India

With a population of more than one billion, India is the second largest country in the world, represents 16% of the global population, and the national average for life expectancy is only 65 years. India leads the world in the largest absolute burden of TB, ranks third for HIV (behind South Africa and Nigeria), and ranks second for diabetes. The country receives funding to support HIV/AIDS prevention, treatment and care programs under the US President's Emergency Plan for AIDS Relief (PEPFAR).

Our Indo-JHU Clinical Research Partnership is dedicated to reversing poor patient outcomes. With operations based in Pune, our extensive research portfolio is directed by Dr. Amita Gupta (Baltimore, MD), with onsite direction from Dr. Vidya MaveDr. Nishi Suryavanshi, and Dr. Nikhil Gupte (Pune). The Indo-JHU Partnership employs more than 200 people and, in addition to our memberships in consortia with many esteemed Indian research institutions, we have formal agreements with:

CCGHE WORK IN INDIA

Change in Vitamin D levels occurs early after antiretroviral therapy initiation and depends on treatment regimen in resource-limited settings

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2014-04-21
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PLOS One
Background: Vitamin D has wide-ranging effects on the immune system, and studies suggest that low serum vitamin D levels are associated with worse clinical outcomes in HIV. Recent studies have identified an interaction between antiretrovirals used to treat HIV and reduced serum vitamin D...

Pregnancy differentially impacts performance of latent tuberculosis diagnostics in a high-burden setting

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2014-03-21
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PLOS One
Background: Targeted screening for latent TB infection (LTBI) in vulnerable populations is a recommended TB control strategy. Pregnant women are at high risk for developing TB and likely to access healthcare, making pregnancy an important screening opportunity in developing countries. The...

Biomarkers for sepsis: a review with special attention to India

Post Date: 
2014-03-19
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BioMed Research International
Sepsis is a serious infection and still a common cause of morbidity and mortality in resource-limited settings such as India. Even when microbiologic diagnostics are available, bacteremia is only identified in a proportion of patients who present with sepsis and bloodstream infections...

Maternal pneumococcal capsular IgG antibodies and transplacental transfer are lower in South Asian HIV-infected mother-infant pairs

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2014-03-14
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Vaccine
Background: Our understanding of the mother-to-child transfer of serotype-specific pneumococcal antibodies is limited in non-immunized, HIV-positive women. Methods: We compared geometric mean antibody concentrations (GMCs), geometric mean transplacental...

Modifiable risk factors associated with tuberculosis disease in children in Pune, India

Post Date: 
2014-02-15
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International Journal of Tuberculosis and Lung Disease
Setting: India accounts for the largest burden of tuberculosis (TB) worldwide, with 26% of the world's cases. Objective: To assess the association between novel modifiable risk factors and TB in Indian children. Design: Cases were children aged...

Improving diagnostic capability for HPV disease internationally within the NIH-NIAID-Division of AIDS Clinical Trial Networks

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2013-12-15
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American Journal of Clinical Pathology
OBJECTIVES: To evaluate an external quality assurance (EQA) program for the laboratory diagnosis of human papillomavirus (HPV) disease that was established to improve international research capability within the Division of AIDS at the National Institute of Allergy and Infectious Disease-supported...

Pediatric tuberculosis in young children in India: a prospective study

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2013-11-11
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BioMed Research International
Background: India has one of the highest tuberculosis (TB) burdens globally. However, few studies have focused on TB in young children, a vulnerable population, where lack of early diagnosis results in poor outcomes. Methods: Young children (≤ 5 years) with...

HIV/AIDS education in traditional Indian systems of medicine: faculty perspectives

Post Date: 
2013-10-24
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Journal of Traditional Medicine and and Clinical Naturopathy
In India, HIV-infected individuals face numerous challenges in their search for treatments. Currently, western allopathic medicine (hereinafter ‘biomedicine’) offers antiretroviral therapy (ART) for HIV/AIDS and associated co-morbidities that have prolonged survival and improved quality of...

India’s new policy to protect research participants

Post Date: 
2013-07-31
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The BMJ
Editorial Introduction: India, the country with the largest disease burden in the world,1 is now a major international hub for clinical research. However, a recent policy that was meant to mitigate important ethical concerns may have profound and unintended consequences for public health and...

Patterns of TB drug-resistance in a tertiary care facility in Pune, India

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2013-07-18
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Clinical Microbiology
Introduction:Globally, the emergence of multi-drug resistant tuberculosis (MDRTB) (defined as resistance to isoniazid (INH) and rifampicin (RIF) and extensively drug resistant (XDR-TB) (defined as resistance to INH, RIF, any fluoroquinolone and to at least one of the three injectable second...

India's conditional cash transfer programme (the JSY) to promote institutional birth: Is there an association between institutional birth proportion and maternal mortality?

Post Date: 
2013-06-27
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PLoS One
Abstract Background: India accounts for 19% of global maternal deaths, three-quarters of which come from nine states. In 2005, India launched a conditional cash transfer (CCT) programme, Janani Suraksha Yojana (JSY), to reduce maternal mortality ratio (MMR) through promotion of...

Effective coverage of institutional deliveries under the Janani Suraksha Yojana programme in high maternal mortality provinces of India: analysis of data from an annual health survey

Post Date: 
2013-06-17
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The Lancet
Abstract Background Three-quarters of India's maternal deaths come from nine (of 35) provinces. In 2005, the government launched a conditional cash transfer programme, Janani Suraksha Yojana (JSY), to reduce maternal mortality through promotion of institutional deliveries (ID)...

Assessment of Gutka ban in Maharashtra: findings from a focus group discussion

Post Date: 
2013-06-11
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International Journal of Head & Neck Surgery
According to Global Adult Tobacco Survey (GATS) India 2009-2010, around 8.3% (13.4% among male and 2.5% amongfemale) of people in Maharashtra are gutka users. Gutkaconsumption not only causes oral cancer, but has also beenlinked with development of oral submucous fibrosis, aprecancerous lesion...

Screening for pulmonary tuberculosis in HIV-infected individuals: AIDS Clinical Trials Group Protocol A5253

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2013-04-15
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International Journal of Tuberculosis and Lung Disease
Background: Improved tuberculosis (TB) screening is urgently needed for human immunodeficiency virus (HIV) infected patients. Methods: An observational, multi-country, cross-sectional study of HIV-infected patients to compare a standardized diagnostic...

Low tuberculosis knowledge among HIV-infected patients in a high HIV prevalence region within Southeast India

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2013-03-21
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Journal of the International Association of Providers of AIDS Care
Setting: A private multispecialty hospital in Kakinada, Andhra Pradesh, India. Methods: A survey of knowledge, attitudes, and perceptions adapted from a pretested questionnaire was administered to 128 HIV-infected adults, from July to August 2008.

Correlates of lower comprehension of informed consent among participants enrolled in a cohort study in Pune, India

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2013-03-15
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International Health
Background: Optimum comprehension of informed consent by research participants is essential yet challenging. This study explored correlates of lower comprehension of informed consent among 1334 participants of a cohort study aimed at estimating HIV incidence in Pune, India. ...

Availability of treatment for eclampsia in public health institutions in Maharashtra, India

Post Date: 
2013-03-15
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Journal of Health, Population, and Nutrition
Abstract Severe pre-eclampsia and eclampsia are common causes of maternal deaths worldwide and more so in developing countries. Magnesium sulphate (MgSO4) is now the most-recommended drug of choice to treat these conditions. Despite favourable policies for the use of MgSO4...

Nutritional status and childhood growth among Korku and Warli tribes of Maharashtra: anthropometric perspective

Post Date: 
2013-01-01
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Explorations in Medical Anthropology
Nutritional status and childhood growth among Korku and Warli tribes of Maharashtra: anthropometric perspective.

Contracting in specialists for emergency obstetric care—does it work in rural India?

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2012-12-31
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BMC Health Services Research
Abstract Background: Contracting in private sector is promoted in developing countries facing human resources shortages as a challenge to reduce maternal mortality. This study explored provision, practice, performance, barriers to execution and views about contracting in...

Growth patterns among HIV-exposed infants receiving nevirapine prophylaxis in Pune, India

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2012-10-31
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BMC Infectious Diseases
Background: India has among the highest rates of infant malnutrition. Few studies investigating the growth patterns of HIV-exposed infants in India or the impact of timing of HIV infection on growth in settings such as India exist. Methods: We used data from...

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