India

With a population of more than one billion, India is the second largest country in the world, represents 16% of the global population, and the national average for life expectancy is only 65 years. India leads the world in the largest absolute burden of TB, ranks third for HIV (behind South Africa and Nigeria), and ranks second for diabetes. The country receives funding to support HIV/AIDS prevention, treatment and care programs under the US President's Emergency Plan for AIDS Relief (PEPFAR).

Our Indo-JHU Clinical Research Partnership is dedicated to reversing poor patient outcomes. With operations based in Pune, our extensive research portfolio is directed by Dr. Amita Gupta (Baltimore, MD), with onsite direction from Dr. Vidya MaveDr. Nishi Suryavanshi, and Dr. Nikhil Gupte (Pune). The Indo-JHU Partnership employs more than 200 people and, in addition to our memberships in consortia with many esteemed Indian research institutions, we have formal agreements with:

CCGHE WORK IN INDIA

The Role of Vitamin D in the Development of Active Tuberculosis Disease in Young Children

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2010-12-09
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This study was terminated September 2014. Mycobacterium tuberculosis (MTB) results in significant morbidity and mortality worldwide, yet remains difficult to diagnose and manage, particularly in resource constrained settings. Deficiency in vitamin D, a recently recognized antimicrobial peptide, is...

P1073: Study of Immune Reconstitution Inflammatory Syndrome (IRIS) for International Sites Initiating Highly Active Antiretroviral Therapy (HAART) in Infants and Children < 72 Months of Age

Post Date: 
2010-11-15
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This study was terminated April 23, 2015. This was a multi-national study conducted in India, South Africa, and Tanzania under the International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) Network and funded by the U.S. National Institutes of Health. P1073 is a case controlled...

Retrospective Characterization of Clinical and Demographic Data of Pediatric Tuberculosis Patients Treated at BJ Medical College in Pune, India

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2010-06-10
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This study ended June 14, 2013.

Hospitalized Pediatric Patients with Pandemic 2009 H1N1 Influenza in India (August-November 2009)

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2010-04-10
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This study ended in April 2013. This was a review and collection of data from the medical records of pediatric patients who were admitted to the BJMC/Sassoon General Hospitals with H1N1 influenza during August-November 2009.

P1077BF: Breastfeeding Version of the PROMISE Study (Promoting Maternal and Infant Survival Everywhere)

Post Date: 
2010-02-02
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This trial was terminated November 6, 2019. This multi-country trial is being conducted in India, Malawi, South Africa, Tanzania, Uganda, Zambia, and Zimbabwe, conducted under the International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) Network and funded by the U.S. National...

P1077FF: Formula Feeding Version of the PROMISE Study (Promoting Maternal and Infant Survival Everywhere)

Post Date: 
2010-02-02
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This trial was terminated November 6, 2019. This multi-country trial is being conducted in India, Malawi, South Africa, Tanzania, Uganda, Zambia, and Zimbabwe, under the International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) Network and funded by the U.S. National Institutes of...

Assessment of Active Tuberculosis amongst Asymptomatic HIV-infected Patients in Kakinada, India

Post Date: 
2009-07-23
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This study was conducted in 2008. Tuberculosis (TB) is a major public health threat in India and is the leading cause of morbidity and mortality amongst people living with HIV/AIDS worldwide.1 According to the WHO, India accounts for one-fifth of the global TB incident cases, with over 1.9 million...

A5225: Phase I/II Dose-Finding Study of High-Dose Fluconazole Treatment in AIDS-Associated Cryptococcal Meningitis

Post Date: 
2009-04-22
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This trial was terminated in March 2015; it was conducted under the AIDS Clinical Trials Group (ACTG) and funded by the U.S. National Institutes of Health. This multi-country study was conducted in India, Kenyam Peru, South Africa, Thailand, Uganda, United States, and Zimbabwe. A5225/HiFLAC is a...

Impact of Malnutrition on HIV Treatment Failure in Resource-limited Settings

Post Date: 
2009-04-02
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This study, NWCS 319, was terminated August 20, 2019. Highly active antiretroviral therapy (HAART) has reduced morbidity and mortality among HIV-infected persons worldwide. However, early treatment failure (i.e. WHO stage 3 or 4 illnesses or death during the first 24 months of HAART) is more than 3...

A5253: Sensitivity and Specificity of Mycobacterium Tuberculosis Screening and Diagnostics in HIV-Infected Individuals

Post Date: 
2009-03-19
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This study was terminated October 15, 2014. An estimated 3 million HIV-infected individuals will enter programs for antiretroviral (ARV) treatment in the coming year, with projected rates of requirement for ARV therapy extending to more than 10 million in sub-Saharan Africa, southeastern Asia, and...

Evaluation of the Impact of Distance Learning For Expanding Capacity for Clinical Research in India

Post Date: 
2009-02-13
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This study ended in March 2012. The Office of AIDS Research has initiated a comprehensive program to expand clinical research capacity in India. This program has utilized a number of platforms for providing research training, including intensive in-country workshops and conferences. These programs...

P1070: Dose-Finding and Pharmacogenetic Study of Efavirenz in HIV-Infected and HIV/TB Co-Infected Infants and Children ≥ 3 Months to < 36 Months of Age

Post Date: 
2008-12-05
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This study ended March 10, 2015. This multi-country trial was conducted in India, South Africa, Tanzania, Uganda, Zambia, and Zimbabwe, under the International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) Network and funded by the U.S. National Institutes of Health. Efavirenz (EFV)...

The Presentation and Disease Progression of HIV Infection Among Indian Children

Post Date: 
2008-09-22
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This study was terminated July 24, 2010.

Cryptococcal Meningitis among Hospitalized HIV Patients in India (June 2008–June 2010)

Post Date: 
2008-06-30
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This study was terminated in 2016. Cryptococcal meningitis secondary to HIV infection is one of the leading causes of mortality from infectious agents worldwide. Recent estimates suggest close to a million infections annually and over six hundred thousand deaths every year. South and Southeast Asia...

The Association of Umbilical Cord Blood IgG Streptococcus pneumoniae and Hemophilus influenzae Antibody Titers with Mortality and Morbidity among HIV-exposed Infants in India

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2007-08-30
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This study ended in August 2010. In India, HIV-exposed infants (infants born to HIV-infected mothers), bear a large burden of mortality and morbidity from S. pneumoniae and H. influenzae type b infections. These bacterial respiratory pathogens are responsible for the majority of mortality and...

Calibration and Application of a Simple Sensitive/Less Sensitive Assay Applicable to Resource-Limited Countries for Determination of Recent HIV Infection and Incidence Estimates

Post Date: 
2007-03-22
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This study was terminated March 31, 2007. Sensitive/Less Sensitive assays (S/LS) to distinguish between recent and established HIV infections have been successfully applied to identify recently infected persons and determine HIV incidence. However, all currently used S/LS assays require laboratory...

BWI CTU: Baltimore-Washington-India Clinical Trials Unit

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2007-02-02
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Comprising clinical trial sites at Johns Hopkins Medicine in Baltimore, Whitman Walker Health in Washington, DC, and the BJGMC-CCGHE collaboration in Pune, India, the Baltimore-Washington-India Clinical Trials Unit (BWI-CTU) is one of only 25 international HIV/TB clinical trial sites funded by the...

BJGMC-JHU Fogarty HIV-TB Training Program

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2007-01-01
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Funded by the Fogarty International Center at the National Institutes of Health, the JHU Fogarty program has nearly 20 years of success with providing training, professional development, and mentorship to clinicians and scientists in low and middle income countries. CCGHE's latest efforts in this...

A Stand Alone Study for Participants of A5175 (A Phase IV, Randomized, Open-Label Evaluation of the Efficacy of Once-Daily Protease Inhibitor and Once-Daily Non-Nucleoside Reverse Transcriptase Inhibitor-Containing Therapy Combinations for Initial Treatme

Post Date: 
2006-05-02
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Globally, 40 million individuals are HIV-infected with 5 million new infections occurring each year; rates are increasing. Three million individuals died from HIV/AIDS in 2003. The global burden of the HIV epidemic is staggering, but in the short term, it is largely unfelt in the developed world...

P1060: Phase II, parallel, randomized, clinical trials comparing the responses to initiation of NNRTI-based antiretroviral therapy in HIV-infected infants who have not previously received Single dose Nevirapine for prevention of Mother-to-child HIV...

Post Date: 
2006-03-27
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This study ended June 28, 2015. This multi-country trial was conducted in India, Malawi, South Africa, Tanzania, Uganda, Zambia, and Zimbabwe under the International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) Network and funded by the U.S. National Institutes of Health. Full Title...

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Pediatric tuberculous meningitis: model-based approach to determining optimal doses of anti-tuberculosis drugs for children

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2015-10-22
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Clinical Pharmacology and Therapeutics
Pediatric tuberculous meningitis (TBM) is a highly morbid, often fatal disease. Standard treatment includes isoniazid, rifampin, pyrazinamide, and ethambutol. Current rifampin dosing achieves low cerebrospinal fluid (CSF) concentrations, and CSF penetration of ethambutol is poor. In adult...

RePORT International: advancing tuberculosis biomarker research through global collaboration

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2015-10-15
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Clinical Infectious Diseases
Progress in tuberculosis clinical research is hampered by a lack of reliable biomarkers that predict progression from latent to active tuberculosis, and subsequent cure, relapse, or failure. Regional Prospective Observational Research for Tuberculosis (RePORT) International represents a...

Knowledge, attitudes, and practices regarding breastfeeding in postpartum mothers at a tertiary care institute during a public health awareness campaign

Post Date: 
2015-10-09
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International Journal of Health Sciences
Background: Breast feeding has several benefits for both the infants and mothers. However, despite strong evidences in support of breast feeding its prevalence has remained low worldwide. The objective of the present study was to examine the knowledge and attitude towards breast feeding and infant...

Soluble CD14: An independent biomarker for risk of HIV mother-to-child transmission in setting of pre- and post-exposure antiretroviral prophylaxis

Post Date: 
2015-10-06
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The Journal of Infectious Diseases
Elevated soluble CD14 (sCD14) concentrations, a marker of monocyte activation, predicts adverse outcomes in human immunodeficiency virus (HIV)-infected adults. To examine the association of sCD14 concentrations with the risk of mother-to-child transmission (MTCT) of HIV, we nested a case-...

Economic and epidemiological impact of early antiretroviral therapy initiation in India

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2015-10-01
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Journal of the International AIDS Society
Introduction: Recent WHO guidance advocates for early antiretroviral therapy (ART) initiation at higher CD4 counts to improve survival and reduce HIV transmission. We sought to quantify how the cost-effectiveness and epidemiological impact of early ART strategies in India are affected by...

Pre-cART elevation of CRP and CD4+ T-cell immune activation associated with HIV clinical progression in a multinational case-cohort study

Post Date: 
2015-10-01
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Journal of Acquired Immune Deficiency Syndromes
Background: Despite the success of combination antiretroviral therapy (cART), a subset of HIV-infected patients who initiate cART develop early clinical progression to AIDS; therefore, some cART initiators are not fully benefitted by cART. Immune activation pre-cART may predict clinical...

Maternal Smokeless Tobacco Use in Pregnancy and Adverse Health Outcomes in Newborn babies

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2015-09-17
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The Asian Man
BACKGROUND: Perinatal morbidity and mortality are important indicators of maternal health and the future health of the child. Smokeless tobacco (ST) use during pregnancy is associated with low birth weight (LBW), preterm births, stillbirths, and small for gestation age (SGA). This study...

Contraceptive use and factors associated with postpartum surgical sterilization among HIV-infected women in Pune, India

Post Date: 
2015-08-21
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Journal of HIV/AIDS & Social Services
The authors desire to better understand contraceptive practices and factors associated with surgical tubal ligation (STL) among HIV-infected women. Secondary data were obtained from HIV-infected women enrolled in a National Institutes of Health–funded clinical trial assessing the efficacy of...

Failure to use and sustain male condom usage: lessons learned from a prospective study among men attending STI clinic in Pune, India

Post Date: 
2015-08-13
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PLOS One
Background: Sustained or consistent use of condoms by men remains a challenge. A study was carried out to identify factors associated with failure to use condoms consistently by men attending STD clinics in Pune, India. Method: Among 14137 STI clinic...

Concurrent anemia and elevated CRP predicts HIV clinical treatment failure, including TB, post-antiretroviral therapy initiation

Post Date: 
2015-07-01
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Clinical Infectious Diseases
Background: Anemia is a known risk factor for clinical failure following antiretroviral therapy (ART). Notably, anemia and inflammation are interrelated, and recent studies have associated elevated C-reactive protein (CRP), an inflammation marker, with adverse human immunodeficiency virus (...

Dengue and chikungunya co-infection associated with more severe clinical disease than mono-infection

Post Date: 
2015-04-15
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International Journal of Healthcare and Biomedical Research
Background: Dengue and chikungunya infections appear to be increasing in India. While Aedies aegypti is the transmitting vector for both viruses and co-infection occurs in the same communities, studies on the clinical significance of co-infection are limited. Materials and Methods: We conducted a...

Availability and distribution of safe abortion services in rural areas: a facility assessment study in Madhya Pradesh, India

Post Date: 
2015-03-20
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Global Health Action
Abstract Background: Unsafe abortion contributes to a significant portion of maternal mortality in India. Access to safe abortion care is known to reduce maternal mortality. Availability and distribution of abortion care facilities can influence women's access to these...

Vitamin D deficiency and risk of postpartum tuberculosis among HIV-infected breastfeeding mothers in India

Post Date: 
2015-03-15
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International Journal of Tuberculosis and Lung Disease
Some studies have associated low vitamin D levels with the risk of tuberculosis (TB), but its association in human immunodeficiency virus (HIV) infected mothers in a TB-endemic region has not been well studied. We conducted a nested 1:2 case-control study among HIV-infected mothers in western...

C-reactive protein (CRP), interferon gamma-inducible protein 10 (IP-10), and lipopolysaccharide (LPS) are associated with risk of tuberculosis after initiation of antiretroviral therapy in resource-limited settings

Post Date: 
2015-02-26
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Publication: 
PLOS One
Objective: The association between pre-antiretroviral (ART) inflammation and immune activation and risk for incident tuberculosis (TB) after ART initiation among adults is uncertain. Design: Nested case-control study (n = 332) within ACTG PEARLS trial of...

Inequalities in institutional delivery uptake and maternal mortality reduction in the context of cash incentive program, Janani Suraksha Yojana: Results from nine states in India

Post Date: 
2014-12-15
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Social Science and Medicine
Abstract Proportion of women giving birth in health institutions has increased sharply in India since the introduction of cash incentive program, Janani Suraksha Yojana (JSY) in 2005. JSY was intended to benefit disadvantaged population who had poor access to institutional care for...

High levels of tobacco-specific N-nitrosamines and nicotine in Chaini Khaini, a product marketed as snus

Post Date: 
2014-12-09
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Tobacco Control
Introduction: Recently, a tobacco product, Chaini Khaini, identified as snus appeared in India. The product marketing emphasizes its discreet nature and explicitly claims safety by referring to the existing evidence on Swedish snus. We here analyzed tobacco-specific nitrosamines and nicotine...

Quit history, intentions to quit, and reasons for considering quitting among tobacco users in India: Findings from the Tobacco Control Policy Evaluation India Wave 1 Survey

Post Date: 
2014-12-05
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Publication: 
Indian Journal of Cancer
Background: GATS India 2009–10 revealed that more than one-third (35%) of adults in India use tobacco in some form: 21% use smokeless tobacco, 9% smoke, and 5% are mixed users (they smoke and use smokeless tobacco), and the quit rate is very low. In an effort to decrease prevalence of tobacco use,...

Pre-antiretroviral therapy selenium status predicts WHO stages 3, 4 or death but not virologic failure post-antiretroviral therapy

Post Date: 
2014-11-13
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Nutrients
A case-cohort study, within a multi-country trial of antiretroviral therapy (ART) efficacy (Prospective Evaluation of Antiretrovirals in Resource Limited Settings (PEARLS)), was conducted to determine if pre-ART serum selenium deficiency is independently associated with human immunodeficiency...

Source case investigation for children with TB disease in Pune, India

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2014-08-27
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Tuberculosis Research and Treatment
Setting. Contact tracing is broadly encouraged for tuberculosis (TB) control. In many high-burden countries, however, little effort is made to identify contacts of newly diagnosed TB patients. This failure puts children, many of whom live in poor crowded communities, at special risk. ...

Impact of maternal hepatitis B virus coinfection on mother-to-child transmission of HIV

Post Date: 
2014-07-15
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HIV Medicine
Objectives: Despite high hepatitis B virus (HBV) endemicity in various resource-limited settings (RLSs), the impact of maternal HIV/HBV coinfection on infant health outcomes has not been defined. We aimed to assess the prevalence of HBV coinfection among HIV-infected pregnant women and its...

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Does Quality of Delivery Care Differ Between Public and Private Facilities in Madhya Pradesh, India?: An Exit Interview Study of Routine Delivery Care Practices

Post Date: 
2015-10-20
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Chaturvedi C, Randive B , Sabde Y, Diwan V, Raven J, De Costa A. Does Quality of Delivery Care Differ Between Public and Private Facilities in Madhya Pradesh, India?: An Exit Interview Study of Routine Delivery Care Practices. Global Maternal Newborn Health Conference 2015. Mexico City, Mexico. 2015

Dengue and Malaria are Common Infections among Adults and Adolescents Hospitalized with Acute Febrile Illness in Western India

Post Date: 
2015-10-09
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Mave V, Kadam D, Bharadwaj R, Kagal A, Sachs J, Raichur P, Kanade S, Gupte N, Joshi S, Chandanwale A, Zenilman JM, Bollinger R, Gupta A. Dengue and Malaria are Common Infections among Adults and Adolescents Hospitalized with Acute Febrile Illness in Western India. Infectious Diseases Society of...

Conducting HIV and TB Research in India: Challenges and Opportunities

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2015-08-27
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Gupta, A. Conducting HIV and TB Research in India: Challenges and Opportunities. Emory University. Atlanta, GA.

Therapeutic Drug Monitoring (TDM) of TB in Young Children: The Role of Hair Assays

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2015-06-17
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Mave, V. Therapeutic Drug Monitoring (TDM) of TB in Young Children: The Role of Hair Assays. IMPAACT Annual Meeting. Washington, DC.

The Association of Exposure to Air Pollution from Biomass Fuels, Kerosene, and Secondhand Tobacco Smoke with TB in Adult Women and Children in Pune, India

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2015-05-01
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Elf JL , Kinikar A, Khadse S, Mave V, Gupte N, Kulkarni V, Patekar S, Raichur P, Breysse P, Gupta A, Golub J. The Association of Exposure to Air Pollution from Biomass Fuels, Kerosene, and Secondhand Tobacco Smoke with TB in Adult Women and Children in Pune, India. American Thoracic Society...

TB in Pregnancy

Post Date: 
2015-03-05
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Gupta, A. TB in Pregnancy. RePORT India TB Workshop. Mumbai, India.

Cost-effectiveness of Isonaizid Preventive Therapy for HIV-Infected Pregnant Women in India

Post Date: 
2015-02-24
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Kapoor S, Chida N, Gupta A, Shah M. Cost-effectiveness of Isonaizid Preventive Therapy for HIV-Infected Pregnant Women in India. Conference on Retroviruses and Opportunistic Infections 2015. Seattle, WA. 2015.

Metabolic Complications/Inflammation

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2015-01-10
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Gupta, A. Metabolic Complications/Inflammation. 5th National Conference on HIV/AIDS Therapy. Mumbai, India.

Quit History, Intentions to Quit, and Reasons for Considering Quitting Among Tobacco Users in India: Findings From the Wave 1 TCP India Survey

Post Date: 
2014-12-05
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Gauri G Dhumal , Mangesh S Pednekar, Lalit J Raute, Prakash C Gupta, Genevieve Sansone, Anne CK Quah, Geoffrey T Fong. Quit History, Intentions to Quit, and Reasons for Considering Quitting Among Tobacco Users in India: Findings From the Wave 1 TCP India Survey. APACT 2013, University of Waterloo,...

RePORT India: Objectives and Future Directions

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2014-04-30
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Mave, V. RePORT India: Objectives and Future Directions. TB Vaccine 4th Global Forum. Shanghai, China.

Epidemiology of HIV/AIDS in India

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2014-04-04
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Bollinger, R. Epidemiology of HIV/AIDS in India. Mylan HIV Course Series. JHU Global mHealth. Baltimore, MD.

An Equity Analysis of Institutional Delivery Uptake and Maternal Mortality Reduction in Context of Cash Transfer Programme (JSY): Results from Nine States of India

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2014-03-10
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Randive B , San Sebastian M, De Costa A, Lindholm L. An Equity Analysis of Institutional Delivery Uptake and Maternal Mortality Reduction in Context of Cash Transfer Programme (JSY): Results from Nine States of India. Third Global Symposium on Health Systems Research. Health Systems Global. Cape...

Latent TB in India and Example Research Solutions for India

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2013-11-10
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Gupta, A. Latent TB in India and Example Research Solutions for India. Global Tuberculosis (TB) Clinical Management and Research. Johns Hopkins School of Nursing Course. Baltimore, MD.

Laboratory Capacity Building for International Clinical Research: The JHU-BJMC Pune, India Example

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2013-09-11
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Gupta, A. Laboratory Capacity Building for International Clinical Research: The JHU-BJMC Pune, India Example. Inaugural Pathology Education Symposium. Johns Hopkins School of Medicine: Department of Pathology. Baltimore, MD.

Quit History, Intentions to Quit, and Reasons for Considering Quitting Among Tobacco Users in India

Post Date: 
2013-09-01
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Countries: 
Gauri G Dhumal, Mangesh S Pednekar, Lalit J Raute, Prakash C Gupta, Genevieve Sansone, Anne CK Quah, Geoffrey T Fong. Quit History, Intentions to Quit, and Reasons for Considering Quitting Among Tobacco Users in India. International Conference on Public Health Priorities in the 21st Century: The...

Effective Coverage of Institutional Deliveries under the Janani Suraksha Yojana Programme in High Maternal Mortality Provinces of India: Analysis of Data from an Annual Health Survey

Post Date: 
2013-06-17
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Randive B , Chaturvedi S, Diwan V, De Costa A. Effective Coverage of Institutional Deliveries under the Janani Suraksha Yojana Programme in High Maternal Mortality Provinces of India: Analysis of Data from an Annual Health Survey. Global Health Metrics & Evaluation 2013. Seattle, Washington...

India’s Conditional Cash Transfer Programme to Promote Institutional Births: What has been the Effect on Maternal Mortality?

Post Date: 
2013-01-17
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Randive B , Diwan V, De Costa A. India’s Conditional Cash Transfer Programme to Promote Institutional Births: What has been the Effect on Maternal Mortality? Global Maternal Health Conference 2013. Maternal Health Task Force, Harvard School of Public Health. Arusha, Tanzania. 2013.

Nutritional Status and Childhood Growth Among Korku and Warli Tribes of Maharashtra: Anthropometric Perspective

Post Date: 
2013-01-01
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Dhumal, G. Nutritional Status and Childhood Growth Among Korku and Warli Tribes of Maharashtra: Anthropometric Perspective. National Seminar on ‘Policies and Issues In the Bio-Cultural Development of Scheduled Tribes, Anthropological Association, Mysore. Maharashtra, India.

Exposure to tuberculosis infected household contact, household food insecurity, and malnutrition, but not Vitamin D deficiency associated with pediatric tuberculosis in young children in Pune, India

Post Date: 
2012-10-17
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Jubulis J , Kinikar A, Ithape M, Hotalkar S, Kulkarni V, Mave V, Gupte N, Kagal A, Bharadwaj R, Jain S, Gupta A. Exposure to tuberculosis infected household contact, household food insecurity, and malnutrition, but not Vitamin D deficiency associated with pediatric tuberculosis in young children in...

Update in TB Diagnosis, Treatment and Prevention

Post Date: 
2012-01-31
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Gupta, A. Update in TB Diagnosis, Treatment and Prevention. 4th National Conference on HIV/AIDS Therapy. Human Healthcare and Research Foundation. Mumbai, India.

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