India

 

With a population of more than one billion, India is the second largest country in the world, represents 16% of the global population, and the national average for life expectancy is only 65 years. India leads the world in the largest absolute burden of TB, ranks third for HIV (behind South Africa and Nigeria), and ranks second for diabetes. The country receives funding to support HIV/AIDS prevention, treatment and care programs under the US President's Emergency Plan for AIDS Relief (PEPFAR).

CCGHE partners with institutions in India tackle grave health issues on the front lines. LEARN ABOUT CCGHE-INDIA PARTNERSHIPS

 
CCGHE WORK IN INDIA

 

RePORT: C-TRIUMPH: Nested Study on Targeting Mycobacterium Tuberculosis Persisters by Enhancing Stringent Response-specific Cellular Immunity

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2017-09-11
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C-TRIUMPH nested study begins to see if stringent response antigen is enhanced while treating drug-susceptible TB using the first-line anti-TB regimen.

Zika Surveillance among Antenatal Clinic Outpatients in BJ Government Medical College and Sassoon General Hospitals, Pune, India

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2017-08-31
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CCGHE is keeping an eye on Zika among pregnant women, which is transmitted by mosquitoes & can cause devastating birth defects.

TB and Pregnancy Impact of Immune Changes of HIV and Stages of Pregnancy on Tuberculosis: Nested Study on Investigating Maternal Antibodies to Modify Infant Tuberculosis Acquisition

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2017-08-29
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New study in Pune, India, aims to identify the profile of TB antibodies between mothers and infants, and to see if the presence of antibodies lowers risk of infant infection.

The Role of Innate Immunity in the Acquisition of Sterile Protection against TB Infection

Post Date: 
2017-08-25
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Tuberculosis (TB) is a major global health problem. Vaccines are the most powerful instruments for limiting the morbidity and mortality of infectious diseases, so the development of highly protective TB vaccines is one of the highest priorities in public health. Bacille de Calmette et Guérin (BCG...

Validation of Transcriptional Signature to Predict Active TB Disease among Advanced HIV Patients

Post Date: 
2017-08-15
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There have been tremendous advances in the diagnosis of patients with tuberculosis (TB) based on nucleic acid amplification of bacteria in the sputum. The GenXpert MTB/RIF provides results in 2 hours. However, in HIV-infected sputum smear is often negative for AFB and the sensitivity of GenXpert...

Antimicrobial Use and Diagnosis among Hospitalized Febrile Patients in Pune, India

Post Date: 
2017-08-07
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Antimicrobial resistance, a leading threat to human health, is enabled by unnecessary antibiotic use. Strategies to reduce unnecessary antibiotic use in India, the world’s largest antibiotic consumer, are urgently needed. Although most patients hospitalized in India with acute febrile illness...

RePORT: C-TRIUMPH: Nested Study on Association of Lipid Mediators of Inflammation with TB Treatment Outcomes

Post Date: 
2017-08-03
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Recent studies have shown the significant role that host lipids play in modulating immunity and disease outcomes. Prostaglandins and leukotrienes are lipids that have a pro-inflammatory role in the fight against infectious agents while Specialized Pro-resolving lipid Mediators (SPMs) including...

Optimizing Treatment to Improve TBM Outcomes in Children: Substudy on Clinical Profile and CSF Biorepository of the Pediatric Suspected Meningitis Cases

Post Date: 
2017-07-18
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This sub-study is being led by PIs Dr. Kelly Dooley and Dr. Chhaya Valvi. Meningoencephalitis is associated with significant morbidity and mortality. Several viruses, bacteria, and fungal pathogens including Neisseria meningitidis, Streptococcus pneumoniae, Mycobacterium tuberculosis, Herpes...

Vaginal Microbiota in HIV Infected Pregnant Women

Post Date: 
2017-07-14
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Led by Dr. Rupak Shivakoti, this is a nested cross-sectional study of 30 HIV-infected and 60 non-HIV infected pregnant women. Pregnant women that are part of the parent study (“Impact of Immune Changes of HIV and Stages of Pregnancy on Tuberculosis” referred to as PRACHITI study from here on) will...

A5349: Rifapentine-containing Treatment Shortening Regimens for Pulmonary Tuberculosis: A Randomized, Open-label, Controlled Phase 3 Clinical Trial

Post Date: 
2017-06-05
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This is an international, multicenter, randomized, controlled, open-label, 3-arm, phase 3 non-inferiority trial. Primary Objectives: To evaluate the efficacy of a rifapentine-containing regimen to determine whether the single substitution of rifapentine for rifampin makes it possible to reduce to...

Understanding Quality of Life during and Loss to Follow-up from Drug-Resistant Tuberculosis Treatment in Pune, India

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2017-05-15
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This study will examine a) risk factors for loss to follow-up from DR-TB treatment, b) actively trace DR-TB patients lost to follow-up from treatment and c) establish a prospective observational cohort of MDR-TB, XDR-TB and DS-TB patients as well as healthy controls nested within ongoing RNTCP...

Risk Factors for Unfavourable Treatment Outcomes among Multidrug-Resistant Tuberculosis Patients in Public Sector Treatment in Pune

Post Date: 
2017-03-29
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This Fogarty funded study seeks to identify risk factors associated with unfavourable treatment outcomes (death, treatment failure, default, XDR-TB) among multidrug-resistant tuberculosis (MDR-TB) patients under public sector Directly Observed Treatment Short-course (DOTS) Plus in Pune, India...

MDR-TB Free: Monitoring Adverse Effects, Utilizing Resources Optimally, Knowing Resistance Patterns, and Treatment Strategy

Post Date: 
2017-03-24
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This study is also known as MDR-TB MUKT: M onitoring Adverse Effects, U tilizing Resources Optimally, K nowing Resistance Patterns, and T reatment Strategy. Purpose: To establish an observational cohort of MDR-TB cases and household contacts with accompanying biorepository at PD Hinduja National...

RePORT: C-TRIUMPH: Biomarkers for Tuberculosis Diagnosis and Treatment Response

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2017-03-24
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Aims: To develop non-sputum, blood-based tools for TB diagnosis and treatment, we urgently need biomarkers that identify active TB (ATB) cases and accurately distinguish them from latent TB infection (LTBI). Such biomarkers, when validated in diverse populations, can be developed into improved...

Impact of HIV and Diabetes Mellitus on TB Drug Resistance and Recurrence

Post Date: 
2017-03-02
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Tuberculosis (TB) is the leading cause of mortality globally. With increasing burden of HIV and diabetes mellitus (DM), there is a critical need to understand the microbial response and ensuing disease dynamics of TB in the HIV-infected and diabetic host to optimally control TB globally. Among...

Multicenter Study of the Accuracy of the BD MAX MDR-TB Assay for Detection of M. tuberculosis Complex and Mutations Associated with Resistance to Rifampin or Isoniazid

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2017-03-01
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In a multi-country study, we are assessing the accuracy of the BD MAX rapid MDR-TB assay to detect rifampin and isoniazid resistance.

TREAT Asia: Pediatric HIV Observational Database

Post Date: 
2017-02-09
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TREAT Asia Pediatric HIV Observational Database (TApHOD) is a collaborative observational cohort study of infants, children, and adolescents living with HIV. TApHOD study participants are enrolled and followed at selected TREAT Asia Network clinical sites in the Asia-Pacific region. Participating...

TREAT Asia Observational Database

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2017-02-09
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The TREAT Asia Observational Database's primary study objective is to: Examine HIV natural history, including the relationship between access to ART, demographics, and disease progression; short- and long-term responses to ART; impact of co-infections; HIV drug resistance patterns; and toxicity of...

Shorter Treatment for Minimal TB in Children (SHINE)

Post Date: 
2017-01-17
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This is a multicountry study being conducted in India, South Africa, Uganda, and Zambia. The principal objective is to determine whether the standard 6 month regimen (8 weeks HRZ(E) followed by 16 weeks HR) can be reduced with similar efficacy, to 4 months (8 weeks HRZ(E) followed by 8 weeks HR),...

Healthcare-Associated Sepsis in the Neonatal Intensive Care Unit in Pune, India

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2017-01-17
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This study is part of CDC's Safe healthcare, Epidemiology, and Prevention Research Development (SHEPheRD) Domain 7: International. Johns Hopkins neonatologist Dr. Julia Johnson is lead investigator for a systematic study of the epidemiology of neonatal sepsis in the Neonatal Intensive Care Unit in...

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Secondhand smoke exposure and validity of self-report in low-income women and children in India

Post Date: 
2018-01-10
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Pediatrics
Pediatrics: Dr. Jessica Elf and colleagues evaluated the validity of standard self-reported measures for secondhand smoke (SHS) exposure among women and children in urban India.

Suboptimal antituberculosis drug concentrations and outcomes in small and HIV‐coinfected children in India: Recommendations for dose modifications

Post Date: 
2017-12-16
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Clinical Pharmacology and Therapeutics
This work aimed to evaluate the once-daily antituberculosis treatment as recommended by the new Indian pediatric guidelines. Isoniazid, rifampin, and pyrazinamide concentration-time profiles and treatment outcome were obtained from 161 Indian children with drug-sensitive tuberculosis undergoing...

Isoniazid concentrations in hair and plasma area-under-the-curve exposure among children with tuberculosis

Post Date: 
2017-12-07
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PLOS One
PLOS One: Mave and colleagues compared TB drug exposure in plasma and hair samples among a small cohort of children.

Antibiotic utilization and the role of suspected and diagnosed mosquito borne illness among adults and children with acute febrile illness in Pune, India

Post Date: 
2017-12-04
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Clinical Infectious Diseases
Mosquito-borne disease identification is associated with reduced empiric antibiotic use and faster antibiotic discontinuation.

Suboptimal anti-tuberculosis drug concentrations and outcomes in small and HIV coinfected children in India: recommendations for dose modifications

Post Date: 
2017-12-01
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Clinical Pharmacology and Therapeutics
This work aimed to evaluate the once-daily anti-tuberculosis treatment as recommended by the new Indian pediatric guidelines. Isoniazid, rifampin and pyrazinamide concentration-time profiles and treatment outcome were obtained from 161 Indian children with drug-sensitive tuberculosis undergoing...

Prevalence of dysglycemia and clinical presentation of pulmonary tuberculosis in Western India

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2017-12-01
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International Journal of Tuberculosis and Lung Disease
Objectives: To estimate the prevalence and risk factors of pre-diabetes mellitus (DM) and DM, and its associations with the clinical presentation of tuberculosis (TB). Design: Screening for DM was conducted among adults (age  18 years) with confirmed TB between December 2013 and January 2017. We...

People with tuberculosis falling through the cracks

Post Date: 
2017-11-01
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National Medical Journal of India
India accounts for approximately one-quarter of the estimated global burden of TB and MDR-TB. [4] Achieving the 2015 WHO End TB Strategy[5] and the latest Government of India target of TB elimination by 2025[6] will require substantial efforts and funding to continue to improve TB care in India...

Risk factors for early mortality on antiretroviral therapy in advanced HIV-infected adults

Post Date: 
2017-10-23
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AIDS
Background: Many HIV-infected individuals present with advanced HIV disease. These patients are at high risk of death after antiretroviral therapy (ART) initiation, but risk factors for death in these patients are unclear. Methods: We used data from a multisite randomized trial comparing empiric vs...

A qualitative study exploring factors influencing clinical decision-making for influenza-like illness in Solapur city, Maharashtra, India

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2017-07-03
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Anthropology and Medicine
Abstract The co-existence of different types of medical systems (medical pluralism) is a typical feature of India's healthcare system. For conditions such as influenza-like illness (ILI), where non-specific disease signs/symptoms exist, clinical reasoning in the context of medical pluralism becomes...

Cardiovascular risk in an HIV-infected population in India

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2017-07-03
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Heart Asia
Findings: HIV+ Indian patients who had cardiovascular disease at a younger age appear to be at imminent risk for morbidity.

Vitamin A and D deficiencies associated with incident tuberculosis in HIV-infected patients initiating antiretroviral therapy in multinational case-cohort study

Post Date: 
2017-07-01
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Journal of Acquired Immune Deficiency Syndromes
Introduction: Numerous micronutrients have immunomodulatory roles that may influence risk of tuberculosis (TB), but the association between baseline micronutrient deficiencies and incident TB after antiretroviral therapy (ART) initiation in HIV-infected individuals is not well characterized...

Constituent variation in smokeless tobacco purchased in Mumbai, India

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2017-07-01
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Tobacco Regulatory Science
Objectives: Worldwide, smokeless tobacco products vary greatly in their formulations and chemical composition. Understanding of toxic and carcinogenic constituent variations in such products can provide valuable insights for the development of effective tobacco control policies. In this study, we...

Household food insecurity is associated with low interferon-gamma levels in pregnant Indian women

Post Date: 
2017-07-01
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International Journal of Tuberculosis and Lung Disease
Objective: To determine the association between household food insecurity and interferon-gamma (IFN-γ) levels in pregnancy. Design: Pregnant women in India were administered the Household Food Insecurity Access Scale (HFIAS) questionnaire and underwent an IFN-γ release assay. Logistic regression...

Maternal syphilis: An independent risk factor for mother to infant human immunodeficiency virus transmission

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2017-06-15
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Sexually Transmitted Diseases
Abstract Syphilis is associated with increased human immunodeficiency virus acquisition and sexual transmission; we examined impact on human immunodeficiency virus mother-to-child transmission among mother-infant pairs enrolled in the India Six-Week Extended-Dose Nevirapine study. Maternal syphilis...

Tuberculosis screening among persons with diabetes mellitus in Pune, India

Post Date: 
2017-06-02
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BMC Infectious Diseases
Background: Diabetes mellitus (DM) increases tuberculosis (TB) risk, and there is increasing concern over the public health implications of the convergence of these two epidemics. Screening for TB among people with DM is now recommended in India. Methods: People with DM seeking care at a large...

High burden of antimicrobial resistance and mortality among adults and children with community-onset bacterial infections in India

Post Date: 
2017-04-15
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Journal of Infectious Diseases
Of 133 isolates from 115 patients, 50% were multi-drug resistant; of 33 isolates tested for carbapenem susceptibility, 36% were resistant.

Resident doctors' attitudes toward tuberculosis patients

Post Date: 
2017-04-15
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Indian Journal of Tuberculosis
Background: The attitude of the resident doctors toward tuberculosis (TB) patients can affect their treatment seeking behavior, compliance to treatment as well as reinforce the stigma attached to the disease by the society at large. Aims: To assess the attitudes of resident medical doctors toward...

Novel interferon-gamma assays for diagnosing tuberculosis in young children in India

Post Date: 
2017-04-01
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International Journal of Tuberculosis and Lung Disease
Setting: The tuberculin skin test (TST) and interferon-gamma release assays (IGRAs) are used as supportive evidence to diagnose active tuberculosis (TB). Novel IGRAs could improve diagnosis, but data are lacking in young children. Design: Children (age 5 years or younger) with suspected TB were...

High prevalence of cryptococcal antigenaemia amongst asymptomatic advanced HIV patients in Pune, India

Post Date: 
2017-03-21
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Indian Journal of Medical Microbiology
Methods : A prospective study was conducted in a large public sector ART centre and the inpatient wards of Sassoon Hospital, Pune, India. All consenting patients> 18 years of age with CD4 count <100 cells/mm3 were screened for CrAg by latex agglutination assay. Those with positive CrAg...

Modelling approaches for tuberculosis: are they realistic?

Post Date: 
2017-03-01
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The Lancet Global Health
Letter by Dr. Sachin Atre in The Lancet Global Health.

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Drug Susceptibility of Rifampin-resistant Tuberculosis using Whole Genome Sequencing to Identify Genes of Interest in Pune, India

Post Date: 
2018-02-15
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Tornheim JA, Madugundu AK, Pradhan N, Bharadwaj R, Mave V, Golub J, Pandey A, Gupta A. Drug Susceptibility of Rifampin-resistant Tuberculosis using Whole Genome Sequencing to Identify Genes of Interest in Pune, India. RePORT India Annual Meeting. New Delhi, India.

Incidence of Mycobacterium tuberculosis Infection among Household Contacts of Adult Pulmonary Tuberculosis Cases in India

Post Date: 
2018-02-15
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Paradkar M, Dhanasekaran K, Kinikar A, Kulkarni R, Bharadwaj R, Gaikwad S, Lokhande R, Meshram S, Dolla CK, Selvaraju S, Murali L, Thiruvengadam K, Jain D, Rajagopal S, Kulkarni V, Pradhan N, John S, Kohli R, Nayagam R, Shivakumar SVBY, Suryavanshi N, Cox S, Gupte A, Chandrasekaran P, Mave V, Gupta...

Poor Understanding of TB Infection among At-risk Tuberculin Skin-test Positive Household Contacts of Pulmonary TB Cases in Pune, India

Post Date: 
2018-02-15
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Dhumal G, DeLuca A, Paradkar M, Suryavanshi N, Mave V, Kohli R, Shivakumar SVBY, Kadam D, Gupta A. Poor Understanding of TB Infection among At-risk Tuberculin Skin-test Positive Household Contacts of Pulmonary TB Cases in Pune, India. RePORT India Annual Meeting. New Delhi, India.

Interleukin-6, Interleukin-13 and Interferon-γ as Potential Biomarkers for Treatment Failure in Pulmonary Tuberculosis

Post Date: 
2018-02-15
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Gupte A, Andrade B, Kumar P, Selvaraju S, Lokhande R, Kulkarni V, Paradkar M, Kohli R, Thiru K, Shivakumar SVBY, Gupte N, Babu S, Golub J, Mave V, Chandrasekaran P, Gupta A. Interleukin-6, Interleukin-13 and Interferon-γ as Potential Biomarkers for Treatment Failure in Pulmonary Tuberculosis...

Hyperhomocysteinemia Screening: A Missed Opportunity to Mitigate CVD Risk among Asian Indian HIV-infected Adults?

Post Date: 
2017-12-28
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Marbaniang I , Sangle S, Kulkarni V, Deshpande P, Shere D, Gupte N, Gupta A, Mave V. Hyperhomocysteinemia Screening: A Missed Opportunity to Mitigate CVD Risk among Asian Indian HIV-infected Adults? AAPI Global Health Summit. American Association of Physicians of Indian Origin. Kolkata, India.

Leveraging Collective Impact to Promote India's Development: The Role of the Indian Diaspora in the Fight Against Tuberculosis

Post Date: 
2017-11-09
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Gupta, A. Leveraging Collective Impact to Promote India's Development: The Role of the Indian Diaspora in the Fight Against Tuberculosis. Roundtable Event. USAID, American India Foundation, Dasra, Indiaspora, Intellecap. Georgetown University, Washington, DC.

Delays and Barriers to Early Treatment Initiation in Childhood Tuberculosis in India

Post Date: 
2017-10-11
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Valvi C, Chandanwale A, Khadse S, Kulkarni R, Kadam D, Dhumal G , Deluca A, Bollinger RC. Delays and Barriers to Early Treatment Initiation in Childhood Tuberculosis in India. The 48th Union World Conference on Lung Health. Guadalajara, Mexico.

High Burden of Genital TB Among Women with Infertility in India: Need for An Intensified Approach

Post Date: 
2017-10-11
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Shilpa Naik, Ajay Chandanwale, Vidya Mave, Pradip Sambarey, Gauri Dhumal , Andrea DeLuca, Amita Gupta, Robert Bollinger. High Burden of Genital TB Among Women with Infertility in India: Need for An Intensified Approach. The 48th Union World Conference on Lung Health. Guadalajara, Mexico.

Lack of TB Knowledge among TST positive Household Contacts of Pulmonary Cases: A Missed Opportunity

Post Date: 
2017-10-11
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DeLuca, A., Dhumal, G., Paradkar, P., Suryavanshi, N., Mave, V., Kohli, K., Shivakumar, S., Gupta. A. Lack of TB Knowledge among TST positive Household Contacts of Pulmonary Cases: A Missed Opportunity. The 48th Union World Conference on Lung Health. Guadalajara, Mexico.

Linezolid Experience among MDRTB Patients in Mumbai

Post Date: 
2017-09-13
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Tornheim J, Ganatra S, Deluca A, Banka R, Rodrigues C, Gupta A, Udwadia Z. Poster Presentation. Linezolid Experience among MDRTB Patients in Mumbai. ERS International Congress. European Respiratory Society. Milan, Italy.

Trends in Glycated Hemoglobin Levels and Implications for Diabetes Screening among Pulmonary Tuberculosis Cases Undergoing Treatment in India

Post Date: 
2017-09-13
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Gupte AN , Mave V, Meshram S, Lokhande R, Kadam D, Dharmshale S, Bharadwaj R, Kagal A, Pradhan N, Deshmukh S, Atre S, Sahasrabudhe T, Barthwal M, Meshram S, Kakrani A, Kulkarni V, Raskar S, Suryavanshi S, Shivakoti R, Chon S, Selvin E, Gupte N, Gupta A, Golub JE. Trends in Glycated Hemoglobin...

High Burden of Diabetes and Prediabetes among Adult Household Contacts of India

Post Date: 
2017-09-13
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Shivakumar SVBY , Chandrasekaran P, Kumar AJMV, Paradkar M, Dhanasekaran K, Suryavanshi N, Thomas B, Kohli R, Thiruvengadam K, Kulkarni V, Hannah LE, Sivaramakrishnan GN, Pradhan N, Dolla C, Gupte A, Ramachandran G, DeLuca A, Meshram S, Bhardawaj R, Bollinger RC, Golub J, Selvaraj K, Gupte N,...

Gene Expression Profiles of Pediatric Tuberculosis Patients and Exposed Controls from India

Post Date: 
2017-09-13
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Tornheim JA , Paradkar M, Madugundu A, Gupte N, Kulkarni V, Sreenivasamurthy S, Raja R, Pradhan N, Shivakumar SVBY, Valvi C, Kohli R, Chandrasekaran P, Mave V, Pandey A, Gupta A. Gene Expression Profiles of Pediatric Tuberculosis Patients and Exposed Controls from India. RePORT International...

Hepatotoxicity in HIV+ Postpartum Women Initiating Efavirenz-Containing Regimens

Post Date: 
2017-07-26
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Bhattacharya D , Gupta A, Tierney C, Huang S, Peters M, Chipato T, Martinson F, Dula D, George K, Chaktoura N, Klingman K, Gnanashanmugam D, Currier J, Fowler MG. Hepatotoxicity in HIV+ Postpartum Women Initiating Efavirenz-Containing Regimens. IAS 2017. International AIDS Society. Paris, France...

CTRIUMPh Pediatric Biomarker Substudy

Post Date: 
2017-05-30
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Tornheim J . Paradkar M. CTRIUMPh Pediatric Biomarker Substudy. 2017 IMPAACT Annual Meeting. Washington, DC. 2017.

A5300/I2003/PHOENIx Preparatory Study of MDR TB Cases and Their Household Contacts: Operational Feasibility to Inform PHOENIx Trial

Post Date: 
2017-05-29
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Gupta, A. A5300/I2003/PHOENIx Preparatory Study of MDR TB Cases and Their Household Contacts: Operational Feasibility to Inform PHOENIx Trial. 2017 IMPAACT Annual Meeting. Washington, DC. 2017.

How Americans Benefit from Global Health Research

Post Date: 
2017-05-25
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Bollinger, R. How Americans Benefit from Global Health Research. The Fogarty International Center: How Americans Benefit from Global Health Research Webinar, Research!America. Washington, DC.

Knowledge, Attitudes and Practices About Multidrug-Resistant Tuberculosis (MDR-TB) and Preventive Therapy Among Adult and Adolescent Household Contacts of MDR-TB Index Cases

Post Date: 
2017-05-22
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Suryavanshi N, Shah S, Murrill M , Gupta A. Knowledge, Attitudes and Practices About Multidrug-Resistant Tuberculosis (MDR-TB) and Preventive Therapy Among Adult and Adolescent Household Contacts of MDR-TB Index Cases. American Thoracic Society 2017 International Conference. Washington, DC. 2017.

It Simply Won’t Work Here – Few Eligible for the Newly Recommended Short Course MDR-TB Regimen in a Mumbai Private Clinic

Post Date: 
2017-05-21
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Tornheim J , DeLuca A, Ganatra S, Radhika B, Gupta A, Udwadia Z. It Simply Won’t Work Here – Few Eligible for the Newly Recommended Short Course MDR-TB Regimen in a Mumbai Private Clinic. American Thoracic Society 2017 International Conference. Washington, DC. 2017.

Communicating Whole Genome Sequencing Results for Tuberculosis: What Does It Mean and Who Needs to Know?

Post Date: 
2017-04-25
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Tornheim, J. Communicating Whole Genome Sequencing Results for Tuberculosis: What Does It Mean and Who Needs to Know? Foundation for Medical Research. Mumbai, India.

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