Screening for pulmonary tuberculosis in HIV-infected individuals: AIDS Clinical Trials Group Protocol A5253

Post Date: 
2013-04-15
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Clinical Sites: 
Publication: 
International Journal of Tuberculosis and Lung Disease
Summary: 
Background: Improved tuberculosis (TB) screening is urgently needed for human immunodeficiency virus (HIV) infected patients.
 
Methods: An observational, multi-country, cross-sectional study of HIV-infected patients to compare a standardized diagnostic evaluation (SDE) for TB with standard of care (SOC). SOC evaluations included TB symptom review (current cough, fever, night sweats and/or weight loss), sputum Ziehl-Neelsen staining and chest radiography. SDE screening added extended clinical signs and symptoms and fluorescent microscopy (FM). All participants underwent all evaluations. Mycobacterium tuberculosis on sputum culture was the primary outcome.
Citation: 
Swindells S, Komarow L, Tripathy S, Cain KP, MacGregor RR, Achkar JM, Gupta A, Veloso VG, Asmelash A, Omoz-Oarhe AE, Gengiah S, Lalloo U, Allen R, Shiboski C, Anderson J, Qasba SS, Katzenstein DK for the AIDS Clinical Trials Group A5253 Study Team. Screening for pulmonary tuberculosis in HIV-infected individuals: AIDS Clinical Trials Group Protocol A5253. Int J Tuberc Lung Dis. 2013 Apr;17(4):532-9. PMCID: PMC3923622.
Collaborators: 
  • University of Nebraska Medical Center, Omaha, NE
  • Harvard School of Public Health, Boston, MA
  • National AIDS Research Institute, Pune, India
  • Centers for Disease Control and Prevention, Atlanta, GA
  • University of Pennsylvania, Philadelphia, PA
  • Albert Einstein College of Medicine, Bronx, NY
  • Instituto de Pesquisa Clinica Evandro, Rio de Janeiro, Rio de Janeiro, Brazil
  • Scottish Livingstone Hospital, Molepole, Botswana
  • Princess Marina Hospital, Gaborone, Botswana
  • Center for the AIDS Programme of Research in South Africa, Durban, South Africa
  • University of KwaZulu-Natal, Durban, South Africa
  • AIDS Clinical Trials Group Operations Center, Silver Spring, MD
  • University of California San Francisco, San Francisco, CA
  • Montgomery County Health Department, Silver Spring, MD
  • Stanford University Medical Center, Stanford, CA