India

 

With a population of more than one billion, India is the second largest country in the world, represents 16% of the global population, and the national average for life expectancy is only 65 years. India leads the world in the largest absolute burden of TB, ranks third for HIV (behind South Africa and Nigeria), and ranks second for diabetes. The country receives funding to support HIV/AIDS prevention, treatment and care programs under the US President's Emergency Plan for AIDS Relief (PEPFAR).

CCGHE partners with institutions in India tackle grave health issues on the front lines. LEARN ABOUT CCGHE-INDIA PARTNERSHIPS

 
CCGHE WORK IN INDIA

 

C-TRIUMPH Pilot Study: Burden and Risk Factors for Drug-resistant Tuberculosis in Pune, India

Post Date: 
2012-05-29
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This pilot study ended in April 2015. Drug resistant TB (MDR-TB and XDR-TB) is increasing worldwide. Although 20% of all global TB cases occur in India, current estimates of the burden of MDR-TB in India are limited. A well-characterized TB clinical cohort, household cohort and control cohort would...

Tuberculosis (TB) Diagnosis, Treatment, and Prevention Course

Post Date: 
2012-01-01
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To strengthen tuberculosis (TB) clinical care and research in India and Pakistan, CCGHE collaborated with BJGMC, the National AIDS Research Institute (NARI) and Indus Hospital to develop and deploy the Tuberculosis (TB) Diagnosis, Treatment ,and Prevention course. Originally developed as a...

Understanding Challenges and Perspectives of Parents about HIV Disclosures to their Children and Develop a Structured HIV Disclosure Model for Pediatric Age Group

Post Date: 
2011-12-08
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This study is terminated. In 2008 an estimated 70,000 children in India were living with HIV, with 21,000 new children are infected each year through mother to child transmission (Singh et al 2008). Increasing availability of antiretroviral treatment (ART) to HIV infected children in India means...

Sexually Transmitted Infections among Women in the Reproductive Age Group in Shevgaon, Ahmednagar District, Maharashtra, India

Post Date: 
2011-05-15
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This study was conducted in 2011. Sexually transmitted infections (STIs) constitute a significant epidemiological burden all over the world especially in middle and low income countries. Women are more vulnerable to STIs due to several biological and socio-economic reasons. Although transmission of...

A5273: Multicenter Study of Options for Second-Line Effective Combination Therapy (SELECT)

Post Date: 
2011-05-12
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This study was terminated May 2, 2017. This was a multinational clinical trial conducted in Brazil, India, Kenya, Malawi, Peru, South Africa, Tanzania, Thailand, and Zimbabwe. The study is being done with people who are taking their first anti-HIV drug regimen (including an Non-Nucleoside Reverse...

Predictors of Perinatal HBV Transmission in an HIV/HBV Infected Cohort

Post Date: 
2011-04-22
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This study ended in 2014. Hepatitis B virus (HBV) coinfection is common; affecting greater than 10% of HIV-infected individuals in resource-limited settings(1-3). Although the impact of HIV disease on HBV coinfection has been studied in non-pregnant adults, little is known about the effects of HIV...

A5282: A Randomized, Phase II Trial to Compare an HPV Test-and-Treat Strategy to a Cytology-Based Strategy for Prevention of CIN 2+ in HIV-Infected Women

Post Date: 
2011-03-15
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This multi-country trial is being conducted in Botswana, Haiti, India, Malawi, Peru, South Africa, Zambia, and Zimbabwe. The investigators are looking for a better way to prevent cervical cancer. This study is comparing two different methods to prevent cancer of the cervix in women who have HIV...

A Prospective Study Evaluating the Role of Cryptococcal Antigen Screening among HIV-infected Adults with Low CD4 Counts

Post Date: 
2011-01-01
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This prospective observational study aimed to evaluate the burden of cryptococcal disease among approximately 200 HIV-infected adults with low CD4 cell counts in Pune, India to determine whether a Cryptococcal screening strategy should be the standard of care among patients with advanced HIV...

The Role of Vitamin D in the Development of Active Tuberculosis Disease in Young Children

Post Date: 
2010-12-09
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This study was terminated September 2014. Mycobacterium tuberculosis (MTB) results in significant morbidity and mortality worldwide, yet remains difficult to diagnose and manage, particularly in resource constrained settings. Deficiency in vitamin D, a recently recognized antimicrobial peptide, is...

P1073: Study of Immune Reconstitution Inflammatory Syndrome (IRIS) for International Sites Initiating Highly Active Antiretroviral Therapy (HAART) in Infants and Children < 72 Months of Age

Post Date: 
2010-11-15
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This study was terminated April 23, 2015. This is a multi-national study conducted in India, South Africa, and Tanzania. P1073 is a case controlled prospective, clinical, observational and pathogenesis study of HIV-infected infants and children (≥ 4 weeks to < 72 months of age) at international...

Retrospective Characterization of Clinical and Demographic Data of Pediatric Tuberculosis Patients Treated at BJ Medical College in Pune, India

Post Date: 
2010-06-10
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This study ended June 14, 2013.

P1077BF: Breastfeeding Version of the PROMISE Study (Promoting Maternal and Infant Survival Everywhere)

Post Date: 
2010-02-02
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This multi-country trial is being conducted in India, Malawi, South Africa, Tanzania, Uganda, Zambia, and Zimbabwe. 1077BF is a randomized strategy trial, which is part of the PROMISE studies (1077BF, 1077FF, P1084s, and 1077HS). The Promoting Maternal and Infant Survival Everywhere (PROMISE)...

P1077FF: Formula Feeding Version of the PROMISE Study (Promoting Maternal and Infant Survival Everywhere)

Post Date: 
2010-02-02
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Countries: 
This multi-country trial is being conducted in India, Malawi, South Africa, Tanzania, Uganda, Zambia, and Zimbabwe. 1077FF is a randomized strategy trial, which is part of the PROMISE studies (1077BF, 1077FF, P1084s, and 1077HS). The Promoting Maternal and Infant Survival Everywhere (PROMISE)...

Impact of Malnutrition on HIV Treatment Failure in Resource-limited Settings

Post Date: 
2010-01-01
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Highly active antiretroviral therapy (HAART) has reduced morbidity and mortality among HIV-infected persons worldwide. However, early treatment failure (i.e. WHO stage 3 or 4 illnesses or death during the first 24 months of HAART) is more than 3-fold higher in resource limited settings (RLS) than...

Assessment of Active Tuberculosis amongst Asymptomatic HIV-infected Patients in Kakinada, India

Post Date: 
2009-07-23
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This study was conducted in 2008. Tuberculosis (TB) is a major public health threat in India and is the leading cause of morbidity and mortality amongst people living with HIV/AIDS worldwide.1 According to the WHO, India accounts for one-fifth of the global TB incident cases, with over 1.9 million...

A5225: Phase I/II Dose-Finding Study of High-Dose Fluconazole Treatment in AIDS-Associated Cryptococcal Meningitis

Post Date: 
2009-04-22
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This trial was terminated in March 2015. This multi-country stidy was conducted in India, Kenyam Peru, South Africa, Thailand, Uganda, United States, and Zimbabwe. A5225/HiFLAC is a Phase I/II dose escalation and validation study of the safety, tolerability, and therapeutic effect of an induction-...

A5253: Sensitivity and Specificity of Mycobacterium Tuberculosis Screening and Diagnostics in HIV-Infected Individuals

Post Date: 
2009-03-19
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This study was terminated October 15, 2014. An estimated 3 million HIV-infected individuals will enter programs for antiretroviral (ARV) treatment in the coming year, with projected rates of requirement for ARV therapy extending to more than 10 million in sub-Saharan Africa, southeastern Asia, and...

Evaluation of the Impact of Distance Learning For Expanding Capacity for Clinical Research in India

Post Date: 
2009-02-13
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This study ended in March 2012. The Office of AIDS Research has initiated a comprehensive program to expand clinical research capacity in India. This program has utilized a number of platforms for providing research training, including intensive in-country workshops and conferences. These programs...

P1070: Dose-Finding and Pharmacogenetic Study of Efavirenz in HIV-Infected and HIV/TB Co-Infected Infants and Children ≥ 3 Months to < 36 Months of Age

Post Date: 
2008-12-05
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This study ended March 10, 2015. This multi-country trial was conducted in India, South Africa, Tanzania, Uganda, Zambia, and Zimbabwe. Efavirenz (EFV) is an anti-HIV medicine that is commonly used to treat HIV infection in adults and children older than 3 years of age. This study is being...

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Patterns of TB drug-resistance in a tertiary care facility in Pune, India

Post Date: 
2013-07-18
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Publication: 
Clinical Microbiology
Introduction:Globally, the emergence of multi-drug resistant tuberculosis (MDRTB) (defined as resistance to isoniazid (INH) and rifampicin (RIF) and extensively drug resistant (XDR-TB) (defined as resistance to INH, RIF, any fluoroquinolone and to at least one of the three injectable second line...

India's conditional cash transfer programme (the JSY) to promote institutional birth: Is there an association between institutional birth proportion and maternal mortality?

Post Date: 
2013-06-27
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Publication: 
PLoS One
Abstract Background: India accounts for 19% of global maternal deaths, three-quarters of which come from nine states. In 2005, India launched a conditional cash transfer (CCT) programme, Janani Suraksha Yojana (JSY), to reduce maternal mortality ratio (MMR) through promotion of institutional births...

Effective coverage of institutional deliveries under the Janani Suraksha Yojana programme in high maternal mortality provinces of India: analysis of data from an annual health survey

Post Date: 
2013-06-17
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Publication: 
The Lancet
Abstract Background Three-quarters of India's maternal deaths come from nine (of 35) provinces. In 2005, the government launched a conditional cash transfer programme, Janani Suraksha Yojana (JSY), to reduce maternal mortality through promotion of institutional deliveries (ID). Despite steep rises...

Assessment of Gutka ban in Maharashtra: findings from focus group discussion

Post Date: 
2013-06-11
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Publication: 
International Journal of Head & Neck Surgery
According to Global Adult Tobacco Survey (GATS) India 2009-2010, around 8.3% (13.4% among male and 2.5% amongfemale) of people in Maharashtra are gutka users. Gutkaconsumption not only causes oral cancer, but has also beenlinked with development of oral submucous fibrosis, aprecancerous lesion...

Screening for pulmonary tuberculosis in HIV-infected individuals: AIDS Clinical Trials Group Protocol A5253

Post Date: 
2013-04-15
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Publication: 
International Journal of Tuberculosis and Lung Disease
Background: Improved tuberculosis (TB) screening is urgently needed for human immunodeficiency virus (HIV) infected patients. Methods: An observational, multi-country, cross-sectional study of HIV-infected patients to compare a standardized diagnostic evaluation (SDE) for TB with standard of care (...

Low tuberculosis knowledge among HIV-infected patients in a high HIV prevalence region within Southeast India

Post Date: 
2013-03-21
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Publication: 
Journal of the International Association of Providers of AIDS Care
Setting: A private multispecialty hospital in Kakinada, Andhra Pradesh, India. Methods: A survey of knowledge, attitudes, and perceptions adapted from a pretested questionnaire was administered to 128 HIV-infected adults, from July to August 2008.

Availability of treatment for eclampsia in public health institutions in Maharashtra, India

Post Date: 
2013-03-15
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Publication: 
Journal of Health, Population, and Nutrition
Abstract Severe pre-eclampsia and eclampsia are common causes of maternal deaths worldwide and more so in developing countries. Magnesium sulphate (MgSO4) is now the most-recommended drug of choice to treat these conditions. Despite favourable policies for the use of MgSO4 treatment in India,...

Correlates of lower comprehension of informed consent among participants enrolled in a cohort study in Pune, India

Post Date: 
2013-03-15
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Publication: 
International Health
Background: Optimum comprehension of informed consent by research participants is essential yet challenging. This study explored correlates of lower comprehension of informed consent among 1334 participants of a cohort study aimed at estimating HIV incidence in Pune, India. Methods: As part of the...

Nutritional status and childhood growth among Korku and Warli tribes of Maharashtra: anthropometric perspective

Post Date: 
2013-01-01
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Publication: 
Explorations in Medical Anthropology
Nutritional status and childhood growth among Korku and Warli tribes of Maharashtra: anthropometric perspective.

Contracting in specialists for emergency obstetric care—does it work in rural India?

Post Date: 
2012-12-31
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Publication: 
BMC Health Services Research
Abstract Background: Contracting in private sector is promoted in developing countries facing human resources shortages as a challenge to reduce maternal mortality. This study explored provision, practice, performance, barriers to execution and views about contracting in specialists for emergency...

Growth patterns among HIV-exposed infants receiving nevirapine prophylaxis in Pune, India

Post Date: 
2012-10-31
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Publication: 
BMC Infectious Diseases
Background: India has among the highest rates of infant malnutrition. Few studies investigating the growth patterns of HIV-exposed infants in India or the impact of timing of HIV infection on growth in settings such as India exist. Methods: We used data from the Six Week Extended Nevirapine (SWEN)...

Pooled individual data analysis of five randomized trials of infant nevirapine prophylaxis to prevent breast-milk HIV-1 transmission

Post Date: 
2012-10-19
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Publication: 
Clinical Infectious Diseases
Background: In resource-limited settings, mothers infected with human immunodeficiency virus type 1 (HIV-1) face a difficult choice: breastfeed their infants but risk transmitting HIV-1 or not breastfeed their infants and risk the infants dying of other infectious diseases or malnutrition. Recent...

Evaluation of a multimodal, distance learning HIV management course for clinical care providers in India

Post Date: 
2012-10-01
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Publication: 
Journal of the International Association of Providers of AIDS Care
Distance learning is an important tool for training HIV health workers. However, there is limited evidence on design and evaluation of distance learning HIV curricula and tools. We therefore designed, implemented, and evaluated a distance learning course on HIV management for clinical care...

Vitamin D deficiency is common among HIV-infected breastfeeding mothers in Pune, India, but not associated with mother-to-child HIV transmission

Post Date: 
2012-10-01
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Publication: 
HIV Clinical Trials
A recent report from Tanzania demonstrated an increased risk of being HIV infected or of dying at birth among children born to breastfeeding mothers with low baseline vitamin D levels. We conducted a nested case-control study among HIV-infected pregnant women in western India to confirm the...

Detection of microbial translocation in HIV and SIV infection using the limulus amebocyte lysate assay is masked by serum and plasma

Post Date: 
2012-08-01
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Publication: 
PLOS One
Objective: Microbial translocation (MT) is thought to be a major contributor to the pathogenesis of HIV-related immune activation, and circulating lipopolysaccharide (LPS) from Gram-negative bacteria is the principle measurement of this process. However, related research has been impeded by...

Authors’ response to Hanrahan et al CID article

Post Date: 
2012-05-15
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Publication: 
Clinical Infectious Diseases
Reply to letter

Predictors of mortality in hospitalized children with pandemic H1N1 influenza 2009 in Pune, India

Post Date: 
2012-04-15
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Publication: 
Indian Journal of Pediatrics
Objective: To analyse the factors associated with increased mortality among Indian Children with H1N1. Methods: Data were abstracted from available hospital records of children less than 12 y of age, who were admitted to Sassoon General Hospital in Pune, India, with confirmed pandemic 2009 H1N1...

Determination of a reference interval in a population

Post Date: 
2012-02-01
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Publication: 
National Medical Journal of India
The reference interval is the most widely used medical decision-making tool that separates healthy from diseased individuals. We briefly discuss the methods used to determine reference interval and its limitations.

Global health education for medical students: New learning opportunities and strategies

Post Date: 
2012-01-17
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Publication: 
Medical Teacher
Background: A new course was offered to introduce basic global health concepts to all first year Johns Hopkins medical students, that took advantage of new distance learning capacity to connect medical students in Baltimore with students and faculty in Uganda, Ethiopia, Pakistan and India. Aims:...

Sexually transmitted infections and risk behaviors among transgender persons (Hijras) of Pune, India

Post Date: 
2012-01-15
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Publication: 
Journal of Acquired Immune Deficiency Syndromes
Background: The objectives of this cross-sectional study were to determine the prevalence of HIV and sexually transmitted infections (STI) in Hijras (self-identified transgenders of South Asia), study associated risk factors, and compare the prevalence with that in heterosexual men and men having...

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TB in Pregnancy

Post Date: 
2015-03-05
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Presentation Location: 
Mumbai, India
Event & Convener: 
RePORT India TB Workshop
Presentation

Cost-effectiveness of Isonaizid Preventive Therapy for HIV-Infected Pregnant Women in India

Post Date: 
2015-02-24
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Countries: 
Presentation Location: 
Seattle, WA
Event & Convener: 
Conference on Retroviruses and Opportunistic Infections 2015
Poster Presentation. Kapoor S, Chida N, Gupta A, Shah M

Metabolic Complications/Inflammation

Post Date: 
2015-01-10
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Clinical Sites: 
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Presentation Location: 
Mumbai, India
Event & Convener: 
5th National Conference on HIV/AIDS Therapy
Panel Discussion: TB and HIV Co-Morbidities & IRIS.

Quit History, Intentions to Quit, and Reasons for Considering Quitting Among Tobacco Users in India: Findings From the Wave 1 TCP India Survey

Post Date: 
2014-12-05
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Presentation Location: 
Chiba, Japan
Event & Convener: 
APACT 2013, University of Waterloo, Ca
Oral Presentation. Gauri G Dhumal , Mangesh S Pednekar, Lalit J Raute, Prakash C Gupta, Genevieve Sansone, Anne CK Quah, Geoffrey T Fong.

RePORT India: Objectives and Future Directions

Post Date: 
2014-04-30
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Countries: 
Presentation Location: 
Shanghai, China
Event & Convener: 
TB Vaccine 4th Global Forum
Presentation

Epidemiology of HIV/AIDS in India

Post Date: 
2014-04-04
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Countries: 
Presentation Location: 
Baltimore, MD
Event & Convener: 
Mylan HIV Course Series. JHU Global mHealth
Lecture

An Equity Analysis of Institutional Delivery Uptake and Maternal Mortality Reduction in Context of Cash Transfer Programme (JSY): Results from Nine States of India

Post Date: 
2014-03-10
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Presentation Location: 
Cape Town, South Africa
Event & Convener: 
Third Global Symposium on Health Systems Research. Health Systems Global
Abstract Presenation. Randive B , San Sebastian M, De Costa A, Lindholm L.

Latent TB in India and Example Research Solutions for India

Post Date: 
2013-11-10
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Countries: 
Presentation Location: 
Baltimore, MD
Event & Convener: 
Global Tuberculosis (TB) Clinical Management and Research. Johns Hopkins School of Nursing Course
Lecture

Laboratory Capacity Building for International Clinical Research: The JHU-BJMC Pune, India Example

Post Date: 
2013-09-11
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Clinical Sites: 
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Presentation Location: 
Baltimore, MD
Event & Convener: 
Inaugural Pathology Education Symposium. Johns Hopkins School of Medicine: Department of Pathology
Presentation

Quit History, Intentions to Quit, and Reasons for Considering Quitting Among Tobacco Users in India

Post Date: 
2013-09-01
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Countries: 
Presentation Location: 
New Delhi, India
Event & Convener: 
International Conference on Public Health Priorities in the 21st Century: The Endgame for Tobacco, World Health Organization
Oral Presentation. Gauri G Dhumal, Mangesh S Pednekar, Lalit J Raute, Prakash C Gupta, Genevieve Sansone, Anne CK Quah, Geoffrey T Fong.

Effective Coverage of Institutional Deliveries under the Janani Suraksha Yojana Programme in High Maternal Mortality Provinces of India: Analysis of Data from an Annual Health Survey

Post Date: 
2013-06-17
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Countries: 
Presentation Location: 
Seattle, Washington
Event & Convener: 
Global Health Metrics & Evaluation 2013
Abstract Presentation. Randive B , Chaturvedi S, Diwan V, De Costa A.

India’s Conditional Cash Transfer Programme to Promote Institutional Births: What has been the Effect on Maternal Mortality?

Post Date: 
2013-01-17
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Countries: 
Presentation Location: 
Arusha, Tanzania
Event & Convener: 
Global Maternal Health Conference 2013. Maternal Health Task Force, Harvard School of Public Health
Abstract Presentation Randive B , Diwan V, De Costa A.

“Nutritional Status and Childhood Growth Among Korku and Warli Tribes of Maharashtra: Anthropometric Perspective

Post Date: 
2013-01-01
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Countries: 
Presentation Location: 
Maharashtra, India
Event & Convener: 
National Seminar on ‘Policies and Issues In the Bio-Cultural Development of Scheduled Tribes, Anthropological Association, Mysore
Oral presentation: Gauri Dhumal

Update in TB Diagnosis, Treatment and Prevention

Post Date: 
2012-01-31
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Countries: 
Presentation Location: 
Mumbai, India
Event & Convener: 
4th National Conference on HIV/AIDS Therapy. Human Healthcare and Research Foundation
Presentation

Early Childhood Growth among Mahadev Koli tribes of Maharashtra

Post Date: 
2011-06-06
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Countries: 
Presentation Location: 
Delhi, India
Event & Convener: 
Paradigm in New Anthropology, Department of Anthropology, University of Delhi
Oral presentation: Gauri Dhumal

TB/HIV in women and children: research in India and beyond

Post Date: 
2010-05-26
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Countries: 
Presentation Location: 
Baltimore, MD
Event & Convener: 
TB Clinical and Epi Lab Meeting. Johns Hopkins University School of Medicine
Presentation

HIV in India

Post Date: 
2009-05-22
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Countries: 
Presentation Location: 
New York, NY
Event & Convener: 
CIDER Seminar. Columbia Mailman School of Public Health
Presentation

HIV in India

Post Date: 
2009-05-04
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Countries: 
Presentation Location: 
Baltimore, MD
Event & Convener: 
Johns Hopkins University AIDS Alliance
Presentation

Challenges in the Management of HIV in India

Post Date: 
2008-03-06
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Countries: 
Presentation Location: 
Washington, DC
Event & Convener: 
Center for Global Development, 1776 Massachusetts Avenue, NW, Third Floor
Presentation

Lessons Learned from bringing the National AIDS Institute of India and JHU researchers together: What was possible, and what wasn’t possible with the level of connection in place

Post Date: 
2007-04-25
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Countries: 
Presentation Location: 
Arlington, VA
Event & Convener: 
2007 Internet2 Annual Meeting
Roundtable Discussion, Panel Session II: The Importance of International Research Collaboration and R&E Networking in South Asia

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