Vidya Mave, MD, MPH

Pune, India
Role: 
Faculty
Associate Professor
Vidya Mave, MD, MPH

Dr. Mave is Associate Professor at the Johns Hopkins School of Medicine as well as Director and Clinical Research Site (CRS) Leader of the Baltimore-Washington-India Clinical Trials Unit (BWI-CTU). The CTU is a collaborative research partnership among BJGMC in Pune, India, Johns Hopkins School of Medicine in Baltimore, Maryland, and Whitman Walker Health in Washington, DC, that is part of the world’s largest HIV therapeutic trial networks (the AIDS Clinical Trials Group [ACTG] and the International Maternal Pediatric and Adolescent AIDS Clinical Trial Network [IMPAACT]).



 



Dr. Mave has more than 15 years of combined experience in clinical practice, education, and research in infectious diseases and has published more than 45 peer-reviewed research articles. Following a short tenure as Assistant Professor of Infectious Diseases at Tulane University School of Medicine, Dr. Mave joined the Johns Hopkins CCGHE. She now coordinates all clinical research activities for the BWI-CTU, which conducts phase I, II, and III clinical trials of therapeutic drug interventions for HIV and co-morbid infections, including TB and hepatitis, in adults (including pregnant women) and children. Dr. Mave’s research interests includes comorbidities (diabetes, HIV) and the use of novel tools (Hair PK, whole genome sequencing, host biomarkers) to study TB treatment outcomes. In addition, Dr. Mave has mentored more than 16 pre- and postdoctoral trainees from Hopkins and is available to mentor trainees participating in the BJGMC-JHU HIV-TB Fogarty Research Training Program.



 



Dr. Mave received an MD in medicine from Karnatak University, Dharwad, India, and an MPH from Tulane University. She completed her internal medicine training at St. Barnabas Hospital in New York, followed by a post-doctoral fellowship in infectious diseases at Tulane University and Long Island Jewish Medical Center. Dr. Mave is board certified in internal medicine and infectious diseases by the American Board of Internal Medicine.

Epidemiological Assessment of Pediatric Tuberculosis in Pune, India, through Contact Tracing

Post Date: 
2013-06-10
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This study ended in June 2016. Approximately 1 million new cases of Tuberculosis occur among children each year around the world, with a large number of these cases occurring among indigent populations without access to adequate healthcare facilities (World Health Organization). Due to their high...

Impact of Diabetes on TB Treatment Outcomes

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2013-02-01
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CCGHE, the JHU Center for TB Research and BJGMC have been awarded a $2.5 million dollar NIH grant (2013-2018) to conduct a study to evaluate treatment outcomes among Indian patients with both diabetes mellitus and active TB. This study is assessing the prevalence of impaired glucose or frank...

Bacterial Antimicrobial Resistance Patterns in Pune, India

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2013-01-10
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This study was terminated September 24, 2019. Evaluate etiology of acute fever and bacterial drug resistance patterns among adults and children in India.

Diagnosis of Active Tuberculosis in HIV-infected and Uninfected Young Children in India

Post Date: 
2012-07-24
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Tuberculosis (TB) is the most common cause of morbidity/mortality in HIV-infected individuals in India. India has the world's highest burden of HIV and TB, and since children acquire HIV/TB from their caregivers, active TB is highly prevalent (14-67.5%) among HIV-infected young children in India...

A5288: MULTIOCTAVE, Management Using the Latest Technologies in Resource-limited Settings to Optimize Combination Therapy After Viral Failure

Post Date: 
2012-07-16
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This study was terminated in March 2020. It was a mult-country clinical trial conducted in Brazil, Haiti, India, Kenya, Malawi, Peru, South Africa, Thailand, Uganda, and Zambia under the AIDS Clinical Trials Group (ACTG) and funded by the U.S. National Institutes of Health. A5288 is a multi-step,...

C-TRIUMPH Pilot Study: Burden and Risk Factors for Drug-resistant Tuberculosis in Pune, India

Post Date: 
2012-05-29
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This pilot study ended in April 2015. Drug resistant TB (MDR-TB and XDR-TB) is increasing worldwide. Although 20% of all global TB cases occur in India, current estimates of the burden of MDR-TB in India are limited. A well-characterized TB clinical cohort, household cohort and control cohort would...

Understanding Challenges and Perspectives of Parents about HIV Disclosures to their Children and Develop a Structured HIV Disclosure Model for Pediatric Age Group

Post Date: 
2011-12-08
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This study is terminated. In 2008 an estimated 70,000 children in India were living with HIV, with 21,000 new children are infected each year through mother to child transmission (Singh et al 2008). Increasing availability of antiretroviral treatment (ART) to HIV infected children in India means...

Predictors of Perinatal HBV Transmission in an HIV/HBV Infected Cohort

Post Date: 
2011-04-22
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This study ended in 2014. Hepatitis B virus (HBV) coinfection is common; affecting greater than 10% of HIV-infected individuals in resource-limited settings(1-3). Although the impact of HIV disease on HBV coinfection has been studied in non-pregnant adults, little is known about the effects of HIV...

A Prospective Study Evaluating the Role of Cryptococcal Antigen Screening among HIV-infected Adults with Low CD4 Counts

Post Date: 
2011-01-01
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This prospective observational study aimed to evaluate the burden of cryptococcal disease among approximately 200 HIV-infected adults with low CD4 cell counts in Pune, India to determine whether a Cryptococcal screening strategy should be the standard of care among patients with advanced HIV...

P1073: Study of Immune Reconstitution Inflammatory Syndrome (IRIS) for International Sites Initiating Highly Active Antiretroviral Therapy (HAART) in Infants and Children < 72 Months of Age

Post Date: 
2010-11-15
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This study was terminated April 23, 2015. This was a multi-national study conducted in India, South Africa, and Tanzania under the International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) Network and funded by the U.S. National Institutes of Health. P1073 is a case controlled...

Hospitalized Pediatric Patients with Pandemic 2009 H1N1 Influenza in India (August-November 2009)

Post Date: 
2010-04-10
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This study ended in April 2013. This was a review and collection of data from the medical records of pediatric patients who were admitted to the BJMC/Sassoon General Hospitals with H1N1 influenza during August-November 2009.

A5225: Phase I/II Dose-Finding Study of High-Dose Fluconazole Treatment in AIDS-Associated Cryptococcal Meningitis

Post Date: 
2009-04-22
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This trial was terminated in March 2015; it was conducted under the AIDS Clinical Trials Group (ACTG) and funded by the U.S. National Institutes of Health. This multi-country study was conducted in India, Kenyam Peru, South Africa, Thailand, Uganda, United States, and Zimbabwe. A5225/HiFLAC is a...

Impact of Malnutrition on HIV Treatment Failure in Resource-limited Settings

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2009-04-02
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This study, NWCS 319, was terminated August 20, 2019. Highly active antiretroviral therapy (HAART) has reduced morbidity and mortality among HIV-infected persons worldwide. However, early treatment failure (i.e. WHO stage 3 or 4 illnesses or death during the first 24 months of HAART) is more than 3...

BWI CTU: Baltimore-Washington-India Clinical Trials Unit

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2007-02-02
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Comprising clinical trial sites at Johns Hopkins Medicine in Baltimore, Whitman Walker Health in Washington, DC, and the BJGMC-CCGHE collaboration in Pune, India, the Baltimore-Washington-India Clinical Trials Unit (BWI-CTU) is one of only 25 international HIV/TB clinical trial sites funded by the...

A5207: Maintaining Options for Mothers Study (MOMS): A Phase II Randomized Comparison of Three Antiretroviral Strategies Administered for 7 or 21 Days to Reduce the Emergence of Nevirapine Resistant HIV-1 Following a Single Intrapartum Dose of Nevirapine

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2004-12-20
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This study was terminated January 16, 2014; it was conducted under the AIDS Clinical Trials Group (ACTG) and funded by the U.S. National Institutes of Health. A major disadvantage of giving SD NVP is the potential for maternal development of NVP resistance and additional resistance to other...

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Challenges to disclosure of HIV status to perinatally infected children: a study of caregiver perspectives in Pune, India

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2014-06-15
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Journal of Pediatric Infectious Diseases
Effective guidelines around disclosure of HIV status are lacking and limited data from India reveal low rates of HIV disclosure to perinatally infected children. This study, conducted in Pune, India, attempts to understand the experiences of caregivers of perinatally infected children around the...

Pregnancy differentially impacts performance of latent tuberculosis diagnostics in a high-burden setting

Post Date: 
2014-03-21
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PLOS One
Background: Targeted screening for latent TB infection (LTBI) in vulnerable populations is a recommended TB control strategy. Pregnant women are at high risk for developing TB and likely to access healthcare, making pregnancy an important screening opportunity in developing countries. The...

Biomarkers for sepsis: a review with special attention to India

Post Date: 
2014-03-19
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BioMed Research International
Sepsis is a serious infection and still a common cause of morbidity and mortality in resource-limited settings such as India. Even when microbiologic diagnostics are available, bacteremia is only identified in a proportion of patients who present with sepsis and bloodstream infections...

Maternal pneumococcal capsular IgG antibodies and transplacental transfer are lower in South Asian HIV-infected mother-infant pairs

Post Date: 
2014-03-14
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Vaccine
Background: Our understanding of the mother-to-child transfer of serotype-specific pneumococcal antibodies is limited in non-immunized, HIV-positive women. Methods: We compared geometric mean antibody concentrations (GMCs), geometric mean transplacental...

Modifiable risk factors associated with tuberculosis disease in children in Pune, India

Post Date: 
2014-02-15
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International Journal of Tuberculosis and Lung Disease
Setting: India accounts for the largest burden of tuberculosis (TB) worldwide, with 26% of the world's cases. Objective: To assess the association between novel modifiable risk factors and TB in Indian children. Design: Cases were children aged...

Improving diagnostic capability for HPV disease internationally within the NIH-NIAID-Division of AIDS Clinical Trial Networks

Post Date: 
2013-12-15
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American Journal of Clinical Pathology
OBJECTIVES: To evaluate an external quality assurance (EQA) program for the laboratory diagnosis of human papillomavirus (HPV) disease that was established to improve international research capability within the Division of AIDS at the National Institute of Allergy and Infectious Disease-supported...

Pediatric tuberculosis in young children in India: a prospective study

Post Date: 
2013-11-11
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BioMed Research International
Background: India has one of the highest tuberculosis (TB) burdens globally. However, few studies have focused on TB in young children, a vulnerable population, where lack of early diagnosis results in poor outcomes. Methods: Young children (≤ 5 years) with...

Patterns of TB drug-resistance in a tertiary care facility in Pune, India

Post Date: 
2013-07-18
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Clinical Microbiology
Introduction:Globally, the emergence of multi-drug resistant tuberculosis (MDRTB) (defined as resistance to isoniazid (INH) and rifampicin (RIF) and extensively drug resistant (XDR-TB) (defined as resistance to INH, RIF, any fluoroquinolone and to at least one of the three injectable second...

Vitamin D deficiency is common among HIV-infected breastfeeding mothers in Pune, India, but not associated with mother-to-child HIV transmission

Post Date: 
2012-10-01
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HIV Clinical Trials
A recent report from Tanzania demonstrated an increased risk of being HIV infected or of dying at birth among children born to breastfeeding mothers with low baseline vitamin D levels. We conducted a nested case-control study among HIV-infected pregnant women in western India to confirm the...

Predictors of mortality in hospitalized children with pandemic H1N1 influenza 2009 in Pune, India

Post Date: 
2012-04-15
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Indian Journal of Pediatrics
Objective: To analyse the factors associated with increased mortality among Indian Children with H1N1. Methods: Data were abstracted from available hospital records of children less than 12 y of age, who were admitted to Sassoon General Hospital in Pune, India, with...

Determination of a reference interval in a population

Post Date: 
2012-02-01
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National Medical Journal of India
The reference interval is the most widely used medical decision-making tool that separates healthy from diseased individuals. We briefly discuss the methods used to determine reference interval and its limitations.

Maternal tuberculosis: a risk factor for mother-to-child transmission of human immunodeficiency virus

Post Date: 
2011-02-01
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The Journal of Infectious Diseases
Background: Maternal human immunodeficiency virus (HIV) RNA load, CD4 cell count, breast-feeding, antiretroviral use, and malaria are well-established factors associated with mother-to-child transmission (MTCT) of HIV; the role of maternal tuberculosis (TB), however, has not been well...

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RePORT India: Objectives and Future Directions

Post Date: 
2014-04-30
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Mave, V. RePORT India: Objectives and Future Directions. TB Vaccine 4th Global Forum. Shanghai, China.

Risk Factors for Adult In-Patient Mortality for Tuberculosis in Pune, India

Post Date: 
2013-10-31
Mave, V. Risk Factors for Adult In-Patient Mortality for Tuberculosis in Pune, India. International Union for Tuberculosis and Lung Disease. 44th Union World Conference on Lung Health. Paris, France.

Vitamin D Insufficiency (VDI) is Common Among HIV-Infected Breastfeeding Mothers in Pune, India, but Not Associated with Risk of Postpartum TB

Post Date: 
2013-10-31
Mave, V. Vitamin D Insufficiency (VDI) is Common Among HIV-Infected Breastfeeding Mothers in Pune, India, but Not Associated with Risk of Postpartum TB. International Union for Tuberculosis and Lung Disease. 44th Union World Conference on Lung Health. Paris, France.

Exposure to tuberculosis infected household contact, household food insecurity, and malnutrition, but not Vitamin D deficiency associated with pediatric tuberculosis in young children in Pune, India

Post Date: 
2012-10-17
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Jubulis J , Kinikar A, Ithape M, Hotalkar S, Kulkarni V, Mave V, Gupte N, Kagal A, Bharadwaj R, Jain S, Gupta A. Exposure to tuberculosis infected household contact, household food insecurity, and malnutrition, but not Vitamin D deficiency associated with pediatric tuberculosis in young children in...

High Prevalence of Vitamin D Deficiency among HIV-infected Breastfeeding Mothers in Pune, India, Has No Association with Mother-to-child Transmission of HIV

Post Date: 
2011-07-17
Mave, V. High Prevalence of Vitamin D Deficiency among HIV-infected Breastfeeding Mothers in Pune, India, Has No Association with Mother-to-child Transmission of HIV. 6th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention. Rome, Italy.

Does HIV-HBV Co-Infection in HIV- infected Pregnant Women have Significant Impact on Infant Clinical Outcomes?

Post Date: 
2010-07-18
Mave, V. Does HIV-HBV Co-Infection in HIV- infected Pregnant Women have Significant Impact on Infant Clinical Outcomes? International AIDS Conference. AIDS 2010. Vienna, Austria. 2010.

RSA Bacteremia: Vancomycin Levels and Clearance of Bacteremia

Post Date: 
2008-10-25
Mave, V. RSA Bacteremia: Vancomycin Levels and Clearance of Bacteremia. Infectious Diseases Society of America. 2008 Annual Meeting. Washington, DC. 2008.

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