India

 

With a population of more than one billion, India is the second largest country in the world, represents 16% of the global population, and the national average for life expectancy is only 65 years. India leads the world in the largest absolute burden of TB, ranks third for HIV (behind South Africa and Nigeria), and ranks second for diabetes. The country receives funding to support HIV/AIDS prevention, treatment and care programs under the US President's Emergency Plan for AIDS Relief (PEPFAR).

CCGHE partners with institutions in India tackle grave health issues on the front lines. LEARN ABOUT CCGHE-INDIA PARTNERSHIPS

 
CCGHE WORK IN INDIA

 

A Prospective Study Evaluating the Role of Cryptococcal Antigen Screening among HIV-infected Adults with Low CD4 Counts

Post Date: 
2011-01-01
Country: 
This prospective observational study aimed to evaluate the burden of cryptococcal disease among approximately 200 HIV-infected adults with low CD4 cell counts in Pune, India to determine whether a Cryptococcal screening strategy should be the standard of care among patients with advanced HIV...

P1073: Study of Immune Reconstitution Inflammatory Syndrome (IRIS) for International Sites Initiating Highly Active Antiretroviral Therapy (HAART) in Infants and Children < 72 Months of Age

Post Date: 
2010-11-15
P1073 is a case controlled prospective, clinical, observational and pathogenesis study of HIV-infected infants and children (≥ 4 weeks to < 72 months of age) at international IMPAACT sites who are within 1 week of HAART initiation and if ≤ 12 months of age have had prior BCG immunization. The...

P1077BF: Breastfeeding Version of the PROMISE Study (Promoting Maternal and Infant Survival Everywhere)

Post Date: 
2010-02-02
1077BF is a randomized strategy trial, which is part of the PROMISE studies (1077BF, 1077FF, P1084s, and 1077HS). The Promoting Maternal and Infant Survival Everywhere (PROMISE) Protocol is a research protocol of the IMPAACT network designed to address in an integrated and comprehensive fashion...

P1077FF: Formula Feeding Version of the PROMISE Study (Promoting Maternal and Infant Survival Everywhere)

Post Date: 
2010-02-02
1077FF is a randomized strategy trial, which is part of the PROMISE studies (1077BF, 1077FF, P1084s, and 1077HS). The Promoting Maternal and Infant Survival Everywhere (PROMISE) Protocol is a research protocol of the IMPAACT network designed to address in an integrated and comprehensive fashion...

Impact of Malnutrition on HIV Treatment Failure in Resource-limited Settings

Post Date: 
2010-01-01
Country: 
Highly active antiretroviral therapy (HAART) has reduced morbidity and mortality among HIV-infected persons worldwide. However, early treatment failure (i.e. WHO stage 3 or 4 illnesses or death during the first 24 months of HAART) is more than 3-fold higher in resource limited settings (RLS) than...

A5225: Phase I/II Dose-Finding Study of High-Dose Fluconazole Treatment in AIDS-Associated Cryptococcal Meningitis

Post Date: 
2009-04-22
A5225/HiFLAC is a Phase I/II dose escalation and validation study of the safety, tolerability, and therapeutic effect of an induction-consolidation strategy of high-dose fluconazole alone for the treatment of cryptococcal meningitis (CM) in HIV-infected participants.

P1070: Dose-Finding and Pharmacogenetic Study of Efavirenz in HIV-Infected and HIV/TB Co-Infected Infants and Children ≥ 3 Months to < 36 Months of Age

Post Date: 
2008-12-05
Efavirenz (EFV) is an anti-HIV medicine that is commonly used to treat HIV infection in adults and children older than 3 years of age. This study is being conducted to look at the safety of EFV, blood levels of EFV, genetic factors that may affect blood levels of EFV, and how easy it is for infants...

BWI CTU: Baltimore-Washington-India Clinical Trials Unit

Post Date: 
2007-02-02
Comprising clinical trial sites at Johns Hopkins Medicine in Baltimore, Whitman Walker Health in Washington, DC, and the BJGMC-CCGHE collaboration in Pune, India, the Baltimore-Washington-India Clinical Trials Unit (BWI-CTU) is one of only 25 international HIV/TB clinical trial sites funded by the...

BJGMC-JHU Fogarty HIV-TB Training Program

Post Date: 
2007-01-01
Country: 
Funded by the Fogarty International Center at the National Institutes of Health, the JHU Fogarty program has nearly 20 years of success with providing training, professional development, and mentorship to clinicians and scientists in low and middle income countries. CCGHE's latest efforts in this...

P1060: Phase II, parallel, randomized, clinical trials comparing the responses to initiation of NNRTI-based antiretroviral therapy in HIV-infected infants who have not previously received Single dose Nevirapine for prevention of Mother-to-child HIV...

Post Date: 
2006-03-27
A single dose of nevirapine (SD NVP) given to an HIV infected pregnant woman followed by a single dose to her infant has been shown to be an effective way of reducing the risk of mother-to-child transmission (MTCT) of HIV. The purpose of this study was to compare the effectiveness of a non-...

Mother-to-Child Transmission (MTCT) of HIV: India SWEN Study

Post Date: 
2002-06-07
Country: 
Primary and secondary analyses of the India SWEN study, an NIH-funded phase III randomized controlled trial of an extended nevirapine prophylaxis regimen among 783 HIV-infected pregnant women and their breastfed infants in Pune, India.

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Inequalities in institutional delivery uptake and maternal mortality reduction in the context of cash incentive program, Janani Suraksha Yojana: Results from nine states in India

Post Date: 
2014-12-15
Publication: 
Social Science and Medicine
Country: 
Abstract Proportion of women giving birth in health institutions has increased sharply in India since the introduction of cash incentive program, Janani Suraksha Yojana (JSY) in 2005. JSY was intended to benefit disadvantaged population who had poor access to institutional care for childbirth and...

High levels of tobacco-specific N-nitrosamines and nicotine in Chaini Khaini, a product marketed as snus

Post Date: 
2014-12-09
Publication: 
Tobacco Control
Country: 
Introduction: Recently, a tobacco product, Chaini Khaini, identified as snus appeared in India. The product marketing emphasizes its discreet nature and explicitly claims safety by referring to the existing evidence on Swedish snus. We here analyzed tobacco-specific nitrosamines and nicotine in 12...

Quit history, intentions to quit, and reasons for considering quitting among tobacco users in India: Findings from the Tobacco Control Policy Evaluation India Wave 1 Survey

Post Date: 
2014-12-05
Publication: 
Indian Journal of Cancer
Country: 
Background: GATS India 2009–10 revealed that more than one-third (35%) of adults in India use tobacco in some form: 21% use smokeless tobacco, 9% smoke, and 5% are mixed users (they smoke and use smokeless tobacco), and the quit rate is very low. In an effort to decrease prevalence of tobacco use,...

Pre-antiretroviral therapy selenium status predicts WHO stages 3, 4 or death but not virologic failure post-antiretroviral therapy

Post Date: 
2014-11-13
Publication: 
Nutrients
A case-cohort study, within a multi-country trial of antiretroviral therapy (ART) efficacy (Prospective Evaluation of Antiretrovirals in Resource Limited Settings (PEARLS)), was conducted to determine if pre-ART serum selenium deficiency is independently associated with human immunodeficiency virus...

Source case investigation for children with TB disease in Pune, India

Post Date: 
2014-08-27
Publication: 
Tuberculosis Research and Treatment
Country: 
Setting. Contact tracing is broadly encouraged for tuberculosis (TB) control. In many high-burden countries, however, little effort is made to identify contacts of newly diagnosed TB patients. This failure puts children, many of whom live in poor crowded communities, at special risk. Objectives. To...

25-Hydroxyvitamin D insufficiency and deficiency is associated with HIV disease progression and virological failure post-antiretroviral therapy initiation in diverse multinational settings

Post Date: 
2014-07-15
Publication: 
The Journal of Infectious Diseases
Background: Low 25-hydroxyvitamin D (25(OH)D) has been associated with increased HIV mortality, but prospective studies assessing treatment outcomes after combination antiretroviral therapy (cART) initiation in resource-limited settings are lacking. Methods: A case-cohort study (N = 411) was nested...

Impact of maternal hepatitis B virus coinfection on mother-to-child transmission of HIV

Post Date: 
2014-07-15
Publication: 
HIV Medicine
Country: 
Objectives: Despite high hepatitis B virus (HBV) endemicity in various resource-limited settings (RLSs), the impact of maternal HIV/HBV coinfection on infant health outcomes has not been defined. We aimed to assess the prevalence of HBV coinfection among HIV-infected pregnant women and its impact...

Challenges to disclosure of HIV status to perinatally infected children: a study of caregiver perspectives in Pune, India

Post Date: 
2014-06-15
Publication: 
Journal of Pediatric Infectious Diseases
Country: 
Effective guidelines around disclosure of HIV status are lacking and limited data from India reveal low rates of HIV disclosure to perinatally infected children. This study, conducted in Pune, India, attempts to understand the experiences of caregivers of perinatally infected children around the...

Quality of obstetric referral services in India's JSY cash transfer programme for institutional births: a study from Madhya Pradesh province

Post Date: 
2014-05-08
Publication: 
PLoS One
Country: 
Abstract Background: India launched JSY cash transfer programme to increase access to emergency obstetric and neonatal care (EmONC) by incentivising in-facility births. This increased in-facility births from 30%in 2005 to 73% in 2012 however, decline in maternal mortality follows a secular trend...

Change in Vitamin D levels occurs early after antiretroviral therapy initiation and depends on treatment regimen in resource-limited settings

Post Date: 
2014-04-21
Publication: 
PLOS One
Background: Vitamin D has wide-ranging effects on the immune system, and studies suggest that low serum vitamin D levels are associated with worse clinical outcomes in HIV. Recent studies have identified an interaction between antiretrovirals used to treat HIV and reduced serum vitamin D levels,...

Pregnancy differentially impacts performance of latent tuberculosis diagnostics in a high-burden setting

Post Date: 
2014-03-21
Publication: 
PLOS One
Country: 
Background: Targeted screening for latent TB infection (LTBI) in vulnerable populations is a recommended TB control strategy. Pregnant women are at high risk for developing TB and likely to access healthcare, making pregnancy an important screening opportunity in developing countries. The...

Biomarkers for sepsis: a review with special attention to India

Post Date: 
2014-03-19
Publication: 
BioMed Research International
Country: 
Sepsis is a serious infection and still a common cause of morbidity and mortality in resource-limited settings such as India. Even when microbiologic diagnostics are available, bacteremia is only identified in a proportion of patients who present with sepsis and bloodstream infections. Biomarkers...

Maternal pneumococcal capsular IgG antibodies and transplacental transfer are lower in South Asian HIV-infected mother-infant pairs

Post Date: 
2014-03-14
Publication: 
Vaccine
Country: 
Background: Our understanding of the mother-to-child transfer of serotype-specific pneumococcal antibodies is limited in non-immunized, HIV-positive women. Methods: We compared geometric mean antibody concentrations (GMCs), geometric mean transplacental cord:maternal ratios (GMRs) and proportions...

Modifiable risk factors associated with tuberculosis disease in children in Pune, India

Post Date: 
2014-02-15
Publication: 
International Journal of Tuberculosis and Lung Disease
Country: 
Setting: India accounts for the largest burden of tuberculosis (TB) worldwide, with 26% of the world's cases. Objective: To assess the association between novel modifiable risk factors and TB in Indian children. Design: Cases were children aged ≤ 5 years with confirmed/probable TB based on World...

Pediatric tuberculosis in young children in India: a prospective study

Post Date: 
2013-11-11
Publication: 
BioMed Research International
Country: 
Background: India has one of the highest tuberculosis (TB) burdens globally. However, few studies have focused on TB in young children, a vulnerable population, where lack of early diagnosis results in poor outcomes. Methods: Young children (≤ 5 years) with suspected TB were prospectively enrolled...

HIV/AIDS education in traditional Indian systems of medicine: faculty perspectives

Post Date: 
2013-10-24
Publication: 
Journal of Traditional Medicine and and Clinical Naturopathy
Country: 
In India, HIV-infected individuals face numerous challenges in their search for treatments. Currently, western allopathic medicine (hereinafter ‘biomedicine’) offers antiretroviral therapy (ART) for HIV/AIDS and associated co-morbidities that have prolonged survival and improved quality of life...

India’s new policy to protect research participants

Post Date: 
2013-07-31
Publication: 
The BMJ
Country: 
Editorial Introduction: India, the country with the largest disease burden in the world,1 is now a major international hub for clinical research. However, a recent policy that was meant to mitigate important ethical concerns may have profound and unintended consequences for public health and may...

Patterns of TB drug-resistance in a tertiary care facility in Pune, India

Post Date: 
2013-07-18
Publication: 
Clinical Microbiology
Country: 
Introduction:Globally, the emergence of multi-drug resistant tuberculosis (MDRTB) (defined as resistance to isoniazid (INH) and rifampicin (RIF) and extensively drug resistant (XDR-TB) (defined as resistance to INH, RIF, any fluoroquinolone and to at least one of the three injectable second line...

India's conditional cash transfer programme (the JSY) to promote institutional birth: Is there an association between institutional birth proportion and maternal mortality?

Post Date: 
2013-06-27
Publication: 
PLoS One
Country: 
Abstract Background: India accounts for 19% of global maternal deaths, three-quarters of which come from nine states. In 2005, India launched a conditional cash transfer (CCT) programme, Janani Suraksha Yojana (JSY), to reduce maternal mortality ratio (MMR) through promotion of institutional births...

Effective coverage of institutional deliveries under the Janani Suraksha Yojana programme in high maternal mortality provinces of India: analysis of data from an annual health survey

Post Date: 
2013-06-17
Publication: 
The Lancet
Country: 
Abstract Background Three-quarters of India's maternal deaths come from nine (of 35) provinces. In 2005, the government launched a conditional cash transfer programme, Janani Suraksha Yojana (JSY), to reduce maternal mortality through promotion of institutional deliveries (ID). Despite steep rises...

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Medicine as a Bridge Between the US and India

Post Date: 
2016-05-21
Presentation Location: 
Philadelphia, PA
Country: 
Event & Convener: 
Indiaspora
Presentation

Double Trouble: Managing and Preventing TB and HIV

Post Date: 
2016-04-20
Presentation Location: 
Pune, India
Country: 
Event & Convener: 
DY Patil University
Presentation

Clinical, Social, and Meteorological Factors Associated with Dengue and Malaria Diagnosis in Adults in Pune, India

Post Date: 
2016-03-03
Presentation Location: 
Hyderabad, India
Country: 
Event & Convener: 
17th International Congress on Infectious Diseases
Poster Session. Kadam D, Raichur P, Chandanwale A, Joshi S, Robinson M, Marbaniang I, Kagal A, Bharadwaj, Mave V.

Frequent Resistant Gram Negative Rod Stool Colonization among Patients Admitted with Acute Febrile Illness in Pune, India

Post Date: 
2016-03-03
Presentation Location: 
Hyderabad, India
Country: 
Event & Convener: 
17th International Congress on Infectious Diseases
Poster Presentation. Bharadwaj RS, Robinson M, Marbaniang I, Kagal A, Raichur PA, Kulkami V, Balasubramanian U, Onawale P, Kanade S, Nelson G, Gupta A, Mave V.

Pregnancy Intensifies the IFN-gamma Suppression of HIV in TB-infected Indian Women

Post Date: 
2016-02-24
Presentation Location: 
Boston, MA
Country: 
Event & Convener: 
Conference on Retroviruses and Opportunistic Infections 2016
Poster Presentation: Tuberculosis and Pregnancy. Mathad J, Bhosale R, Balasubramanian U, Deshpande P, Kanade S, Mave V, Gupta A.

High TB Risk in HIV-Positive Patients on Second line Antiretrovirals in Pune, India

Post Date: 
2016-02-24
Presentation Location: 
Boston, MA
Country: 
Event & Convener: 
Conference on Retroviruses and Opportunistic Infections 2016
Poster Presentation: TB and Antiretroviral Therapy. Authors: Mave V , Kadam D, Salvi S, Basavaraj A, Joshi S, Chandanwale A, Gupte N, Bollinger RC, Gupta A.

TB Risk Perceptions Among Medical Residents at a Tertiary Care Center in India

Post Date: 
2015-12-06
Presentation Location: 
Cape Town, South Africa
Country: 
Event & Convener: 
46th Union World Conference on Lung Health. International Union for Tuberculosis and Lung Disease.
Oral Abstract. Session: The Wide Swath of Vulnerable Populations. Pardeshi G , Parande M, Kadam D, Chandanwale A, Deluca A, Bollinger R, Farley J, Suryavanshi N.

TB Outbreak among Health Care Workers and Trainees in a Tertiary-care Hospital in Pune, India

Post Date: 
2015-12-05
Presentation Location: 
Cape Town, South Africa
Country: 
Event & Convener: 
46th Union World Conference on Lung Health
E-Poster Discussion. Session: Preventing Infection and Transmission of TB in Health Facilities and the Community. Authors: Basavaraj A , Patil A, Kadam DB, Chandanwale A, Jain D, DeLuca A, Mave V, Bollinger R.

Isoniazid Hair Concentrations in Children with TB

Post Date: 
2015-12-05
Presentation Location: 
Cape Town, South Africa
Country: 
Event & Convener: 
46th Union World Conference on Lung Health. International Union for Tuberculosis and Lung Disease.
Poster Session. Authors: Mave V, Kinikar AA, Gupte N, Nimkar S, Kagal A, Horng H, Ramachandran G, Dooley K, Gupta A.

Incidence and Risk Factors for TB among HIV+ Children in India

Post Date: 
2015-12-05
Presentation Location: 
Cape Town, South Africa
Country: 
Event & Convener: 
The 46th Union World Conference on Lung Health
Poster Discussion. Session: TART: TB Risk and Impact of ART. Authors: Kinikar AA , DeLuca A, Gupte N, Kadam DB, Khadse S, Chandanwale A, Gupta A, Bollinger R.

Characteristics Associated with Mobile Phone Access among TB Patients in Pune, India

Post Date: 
2015-12-04
Presentation Location: 
Cape Town, South Africa
Country: 
Event & Convener: 
The 46th Union World Conference on Lung Health
Poster Discussion. Session: What's App Doc? Use of m-Health. Authors: Ogale YP, Elf J, Lokhande R, Mave V, Roy S, Gupta A, Golub J, Mathad J.

Risk Factors for Unfavorable Treatment Outcomes in DOTs-treated Pediatric TB Patients

Post Date: 
2015-12-04
Presentation Location: 
Cape Town, South Africa
Country: 
Event & Convener: 
The 46th Union World Conference on Lung Health
Poster Discussion. Session: TB in Children: Epidemiology–I. Authors: Shelke S, Bollinger R, Chandanwale A, DeLuca A, Gupta A, Gupte N, Adhav PS, Kadam DB.

Utility of GeneXpert for Diagnosis of Rifampicin-resistant Extra-pulmonary TB—A Retrospective Review of 70 Cases, SGH, Pune, India

Post Date: 
2015-12-04
Presentation Location: 
Cape Town, South Africa
Country: 
Event & Convener: 
The 46th Union World Conference on Lung Health
Poster Session. TB Diagnostic Challenges: Molecular and Other Techniques. Authors: Girish S, Dharmashle S, Desai S, Kagal A, Bharadwaj R, Chandanwale A, Lokhande R, Kadam DB, DeLuca A, Gupte N, Jain D, Gupta A, Bollinger R, Mave V.

Does Quality of Delivery Care Differ Between Public and Private Facilities in Madhya Pradesh, India?: An Exit Interview Study of Routine Delivery Care Practices

Post Date: 
2015-10-20
Presentation Location: 
Mexico City, Mexico
Country: 
Event & Convener: 
Global Maternal Newborn Health Conference 2015
Abstract Presentation. Chaturvedi C, Randive B , Sabde Y, Diwan V, Raven J, De Costa A.

Dengue and Malaria are Common Infections among Adults and Adolescents Hospitalized with Acute Febrile Illness in Western India

Post Date: 
2015-10-09
Presentation Location: 
San Diego, CA
Country: 
Event & Convener: 
Infectious Diseases Society of America. ID Week 2015.
Poster Session: Student and Resident Poster Gallery during Posters in the Park. Mave V, Kadam D, Bharadwaj R, Kagal A, Sachs J, Raichur P, Kanade S, Gupte N, Joshi S, Chandanwale A, Zenilman JM, Bollinger R, Gupta A.

Conducting HIV and TB Research in India: Challenges and Opportunities

Post Date: 
2015-08-27
Presentation Location: 
Atlanta, GA
Country: 
Event & Convener: 
Emory University
Presentation

Therapeutic Drug Monitoring (TDM) of TB in Young Children: The Role of Hair Assays

Post Date: 
2015-06-17
Presentation Location: 
Washington, DC
Country: 
Event & Convener: 
IMPAACT Annual Meeting
Lecture

The Association of Exposure to Air Pollution from Biomass Fuels, Kerosene, and Secondhand Tobacco Smoke with TB in Adult Women and Children in Pune, India

Post Date: 
2015-05-01
Presentation Location: 
Denver, CO
Country: 
Event & Convener: 
American Thoracic Society International Conference
Poster Session: Latent TB Infection: Diagnosis and Treatment. Oral Presentation. Elf JL , Kinikar A, Khadse S, Mave V, Gupte N, Kulkarni V, Patekar S, Raichur P, Breysse P, Gupta A, Golub J.

TB in Pregnancy

Post Date: 
2015-03-05
Presentation Location: 
Mumbai, India
Country: 
Event & Convener: 
RePORT India TB Workshop
Presentation

Cost-effectiveness of Isonaizid Preventive Therapy for HIV-Infected Pregnant Women in India

Post Date: 
2015-02-24
Presentation Location: 
Seattle, WA
Country: 
Event & Convener: 
Conference on Retroviruses and Opportunistic Infections 2015
Poster Presentation. Kapoor S, Chida N, Gupta A, Shah M

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