Sex-based differences in T lymphocyte responses in HIV-1-seropositive individuals

Post Date: 
2005-03-15
Publication: 
Journal of Infectious Diseases
Summary: 
Sex-based differences in the levels of human immunodeficiency virus 1 (HIV-1) RNA in plasma could be associated with differences in the strength of HIV-1-specific CD8(+) T cell responses. CD8(+) effector responses in 18 men and 15 women were measured 0-2 years (time A) and 5-7 years (time B) after seroconversion. CD8(+) effector responses were seen in 7 (39%) of 18 men and 2 (13%) of 15 women at time A (P=.13) and in 12 (67%) of 18 men and 10 (67%) of 15 women at time B (P=.99). At time B, the strength of CD8(+) effector responses correlated with the number of CD4(+) lymphocytes in women ( rho =-0.68; P=.005) but not in men ( rho =-0.14; P=.58). The level of HIV-1 RNA was not associated with the strength of CD8(+) effector responses according to sex, but there was a sex-based difference in the correlation between the strength of CD8(+) effector response and the number of CD4(+) lymphocytes.
Citation: 
Sterling TR, Pisell-Noland T, Perez JL, Astemborski J, McGriff JR, Nutting L, Hoover DR, Vlahov D, Bollinger RC. Sex-based differences in T lymphocyte responses in HIV-1-seropositive individuals. J Infect Dis. 2005 Mar 15; 191(6):881-885. doi: 10.1086/427827.
Collaborators: 
  • Johns Hopkins Bloomberg School of Public Health, Baltimore, MD
  • Vanderbilt University Medical Center, Nashville, TN
  • Rutgers University, Piscataway, NJ
  • New York Academy of Medicine, New York, NY