India

 

With a population of more than one billion, India is the second largest country in the world, represents 16% of the global population, and the national average for life expectancy is only 65 years. India leads the world in the largest absolute burden of TB, ranks third for HIV (behind South Africa and Nigeria), and ranks second for diabetes. The country receives funding to support HIV/AIDS prevention, treatment and care programs under the US President's Emergency Plan for AIDS Relief (PEPFAR).

CCGHE partners with institutions in India tackle grave health issues on the front lines. LEARN ABOUT CCGHE-INDIA PARTNERSHIPS

 
CCGHE WORK IN INDIA

 

Diagnosis of Tuberculosis Infection and Th1 Immune Response in Pregnant Women in India

Post Date: 
2014-09-01
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This study was terminated April 16, 2018. Tuberculosis (TB) disease is a major cause of mortality among Indian women of reproductive age; approximately 20-50% of women in India are latently infected with Mycobacterium tuberculosis (MTB). Due to immune changes of pregnancy, women are particularly at...

TB and Pregnancy Impact of Immune Changes of HIV and Stages of Pregnancy on Tuberculosis

Post Date: 
2014-09-01
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Purpose: TB is a leading cause of maternal mortality, especially among HIV-infected women. Women are most likely to develop active TB during and immediately after pregnancy. The immunologic conditions responsible for this phenomenon are not understood. Our recent research shows that pregnant women...

TBM Kids Substudy: Assessment of Neurocognitive Functions in Children with Tuberculosis Meningitis and Healthy Control Children Using the Mullen Scale of Early Learning Attending a Tertiary Care Public Hospital in Pune, India

Post Date: 
2014-09-01
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Objectives: The aim of the present study is to examine the neurological deficit in TBM kids and for that we need to assess, feasibility of the MSEL in our set up an Indian population of healthy children and children with meningitis in particular TB meningitis(TBM). The primary objective of the...

A5279: Phase III Clinical Trial of Ultra-Short-Course Rifapentine/Isoniazid for the Prevention of Active Tuberculosis in HIV-infected Individuals with Latent Tuberculosis Infection

Post Date: 
2014-06-30
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This study ended April 27, 2015. Dr. Amita Gupta is Protocol Co-Vice Chair for this multinational clinical trial being conducted in Botswana, Brazil, Haiti, Kenya, Malawi, Peru, Puerto Rico, South Africa, Tanzania, Thailand, Uganda, United States, Zambia, Zimbabwe, and India by the Baltimore-...

Evaluation of Longitudinal Blood Culture Isolates from BJ Medical College in Pune, India, 2003-2013

Post Date: 
2014-06-16
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This study was terminated July 31, 2014. Antibiotic resistance is a serious global problem and is caused by multiple factors which have led to difficulty in the management of life-threatening, multi-drug resistant (MDR) bacterial bloodstream infections. The knowledge of antibiotic resistance...

Optimizing Treatment to Improve TBM Outcomes in Children

Post Date: 
2014-05-01
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This study is being conducted in India and Malawi. Primary Objectives To characterize the pharmacokinetics (PK) (plasma and cerebrospinal fluid (CSF)) of rifampicin given at model-derived optimal daily doses and levofloxacin in children ages 6 months to 12 years of age with TBM To assess the...

P1078: A Phase IV Randomized Double-Blind Placebo-Controlled Trial to Evaluate the Safety of Immediate (Antepartum-Initiated) Versus Deferred (Postpartum-Initiated) Isoniazid Preventive Therapy Among HIV-Infected Women in High TB Incidence Settings

Post Date: 
2014-04-01
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Dr. Amita Gupta is Protocol Chair for this multinational clinical trial being conducted in Botswana, Haiti, South Africa, Tanzania, Thailand, Uganda, and Zimbabwe, and in India by the Baltimore-Washington-India Clinical Trials Unit, of which CCGHE is a member. Background Tuberculosis (TB) is the...

Screening for Gender Based-violence (GBV) and Feasibility and Acceptability of mHealth GBV Screening and Support Tools

Post Date: 
2014-03-26
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This study was terminated February 14, 2017. Gender-based violence (GBV) is a significant public health issue in India, with estimates that over a third of women and girls are impacted at some point in their lifetime. This pilot qualitative study examined the feasibility of enhancing GBV prevention...

Evaluation of HIV Disease Burden in Hospitalized Patients at Sassoon General Hospital in Pune, India

Post Date: 
2013-11-18
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This study was terminated September 13, 2005. The goal of this project was to conduct both a retrospective and prospective epidemiological study of the burden of HIV disease at Sassoon General Hospital. The specific objectives of the study were to establish the proportion of HIV-infected...

Tuberculosis Noon Conference

Post Date: 
2013-10-24
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This effort ended in 2015. As part of the BJGMC-Johns Hopkins India Fogarty Training Program, from 2013-2015 CCGHE hosted the live Tuberculosis Noon Conference webcast. Led by Drs. Maunank Shah, Jonathan Golub, and Richard Chaisson, these webcast meetings brought together Johns Hopkins TB...

RePORT: C-TRIUMPH: Cohort for Tuberculosis Research by the Indo-US Medical Partnership

Post Date: 
2013-09-28
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Collaboratively funded by the US NIH, India’s Department of Biotechnology [DBT], and Indian Council of Medical Research, the Cohort for TB Research by the Indo-US Medical Partnership (C-TRIUMPH) is an Indo-US research consortium that is part of RePORT India, a countrywide consortium for TB research...

RePORT: C-TRIUMPH: Substudy on Assessing the Association of Indoor Air Pollution with Tuberculosis in Adult Women and Children under 5 Years of Age

Post Date: 
2013-09-15
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Addressing social and environmental risk factors contributing to TB disease is becoming increasingly important for national TB programs. We are leveraging the pediatric participants in 1,100 homes participating in the C-TRIUMPH study, enhancing data collection regarding household and individual...

Community Home Based India Prevention of Mother to Child Transmission of HIV (COMBIND)

Post Date: 
2013-09-02
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CCGHE is assessing whether equipping Community Health Workers with mobile health technology and involving them in technology training and personal empowerment seminars can help prevent mother-to-child transmission of HIV. CHWs who care for HIV + pregnant and nursing women are using the emocha...

Epidemiological Assessment of Pediatric Tuberculosis in Pune, India, through Contact Tracing

Post Date: 
2013-06-10
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This study ended in June 2016. Approximately 1 million new cases of Tuberculosis occur among children each year around the world, with a large number of these cases occurring among indigent populations without access to adequate healthcare facilities (World Health Organization). Due to their high...

Impact of Diabetes on TB Treatment Outcomes

Post Date: 
2013-02-01
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CCGHE, the JHU Center for TB Research and BJGMC have been awarded a $2.5 million dollar NIH grant (2013-2018) to conduct a study to evaluate treatment outcomes among Indian patients with both diabetes mellitus and active TB. This study is assessing the prevalence of impaired glucose or frank...

Acute Febrile Illness and Antimicrobial Resistance Patterns in Pune, India

Post Date: 
2013-01-10
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Evaluate etiology of acute fever and bacterial drug resistance patterns among adults and children in India.

ONCOGRID: An mHealth Approach to Prevention and Early Diagnosis of Oral Cancer in Rural South India

Post Date: 
2012-11-01
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This study ended February 7, 2017. The Indian sub-continent is burdened with 80% of the world’s patients with oral cancer, and delay in oral cancer diagnosis is one of the major problems that leads to poor treatment outcomes (V. Shanta, R. Swaminathan, R. Rama. Cancer Control 2013). Current...

Diagnosis of Active Tuberculosis in HIV-infected and Uninfected Young Children in India

Post Date: 
2012-07-24
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Tuberculosis (TB) is the most common cause of morbidity/mortality in HIV-infected individuals in India. India has the world's highest burden of HIV and TB, and since children acquire HIV/TB from their caregivers, active TB is highly prevalent (14-67.5%) among HIV-infected young children in India...

A5288: MULTIOCTAVE, Management Using the Latest Technologies in Resource-limited Settings to Optimize Combination Therapy After Viral Failure

Post Date: 
2012-07-16
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This is a mult-country clinical trial being conducted in Brazil, Haiti, India, Kenya, Malawi, Peru, South Africa, Thailand, Uganda, and Zambia. A5288 is a multi-step, open-label phase IV, prospective, interventional strategy study in resource-limited settings (RLS) for HIV-infected participants...

RePORT India

Post Date: 
2012-06-30
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RePORT India is a joint venture between the Indian and US governments. The Indo-US Vaccine Action Program, a collaboration between the Indian Department of Biotechnology (DBT), the Indian Council of Medical Research (ICMR), and the US NIH, is co-funding six teams of India- and US-based...

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Availability and distribution of safe abortion services in rural areas: a facility assessment study in Madhya Pradesh, India

Post Date: 
2015-03-20
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Publication: 
Global Health Action
Abstract Background: Unsafe abortion contributes to a significant portion of maternal mortality in India. Access to safe abortion care is known to reduce maternal mortality. Availability and distribution of abortion care facilities can influence women's access to these services, especially in rural...

Vitamin D deficiency and risk of postpartum tuberculosis among HIV-infected breastfeeding mothers in India

Post Date: 
2015-03-15
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Publication: 
International Journal of Tuberculosis and Lung Disease
Some studies have associated low vitamin D levels with the risk of tuberculosis (TB), but its association in human immunodeficiency virus (HIV) infected mothers in a TB-endemic region has not been well studied. We conducted a nested 1:2 case-control study among HIV-infected mothers in western India...

C-reactive protein (CRP), interferon gamma-inducible protein 10 (IP-10), and lipopolysaccharide (LPS) are associated with risk of tuberculosis after initiation of antiretroviral therapy in resource-limited settings

Post Date: 
2015-02-26
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Publication: 
PLOS One
Objective: The association between pre-antiretroviral (ART) inflammation and immune activation and risk for incident tuberculosis (TB) after ART initiation among adults is uncertain. Design: Nested case-control study (n = 332) within ACTG PEARLS trial of three ART regimens among 1571 HIV-infected,...

Inequalities in institutional delivery uptake and maternal mortality reduction in the context of cash incentive program, Janani Suraksha Yojana: Results from nine states in India

Post Date: 
2014-12-15
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Publication: 
Social Science and Medicine
Abstract Proportion of women giving birth in health institutions has increased sharply in India since the introduction of cash incentive program, Janani Suraksha Yojana (JSY) in 2005. JSY was intended to benefit disadvantaged population who had poor access to institutional care for childbirth and...

High levels of tobacco-specific N-nitrosamines and nicotine in Chaini Khaini, a product marketed as snus

Post Date: 
2014-12-09
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Publication: 
Tobacco Control
Introduction: Recently, a tobacco product, Chaini Khaini, identified as snus appeared in India. The product marketing emphasizes its discreet nature and explicitly claims safety by referring to the existing evidence on Swedish snus. We here analyzed tobacco-specific nitrosamines and nicotine...

Quit history, intentions to quit, and reasons for considering quitting among tobacco users in India: Findings from the Tobacco Control Policy Evaluation India Wave 1 Survey

Post Date: 
2014-12-05
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Publication: 
Indian Journal of Cancer
Background: GATS India 2009–10 revealed that more than one-third (35%) of adults in India use tobacco in some form: 21% use smokeless tobacco, 9% smoke, and 5% are mixed users (they smoke and use smokeless tobacco), and the quit rate is very low. In an effort to decrease prevalence of tobacco use,...

Pre-antiretroviral therapy selenium status predicts WHO stages 3, 4 or death but not virologic failure post-antiretroviral therapy

Post Date: 
2014-11-13
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Publication: 
Nutrients
A case-cohort study, within a multi-country trial of antiretroviral therapy (ART) efficacy (Prospective Evaluation of Antiretrovirals in Resource Limited Settings (PEARLS)), was conducted to determine if pre-ART serum selenium deficiency is independently associated with human immunodeficiency virus...

Source case investigation for children with TB disease in Pune, India

Post Date: 
2014-08-27
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Publication: 
Tuberculosis Research and Treatment
Setting. Contact tracing is broadly encouraged for tuberculosis (TB) control. In many high-burden countries, however, little effort is made to identify contacts of newly diagnosed TB patients. This failure puts children, many of whom live in poor crowded communities, at special risk. Objectives. To...

Impact of maternal hepatitis B virus coinfection on mother-to-child transmission of HIV

Post Date: 
2014-07-15
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Publication: 
HIV Medicine
Objectives: Despite high hepatitis B virus (HBV) endemicity in various resource-limited settings (RLSs), the impact of maternal HIV/HBV coinfection on infant health outcomes has not been defined. We aimed to assess the prevalence of HBV coinfection among HIV-infected pregnant women and its impact...

25-Hydroxyvitamin D insufficiency and deficiency is associated with HIV disease progression and virological failure post-antiretroviral therapy initiation in diverse multinational settings

Post Date: 
2014-07-15
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Publication: 
The Journal of Infectious Diseases
Background: Low 25-hydroxyvitamin D (25(OH)D) has been associated with increased HIV mortality, but prospective studies assessing treatment outcomes after combination antiretroviral therapy (cART) initiation in resource-limited settings are lacking. Methods: A case-cohort study (N = 411) was nested...

Challenges to disclosure of HIV status to perinatally infected children: a study of caregiver perspectives in Pune, India

Post Date: 
2014-06-15
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Publication: 
Journal of Pediatric Infectious Diseases
Effective guidelines around disclosure of HIV status are lacking and limited data from India reveal low rates of HIV disclosure to perinatally infected children. This study, conducted in Pune, India, attempts to understand the experiences of caregivers of perinatally infected children around the...

Quality of obstetric referral services in India's JSY cash transfer programme for institutional births: a study from Madhya Pradesh province

Post Date: 
2014-05-08
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Publication: 
PLoS One
Abstract Background: India launched JSY cash transfer programme to increase access to emergency obstetric and neonatal care (EmONC) by incentivising in-facility births. This increased in-facility births from 30%in 2005 to 73% in 2012 however, decline in maternal mortality follows a secular trend...

Change in Vitamin D levels occurs early after antiretroviral therapy initiation and depends on treatment regimen in resource-limited settings

Post Date: 
2014-04-21
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Publication: 
PLOS One
Background: Vitamin D has wide-ranging effects on the immune system, and studies suggest that low serum vitamin D levels are associated with worse clinical outcomes in HIV. Recent studies have identified an interaction between antiretrovirals used to treat HIV and reduced serum vitamin D levels,...

Pregnancy differentially impacts performance of latent tuberculosis diagnostics in a high-burden setting

Post Date: 
2014-03-21
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Publication: 
PLOS One
Background: Targeted screening for latent TB infection (LTBI) in vulnerable populations is a recommended TB control strategy. Pregnant women are at high risk for developing TB and likely to access healthcare, making pregnancy an important screening opportunity in developing countries. The...

Biomarkers for sepsis: a review with special attention to India

Post Date: 
2014-03-19
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Publication: 
BioMed Research International
Sepsis is a serious infection and still a common cause of morbidity and mortality in resource-limited settings such as India. Even when microbiologic diagnostics are available, bacteremia is only identified in a proportion of patients who present with sepsis and bloodstream infections. Biomarkers...

Maternal pneumococcal capsular IgG antibodies and transplacental transfer are lower in South Asian HIV-infected mother-infant pairs

Post Date: 
2014-03-14
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Publication: 
Vaccine
Background: Our understanding of the mother-to-child transfer of serotype-specific pneumococcal antibodies is limited in non-immunized, HIV-positive women. Methods: We compared geometric mean antibody concentrations (GMCs), geometric mean transplacental cord:maternal ratios (GMRs) and proportions...

Modifiable risk factors associated with tuberculosis disease in children in Pune, India

Post Date: 
2014-02-15
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Publication: 
International Journal of Tuberculosis and Lung Disease
Setting: India accounts for the largest burden of tuberculosis (TB) worldwide, with 26% of the world's cases. Objective: To assess the association between novel modifiable risk factors and TB in Indian children. Design: Cases were children aged ≤ 5 years with confirmed/probable TB based on World...

Pediatric tuberculosis in young children in India: a prospective study

Post Date: 
2013-11-11
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Publication: 
BioMed Research International
Background: India has one of the highest tuberculosis (TB) burdens globally. However, few studies have focused on TB in young children, a vulnerable population, where lack of early diagnosis results in poor outcomes. Methods: Young children (≤ 5 years) with suspected TB were prospectively enrolled...

HIV/AIDS education in traditional Indian systems of medicine: faculty perspectives

Post Date: 
2013-10-24
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Publication: 
Journal of Traditional Medicine and and Clinical Naturopathy
In India, HIV-infected individuals face numerous challenges in their search for treatments. Currently, western allopathic medicine (hereinafter ‘biomedicine’) offers antiretroviral therapy (ART) for HIV/AIDS and associated co-morbidities that have prolonged survival and improved quality of life...

India’s new policy to protect research participants

Post Date: 
2013-07-31
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Publication: 
The BMJ
Editorial Introduction: India, the country with the largest disease burden in the world,1 is now a major international hub for clinical research. However, a recent policy that was meant to mitigate important ethical concerns may have profound and unintended consequences for public health and may...

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The Association of Household Air Pollution and Tuberculosis in Women and Children in Pune, India

Post Date: 
2016-06-21
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Presentation Location: 
Baltimore, MD
Event & Convener: 
2016 Annual Meeting. Johns Hopkins Center for Tuberculosis Research
Presentation

Inflammation in HIV-infected Pregnant Women: Relationship with Diet, Gut Microbiome, and Preterm Birth

Post Date: 
2016-06-10
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Presentation Location: 
Baltimore, MD
Event & Convener: 
JHU Center for AIDS Research Annual Meeting
Presentation

Medicine as a Bridge Between the US and India

Post Date: 
2016-05-21
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Presentation Location: 
Philadelphia, PA
Event & Convener: 
Indiaspora
Presentation

Double Trouble: Managing and Preventing TB and HIV

Post Date: 
2016-04-20
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Presentation Location: 
Pune, India
Event & Convener: 
DY Patil University
Presentation

Clinical, Social, and Meteorological Factors Associated with Dengue and Malaria Diagnosis in Adults in Pune, India

Post Date: 
2016-03-03
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Presentation Location: 
Hyderabad, India
Event & Convener: 
17th International Congress on Infectious Diseases
Poster Session. Kadam D, Raichur P, Chandanwale A, Joshi S, Robinson M, Marbaniang I, Kagal A, Bharadwaj, Mave V.

Frequent Resistant Gram Negative Rod Stool Colonization among Patients Admitted with Acute Febrile Illness in Pune, India

Post Date: 
2016-03-03
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Presentation Location: 
Hyderabad, India
Event & Convener: 
17th International Congress on Infectious Diseases
Poster Presentation. Bharadwaj RS, Robinson M, Marbaniang I, Kagal A, Raichur PA, Kulkami V, Balasubramanian U, Onawale P, Kanade S, Nelson G, Gupta A, Mave V.

High TB Risk in HIV-Positive Patients on Second line Antiretrovirals in Pune, India

Post Date: 
2016-02-24
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Presentation Location: 
Boston, MA
Event & Convener: 
Conference on Retroviruses and Opportunistic Infections 2016
Poster Presentation: TB and Antiretroviral Therapy. Authors: Mave V , Kadam D, Salvi S, Basavaraj A, Joshi S, Chandanwale A, Gupte N, Bollinger RC, Gupta A.

Pregnancy Intensifies the IFN-gamma Suppression of HIV in TB-infected Indian Women

Post Date: 
2016-02-24
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Presentation Location: 
Boston, MA
Event & Convener: 
Conference on Retroviruses and Opportunistic Infections 2016
Poster Presentation: Tuberculosis and Pregnancy. Mathad J, Bhosale R, Balasubramanian U, Deshpande P, Kanade S, Mave V, Gupta A.

TB Risk Perceptions Among Medical Residents at a Tertiary Care Center in India

Post Date: 
2015-12-06
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Presentation Location: 
Cape Town, South Africa
Event & Convener: 
46th Union World Conference on Lung Health. International Union for Tuberculosis and Lung Disease.
Oral Abstract. Session: The Wide Swath of Vulnerable Populations. Pardeshi G , Parande M, Kadam D, Chandanwale A, Deluca A, Bollinger R, Farley J, Suryavanshi N.

TB Outbreak among Health Care Workers and Trainees in a Tertiary-care Hospital in Pune, India

Post Date: 
2015-12-05
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Presentation Location: 
Cape Town, South Africa
Event & Convener: 
46th Union World Conference on Lung Health
E-Poster Discussion. Session: Preventing Infection and Transmission of TB in Health Facilities and the Community. Authors: Basavaraj A , Patil A, Kadam DB, Chandanwale A, Jain D, DeLuca A, Mave V, Bollinger R.

Isoniazid Hair Concentrations in Children with TB

Post Date: 
2015-12-05
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Presentation Location: 
Cape Town, South Africa
Event & Convener: 
46th Union World Conference on Lung Health. International Union for Tuberculosis and Lung Disease.
Poster Session. Authors: Mave V, Kinikar AA, Gupte N, Nimkar S, Kagal A, Horng H, Ramachandran G, Dooley K, Gupta A.

Incidence and Risk Factors for TB among HIV+ Children in India

Post Date: 
2015-12-05
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Presentation Location: 
Cape Town, South Africa
Event & Convener: 
The 46th Union World Conference on Lung Health
Poster Discussion. Session: TART: TB Risk and Impact of ART. Authors: Kinikar AA , DeLuca A, Gupte N, Kadam DB, Khadse S, Chandanwale A, Gupta A, Bollinger R.

Characteristics Associated with Mobile Phone Access among TB Patients in Pune, India

Post Date: 
2015-12-04
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Presentation Location: 
Cape Town, South Africa
Event & Convener: 
The 46th Union World Conference on Lung Health
Poster Discussion. Session: What's App Doc? Use of m-Health. Authors: Ogale YP, Elf J, Lokhande R, Mave V, Roy S, Gupta A, Golub J, Mathad J.

Risk Factors for Unfavorable Treatment Outcomes in DOTs-treated Pediatric TB Patients

Post Date: 
2015-12-04
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Clinical Sites: 
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Presentation Location: 
Cape Town, South Africa
Event & Convener: 
The 46th Union World Conference on Lung Health
Poster Discussion. Session: TB in Children: Epidemiology–I. Authors: Shelke S, Bollinger R, Chandanwale A, DeLuca A, Gupta A, Gupte N, Adhav PS, Kadam DB.

Utility of GeneXpert for Diagnosis of Rifampicin-resistant Extra-pulmonary TB—A Retrospective Review of 70 Cases, SGH, Pune, India

Post Date: 
2015-12-04
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Clinical Sites: 
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Presentation Location: 
Cape Town, South Africa
Event & Convener: 
The 46th Union World Conference on Lung Health
Poster Session. TB Diagnostic Challenges: Molecular and Other Techniques. Authors: Girish S, Dharmashle S, Desai S, Kagal A, Bharadwaj R, Chandanwale A, Lokhande R, Kadam DB, DeLuca A, Gupte N, Jain D, Gupta A, Bollinger R, Mave V.

Does Quality of Delivery Care Differ Between Public and Private Facilities in Madhya Pradesh, India?: An Exit Interview Study of Routine Delivery Care Practices

Post Date: 
2015-10-20
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Presentation Location: 
Mexico City, Mexico
Event & Convener: 
Global Maternal Newborn Health Conference 2015
Abstract Presentation. Chaturvedi C, Randive B , Sabde Y, Diwan V, Raven J, De Costa A.

Dengue and Malaria are Common Infections among Adults and Adolescents Hospitalized with Acute Febrile Illness in Western India

Post Date: 
2015-10-09
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Presentation Location: 
San Diego, CA
Event & Convener: 
Infectious Diseases Society of America. ID Week 2015.
Poster Session: Student and Resident Poster Gallery during Posters in the Park. Mave V, Kadam D, Bharadwaj R, Kagal A, Sachs J, Raichur P, Kanade S, Gupte N, Joshi S, Chandanwale A, Zenilman JM, Bollinger R, Gupta A.

Conducting HIV and TB Research in India: Challenges and Opportunities

Post Date: 
2015-08-27
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Presentation Location: 
Atlanta, GA
Event & Convener: 
Emory University
Presentation

Therapeutic Drug Monitoring (TDM) of TB in Young Children: The Role of Hair Assays

Post Date: 
2015-06-17
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Presentation Location: 
Washington, DC
Event & Convener: 
IMPAACT Annual Meeting
Lecture

The Association of Exposure to Air Pollution from Biomass Fuels, Kerosene, and Secondhand Tobacco Smoke with TB in Adult Women and Children in Pune, India

Post Date: 
2015-05-01
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Presentation Location: 
Denver, CO
Event & Convener: 
American Thoracic Society International Conference
Poster Session: Latent TB Infection: Diagnosis and Treatment. Oral Presentation. Elf JL , Kinikar A, Khadse S, Mave V, Gupte N, Kulkarni V, Patekar S, Raichur P, Breysse P, Gupta A, Golub J.

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