Yukari C. Manabe, MD

Role: 
Faculty
Professor of Medicine, International Health, and Molecular Microbiology and Immunology
Yukari Manabe, MD

Dr. Manabe is currently the Associate Director of Global Health Research and Innovation within the Johns Hopkins Center for Global Health, Professor of Medicine, International Health, and Molecular Microbiology and Immunology, and a faculty member of both the Center for Tuberculosis Research and Center for Clinical Global Health Education.

Dr. Manabe is the first Clinical Director of the John G. Bartlett Speciality Practice, a state-of-the-art clinic at established at Johns Hopkins in May 2017 for patients with infectious diseases.  

From 2007 until 2012, she was the Head of Research at the Infectious Diseases Institute (IDI) in Kampala, Uganda, where she built research infrastructure, improved research regulatory compliance, enlarged the pool of statistical expertise, began a translational research lab to build basic science research, and streamlined scientific research at the IDI which has led to increased academic productivity and formal recognition of the IDI as a Research Center of Excellence. She also consolidated and built the research capacity building programs which has trained numerous Ugandan masters and PhD students within country. Her own research is in health systems strengthening and implementation science particularly in the area of TB-HIV infection and point-of-care diagnostics as well as translational research in HIV, TB and opportunistic infections.

Dr. Manabe is an author of more than 100 peer-reviewed publications.

Dr. Manabe obtained her undergraduate degree from Yale University and her MD from Columbia University College of Physicians and Surgeons. She joined the Johns Hopkins School of Medicine faculty in 1999 after completing her residency in internal medicine and fellowship in infectious diseases at Johns Hopkins Hospital.

Multicenter Study of the Accuracy of the BD MAX MDR-TB Assay for Detection of M. tuberculosis Complex and Mutations Associated with Resistance to Rifampin or Isoniazid

Post Date: 
2017-03-01
Country: 
In a multi-country study, we are assessing the accuracy of the BD MAX rapid MDR-TB assay to detect rifampin and isoniazid resistance.

Healthcare-Associated Sepsis in the Neonatal Intensive Care Unit in Pune, India

Post Date: 
2017-01-17
Country: 
Johns Hopkins neonatologist Dr. Julia Johnson is lead investigator for a systematic study of the epidemiology of neonatal sepsis in the Neonatal Intensive Care Unit in tertiary care facilities in India. This study is providing important baseline data to serve as the basis for future interventional...

Acute Febrile Illness and Antimicrobial Resistance Patterns in Pune, India: Substudy on the Characterization of the Human Virome

Post Date: 
2016-02-21
Country: 
Objective 1: To use novel molecular techniques to characterize the human virome in the circulating blood of patients in clinical settings who presented to an acute care setting with an acute febrile illness and in whom a diagnosis cannot be achieved by conventional methods. Healthy controls will be...

Clinical features and diagnosis of tuberculosis: primary infection and progressive pulmonary tuberculosis

Post Date: 
2017-04-27
Publication: 
Handbook of Tuberculosis
In this chapter, we will review the clinical manifestations of intrathoracic tuberculosis (TB), including pathophysiology and clinical features of primary and secondary or reactivation TB. Specific topics discussed are the physical examination, and microbiological, radiological, and immunological...

Reducing uncertainty for acute febrile illness in resource-limited settings: the current diagnostic landscape

Post Date: 
2017-03-27
Publication: 
The American Journal of Tropical Medicine and Hygiene
After decades of slow progress in diagnostics for acute febrile illness in resource-limited settings, a wave of converging advancements will enable clinicians in resource limited settings to reduce uncertainty for the diagnosis of acute febrile illness.

Predictors and outcomes of mycobacteremia among HIV-infected smear- negative presumptive tuberculosis patients in Uganda

Post Date: 
2015-02-15
Publication: 
BMC Infectious Diseases
Country: 
Background : Sputum smear microscopy for tuberculosis (TB) diagnosis lacks sensitivity in HIV-infected symptomatic patients and increases the likelihood that mycobacterial infections particularly disseminated TB will be missed; delays in diagnosis can be fatal. Given the duration for MTB growth in...

Diagnostic accuracy of a rapid urine lipoarabinomannan test for tuberculosis in HIV-infected adults

Post Date: 
2014-07-01
Publication: 
Journal of Acquired Immune Deficiency Syndromes
Objective : In settings of high HIV prevalence, tuberculosis control and patient management are hindered by lack of accurate, rapid tuberculosis diagnostic tests that can be performed at point-of-care. The Determine TB LAM Ag (TB LAM) test is a lateral flow immunochromatographic test for detection...

Optimisation of the Medical Education Partnership Initiative to address African health-care challenges

Post Date: 
2014-06-25
Publication: 
The Lancet Global Health
Country: 
The Medical Education Partnership Initiative (MEPI) is an innovative and potentially transformative 5-year programme, established by the US Government in 2010, to increase the number of doctors to meet crucial human resource needs in sub-Saharan Africa.1 MEPI allows African institutions that are...

Comparative performance of urinary lipoarabinomannan assays and Xpert MTB/RIF in HIV-infected individuals

Post Date: 
2014-06-01
Publication: 
AIDS
Country: 
Background : Xpert MTB/RIF ('Xpert') and urinary lipoarabinomannan (LAM) assays offer rapid tuberculosis (TB) diagnosis, but have suboptimal sensitivity when used individually in HIV-positive patients. The yield of these tests used in combination for the diagnosis of active TB among HIV-infected TB...

Cost-effectiveness of novel algorithms for rapid diagnosis of tuberculosis in HIV-infected individuals in Uganda

Post Date: 
2013-11-28
Publication: 
AIDS
Country: 
Objective : Xpert MTB/RIF ('Xpert') and urinary lateral-flow lipoarabinomannan (LF-LAM) assays offer rapid tuberculosis (TB) diagnosis. This study evaluated the cost-effectiveness of novel diagnostic algorithms utilizing combinations of Xpert and LF-LAM for the detection of active TB among people...

Cost-utility of lateral-flow urine lipoarabinomannan for tuberculosis diagnosis in HIV-infected African adults

Post Date: 
2013-04-15
Publication: 
International Journal of Tuberculosis and Lung Disease
Setting : In-patient hospitals in South Africa and Uganda. Objective : To evaluate the cost-effectiveness of a lateral-flow urine lipoarabinomannan (LAM) test when added to existing strategies for tuberculosis (TB) diagnosis in human immunodeficiency virus infected adults (CD4(+) T-cell counts...

Timing of therapy for latent tuberculosis infection among immigrants presenting to a U.S. public health clinic: a retrospective study

Post Date: 
2008-05-12
Publication: 
BMC Public Health
Country: 
Background: In the U.S. more than half of incident tuberculosis (TB) cases occur in immigrants. Current guidelines recommend screening and treatment for latent TB infection (LTBI) within 5 years of arrival to the U.S. This study evaluates the timing of LTBI therapy among immigrants presenting for...

U.S. medical resident familiarity with national tuberculosis guidelines

Post Date: 
2007-08-02
Publication: 
BMC Infectious Diseases
Country: 
Background: The ability of medical residents training at U.S. urban medical centers to diagnose and manage tuberculosis cases has important public health implications. We assessed medical resident knowledge about tuberculosis diagnosis and early management based on American Thoracic Society...

The expanding realm of heterologous immunity: friend or foe?

Post Date: 
2006-02-15
Publication: 
Cellular Microbiology
Antecedent or current infections can alter the immunopathologic outcome of a subsequent unrelated infection. Immunomodulation by co-infecting pathogens has been referred to as 'heterologous immunity' and has been postulated to play a role in host susceptibility to disease, tolerance to organ...

Mycobacterial-induced potentiation of type 1 immune responses and protection against malaria is host-specific

Post Date: 
2005-12-15
Publication: 
Infection and Immunity
Malaria and tuberculosis are endemic in many regions of the world, and coinfection with the two pathogens is common. In this study, we examined the effects of long- and short-term infection with Mycobacterium tuberculosis on the course of a lethal form of murine malaria in resistant (C57BL/6) and...

Indo-Hopkins Partnership Seeks Causes of Sepsis in the NICU

Post Date: 
2017-08-10
Sepsis among newborns in the neonatal intensive care unit (NICU) is a big problem in India, and a complex one to untangle.

How can we encourage female leaders in global health?

Post Date: 
2017-08-09
Source: 
Global Health Matters
Fogarty Director Dr. Roger Glass asks why so few women are leading global health centers at med schools or filling other leadership roles.

Amita Gupta and colleagues discuss female leadership in academic global health

Post Date: 
2017-05-04
Amita Gupta
Drs. Gupta, Manabe, Mathad discuss need for more women in global health leadership at CUGH's annual meeting.