India

 

With a population of more than one billion, India is the second largest country in the world, represents 16% of the global population, and the national average for life expectancy is only 65 years. India leads the world in the largest absolute burden of TB, ranks third for HIV (behind South Africa and Nigeria), and ranks second for diabetes. The country receives funding to support HIV/AIDS prevention, treatment and care programs under the US President's Emergency Plan for AIDS Relief (PEPFAR).

CCGHE partners with institutions in India tackle grave health issues on the front lines. LEARN ABOUT CCGHE-INDIA PARTNERSHIPS

 
CCGHE WORK IN INDIA

 

Tuberculosis Noon Conference

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2013-10-24
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This effort ended in 2015. As part of the BJGMC-Johns Hopkins India Fogarty Training Program, from 2013-2015 CCGHE hosted the live Tuberculosis Noon Conference webcast. Led by Drs. Maunank Shah, Jonathan Golub, and Richard Chaisson, these webcast meetings brought together Johns Hopkins TB...

RePORT: C-TRIUMPH: Cohort for Tuberculosis Research by the Indo-US Medical Partnership

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2013-09-28
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Collaboratively funded by the US NIH, India’s Department of Biotechnology [DBT], and Indian Council of Medical Research, the Cohort for TB Research by the Indo-US Medical Partnership (C-TRIUMPH) is an Indo-US research consortium that is part of RePORT India, a countrywide consortium for TB research...

RePORT: C-TRIUMPH: Substudy on Assessing the Association of Indoor Air Pollution with Tuberculosis in Adult Women and Children under 5 Years of Age

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2013-09-15
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Addressing social and environmental risk factors contributing to TB disease is becoming increasingly important for national TB programs. We are leveraging the pediatric participants in 1,100 homes participating in the C-TRIUMPH study, enhancing data collection regarding household and individual...

Community Home Based India Prevention of Mother to Child Transmission of HIV (COMBIND)

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2013-09-02
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CCGHE is assessing whether equipping Community Health Workers with mobile health technology and involving them in technology training and personal empowerment seminars can help prevent mother-to-child transmission of HIV. CHWs who care for HIV + pregnant and nursing women are using the emocha...

Epidemiological Assessment of Pediatric Tuberculosis in Pune, India, through Contact Tracing

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2013-06-10
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This study ended in June 2016. Approximately 1 million new cases of Tuberculosis occur among children each year around the world, with a large number of these cases occurring among indigent populations without access to adequate healthcare facilities (World Health Organization). Due to their high...

Impact of Diabetes on TB Treatment Outcomes

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2013-02-01
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CCGHE, the JHU Center for TB Research and BJGMC have been awarded a $2.5 million dollar NIH grant (2013-2018) to conduct a study to evaluate treatment outcomes among Indian patients with both diabetes mellitus and active TB. This study is assessing the prevalence of impaired glucose or frank...

Bacterial Antimicrobial Resistance Patterns in Pune, India

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2013-01-10
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Evaluate etiology of acute fever and bacterial drug resistance patterns among adults and children in India.

ONCOGRID: An mHealth Approach to Prevention and Early Diagnosis of Oral Cancer in Rural South India

Post Date: 
2012-11-01
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This study ended February 7, 2017. The Indian sub-continent is burdened with 80% of the world’s patients with oral cancer, and delay in oral cancer diagnosis is one of the major problems that leads to poor treatment outcomes (V. Shanta, R. Swaminathan, R. Rama. Cancer Control 2013). Current...

Diagnosis of Active Tuberculosis in HIV-infected and Uninfected Young Children in India

Post Date: 
2012-07-24
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Tuberculosis (TB) is the most common cause of morbidity/mortality in HIV-infected individuals in India. India has the world's highest burden of HIV and TB, and since children acquire HIV/TB from their caregivers, active TB is highly prevalent (14-67.5%) among HIV-infected young children in India...

A5288: MULTIOCTAVE, Management Using the Latest Technologies in Resource-limited Settings to Optimize Combination Therapy After Viral Failure

Post Date: 
2012-07-16
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This is a mult-country clinical trial being conducted in Brazil, Haiti, India, Kenya, Malawi, Peru, South Africa, Thailand, Uganda, and Zambia. A5288 is a multi-step, open-label phase IV, prospective, interventional strategy study in resource-limited settings (RLS) for HIV-infected participants...

RePORT India

Post Date: 
2012-06-30
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RePORT India is a joint venture between the Indian and US governments. The Indo-US Vaccine Action Program, a collaboration between the Indian Department of Biotechnology (DBT), the Indian Council of Medical Research (ICMR), and the US NIH, is co-funding six teams of India- and US-based...

C-TRIUMPH Pilot Study: Burden and Risk Factors for Drug-resistant Tuberculosis in Pune, India

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2012-05-29
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This pilot study ended in April 2015. Drug resistant TB (MDR-TB and XDR-TB) is increasing worldwide. Although 20% of all global TB cases occur in India, current estimates of the burden of MDR-TB in India are limited. A well-characterized TB clinical cohort, household cohort and control cohort would...

Tuberculosis (TB) Diagnosis, Treatment, and Prevention Course

Post Date: 
2012-01-01
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To strengthen tuberculosis (TB) clinical care and research in India and Pakistan, CCGHE collaborated with BJGMC, the National AIDS Research Institute (NARI) and Indus Hospital to develop and deploy the Tuberculosis (TB) Diagnosis, Treatment ,and Prevention course. Originally developed as a...

Understanding Challenges and Perspectives of Parents about HIV Disclosures to their Children and Develop a Structured HIV Disclosure Model for Pediatric Age Group

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2011-12-08
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This study is terminated. In 2008 an estimated 70,000 children in India were living with HIV, with 21,000 new children are infected each year through mother to child transmission (Singh et al 2008). Increasing availability of antiretroviral treatment (ART) to HIV infected children in India means...

Sexually Transmitted Infections among Women in the Reproductive Age Group in Shevgaon, Ahmednagar District, Maharashtra, India

Post Date: 
2011-05-15
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This study was conducted in 2011. Sexually transmitted infections (STIs) constitute a significant epidemiological burden all over the world especially in middle and low income countries. Women are more vulnerable to STIs due to several biological and socio-economic reasons. Although transmission of...

A5273: Multicenter Study of Options for Second-Line Effective Combination Therapy (SELECT)

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2011-05-12
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This study was terminated May 2, 2017. This was a multinational clinical trial conducted in Brazil, India, Kenya, Malawi, Peru, South Africa, Tanzania, Thailand, and Zimbabwe. The study is being done with people who are taking their first anti-HIV drug regimen (including an Non-Nucleoside Reverse...

Predictors of Perinatal HBV Transmission in an HIV/HBV Infected Cohort

Post Date: 
2011-04-22
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This study ended in 2014. Hepatitis B virus (HBV) coinfection is common; affecting greater than 10% of HIV-infected individuals in resource-limited settings(1-3). Although the impact of HIV disease on HBV coinfection has been studied in non-pregnant adults, little is known about the effects of HIV...

A5282: A Randomized, Phase II Trial to Compare an HPV Test-and-Treat Strategy to a Cytology-Based Strategy for Prevention of CIN 2+ in HIV-Infected Women

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2011-03-15
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Indo-JHU partnership work on this trial was officially terminated September 10, 2018. This multi-country trial is being conducted in Botswana, Haiti, India, Malawi, Peru, South Africa, Zambia, and Zimbabwe. The investigators are looking for a better way to prevent cervical cancer. This study is...

A Prospective Study Evaluating the Role of Cryptococcal Antigen Screening among HIV-infected Adults with Low CD4 Counts

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2011-01-01
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This prospective observational study aimed to evaluate the burden of cryptococcal disease among approximately 200 HIV-infected adults with low CD4 cell counts in Pune, India to determine whether a Cryptococcal screening strategy should be the standard of care among patients with advanced HIV...

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Quit history, intentions to quit, and reasons for considering quitting among tobacco users in India: Findings from the Tobacco Control Policy Evaluation India Wave 1 Survey

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2014-12-05
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Publication: 
Indian Journal of Cancer
Background: GATS India 2009–10 revealed that more than one-third (35%) of adults in India use tobacco in some form: 21% use smokeless tobacco, 9% smoke, and 5% are mixed users (they smoke and use smokeless tobacco), and the quit rate is very low. In an effort to decrease prevalence of tobacco use,...

Pre-antiretroviral therapy selenium status predicts WHO stages 3, 4 or death but not virologic failure post-antiretroviral therapy

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2014-11-13
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Nutrients
A case-cohort study, within a multi-country trial of antiretroviral therapy (ART) efficacy (Prospective Evaluation of Antiretrovirals in Resource Limited Settings (PEARLS)), was conducted to determine if pre-ART serum selenium deficiency is independently associated with human immunodeficiency virus...

Source case investigation for children with TB disease in Pune, India

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2014-08-27
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Tuberculosis Research and Treatment
Setting. Contact tracing is broadly encouraged for tuberculosis (TB) control. In many high-burden countries, however, little effort is made to identify contacts of newly diagnosed TB patients. This failure puts children, many of whom live in poor crowded communities, at special risk. Objectives. To...

25-Hydroxyvitamin D insufficiency and deficiency is associated with HIV disease progression and virological failure post-antiretroviral therapy initiation in diverse multinational settings

Post Date: 
2014-07-15
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The Journal of Infectious Diseases
Background: Low 25-hydroxyvitamin D (25(OH)D) has been associated with increased HIV mortality, but prospective studies assessing treatment outcomes after combination antiretroviral therapy (cART) initiation in resource-limited settings are lacking. Methods: A case-cohort study (N = 411) was nested...

Impact of maternal hepatitis B virus coinfection on mother-to-child transmission of HIV

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2014-07-15
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HIV Medicine
Objectives: Despite high hepatitis B virus (HBV) endemicity in various resource-limited settings (RLSs), the impact of maternal HIV/HBV coinfection on infant health outcomes has not been defined. We aimed to assess the prevalence of HBV coinfection among HIV-infected pregnant women and its impact...

Challenges to disclosure of HIV status to perinatally infected children: a study of caregiver perspectives in Pune, India

Post Date: 
2014-06-15
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Journal of Pediatric Infectious Diseases
Effective guidelines around disclosure of HIV status are lacking and limited data from India reveal low rates of HIV disclosure to perinatally infected children. This study, conducted in Pune, India, attempts to understand the experiences of caregivers of perinatally infected children around the...

Quality of obstetric referral services in India's JSY cash transfer programme for institutional births: a study from Madhya Pradesh province

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2014-05-08
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PLoS One
Abstract Background: India launched JSY cash transfer programme to increase access to emergency obstetric and neonatal care (EmONC) by incentivising in-facility births. This increased in-facility births from 30%in 2005 to 73% in 2012 however, decline in maternal mortality follows a secular trend...

Change in Vitamin D levels occurs early after antiretroviral therapy initiation and depends on treatment regimen in resource-limited settings

Post Date: 
2014-04-21
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PLOS One
Background: Vitamin D has wide-ranging effects on the immune system, and studies suggest that low serum vitamin D levels are associated with worse clinical outcomes in HIV. Recent studies have identified an interaction between antiretrovirals used to treat HIV and reduced serum vitamin D levels,...

Pregnancy differentially impacts performance of latent tuberculosis diagnostics in a high-burden setting

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2014-03-21
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PLOS One
Background: Targeted screening for latent TB infection (LTBI) in vulnerable populations is a recommended TB control strategy. Pregnant women are at high risk for developing TB and likely to access healthcare, making pregnancy an important screening opportunity in developing countries. The...

Biomarkers for sepsis: a review with special attention to India

Post Date: 
2014-03-19
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Publication: 
BioMed Research International
Sepsis is a serious infection and still a common cause of morbidity and mortality in resource-limited settings such as India. Even when microbiologic diagnostics are available, bacteremia is only identified in a proportion of patients who present with sepsis and bloodstream infections. Biomarkers...

Maternal pneumococcal capsular IgG antibodies and transplacental transfer are lower in South Asian HIV-infected mother-infant pairs

Post Date: 
2014-03-14
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Vaccine
Background: Our understanding of the mother-to-child transfer of serotype-specific pneumococcal antibodies is limited in non-immunized, HIV-positive women. Methods: We compared geometric mean antibody concentrations (GMCs), geometric mean transplacental cord:maternal ratios (GMRs) and proportions...

Modifiable risk factors associated with tuberculosis disease in children in Pune, India

Post Date: 
2014-02-15
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Publication: 
International Journal of Tuberculosis and Lung Disease
Setting: India accounts for the largest burden of tuberculosis (TB) worldwide, with 26% of the world's cases. Objective: To assess the association between novel modifiable risk factors and TB in Indian children. Design: Cases were children aged ≤ 5 years with confirmed/probable TB based on World...

Pediatric tuberculosis in young children in India: a prospective study

Post Date: 
2013-11-11
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BioMed Research International
Background: India has one of the highest tuberculosis (TB) burdens globally. However, few studies have focused on TB in young children, a vulnerable population, where lack of early diagnosis results in poor outcomes. Methods: Young children (≤ 5 years) with suspected TB were prospectively enrolled...

HIV/AIDS education in traditional Indian systems of medicine: faculty perspectives

Post Date: 
2013-10-24
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Journal of Traditional Medicine and and Clinical Naturopathy
In India, HIV-infected individuals face numerous challenges in their search for treatments. Currently, western allopathic medicine (hereinafter ‘biomedicine’) offers antiretroviral therapy (ART) for HIV/AIDS and associated co-morbidities that have prolonged survival and improved quality of life...

India’s new policy to protect research participants

Post Date: 
2013-07-31
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The BMJ
Editorial Introduction: India, the country with the largest disease burden in the world,1 is now a major international hub for clinical research. However, a recent policy that was meant to mitigate important ethical concerns may have profound and unintended consequences for public health and may...

Patterns of TB drug-resistance in a tertiary care facility in Pune, India

Post Date: 
2013-07-18
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Clinical Microbiology
Introduction:Globally, the emergence of multi-drug resistant tuberculosis (MDRTB) (defined as resistance to isoniazid (INH) and rifampicin (RIF) and extensively drug resistant (XDR-TB) (defined as resistance to INH, RIF, any fluoroquinolone and to at least one of the three injectable second line...

India's conditional cash transfer programme (the JSY) to promote institutional birth: Is there an association between institutional birth proportion and maternal mortality?

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2013-06-27
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PLoS One
Abstract Background: India accounts for 19% of global maternal deaths, three-quarters of which come from nine states. In 2005, India launched a conditional cash transfer (CCT) programme, Janani Suraksha Yojana (JSY), to reduce maternal mortality ratio (MMR) through promotion of institutional births...

Effective coverage of institutional deliveries under the Janani Suraksha Yojana programme in high maternal mortality provinces of India: analysis of data from an annual health survey

Post Date: 
2013-06-17
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The Lancet
Abstract Background Three-quarters of India's maternal deaths come from nine (of 35) provinces. In 2005, the government launched a conditional cash transfer programme, Janani Suraksha Yojana (JSY), to reduce maternal mortality through promotion of institutional deliveries (ID)...

Assessment of Gutka ban in Maharashtra: findings from focus group discussion

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2013-06-11
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Publication: 
International Journal of Head & Neck Surgery
According to Global Adult Tobacco Survey (GATS) India 2009-2010, around 8.3% (13.4% among male and 2.5% amongfemale) of people in Maharashtra are gutka users. Gutkaconsumption not only causes oral cancer, but has also beenlinked with development of oral submucous fibrosis, aprecancerous lesion...

Screening for pulmonary tuberculosis in HIV-infected individuals: AIDS Clinical Trials Group Protocol A5253

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2013-04-15
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Publication: 
International Journal of Tuberculosis and Lung Disease
Background: Improved tuberculosis (TB) screening is urgently needed for human immunodeficiency virus (HIV) infected patients. Methods: An observational, multi-country, cross-sectional study of HIV-infected patients to compare a standardized diagnostic evaluation (SDE) for TB with standard of care (...

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Risk Factors for Unfavorable Treatment Outcomes in DOTs-treated Pediatric TB Patients

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2015-12-04
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Shelke S, Bollinger R, Chandanwale A, DeLuca A, Gupta A, Gupte N, Adhav PS, Kadam DB. Risk Factors for Unfavorable Treatment Outcomes in DOTs-treated Pediatric TB Patients. The 46th Union World Conference on Lung Health. Cape Town, South Africa.

Does Quality of Delivery Care Differ Between Public and Private Facilities in Madhya Pradesh, India?: An Exit Interview Study of Routine Delivery Care Practices

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2015-10-20
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Chaturvedi C, Randive B , Sabde Y, Diwan V, Raven J, De Costa A. Does Quality of Delivery Care Differ Between Public and Private Facilities in Madhya Pradesh, India?: An Exit Interview Study of Routine Delivery Care Practices. Global Maternal Newborn Health Conference 2015. Mexico City, Mexico. 2015

Dengue and Malaria are Common Infections among Adults and Adolescents Hospitalized with Acute Febrile Illness in Western India

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2015-10-09
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Mave V, Kadam D, Bharadwaj R, Kagal A, Sachs J, Raichur P, Kanade S, Gupte N, Joshi S, Chandanwale A, Zenilman JM, Bollinger R, Gupta A. Dengue and Malaria are Common Infections among Adults and Adolescents Hospitalized with Acute Febrile Illness in Western India. Infectious Diseases Society of...

Conducting HIV and TB Research in India: Challenges and Opportunities

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2015-08-27
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Gupta, A. Conducting HIV and TB Research in India: Challenges and Opportunities. Emory University. Atlanta, GA.

Therapeutic Drug Monitoring (TDM) of TB in Young Children: The Role of Hair Assays

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2015-06-17
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Mave, V. Therapeutic Drug Monitoring (TDM) of TB in Young Children: The Role of Hair Assays. IMPAACT Annual Meeting. Washington, DC.

The Association of Exposure to Air Pollution from Biomass Fuels, Kerosene, and Secondhand Tobacco Smoke with TB in Adult Women and Children in Pune, India

Post Date: 
2015-05-01
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Elf JL , Kinikar A, Khadse S, Mave V, Gupte N, Kulkarni V, Patekar S, Raichur P, Breysse P, Gupta A, Golub J. The Association of Exposure to Air Pollution from Biomass Fuels, Kerosene, and Secondhand Tobacco Smoke with TB in Adult Women and Children in Pune, India. American Thoracic Society...

TB in Pregnancy

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2015-03-05
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Gupta, A. TB in Pregnancy. RePORT India TB Workshop. Mumbai, India.

Cost-effectiveness of Isonaizid Preventive Therapy for HIV-Infected Pregnant Women in India

Post Date: 
2015-02-24
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Kapoor S, Chida N, Gupta A, Shah M. Cost-effectiveness of Isonaizid Preventive Therapy for HIV-Infected Pregnant Women in India. Conference on Retroviruses and Opportunistic Infections 2015. Seattle, WA. 2015.

Metabolic Complications/Inflammation

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2015-01-10
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Gupta, A. Metabolic Complications/Inflammation. 5th National Conference on HIV/AIDS Therapy. Mumbai, India.

Quit History, Intentions to Quit, and Reasons for Considering Quitting Among Tobacco Users in India: Findings From the Wave 1 TCP India Survey

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2014-12-05
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Gauri G Dhumal , Mangesh S Pednekar, Lalit J Raute, Prakash C Gupta, Genevieve Sansone, Anne CK Quah, Geoffrey T Fong. Quit History, Intentions to Quit, and Reasons for Considering Quitting Among Tobacco Users in India: Findings From the Wave 1 TCP India Survey. APACT 2013, University of Waterloo,...

RePORT India: Objectives and Future Directions

Post Date: 
2014-04-30
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Mave, V. RePORT India: Objectives and Future Directions. TB Vaccine 4th Global Forum. Shanghai, China.

Epidemiology of HIV/AIDS in India

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2014-04-04
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Bollinger, R. Epidemiology of HIV/AIDS in India. Mylan HIV Course Series. JHU Global mHealth. Baltimore, MD.

An Equity Analysis of Institutional Delivery Uptake and Maternal Mortality Reduction in Context of Cash Transfer Programme (JSY): Results from Nine States of India

Post Date: 
2014-03-10
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Randive B , San Sebastian M, De Costa A, Lindholm L. An Equity Analysis of Institutional Delivery Uptake and Maternal Mortality Reduction in Context of Cash Transfer Programme (JSY): Results from Nine States of India. Third Global Symposium on Health Systems Research. Health Systems Global. Cape...

Latent TB in India and Example Research Solutions for India

Post Date: 
2013-11-10
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Gupta, A. Latent TB in India and Example Research Solutions for India. Global Tuberculosis (TB) Clinical Management and Research. Johns Hopkins School of Nursing Course. Baltimore, MD.

Laboratory Capacity Building for International Clinical Research: The JHU-BJMC Pune, India Example

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2013-09-11
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Gupta, A. Laboratory Capacity Building for International Clinical Research: The JHU-BJMC Pune, India Example. Inaugural Pathology Education Symposium. Johns Hopkins School of Medicine: Department of Pathology. Baltimore, MD.

Quit History, Intentions to Quit, and Reasons for Considering Quitting Among Tobacco Users in India

Post Date: 
2013-09-01
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Gauri G Dhumal, Mangesh S Pednekar, Lalit J Raute, Prakash C Gupta, Genevieve Sansone, Anne CK Quah, Geoffrey T Fong. Quit History, Intentions to Quit, and Reasons for Considering Quitting Among Tobacco Users in India. International Conference on Public Health Priorities in the 21st Century: The...

Effective Coverage of Institutional Deliveries under the Janani Suraksha Yojana Programme in High Maternal Mortality Provinces of India: Analysis of Data from an Annual Health Survey

Post Date: 
2013-06-17
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Randive B , Chaturvedi S, Diwan V, De Costa A. Effective Coverage of Institutional Deliveries under the Janani Suraksha Yojana Programme in High Maternal Mortality Provinces of India: Analysis of Data from an Annual Health Survey. Global Health Metrics & Evaluation 2013. Seattle, Washington...

India’s Conditional Cash Transfer Programme to Promote Institutional Births: What has been the Effect on Maternal Mortality?

Post Date: 
2013-01-17
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Randive B , Diwan V, De Costa A. India’s Conditional Cash Transfer Programme to Promote Institutional Births: What has been the Effect on Maternal Mortality? Global Maternal Health Conference 2013. Maternal Health Task Force, Harvard School of Public Health. Arusha, Tanzania. 2013.

Nutritional Status and Childhood Growth Among Korku and Warli Tribes of Maharashtra: Anthropometric Perspective

Post Date: 
2013-01-01
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Dhumal, G. Nutritional Status and Childhood Growth Among Korku and Warli Tribes of Maharashtra: Anthropometric Perspective. National Seminar on ‘Policies and Issues In the Bio-Cultural Development of Scheduled Tribes, Anthropological Association, Mysore. Maharashtra, India.

Exposure to tuberculosis infected household contact, household food insecurity, and malnutrition, but not Vitamin D deficiency associated with pediatric tuberculosis in young children in Pune, India

Post Date: 
2012-10-17
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Jubulis J , Kinikar A, Ithape M, Hotalkar S, Kulkarni V, Mave V, Gupte N, Kagal A, Bharadwaj R, Jain S, Gupta A. Exposure to tuberculosis infected household contact, household food insecurity, and malnutrition, but not Vitamin D deficiency associated with pediatric tuberculosis in young children in...

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