India

With a population of more than one billion, India is the second largest country in the world, represents 16% of the global population, and the national average for life expectancy is only 65 years. India leads the world in the largest absolute burden of TB, ranks third for HIV (behind South Africa and Nigeria), and ranks second for diabetes. The country receives funding to support HIV/AIDS prevention, treatment and care programs under the US President's Emergency Plan for AIDS Relief (PEPFAR).

Our Indo-JHU Clinical Research Partnership is dedicated to reversing poor patient outcomes. With operations based in Pune, our extensive research portfolio is directed by Dr. Amita Gupta (Baltimore, MD), with onsite direction from Dr. Vidya MaveDr. Nishi Suryavanshi, and Dr. Nikhil Gupte (Pune). The Indo-JHU Partnership employs more than 200 people and, in addition to our memberships in consortia with many esteemed Indian research institutions, we have formal agreements with:

CCGHE WORK IN INDIA

Risk of Tuberculosis among Health Care Workers and Trainees in a Tertiary-care Hospital in Pune, India

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2015-04-15
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This study was terminated April 24, 2018. It was funded by the Fogarty International Center at the U.S. National Institutes of Health. A retrospective study of health care workers (HCWs) was conducted by investigators of the Byramjee Jeejeebhoy Medical and Sassoon General Hospitals (BJMC-SGH) in...

Predictive Value of TB-symptom Screen in HIV-infected and HIV-uninfected Pregnant Women in Pune, India

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2014-10-28
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This study was terminated July 17, 2017. This is a cross sectional observational study will be conducted at BJGMC to establish what the predictive value of the WHO TB symptom screen is in pregnant women in India. We hypothesize that the WHO TB symptom screen will have a higher positive predictive...

Inflammation in HIV-infected Pregnant Women: Relationship with Diet, Gut Microbiome and Preterm Birth

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2014-10-28
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This study was terminated May 7, 2018. P regnancy is a state of relative immunosuppression in order to protect the fetus from being rejected. It has also been shown that the Th-1 helper cell response, which is normally necessary for overcoming TB infection, is suppressed in pregnancy. Thus,...

TBM Kids Substudy: Assessment of Neurocognitive Functions in Children with Tuberculosis Meningitis and Healthy Control Children Using the Mullen Scale of Early Learning Attending a Tertiary Care Public Hospital in Pune, India

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2014-09-01
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Objectives: The aim of the present study is to examine the neurological deficit in TBM kids and for that we need to assess, feasibility of the MSEL in our set up an Indian population of healthy children and children with meningitis in particular TB meningitis(TBM). The primary objective of the...

Impact of Immune Changes of HIV and Stages of Pregnancy on Tuberculosis

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2014-09-01
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This is the Parent Study for CCGHE’s PRACHITI (PRegnancy And CHanges In TuberculosIs) effort. It's supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development at the U.S. National Institutes of Health. Purpose: TB is a leading cause of maternal mortality,...

Diagnosis of Tuberculosis Infection and Th1 Immune Response in Pregnant Women in India

Post Date: 
2014-09-01
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This study was terminated April 16, 2018. Tuberculosis (TB) disease is a major cause of mortality among Indian women of reproductive age; approximately 20-50% of women in India are latently infected with Mycobacterium tuberculosis (MTB). Due to immune changes of pregnancy, women are particularly at...

A5279: Phase III Clinical Trial of Ultra-Short-Course Rifapentine/Isoniazid for the Prevention of Active Tuberculosis in HIV-infected Individuals with Latent Tuberculosis Infection

Post Date: 
2014-06-30
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This study ended April 27, 2015; it was conducted under the AIDS Clinical Trials Group (ACTG) and funded by the U.S. National Institutes of Health. Dr. Amita Gupta was Protocol Co-Vice Chair for this multinational clinical trial being conducted in Botswana, Brazil, Haiti, Kenya, Malawi, Peru,...

Evaluation of Longitudinal Blood Culture Isolates from BJ Medical College in Pune, India, 2003-2013

Post Date: 
2014-06-16
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This study was terminated July 31, 2014. Antibiotic resistance is a serious global problem and is caused by multiple factors which have led to difficulty in the management of life-threatening, multi-drug resistant (MDR) bacterial bloodstream infections. The knowledge of antibiotic resistance...

ART Study 1: Database: Epidemiology of HIV/AIDS and Associated Comorbidities in a Public Antiretroviral Treatment (ART) Clinic at BJGMC in Pune

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2014-06-14
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Since 2004, the National AIDS Control Program of India has been rolling out free antiretroviral therapy. Byramjee Jeejeebhoy Government Medical College (BJGMC), located in Pune, India, is now the largest HIV clinic in India, with over 26,000 adult and pediatric patients registered since 2005. We...

Optimizing Treatment to Improve TBM Outcomes in Children

Post Date: 
2014-05-01
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This study, known as TBM Kids, is being conducted in India and Malawi. Primary Objectives To characterize the pharmacokinetics (PK) (plasma and cerebrospinal fluid (CSF)) of rifampicin given at model-derived optimal daily doses and levofloxacin in children ages 6 months to 12 years of age with TBM...

P1078: A Phase IV Randomized Double-Blind Placebo-Controlled Trial to Evaluate the Safety of Immediate (Antepartum-Initiated) Versus Deferred (Postpartum-Initiated) Isoniazid Preventive Therapy Among HIV-Infected Women in High TB Incidence Settings

Post Date: 
2014-04-01
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This is a clinical trial conducted under the International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) Network and funded by the U.S. National Institutes of Health. Dr. Amita Gupta is Protocol Chair for this multinational clinical trial being conducted in...

Screening for Gender Based-violence (GBV) and Feasibility and Acceptability of mHealth GBV Screening and Support Tools

Post Date: 
2014-03-26
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This study was terminated February 14, 2017. Gender-based violence (GBV) is a significant public health issue in India, with estimates that over a third of women and girls are impacted at some point in their lifetime. This pilot qualitative study examined the feasibility of enhancing GBV prevention...

Evaluation of HIV Disease Burden in Hospitalized Patients at Sassoon General Hospital in Pune, India

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2013-11-18
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This study was terminated September 13, 2005. The goal of this project was to conduct both a retrospective and prospective epidemiological study of the burden of HIV disease at Sassoon General Hospital. The specific objectives of the study were to establish the proportion of HIV-infected...

Tuberculosis Noon Conference

Post Date: 
2013-10-24
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This effort ended in 2015. As part of the BJGMC-Johns Hopkins India Fogarty Training Program, from 2013-2015 CCGHE hosted the live Tuberculosis Noon Conference webcast. Led by Drs. Maunank Shah, Jonathan Golub, and Richard Chaisson, these webcast meetings brought together Johns Hopkins TB...

Cohort for Tuberculosis Research by the Indo-US Medical Partnership (C-TRIUMPH)

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2013-09-28
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Collaboratively funded by the US NIH, India’s Department of Biotechnology [DBT], and Indian Council of Medical Research, the Cohort for TB Research by the Indo-US Medical Partnership (C-TRIUMPH) is an Indo-US research consortium that is part of RePORT India, a countrywide consortium for TB...

Assessing the Association of Indoor Air Pollution with Tuberculosis in Adult Women and Children under 5 Years of Age

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2013-09-15
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This study is conducted the Cohort for Tuberculosis Research by the Indo-US Medical Partnership (C-TRIUMPH) under the Regional Prospective Observational Research for Tuberculosis (RePORT) Network, an international TB consortium. Addressing social and...

Community Home Based India Prevention of Mother to Child Transmission of HIV (COMBIND)

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2013-09-02
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This study ended May 14, 2019. CCGHE is assessing whether equipping Community Health Workers with mobile health technology and involving them in technology training and personal empowerment seminars can help prevent mother-to-child...

Epidemiological Assessment of Pediatric Tuberculosis in Pune, India, through Contact Tracing

Post Date: 
2013-06-10
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This study ended in June 2016. Approximately 1 million new cases of Tuberculosis occur among children each year around the world, with a large number of these cases occurring among indigent populations without access to adequate healthcare facilities (World Health Organization). Due to their high...

Impact of Diabetes on TB Treatment Outcomes

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2013-02-01
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CCGHE, the JHU Center for TB Research and BJGMC have been awarded a $2.5 million dollar NIH grant (2013-2018) to conduct a study to evaluate treatment outcomes among Indian patients with both diabetes mellitus and active TB. This study is assessing the prevalence of impaired glucose or frank...

Bacterial Antimicrobial Resistance Patterns in Pune, India

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2013-01-10
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This study was terminated September 24, 2019. Evaluate etiology of acute fever and bacterial drug resistance patterns among adults and children in India.

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Suboptimal anti-tuberculosis drug concentrations and outcomes in small and HIV coinfected children in India: recommendations for dose modifications

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2017-12-01
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Clinical Pharmacology and Therapeutics
This work aimed to evaluate the once-daily anti-tuberculosis treatment as recommended by the new Indian pediatric guidelines. Isoniazid, rifampin and pyrazinamide concentration-time profiles and treatment outcome were obtained from 161 Indian children with drug-sensitive tuberculosis...

Prevalence of dysglycemia and clinical presentation of pulmonary tuberculosis in Western India

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2017-12-01
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International Journal of Tuberculosis and Lung Disease
Objectives: To estimate the prevalence and risk factors of pre-diabetes mellitus (DM) and DM, and its associations with the clinical presentation of tuberculosis (TB). Design: Screening for DM was conducted among adults (age  18 years) with confirmed TB between December 2013 and...

People with tuberculosis falling through the cracks

Post Date: 
2017-11-01
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National Medical Journal of India
India accounts for approximately one-quarter of the estimated global burden of TB and MDR-TB. [4] Achieving the 2015 WHO End TB Strategy[5] and the latest Government of India target of TB elimination by 2025[6] will require substantial efforts and funding to continue to improve TB care in...

Risk factors for early mortality on antiretroviral therapy in advanced HIV-infected adults

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2017-10-23
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AIDS
Background: Many HIV-infected individuals present with advanced HIV disease. These patients are at high risk of death after antiretroviral therapy (ART) initiation, but risk factors for death in these patients are unclear. Methods: We used data from a multisite randomized trial...

A qualitative study exploring factors influencing clinical decision-making for influenza-like illness in Solapur city, Maharashtra, India

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2017-07-03
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Anthropology and Medicine
Abstract The co-existence of different types of medical systems (medical pluralism) is a typical feature of India's healthcare system. For conditions such as influenza-like illness (ILI), where non-specific disease signs/symptoms exist, clinical reasoning in the context of medical...

Cardiovascular risk in an HIV-infected population in India

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2017-07-03
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Heart Asia
Findings: HIV+ Indian patients who had cardiovascular disease at a younger age appear to be at imminent risk for morbidity.

Vitamin A and D deficiencies associated with incident tuberculosis in HIV-infected patients initiating antiretroviral therapy in multinational case-cohort study

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2017-07-01
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Journal of Acquired Immune Deficiency Syndromes
Introduction: Numerous micronutrients have immunomodulatory roles that may influence risk of tuberculosis (TB), but the association between baseline micronutrient deficiencies and incident TB after antiretroviral therapy (ART) initiation in HIV-infected individuals is not well characterized...

Constituent variation in smokeless tobacco purchased in Mumbai, India

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2017-07-01
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Tobacco Regulatory Science
Objectives: Worldwide, smokeless tobacco products vary greatly in their formulations and chemical composition. Understanding of toxic and carcinogenic constituent variations in such products can provide valuable insights for the development of effective tobacco control policies. In this study...

Household food insecurity is associated with low interferon-gamma levels in pregnant Indian women

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2017-07-01
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International Journal of Tuberculosis and Lung Disease
Objective: To determine the association between household food insecurity and interferon-gamma (IFN-γ) levels in pregnancy. Design: Pregnant women in India were administered the Household Food Insecurity Access Scale (HFIAS) questionnaire and underwent an IFN-γ release assay...

Maternal syphilis: An independent risk factor for mother to infant human immunodeficiency virus transmission

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2017-06-15
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Sexually Transmitted Diseases
Abstract Syphilis is associated with increased human immunodeficiency virus acquisition and sexual transmission; we examined impact on human immunodeficiency virus mother-to-child transmission among mother-infant pairs enrolled in the India Six-Week Extended-Dose Nevirapine study...

Tuberculosis screening among persons with diabetes mellitus in Pune, India

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2017-06-02
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BMC Infectious Diseases
Background: Diabetes mellitus (DM) increases tuberculosis (TB) risk, and there is increasing concern over the public health implications of the convergence of these two epidemics. Screening for TB among people with DM is now recommended in India. Methods: People with DM seeking care at a large...

High burden of antimicrobial resistance and mortality among adults and children with community-onset bacterial infections in India

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2017-04-15
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Journal of Infectious Diseases
Of 133 isolates from 115 patients, 50% were multi-drug resistant; of 33 isolates tested for carbapenem susceptibility, 36% were resistant.

Resident doctors' attitudes toward tuberculosis patients

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2017-04-15
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Indian Journal of Tuberculosis
Background: The attitude of the resident doctors toward tuberculosis (TB) patients can affect their treatment seeking behavior, compliance to treatment as well as reinforce the stigma attached to the disease by the society at large. Aims: To assess the attitudes...

Novel interferon-gamma assays for diagnosing tuberculosis in young children in India

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2017-04-01
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International Journal of Tuberculosis and Lung Disease
Setting: The tuberculin skin test (TST) and interferon-gamma release assays (IGRAs) are used as supportive evidence to diagnose active tuberculosis (TB). Novel IGRAs could improve diagnosis, but data are lacking in young children. Design: Children (age 5 years or...

High prevalence of cryptococcal antigenaemia amongst asymptomatic advanced HIV patients in Pune, India

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2017-03-21
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Indian Journal of Medical Microbiology
Methods : A prospective study was conducted in a large public sector ART centre and the inpatient wards of Sassoon Hospital, Pune, India. All consenting patients> 18 years of age with CD4 count <100 cells/mm3 were screened for CrAg by latex agglutination assay. Those with positive CrAg...

Modelling approaches for tuberculosis: are they realistic?

Post Date: 
2017-03-01
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The Lancet Global Health
Letter by Dr. Sachin Atre in The Lancet Global Health.

Vitamin A and D deficiencies associated with incident tuberculosis in HIV-infected patients initiating antiretroviral therapy in multinational case-cohort study

Post Date: 
2017-02-06
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Journal of Acquired Immune Deficiency Syndromes
Introduction: Numerous micronutrients have immunomodulatory roles that may influence risk of tuberculosis (TB), but the association between baseline micronutrient deficiencies and incident TB after antiretroviral (ART) initiation in HIV-infected individuals is not well characterized. ...

Patterns of use and perceptions of harm of smokeless tobacco in Navi Mumbai, India and Dhaka, Bangladesh

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2016-12-04
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Indian Journal of Community Medicine
Background: Globally, smokeless tobacco use is disproportionately concentrated in low-income and middle-income countries like India and Bangladesh. Objectives: The current study examined comparative patterns of use and perceptions of harm for different smokeless tobacco products among adults and...

Tuberculosis burden in India's private sector

Post Date: 
2016-11-15
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The Lancet Infectious Disease
Reply to author's reply

Sex-related differences in inflammatory and immune activation markers before and after combined antiretroviral therapy initiation

Post Date: 
2016-10-01
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Journal of Acquired Immune Deficiency Syndromes
Background: Women progress to death at the same rate as men despite lower plasma HIV RNA (viral load). We investigated sex-specific differences in immune activation and inflammation as a potential explanation. Methods: Inflammatory and immune activation markers [...

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