Yukari C. Manabe, MD

Role: 
Faculty
Professor of Medicine, International Health, and Molecular Microbiology and Immunology
Yukari Manabe, MD

Dr. Manabe is currently the Associate Director of Global Health Research and Innovation within the Johns Hopkins Center for Global Health, Professor of Medicine, International Health, and Molecular Microbiology and Immunology, and a faculty member of both the Center for Tuberculosis Research and Center for Clinical Global Health Education.

Dr. Manabe is the first Clinical Director of the John G. Bartlett Speciality Practice, a state-of-the-art clinic at established at Johns Hopkins in May 2017 for patients with infectious diseases.  

From 2007 until 2012, she was the Head of Research at the Infectious Diseases Institute (IDI) in Kampala, Uganda, where she built research infrastructure, improved research regulatory compliance, enlarged the pool of statistical expertise, began a translational research lab to build basic science research, and streamlined scientific research at the IDI which has led to increased academic productivity and formal recognition of the IDI as a Research Center of Excellence. She also consolidated and built the research capacity building programs which has trained numerous Ugandan masters and PhD students within country. Her own research is in health systems strengthening and implementation science particularly in the area of TB-HIV infection and point-of-care diagnostics as well as translational research in HIV, TB and opportunistic infections.

Dr. Manabe is an author of more than 150 peer-reviewed publications.

Dr. Manabe obtained her undergraduate degree from Yale University and her MD from Columbia University College of Physicians and Surgeons. She joined the Johns Hopkins School of Medicine faculty in 1999 after completing her residency in internal medicine and fellowship in infectious diseases at Johns Hopkins Hospital.

Health Professions Education and Training for Strengthening the Health System and Services in Uganda

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2018-09-19
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Led by Sarah Kiguli at the Makerere University College of Health Sciences, the goal of this effort is to improve service delivery of the Ugandan health system through strengthened health professional interdisciplinary education and research training to produce graduates with competencies to address...

Evaluating the Source of Neonatal Bloodstream Infections due to Classically Hospital Acquired Pathogens in the Neonatal Intensive Care Unit in Pune, India

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2018-07-12
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This study is part of CDC's Safe Healthcare, Epidemiology, and Prevention Research Development (SHEPheRD) Program under Domain 7: International HAI and Other Adverse Healthcare Event Prevention. The PIs for this study are Dr. Julia Johnson of Johns Hopkins and Dr. Shilpa Naik of BJGMC. CoPIs are Dr...

Implementing the Comprehensive Unit-based Safety Program to Reduce Healthcare-Associated Sepsis in the Neonatal Intensive Care Unit in Pune, India

Post Date: 
2018-04-19
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This study is part of CDC's Safe Healthcare, Epidemiology, and Prevention Research Development (SHEPheRD) Program under Domain 7: International HAI and Other Adverse Healthcare Event Prevention. Dr. Aaron Milstone is the PI, and Dr. Amita Gupta and Yuka Manabe are Co-PIs. The Study Investigator is...

Multicenter Study of the Accuracy of the BD MAX MDR-TB Assay for Detection of M. tuberculosis Complex and Mutations Associated with Resistance to Rifampin or Isoniazid

Post Date: 
2017-03-01
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In a multi-country study, we are assessing the accuracy of the BD MAX rapid MDR-TB assay to detect rifampin and isoniazid resistance.

Healthcare-Associated Sepsis in the Neonatal Intensive Care Unit in Pune, India

Post Date: 
2017-01-17
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This study is part of CDC's Safe Healthcare, Epidemiology, and Prevention Research Development (SHEPheRD) Program under Domain 7: International HAI and Other Adverse Healthcare Event Prevention. Johns Hopkins neonatologist Dr. Julia Johnson is lead investigator for a systematic study of the...

The Human Virome in Health and Disease

Post Date: 
2016-02-21
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This study is part of the Antimicrobial Resistance study referenced below, Some samples were used from the Cohort for Tuberculosis Research by the Indo-US Medical Partnership (C-TRIUMPH), under the Regional Prospective Observational Research for Tuberculosis (RePORT) Network, an international TB...

Group mentorship model to enhance the efficiency and productivity of PhD research training in Sub-Saharan Africa

Post Date: 
2018-05-04
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Publication: 
Annals of Global Health
Annals of Global Health : Systems capacity building approach to PhD training allowed strong outputs at lower cost and with relatively few additional mentors to train independent scientists able to conduct original research and mentor others.

Vector-borne disease is a common cause of hospitalized febrile illness in India

Post Date: 
2018-03-26
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Publication: 
American Journal of Tropical Medicine and Hygiene
Diagnostic strategies adapted for season and age may reduce diagnostic uncertainty and identify causative organisms in treatable, fatal causes of AFI.

Risk factors for early mortality on antiretroviral therapy in advanced HIV-infected adults

Post Date: 
2017-10-23
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AIDS
Background: Many HIV-infected individuals present with advanced HIV disease. These patients are at high risk of death after antiretroviral therapy (ART) initiation, but risk factors for death in these patients are unclear. Methods: We used data from a multisite randomized trial comparing empiric vs...

Clinical features and diagnosis of tuberculosis: primary infection and progressive pulmonary tuberculosis

Post Date: 
2017-04-27
Publication: 
Handbook of Tuberculosis
In this chapter, we will review the clinical manifestations of intrathoracic tuberculosis (TB), including pathophysiology and clinical features of primary and secondary or reactivation TB. Specific topics discussed are the physical examination, and microbiological, radiological, and immunological...

Reducing uncertainty for acute febrile illness in resource-limited settings: the current diagnostic landscape

Post Date: 
2017-03-27
Publication: 
The American Journal of Tropical Medicine and Hygiene
After decades of slow progress in diagnostics for acute febrile illness in resource-limited settings, a wave of converging advancements will enable clinicians in resource limited settings to reduce uncertainty for the diagnosis of acute febrile illness.

Predictors and outcomes of mycobacteremia among HIV-infected smear- negative presumptive tuberculosis patients in Uganda

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2015-02-15
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BMC Infectious Diseases
Background : Sputum smear microscopy for tuberculosis (TB) diagnosis lacks sensitivity in HIV-infected symptomatic patients and increases the likelihood that mycobacterial infections particularly disseminated TB will be missed; delays in diagnosis can be fatal. Given the duration for MTB growth in...

Diagnostic accuracy of a rapid urine lipoarabinomannan test for tuberculosis in HIV-infected adults

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2014-07-01
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Publication: 
Journal of Acquired Immune Deficiency Syndromes
Objective : In settings of high HIV prevalence, tuberculosis control and patient management are hindered by lack of accurate, rapid tuberculosis diagnostic tests that can be performed at point-of-care. The Determine TB LAM Ag (TB LAM) test is a lateral flow immunochromatographic test for detection...

Optimisation of the Medical Education Partnership Initiative to address African health-care challenges

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2014-06-25
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The Lancet Global Health
The Medical Education Partnership Initiative (MEPI) is an innovative and potentially transformative 5-year programme, established by the US Government in 2010, to increase the number of doctors to meet crucial human resource needs in sub-Saharan Africa.1 MEPI allows African institutions that are...

Comparative performance of urinary lipoarabinomannan assays and Xpert MTB/RIF in HIV-infected individuals

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2014-06-01
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AIDS
Background : Xpert MTB/RIF ('Xpert') and urinary lipoarabinomannan (LAM) assays offer rapid tuberculosis (TB) diagnosis, but have suboptimal sensitivity when used individually in HIV-positive patients. The yield of these tests used in combination for the diagnosis of active TB among HIV-infected TB...

Cost-effectiveness of novel algorithms for rapid diagnosis of tuberculosis in HIV-infected individuals in Uganda

Post Date: 
2013-11-28
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Publication: 
AIDS
Objective : Xpert MTB/RIF ('Xpert') and urinary lateral-flow lipoarabinomannan (LF-LAM) assays offer rapid tuberculosis (TB) diagnosis. This study evaluated the cost-effectiveness of novel diagnostic algorithms utilizing combinations of Xpert and LF-LAM for the detection of active TB among people...

Cost-utility of lateral-flow urine lipoarabinomannan for tuberculosis diagnosis in HIV-infected African adults

Post Date: 
2013-04-15
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International Journal of Tuberculosis and Lung Disease
Setting : In-patient hospitals in South Africa and Uganda. Objective : To evaluate the cost-effectiveness of a lateral-flow urine lipoarabinomannan (LAM) test when added to existing strategies for tuberculosis (TB) diagnosis in human immunodeficiency virus infected adults (CD4(+) T-cell counts...

Timing of therapy for latent tuberculosis infection among immigrants presenting to a U.S. public health clinic: a retrospective study

Post Date: 
2008-05-12
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BMC Public Health
Background: In the U.S. more than half of incident tuberculosis (TB) cases occur in immigrants. Current guidelines recommend screening and treatment for latent TB infection (LTBI) within 5 years of arrival to the U.S. This study evaluates the timing of LTBI therapy among immigrants presenting for...

U.S. medical resident familiarity with national tuberculosis guidelines

Post Date: 
2007-08-02
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Publication: 
BMC Infectious Diseases
Background: The ability of medical residents training at U.S. urban medical centers to diagnose and manage tuberculosis cases has important public health implications. We assessed medical resident knowledge about tuberculosis diagnosis and early management based on American Thoracic Society...

The expanding realm of heterologous immunity: friend or foe?

Post Date: 
2006-02-15
Publication: 
Cellular Microbiology
Antecedent or current infections can alter the immunopathologic outcome of a subsequent unrelated infection. Immunomodulation by co-infecting pathogens has been referred to as 'heterologous immunity' and has been postulated to play a role in host susceptibility to disease, tolerance to organ...

Mycobacterial-induced potentiation of type 1 immune responses and protection against malaria is host-specific

Post Date: 
2005-12-15
Publication: 
Infection and Immunity
Malaria and tuberculosis are endemic in many regions of the world, and coinfection with the two pathogens is common. In this study, we examined the effects of long- and short-term infection with Mycobacterium tuberculosis on the course of a lethal form of murine malaria in resistant (C57BL/6) and...

Host Inflammation Markers IFN- γ, IL-6 and IL-15 Strongly Associated with Risk of Incident TB in Advanced HI

Post Date: 
2018-10-25
Manabe YC, Gupte N, Leong S, Kintali M, Bisson G, Hosseinipour M, Salgame P, Gupta A for the ACTG 5274 REMEMBER and NWCS 408 Study Team. Host Inflammation Markers IFN- γ, IL-6 and IL-15 Strongly Associated with Risk of Incident TB in Advanced HI. Session: Diagnosis, Screening, Prediction of Disease...

Antibiotic Use and Drug-Resistant Late-Onset Infections Among Neonates Admitted to Neonatal Intensive Care Units in Pune, India

Post Date: 
2018-08-28
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Agarkhedkar S, Armstrong D, Bharadwaj R, Cox SR, Dohe V, Gupta A, Gupte N, Johnson J, Kadam A, Kinikar A, Malwade S, Manabe Y, Mave V, Milstone A, Parikh T, Rajput U, Randive B, Robinson M , Smith R, Suryavanshi N, Vaidya U, Westercamp M. Antibiotic Use and Drug-Resistant Late-Onset Infections...

Bloodstream Infections among Neonates Admitted to Neonatal Intensive Care Units in Pune, India

Post Date: 
2018-05-05
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Johnson J , Rajput U, Valvi C, Bharadwaj R, Parikh T, Agarkhedkar S, Robinson M, Randive B, Gupte N, Smith R, Westercamp M, Mave V, Manabe Y, Milstone A, for the CDC SHEPheRD India Study Team. Bloodstream Infections among Neonates Admitted to Neonatal Intensive Care Units in Pune, India. Pediatric...

Rahul Rajkumar, MD

Pune, India
Dr. Rahul Rajkumar visited BJGMC from January 9, 2018 to January 20, 2018, where he provided targeted lab support on a CDC ShePHERD protocol, "Healthcare-Associated Sepsis in the Neonatal Intensive Care Unit in Pune, India." Dr. Rajkumar is a Johns Hopkins Master of Public Health (MPH) student with a medical degree. Dr. Rajkumar is mentored by Dr. Yuka Manabe, and worked under Derek Armstrong, a Johns Hopkins microbiologist who collaborates closely with BJGMC on lab strengthening activities. Whiel on site, Dr. Rajkumar supported Derek Armstrong in conducting quality checks of specific...

Indo-Hopkins Partnership Seeks Causes of Sepsis in the NICU

Post Date: 
2017-08-10
Sepsis among newborns in the neonatal intensive care unit (NICU) is a big problem in India, and a complex one to untangle.

How can we encourage female leaders in global health?

Post Date: 
2017-08-09
Source: 
Global Health Matters
Fogarty Director Dr. Roger Glass asks why so few women are leading global health centers at med schools or filling other leadership roles.

Amita Gupta and colleagues discuss female leadership in academic global health

Post Date: 
2017-05-04
Drs. Gupta, Manabe, Mathad discuss need for more women in global health leadership at CUGH's annual meeting.