India

 

With a population of more than one billion, India is the second largest country in the world, represents 16% of the global population, and the national average for life expectancy is only 65 years. India leads the world in the largest absolute burden of TB, ranks third for HIV (behind South Africa and Nigeria), and ranks second for diabetes. The country receives funding to support HIV/AIDS prevention, treatment and care programs under the US President's Emergency Plan for AIDS Relief (PEPFAR).

CCGHE partners with institutions in India tackle grave health issues on the front lines. LEARN ABOUT CCGHE-INDIA PARTNERSHIPS

 
CCGHE WORK IN INDIA

 

Risk of Tuberculosis among Health Care Workers and Trainees in a Tertiary-care Hospital in Pune, India

Post Date: 
2015-04-15
Country: 
A retrospective study of health care workers (HCWs) was conducted by investigators of the Byramjee Jeejeebhoy Medical and Sassoon General Hospitals (BJMC-SGH) in Pune, India. The purpose of the study was to estimate TB prevalence and incidence and investigate frequency and treatment failure,...

Predictive Value of TB-symptom Screen in HIV-infected and HIV-uninfected Pregnant Women in Pune, India

Post Date: 
2014-10-28
Country: 
This is a cross sectional observational study that will be conducted at BJGMC to establish what the predictive value of the WHO TB symptom screen is in pregnant women in India. We hypothesize that the WHO TB symptom screen will have a higher positive predictive value (PPV) in HIV-seronegative...

Diagnosis of Tuberculosis Infection and Th1 Immune Response in Pregnant Women in India

Post Date: 
2014-09-01
Country: 
Tuberculosis (TB) disease is a major cause of mortality among Indian women of reproductive age; approximately 20-50% of women in India are latently infected with Mycobacterium tuberculosis (MTB). Due to immune changes of pregnancy, women are particularly at risk of reactivation and progression to...

TBM Kids Substudy: Assessment of Neurocognitive Functions in Children with Tuberculosis Meningitis and Healthy Control Children Using the Mullen Scale of Early Learning Attending a Tertiary Care Public Hospital in Pune, India

Post Date: 
2014-09-01
Country: 
Objectives: The aim of the present study is to examine the neurological deficit in TBM kids and for that we need to assess, feasibility of the MSEL in our set up an Indian population of healthy children and children with meningitis in particular TB meningitis(TBM). The primary objective of the...

TB and Pregnancy Impact of Immune Changes of HIV and Stages of Pregnancy on Tuberculosis

Post Date: 
2014-09-01
Country: 
Purpose: TB is a leading cause of maternal mortality, especially among HIV-infected women. Women are most likely to develop active TB during and immediately after pregnancy. The immunologic conditions responsible for this phenomenon are not understood. Our recent research shows that pregnant women...

Evaluation of Longitudinal Blood Culture Isolates from BJ Medical College in Pune, India

Post Date: 
2014-06-16
Country: 
Antibiotic resistance is a serious global problem and is caused by multiple factors which have led to difficulty in the management of life-threatening, multi-drug resistant (MDR) bacterial bloodstream infections. The knowledge of antibiotic resistance patterns and availability of appropriate...

Optimizing Treatment to Improve TBM Outcomes in Children

Post Date: 
2014-05-01
Country: 
This study is being conducted in India and Malawi. Primary Objectives To characterize the pharmacokinetics (PK) (plasma and cerebrospinal fluid (CSF)) of rifampicin given at model-derived optimal daily doses and levofloxacin in children ages 6 months to 12 years of age with TBM To assess the...

P1078: A Phase IV Randomized Double-Blind Placebo-Controlled Trial to Evaluate the Safety of Immediate (Antepartum-Initiated) Versus Deferred (Postpartum-Initiated) Isoniazid Preventive Therapy Among HIV-Infected Women in High TB Incidence Settings

Post Date: 
2014-04-01
Country: 
Dr. Amita Gupta is Protocol Chair for this multinational clinical trial being conducted in Botswana, Haiti, South Africa, Tanzania, Thailand, Uganda, and Zimbabwe, and in India by the Baltimore-Washington-India Clinical Trials Unit, of which CCGHE is a member. Background Tuberculosis (TB) is the...

RePORT: C-TRIUMPH: Cohort for Tuberculosis Research by the Indo-US Medical Partnership

Post Date: 
2013-09-28
Country: 
Collaboratively funded by the US NIH, India’s Department of Biotechnology [DBT], and Indian Council of Medical Research, the Cohort for TB Research by the Indo-US Medical Partnership (C-TRIUMPH) is an Indo-US research consortium that is part of RePORT India, a countrywide consortium for TB research...

RePORT: C-TRIUMPH: Substudy on Assessing the Association of Indoor Air Pollution with Tuberculosis in Adult Women and Children under 5 Years of Age

Post Date: 
2013-09-15
Country: 
Addressing social and environmental risk factors contributing to TB disease is becoming increasingly important for national TB programs. We are leveraging the pediatric participants in 1,100 homes participating in the C-TRIUMPH study, enhancing data collection regarding household and individual...

Community Home Based India Prevention of Mother to Child Transmission of HIV

Post Date: 
2013-09-02
Country: 
CCGHE is assessing whether equipping Community Health Workers with mobile health technology and involving them in technology training and personal empowerment seminars can help prevent mother-to-child transmission of HIV. CHWs who care for HIV + pregnant and nursing women are using the emocha...

Impact of Diabetes on TB Treatment Outcomes

Post Date: 
2013-02-01
Country: 
CCGHE, the JHU Center for TB Research and BJGMC have been awarded a $2.5 million dollar NIH grant (2013-2018) to conduct a study to evaluate treatment outcomes among Indian patients with both diabetes mellitus and active TB. This study is assessing the prevalence of impaired glucose or frank...

Acute Febrile Illness and Antimicrobial Resistance Patterns in Pune, India

Post Date: 
2013-01-10
Country: 
Evaluate etiology of acute fever and bacterial drug resistance patterns among adults and children in India.

ONCOGRID: An mHealth Approach to Prevention and Early Diagnosis of Oral Cancer in Rural South India

Post Date: 
2012-11-01
Country: 
The Indian sub-continent is burdened with 80% of the world’s patients with oral cancer, and delay in oral cancer diagnosis is one of the major problems that leads to poor treatment outcomes (V. Shanta, R. Swaminathan, R. Rama. Cancer Control 2013). Current screening and treatment programs are not...

Diagnosis of Active Tuberculosis in HIV-infected and Uninfected Young Children in India

Post Date: 
2012-07-24
Country: 
Tuberculosis (TB) is the most common cause of morbidity/mortality in HIV-infected individuals in India. India has the world's highest burden of HIV and TB, and since children acquire HIV/TB from their caregivers, active TB is highly prevalent (14-67.5%) among HIV-infected young children in India...

RePORT India

Post Date: 
2012-06-30
Country: 
RePORT India is a joint venture between the Indian and US governments. The Indo-US Vaccine Action Program, a collaboration between the Indian Department of Biotechnology (DBT), the Indian Council of Medical Research (ICMR), and the US NIH, is co-funding six teams of India- and US-based...

C-TRIUMPH Pilot Study: Burden and Risk Factors for Drug-resistant Tuberculosis in Pune, India

Post Date: 
2012-05-29
Country: 
Drug resistant TB (MDR-TB and XDR-TB) is increasing worldwide. Although 20% of all global TB cases occur in India, current estimates of the burden of MDR-TB in India are limited. A well-characterized TB clinical cohort, household cohort and control cohort would provide important epidemiological,...

A Prospective Study Evaluating the Role of Cryptococcal Antigen Screening among HIV-infected Adults with Low CD4 Counts

Post Date: 
2011-01-01
Country: 
This prospective observational study aimed to evaluate the burden of cryptococcal disease among approximately 200 HIV-infected adults with low CD4 cell counts in Pune, India to determine whether a Cryptococcal screening strategy should be the standard of care among patients with advanced HIV...

Impact of Malnutrition on HIV Treatment Failure in Resource-limited Settings

Post Date: 
2010-01-01
Country: 
Highly active antiretroviral therapy (HAART) has reduced morbidity and mortality among HIV-infected persons worldwide. However, early treatment failure (i.e. WHO stage 3 or 4 illnesses or death during the first 24 months of HAART) is more than 3-fold higher in resource limited settings (RLS) than...

BWI CTU: Baltimore-Washington-India Clinical Trials Unit

Post Date: 
2007-02-02
Comprising clinical trial sites at Johns Hopkins Medicine in Baltimore, Whitman Walker Health in Washington, DC, and the BJGMC-CCGHE collaboration in Pune, India, the Baltimore-Washington-India Clinical Trials Unit (BWI-CTU) is one of only 25 international HIV/TB clinical trial sites funded by the...

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Challenges to disclosure of HIV status to perinatally infected children: a study of caregiver perspectives in Pune, India

Post Date: 
2014-06-15
Publication: 
Journal of Pediatric Infectious Diseases
Country: 
Effective guidelines around disclosure of HIV status are lacking and limited data from India reveal low rates of HIV disclosure to perinatally infected children. This study, conducted in Pune, India, attempts to understand the experiences of caregivers of perinatally infected children around the...

Change in Vitamin D levels occurs early after antiretroviral therapy initiation and depends on treatment regimen in resource-limited settings

Post Date: 
2014-04-21
Publication: 
PLOS One
Background: Vitamin D has wide-ranging effects on the immune system, and studies suggest that low serum vitamin D levels are associated with worse clinical outcomes in HIV. Recent studies have identified an interaction between antiretrovirals used to treat HIV and reduced serum vitamin D levels,...

Pregnancy differentially impacts performance of latent tuberculosis diagnostics in a high-burden setting

Post Date: 
2014-03-21
Publication: 
PLOS One
Country: 
Background: Targeted screening for latent TB infection (LTBI) in vulnerable populations is a recommended TB control strategy. Pregnant women are at high risk for developing TB and likely to access healthcare, making pregnancy an important screening opportunity in developing countries. The...

Biomarkers for sepsis: a review with special attention to India

Post Date: 
2014-03-19
Publication: 
BioMed Research International
Country: 
Sepsis is a serious infection and still a common cause of morbidity and mortality in resource-limited settings such as India. Even when microbiologic diagnostics are available, bacteremia is only identified in a proportion of patients who present with sepsis and bloodstream infections. Biomarkers...

Maternal pneumococcal capsular IgG antibodies and transplacental transfer are lower in South Asian HIV-infected mother-infant pairs

Post Date: 
2014-03-14
Publication: 
Vaccine
Country: 
Background: Our understanding of the mother-to-child transfer of serotype-specific pneumococcal antibodies is limited in non-immunized, HIV-positive women. Methods: We compared geometric mean antibody concentrations (GMCs), geometric mean transplacental cord:maternal ratios (GMRs) and proportions...

Modifiable risk factors associated with tuberculosis disease in children in Pune, India

Post Date: 
2014-02-15
Publication: 
International Journal of Tuberculosis and Lung Disease
Country: 
Setting: India accounts for the largest burden of tuberculosis (TB) worldwide, with 26% of the world's cases. Objective: To assess the association between novel modifiable risk factors and TB in Indian children. Design: Cases were children aged ≤ 5 years with confirmed/probable TB based on World...

Pediatric tuberculosis in young children in India: a prospective study

Post Date: 
2013-11-11
Publication: 
BioMed Research International
Country: 
Background: India has one of the highest tuberculosis (TB) burdens globally. However, few studies have focused on TB in young children, a vulnerable population, where lack of early diagnosis results in poor outcomes. Methods: Young children (≤ 5 years) with suspected TB were prospectively enrolled...

HIV/AIDS education in traditional Indian systems of medicine: faculty perspectives

Post Date: 
2013-10-24
Publication: 
Journal of Traditional Medicine and and Clinical Naturopathy
Country: 
In India, HIV-infected individuals face numerous challenges in their search for treatments. Currently, western allopathic medicine (hereinafter ‘biomedicine’) offers antiretroviral therapy (ART) for HIV/AIDS and associated co-morbidities that have prolonged survival and improved quality of life...

India’s new policy to protect research participants

Post Date: 
2013-07-31
Publication: 
The BMJ
Country: 
Editorial Introduction: India, the country with the largest disease burden in the world,1 is now a major international hub for clinical research. However, a recent policy that was meant to mitigate important ethical concerns may have profound and unintended consequences for public health and may...

Patterns of TB drug-resistance in a tertiary care facility in Pune, India

Post Date: 
2013-07-18
Publication: 
Clinical Microbiology
Country: 
Introduction:Globally, the emergence of multi-drug resistant tuberculosis (MDRTB) (defined as resistance to isoniazid (INH) and rifampicin (RIF) and extensively drug resistant (XDR-TB) (defined as resistance to INH, RIF, any fluoroquinolone and to at least one of the three injectable second line...

Screening for pulmonary tuberculosis in HIV-infected individuals: AIDS Clinical Trials Group Protocol A5253

Post Date: 
2013-04-15
Publication: 
International Journal of Tuberculosis and Lung Disease
Background: Improved tuberculosis (TB) screening is urgently needed for human immunodeficiency virus (HIV) infected patients. Methods: An observational, multi-country, cross-sectional study of HIV-infected patients to compare a standardized diagnostic evaluation (SDE) for TB with standard of care (...

Low tuberculosis knowledge among HIV-infected patients in a high HIV prevalence region within Southeast India

Post Date: 
2013-03-21
Publication: 
Journal of the International Association of Providers of AIDS Care
Country: 
Setting: A private multispecialty hospital in Kakinada, Andhra Pradesh, India. Methods: A survey of knowledge, attitudes, and perceptions adapted from a pretested questionnaire was administered to 128 HIV-infected adults, from July to August 2008.

Correlates of lower comprehension of informed consent among participants enrolled in a cohort study in Pune, India

Post Date: 
2013-03-15
Publication: 
International Health
Country: 
Background: Optimum comprehension of informed consent by research participants is essential yet challenging. This study explored correlates of lower comprehension of informed consent among 1334 participants of a cohort study aimed at estimating HIV incidence in Pune, India. Methods: As part of the...

Growth patterns among HIV-exposed infants receiving nevirapine prophylaxis in Pune, India

Post Date: 
2012-10-31
Publication: 
BMC Infectious Diseases
Country: 
Background: India has among the highest rates of infant malnutrition. Few studies investigating the growth patterns of HIV-exposed infants in India or the impact of timing of HIV infection on growth in settings such as India exist. Methods: We used data from the Six Week Extended Nevirapine (SWEN)...

Pooled individual data analysis of five randomized trials of infant nevirapine prophylaxis to prevent breast-milk HIV-1 transmission

Post Date: 
2012-10-19
Publication: 
Clinical Infectious Diseases
Background: In resource-limited settings, mothers infected with human immunodeficiency virus type 1 (HIV-1) face a difficult choice: breastfeed their infants but risk transmitting HIV-1 or not breastfeed their infants and risk the infants dying of other infectious diseases or malnutrition. Recent...

Evaluation of a multimodal, distance learning HIV management course for clinical care providers in India

Post Date: 
2012-10-01
Publication: 
Journal of the International Association of Providers of AIDS Care
Country: 
Distance learning is an important tool for training HIV health workers. However, there is limited evidence on design and evaluation of distance learning HIV curricula and tools. We therefore designed, implemented, and evaluated a distance learning course on HIV management for clinical care...

Vitamin D deficiency is common among HIV-infected breastfeeding mothers in Pune, India, but not associated with mother-to-child HIV transmission

Post Date: 
2012-10-01
Publication: 
HIV Clinical Trials
Country: 
A recent report from Tanzania demonstrated an increased risk of being HIV infected or of dying at birth among children born to breastfeeding mothers with low baseline vitamin D levels. We conducted a nested case-control study among HIV-infected pregnant women in western India to confirm the...

Detection of microbial translocation in HIV and SIV infection using the limulus amebocyte lysate assay is masked by serum and plasma

Post Date: 
2012-08-01
Publication: 
PLOS One
Objective: Microbial translocation (MT) is thought to be a major contributor to the pathogenesis of HIV-related immune activation, and circulating lipopolysaccharide (LPS) from Gram-negative bacteria is the principle measurement of this process. However, related research has been impeded by...

Authors’ response to Hanrahan et al CID article

Post Date: 
2012-05-15
Publication: 
Clinical Infectious Diseases
Country: 
Reply to letter

Predictors of mortality in hospitalized children with pandemic H1N1 influenza 2009 in Pune, India

Post Date: 
2012-04-15
Publication: 
Indian Journal of Pediatrics
Country: 
Objective: To analyse the factors associated with increased mortality among Indian Children with H1N1. Methods: Data were abstracted from available hospital records of children less than 12 y of age, who were admitted to Sassoon General Hospital in Pune, India, with confirmed pandemic 2009 H1N1...

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Inflammation in HIV-infected Pregnant Women: Relationship with Diet, Gut Microbiome, and Preterm Birth

Post Date: 
2016-06-10
Presentation Location: 
Baltimore, MD
Country: 
Event & Convener: 
JHU Center for AIDS Research Annual Meeting
Presentation

Medicine as a Bridge Between the US and India

Post Date: 
2016-05-21
Presentation Location: 
Philadelphia, PA
Country: 
Event & Convener: 
Indiaspora
Presentation

Double Trouble: Managing and Preventing TB and HIV

Post Date: 
2016-04-20
Presentation Location: 
Pune, India
Country: 
Event & Convener: 
DY Patil University
Presentation

Clinical, Social, and Meteorological Factors Associated with Dengue and Malaria Diagnosis in Adults in Pune, India

Post Date: 
2016-03-03
Presentation Location: 
Hyderabad, India
Country: 
Event & Convener: 
17th International Congress on Infectious Diseases
Poster Session. Kadam D, Raichur P, Chandanwale A, Joshi S, Robinson M, Marbaniang I, Kagal A, Bharadwaj, Mave V.

Frequent Resistant Gram Negative Rod Stool Colonization among Patients Admitted with Acute Febrile Illness in Pune, India

Post Date: 
2016-03-03
Presentation Location: 
Hyderabad, India
Country: 
Event & Convener: 
17th International Congress on Infectious Diseases
Poster Presentation. Bharadwaj RS, Robinson M, Marbaniang I, Kagal A, Raichur PA, Kulkami V, Balasubramanian U, Onawale P, Kanade S, Nelson G, Gupta A, Mave V.

Pregnancy Intensifies the IFN-gamma Suppression of HIV in TB-infected Indian Women

Post Date: 
2016-02-24
Presentation Location: 
Boston, MA
Country: 
Event & Convener: 
Conference on Retroviruses and Opportunistic Infections 2016
Poster Presentation: Tuberculosis and Pregnancy. Mathad J, Bhosale R, Balasubramanian U, Deshpande P, Kanade S, Mave V, Gupta A.

High TB Risk in HIV-Positive Patients on Second line Antiretrovirals in Pune, India

Post Date: 
2016-02-24
Presentation Location: 
Boston, MA
Country: 
Event & Convener: 
Conference on Retroviruses and Opportunistic Infections 2016
Poster Presentation: TB and Antiretroviral Therapy. Authors: Mave V , Kadam D, Salvi S, Basavaraj A, Joshi S, Chandanwale A, Gupte N, Bollinger RC, Gupta A.

TB Risk Perceptions Among Medical Residents at a Tertiary Care Center in India

Post Date: 
2015-12-06
Presentation Location: 
Cape Town, South Africa
Country: 
Event & Convener: 
46th Union World Conference on Lung Health. International Union for Tuberculosis and Lung Disease.
Oral Abstract. Session: The Wide Swath of Vulnerable Populations. Pardeshi G , Parande M, Kadam D, Chandanwale A, Deluca A, Bollinger R, Farley J, Suryavanshi N.

TB Outbreak among Health Care Workers and Trainees in a Tertiary-care Hospital in Pune, India

Post Date: 
2015-12-05
Presentation Location: 
Cape Town, South Africa
Country: 
Event & Convener: 
46th Union World Conference on Lung Health
E-Poster Discussion. Session: Preventing Infection and Transmission of TB in Health Facilities and the Community. Authors: Basavaraj A , Patil A, Kadam DB, Chandanwale A, Jain D, DeLuca A, Mave V, Bollinger R.

Isoniazid Hair Concentrations in Children with TB

Post Date: 
2015-12-05
Presentation Location: 
Cape Town, South Africa
Country: 
Event & Convener: 
46th Union World Conference on Lung Health. International Union for Tuberculosis and Lung Disease.
Poster Session. Authors: Mave V, Kinikar AA, Gupte N, Nimkar S, Kagal A, Horng H, Ramachandran G, Dooley K, Gupta A.

Incidence and Risk Factors for TB among HIV+ Children in India

Post Date: 
2015-12-05
Presentation Location: 
Cape Town, South Africa
Country: 
Event & Convener: 
The 46th Union World Conference on Lung Health
Poster Discussion. Session: TART: TB Risk and Impact of ART. Authors: Kinikar AA , DeLuca A, Gupte N, Kadam DB, Khadse S, Chandanwale A, Gupta A, Bollinger R.

Utility of GeneXpert for Diagnosis of Rifampicin-resistant Extra-pulmonary TB—A Retrospective Review of 70 Cases, SGH, Pune, India

Post Date: 
2015-12-04
Presentation Location: 
Cape Town, South Africa
Country: 
Event & Convener: 
The 46th Union World Conference on Lung Health
Poster Session. TB Diagnostic Challenges: Molecular and Other Techniques. Authors: Girish S, Dharmashle S, Desai S, Kagal A, Bharadwaj R, Chandanwale A, Lokhande R, Kadam DB, DeLuca A, Gupte N, Jain D, Gupta A, Bollinger R, Mave V.

Characteristics Associated with Mobile Phone Access among TB Patients in Pune, India

Post Date: 
2015-12-04
Presentation Location: 
Cape Town, South Africa
Country: 
Event & Convener: 
The 46th Union World Conference on Lung Health
Poster Discussion. Session: What's App Doc? Use of m-Health. Authors: Ogale YP, Elf J, Lokhande R, Mave V, Roy S, Gupta A, Golub J, Mathad J.

Risk Factors for Unfavorable Treatment Outcomes in DOTs-treated Pediatric TB Patients

Post Date: 
2015-12-04
Presentation Location: 
Cape Town, South Africa
Country: 
Event & Convener: 
The 46th Union World Conference on Lung Health
Poster Discussion. Session: TB in Children: Epidemiology–I. Authors: Shelke S, Bollinger R, Chandanwale A, DeLuca A, Gupta A, Gupte N, Adhav PS, Kadam DB.

Dengue and Malaria are Common Infections among Adults and Adolescents Hospitalized with Acute Febrile Illness in Western India

Post Date: 
2015-10-09
Presentation Location: 
San Diego, CA
Country: 
Event & Convener: 
Infectious Diseases Society of America. ID Week 2015.
Poster Session: Student and Resident Poster Gallery during Posters in the Park. Mave V, Kadam D, Bharadwaj R, Kagal A, Sachs J, Raichur P, Kanade S, Gupte N, Joshi S, Chandanwale A, Zenilman JM, Bollinger R, Gupta A.

Conducting HIV and TB Research in India: Challenges and Opportunities

Post Date: 
2015-08-27
Presentation Location: 
Atlanta, GA
Country: 
Event & Convener: 
Emory University
Presentation

Therapeutic Drug Monitoring (TDM) of TB in Young Children: The Role of Hair Assays

Post Date: 
2015-06-17
Presentation Location: 
Washington, DC
Country: 
Event & Convener: 
IMPAACT Annual Meeting
Lecture

The Association of Exposure to Air Pollution from Biomass Fuels, Kerosene, and Secondhand Tobacco Smoke with TB in Adult Women and Children in Pune, India

Post Date: 
2015-05-01
Presentation Location: 
Denver, CO
Country: 
Event & Convener: 
American Thoracic Society International Conference
Poster Session: Latent TB Infection: Diagnosis and Treatment. Oral Presentation. Elf JL , Kinikar A, Khadse S, Mave V, Gupte N, Kulkarni V, Patekar S, Raichur P, Breysse P, Gupta A, Golub J.

TB in Pregnancy

Post Date: 
2015-03-05
Presentation Location: 
Mumbai, India
Country: 
Event & Convener: 
RePORT India TB Workshop
Presentation

Cost-effectiveness of Isonaizid Preventive Therapy for HIV-Infected Pregnant Women in India

Post Date: 
2015-02-24
Presentation Location: 
Seattle, WA
Country: 
Event & Convener: 
Conference on Retroviruses and Opportunistic Infections 2015
Poster Presentation. Kapoor S, Chida N, Gupta A, Shah M

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