Botswana

A5253: Sensitivity and Specificity of Mycobacterium Tuberculosis Screening and Diagnostics in HIV-Infected Individuals

Post Date: 
2009-03-19
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Clinical Sites: 
This study was terminated October 15, 2014. An estimated 3 million HIV-infected individuals will enter programs for antiretroviral (ARV) treatment in the coming year, with projected rates of requirement for ARV therapy extending to more than 10 million in sub-Saharan Africa, southeastern Asia, and...

Isoniazid preventive therapy in HIV-infected pregnant and postpartum women

Post Date: 
2019-10-03
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Clinical Sites: 
Publication: 
New England Journal of Medicine
New England Journal of Medicine: Dr. Amita Gupta and colleagues found that the current standard of care given to HIV+ pregnant women to prevent TB should wait until 12 weeks after delivery. The study underscores the need to include pregnant women in clinical trials.

Screening for pulmonary tuberculosis in HIV-infected individuals: AIDS Clinical Trials Group Protocol A5253

Post Date: 
2013-04-15
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Clinical Sites: 
Publication: 
International Journal of Tuberculosis and Lung Disease
Background: Improved tuberculosis (TB) screening is urgently needed for human immunodeficiency virus (HIV) infected patients. Methods: An observational, multi-country, cross-sectional study of HIV-infected patients to compare a standardized diagnostic evaluation (SDE) for TB with standard of care (...

Prevention of HIV-1 infection with early antiretroviral therapy

Publication: 
New England Journal of Medicine
Background: Antiretroviral therapy that reduces viral replication could limit the transmission of human immunodeficiency virus type 1 (HIV-1) in serodiscordant couples. Methods: In nine countries, we enrolled 1763 couples in which one partner was HIV-1–positive and the other was HIV-1–negative; 54...

The Afya Bora Consortium: an Africa-US partnership to train leaders in global health

Post Date: 
2011-06-15
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Publication: 
Infectious Disease Clinics of North America
The Afya Bora Consortium is a partnership of eight academic health institutions, four in Africa and four in the United States. The Consortium members have a history of collaboration in four African-U.S. pairs: Makerere University, Kampala, Uganda, and Johns Hopkins University, Baltimore, Maryland,...
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