antiretroviral Strategies Administered for 7 or 21 Days to Reduce the Emergence of Nevirapine Resistant HIV-1 Following a Single Intrapartum Dose of Nevirapine

Post Date:

2004-12-20

Countries:

This study was terminated January 16, 2014; it was conducted under the AIDS Clinical Trials Group (ACTG) and funded by the U.S. National Institutes of Health. A major disadvantage of giving SD NVP is the potential for maternal development of NVP resistance and additional resistance to other...

Elevated highly sensitive C-reactive protein and d-dimer levels are associated with food insecurity among people living with HIV in Pune, India

Post Date:

2019-03-04

Countries:

India

Clinical Sites:

BJGMC

Publication:

Public Health Nutrition

Abstract OBJECTIVE: To assess the prevalence and determinants of food insecurity among people living with HIV (PLWH) in Pune, India and its association with biomarkers known to confer increased risks of morbidity and mortality in this population. DESIGN: Cross-sectional analysis assessing food...

Prevention of HIV-1 transmission through breastfeeding:efficacy of safety of maternal antiretroviral therapy versus infant nevirapine prophylaxis for duration of breastfeeding in HIV-1-infected women with high CD4 cell count (IMPAACT PROMISE)

Post Date:

2018-04-01

Countries:

India

Clinical Sites:

BJGMC

Publication:

Journal of Acquired Immune Deficiency Syndromes

BACKGROUND: No randomized trial has directly compared the efficacy of prolonged infant antiretroviral prophylaxis versus maternal antiretroviral therapy (mART) for prevention of mother-to-child transmission throughout the breastfeeding period. SETTING: Fourteen sites in Sub-Saharan Africa and India...

Intestinal barrier dysfunction and microbial translocation in HIV-infected pregnant women is associated with preterm birth

Post Date:

2018-03-24

Countries:

India

Clinical Sites:

BJGMC

NIRT

Publication:

Clinical Infectious Diseases

Our results show select immune markers can identify women at higher risk for PTB in HIV-1-infected populations and suggest modulating gut barrier integrity and microbial translocation may affect PTB.

Cardiovascular risk in an HIV-infected population in India

Post Date:

2017-07-03

Countries:

India

Clinical Sites:

BJGMC

Publication:

Heart Asia

Findings: HIV+ Indian patients who had cardiovascular disease at a younger age appear to be at imminent risk for morbidity.

Maternal syphilis: An independent risk factor for mother to infant human immunodeficiency virus transmission

Post Date:

2017-06-15

Countries:

India

Clinical Sites:

BJGMC

Publication:

Sexually Transmitted Diseases

Abstract Syphilis is associated with increased human immunodeficiency virus acquisition and sexual transmission; we examined impact on human immunodeficiency virus mother-to-child transmission among mother-infant pairs enrolled in the India Six-Week Extended-Dose Nevirapine study. Maternal syphilis...

High prevalence of cryptococcal antigenaemia amongst asymptomatic advanced HIV patients in Pune, India

Post Date:

2017-03-21

Countries:

India

Clinical Sites:

BJGMC

Publication:

Indian Journal of Medical Microbiology

Methods : A prospective study was conducted in a large public sector ART centre and the inpatient wards of Sassoon Hospital, Pune, India. All consenting patients> 18 years of age with CD4 count <100 cells/mm3 were screened for CrAg by latex agglutination assay. Those with positive CrAg...

Efficacy of six-week extended-dose nevirapine varies by infant birth weight with greatest relative efficacy in low birth weight infants

Post Date:

2016-09-30

Countries:

India

Clinical Sites:

BJGMC

Publication:

PLOS One

Low birth weight (LBW), defined by the World Health Organization (WHO) as birth weight less than 2500 g, is a significant public health issue in resource-limited settings, particularly in Sub Saharan Africa and South Asia where the estimated annual incidence is 14% and 28–31%, respectively,...

Soluble CD14: An independent biomarker for risk of HIV mother-to-child transmission in setting of pre- and post-exposure antiretroviral prophylaxis

Post Date:

2015-10-06

Countries:

Clinical Sites:

Publication:

The Journal of Infectious Diseases

Elevated soluble CD14 (sCD14) concentrations, a marker of monocyte activation, predicts adverse outcomes in human immunodeficiency virus (HIV)-infected adults. To examine the association of sCD14 concentrations with the risk of mother-to-child transmission (MTCT) of HIV, we nested a case-control...

Impact of maternal hepatitis B virus coinfection on mother-to-child transmission of HIV

Post Date:

2014-07-15

Countries:

India

Clinical Sites:

BJGMC

Publication:

HIV Medicine

Objectives: Despite high hepatitis B virus (HBV) endemicity in various resource-limited settings (RLSs), the impact of maternal HIV/HBV coinfection on infant health outcomes has not been defined. We aimed to assess the prevalence of HBV coinfection among HIV-infected pregnant women and its impact...

Vitamin D deficiency is common among HIV-infected breastfeeding mothers in Pune, India, but not associated with mother-to-child HIV transmission

Post Date:

2012-10-01

Countries:

India

Clinical Sites:

BJGMC

Publication:

HIV Clinical Trials

A recent report from Tanzania demonstrated an increased risk of being HIV infected or of dying at birth among children born to breastfeeding mothers with low baseline vitamin D levels. We conducted a nested case-control study among HIV-infected pregnant women in western India to confirm the...

Authors’ response to Hanrahan et al CID article

Post Date:

2012-05-15

Countries:

India

Clinical Sites:

BJGMC

Publication:

Clinical Infectious Diseases

Reply to letter

Impact of maternal human immunodeficiency virus infection on pregnancy and birth outcomes in Pune, India

Post Date:

2011-12-15

Countries:

India

Clinical Sites:

BJGMC

Publication:

AIDS Care

Little is known about birth outcomes for HIV-infected women in India. We examine maternal and neonatal birth outcomes in HIV-infected women within the context of enhanced pre-natal care associated with a randomized clinical trial conducted in Pune, India. Birth outcomes of 212 HIV-infected pregnant...

Symptom screening among HIV-infected pregnant women is acceptable and has high negative predictive value for active tuberculosis

Post Date:

2011-11-15

Countries:

India

Clinical Sites:

BJGMC

Publication:

Clinical Infectious Diseases

Symptom screening is a recommended component of intensified case-finding (ICF) for pulmonary tuberculosis (TB) among HIV-infected individuals. Symptomatic individuals are further investigated to either exclude or diagnose pulmonary TB, thus reducing the number of individuals requiring costly...

Maternal tuberculosis: a risk factor for mother-to-child transmission of human immunodeficiency virus

Post Date:

2011-02-01

Countries:

India

Clinical Sites:

BJGMC

Publication:

The Journal of Infectious Diseases

Background: Maternal human immunodeficiency virus (HIV) RNA load, CD4 cell count, breast-feeding, antiretroviral use, and malaria are well-established factors associated with mother-to-child transmission (MTCT) of HIV; the role of maternal tuberculosis (TB), however, has not been well established...

Nevirapine resistance and breast-milk HIV transmission: effects of single and extended-dose nevirapine prophylaxis in subtype C HIV-infected infants

Post Date:

2009-01-01

Countries:

India

Clinical Sites:

BJGMC

Publication:

PLOS One

Background: Daily nevirapine (NVP) prophylaxis to HIV-exposed infants significantly reduces breast-milk HIV transmission. We assessed NVP-resistance in Indian infants enrolled in the “six-week extended-dose nevirapine” (SWEN) trial who received single-dose NVP (SD-NVP) or SWEN for prevention of...

Post-partum TB incidence and mortality among HIV-infected women and their infants in Pune, India 2002-2005

Post Date:

2007-07-15

Countries:

India

Clinical Sites:

BJGMC

Publication:

Clinical Infectious Diseases

Background: In contrast with many other countries, isoniazid preventative therapy is not recommended in clinical care guidelines for human immunodeficiency virus (HIV)-infected persons with latent tuberculosis (TB) in India. Methods: Seven hundred fifteen HIV-infected mothers and their infants were...

Association of Maternal Viral Load and CD4 Count with Perinatal HIV-1 Transmission Risk during Breastfeeding in the PROMISE Postpartum Component

Post Date:

2018-07-26

Countries:

India

Clinical Sites:

BJGMC

Flynn P, Taha T, Cababasay M, Butler K, Fowler MG, Mofenson L, Owor M, Fiscus S, Stranix-Chibanda L, Coutsoudis A, Gnanshanmugam D, Chakhtoura N, McCarthy K, Mukuzunga C, Makanani B, Moodley D, Nematadzira T, Kusakara B, Patil S, Vhembo T, Bobat R, Mmbaga B, Masenya M, Nyati M, Theron G, Mulenga H...

Role of Maternal Viral Load and CD4 Count on Perinatal HIV-1 Transmission during Breastfeeding in the PROMISE Postpartum Component

Post Date:

2018-07-20

Clinical Sites:

BJGMC

Flynn P, Taha T, Cababasay M, Butler K, Fowler MG, Mofenson L, Owor M, Fiscus S, Stranix-Chibanda L, Coutsoudis A, Gnanshanmugam D, Chakhtoura N, McCarthy K, Mukuzunga C, Makanani B, Moodley D, Nematadzira T, Kusakara B, Patil S , Vhembo T, Bobat R, Mmbaga B, Masenya M, Nyati M, Theron G, Mulenga H...

Inflammation in HIV-Infected Pregnant Women is Associated with Pre-term Birth

Post Date:

2018-03-07

Countries:

India

Clinical Sites:

BJGMC

Shivakoti R , Gupte N, Kumar NP, Kulkarni V, Balasubramanian U, Bhosale R, Sambarey P, Kinikar A, Bharadwaj R, Patil S, Inamdar S, Suryavanshi N, Babu S, Bollinger R, Gupta A. Inflammation in HIV-Infected Pregnant Women is Associated with Pre-term Birth. CROI 2018. Boston, MA. 2018

The Effect of HIV on the Immune Response to Myobacterium tuberculosis in Pregnant Women from Pune, India.

Post Date:

2018-02-15

Mathad J, Alexander M, Bhosale R, Naik S, Suryavanshi N, Mave V, Deshpande P, Balasubramanian U, Kulkarni V, Kumar P, Babu S, Gupte N, Nevrekar N, Patil S, Chandanwale A, Gupta A. The Effect of HIV on the Immune Response to Myobacterium tuberculosis in Pregnant Women from Pune, India. RePORT India...

High Risk for Loss to Follow-Up among Adolescents Living with HIV in Pune, India

Post Date:

2016-07-19

Countries:

India

Clinical Sites:

BJGMC

DY Patil

Nimkar S , Valvi C, Khadse S, Kadam D, Kinikar A, Marbaniang I, Rewari BB, Chandanwale A, Suryavanshi N, Patil S, Nevrekar N, Raichur P, Gupta A, Mave V. High Risk for Loss to Follow-Up among Adolescents Living with HIV in Pune, India. 21st International AIDS Conference. International AIDS Society...

Operational Challenges Undermine WHO TB Symptom Screen in Pregnant Women

Post Date:

2015-10-11

Vaidya A , Tambe S, Bhosale R, Mave V, Elf J, Pradhan N, Nevrekar N, Patil S, Kagal A, Joshi S, Chandanwale A, Gupta A, MathadJ. Operational Challenges Undermine WHO TB Symptom Screen in Pregnant Women. ID Week 2015. San Diego, CA. San Diego, CA. 2015

BJGMC Team Convenes PHOENIx Pre-study Event for Maharashtra Government TB Program Officials

Post Date:

2019-08-19

Collaboration and coordination with local government TB program officials are critical for ensuring transparency and a shared understanding of the study’s purpose, methods, consent process, logistics, and potential implications for India’s national TB control efforts.

Celebration of the Dedicated Participants and Staff of the REPRIEVE Study in Pune, India

Post Date:

2019-02-18

REPRIEVE Team Members of the BJGMC Clinical Research Site

Staff and nearly 140 participants in the REPRIEVE study gathered for a community event in Pune, India

World AIDS Week Is Local at BJGMC in Pune, India

Post Date:

2018-12-20

The BJGMC Clinical Research Site convened community awareness activities that focused on HIV and HPV

Uniting for a Healthier India

Post Date:

2018-02-14

"The Indo-US clinical research & education partnership started with a single NIH grant to study maternal-infant HIV transmission." Now with 76 studies underway, this short film chronicles the history & impact of our work in India.

World AIDS Day 2016 at BJGMC

Post Date:

2016-12-06

Read more about 2016 World AIDS Day activities at the BJGMC Clinical Site in Pune, India.

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Sandesh Patil, MBBS, DGO, MPH