Symptom screening for active tuberculosis in pregnant women living with HIV

Post Date: 
2019-01-24
Publication: 
Cochrane Database of Systematic Reviews
Summary: 

This is a protocol for a Cochrane Review (Diagnostic test accuracy). The objectives are as follows: To assess the accuracy of the four-symptom screen (cough, fever, night sweats, or weight loss) for identifying active TB in pregnant PLHIV who are screened in an outpatient or community setting. To investigate potential sources of heterogeneity of the accuracy of the four-symptom screen between studies including: ART status, CD4 cell count, gestational age, pregnancy stage (pregnancy vs. postpartum), screening test definition of cough (any cough vs. cough greater than 2 weeks).To describe the accuracy of single symptoms included within the four-symptom screen, additioal symptoms or symptom combinations, for identifying active TB in pregnant PLHIV. For example, additional symptoms may include failure to gain weight or fatigue.

Citation: 
LaCourse SM, Cranmer LM, Bekker A, Steingart KR, Black D, Horne DJ, Oren E, Pals S, Modi S, Mathad J. Symptom screening for active tuberculosis in pregnant women living with HIV. Cochrane Database Syst Rev. 2018;2018(1). pii: CD012934. DOI: 10.1002/14651858.CD012934. PMCID: PMC5997280.
Collaborators: 
  • Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington, USA.
  • Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia, USA.
  • Department of Paediatrics, Stellenbosch University, Cape Town, South Africa.
  • Cochrane Infectious Diseases Group, Liverpool School of Tropical Medicine, Liverpool, UK.
  • Department of Epidemiology, University of Washington, Seattle, Washington, USA.
  • Department of Medicine, Division of Pulmonary and Critical Care Medicine, and Firland Northwest TB Center, University of Washington, Seattle, WA, USA.
  • Division of Epidemiology and Biostatistics, San Diego State University, San Diego, California, USA.
  • Division of Global HIV and Tuberculosis, Center for Global Health, US Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, USA.
  • Department of Medicine, Division of Infectious Diseases, Center for Global Health, Weill Cornell Medical College, New York, USA.