United States

ACTIV-2/A5401: Adaptive Platform Treatment for Outpatients with COVID-19 (Adapt Out COVID)

Post Date: 
2021-07-21
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Clinical Sites: 
Rationale: There is an urgent need for a platform to rapidly evaluate therapies in the outpatient setting, to prevent disease progression, and reduce serious complications of COVID-19 and transmission [10]. ACTIV-2/A5401 is a phase II/III randomized, blinded, controlled adaptive platform trial to...

Project COVID-19 Test At Home

Post Date: 
2021-06-28
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Countries: 
This study to test the accuracy of a COVID-19 test for use at home. This test has been authorized by the FDA to be done in a health care setting by a health care provider, but the study is evaluating diagnostic accuracy of tests administered at home

P2026: Pharmacokinetic Properties of Antiretroviral and Anti-Tuberculosis Drugs during Pregnancy and Postpartum

Post Date: 
2021-05-18
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Clinical Sites: 
IMPAACT P1026s, the predecessor of this study, was first approved in 2003. P1026s enrolled over 1000 pregnant/postpartum women, studied the PK of more than 25 HIV and TB drugs in these women and published 27 manuscripts presenting these data. P1026s data was cited in 32% of the 76 perinatal...

COVID-19 Viral Dynamics

Post Date: 
2020-12-20
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Countries: 
Purpose of the study: This study aims to quantitatively define the relationships between (a) testing results obtained via multiple distinct platforms (antigen vs. RT-qPCR), (b) shedding of infectious virus, and (c) self-reported disease symptoms over the course of SARS-CoV-2 infection.

RADx Tech COVID-19 Test US Study

Post Date: 
2020-08-05
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Countries: 
Rationale: Scalable, inexpensive point-of-care (PoC) technologies that enable detection of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus are desperately needed. However, understanding the accuracy and usability of novel PoC technologies for SARS-CoV-2 is critical. Each PoC...

RADx Tech COVID-19 Test Us Bank

Post Date: 
2020-08-05
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Countries: 
This study is collecting and storing lab samples of COVID-19 diagnostic tests among both people who have tested positive for COVID and those who haven’t to evaluate new COVID test and study how COVID-19 and related viruses cause disease in people.

RADx Tech COVID-19 Test Us Study

Post Date: 
2020-07-27
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Countries: 
Scalable, inexpensive novel technologies that enable detection of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus are desperately needed. However, understanding the accuracy and usability of novel technologies for SARS-CoV-2 is critical. Each novel test needs to be evaluated...

Leveraging mHealth and peers to Engage African- Americans and Latinxs in HIV care (LEAN)

Post Date: 
2020-05-12
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Countries: 
Baltimore’s HIV prevalence rate (586/100,000) is among the top 5 in metropolitan areas in the US, and disparities are profound. African Americans have an HIV prevalence that is 5 times higher than among whites, and they account for 78% of all HIV cases. Latinxs also have a higher prevalence of HIV...

¡Sólo Se Vive Una Vez! (You Only Live Once)

Post Date: 
2019-04-01
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Countries: 
When CFAR Scholar Dr. Kathleen Page began working at the Baltimore City Health Department (BCHD) STD/HIV clinic in 2006, she noticed a growing number of Spanish-speaking patients. Here at Hopkins, she also began receiving requests to see Latino patients who had been newly diagnosed with HIV, many of whom had already been infected for long periods of time. Dr. Page quickly realized we weren’t doing enough to bring prevention and testing programs to the Spanish-speaking population of Baltimore.

Evaluation of National Video Directly Observed Therapy Implementation

Post Date: 
2018-08-05
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Countries: 
emocha Mobile Health, Inc., and Johns Hopkins investigators have developed a user-friendly, HIPAA compliant application for asynchronous video directly observed therapy (DOT) miDOT. The miDOT platform consists of a patient-facing mobile application where patients can record videos of themselves...

Technology Based Community Health Nursing to Improve Combination Anti-Retroviral Therapy (cART) Adherence and Virologic Suppression in Youth Living With HIV (Tech2Check)

Post Date: 
2018-07-11
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Countries: 
Dr. Maunank Shah is a co-Investigator on this clinical trial. Human immunodeficiency virus (HIV) infection has disproportionately persisted as a public health threat to adolescents and young adults (AYA) from minority communities in the United States. HIV has evolved into a chronic disease, which...

Evaluation of Video-Based Directly Observed Therapy for Tuberculosis in India

Post Date: 
2018-05-14
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Countries: 
This study was designed to evaluate Directly Observed Therapy conducted through miDOT, a secure mobile health interface, with traditional in-person Directly Observed Therapy.

Building on Needle Exchange to Optimize HIV Prevention/Treatment

Post Date: 
2017-12-01
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Countries: 
Biomedical interventions that have direct applicability to people who inject drugs (PWID) have flourished over the past 15 years (HIV treatment as prevention, pre-exposure prophylaxis, office-based medication-assisted treatment (MAT) with buprenorphine, and hepatitis C virus (HCV) treatment with...

Role of Specialized Pro-resolving Mediators (SPMs) on Markers of Inflammation in HIV-infected Adults

Post Date: 
2017-08-03
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Countries: 
Dr. Rupak Shivikoti is leading this study. There has been a surge of recent studies focusing on the role of novel lipid mediators of inflammation called specialized pro-resolving mediators (SPMs). They are produced during inflammation as a negative feedback to resolve inflammation. However, the...

LaMocha: A Mobile Technology to Promote HIV Testing among Immigrant Latino Men

Post Date: 
2016-12-15
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Countries: 
Foreign-born Latino males have a high risk of late HIV diagnosis and presentation to care, which can lead to poor clinical outcomes and ongoing HIV transmission in the community. We propose to evaluate if tailored videos delivered through a tablet by a Latino Health Worker and regular SMS text...

mHealth-enhanced Peer Navigation Intervention for PrEP Delivery among MSM at STD Clinics

Post Date: 
2016-08-01
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Countries: 
Using mixed methodology (quantitative surveys, qualitative interviews, and administrative data), this study will assess acceptability and feasibility of an mHealth-enhanced peer navigation to promote PrEP initiation, retention and adherence among men who have sex with men (MSM) in the Baltimore...

Enhancing Models of HIV, Viral Hepatitis, STIs and Tuberculosis to Inform and Improve Public Health Impact

Post Date: 
2015-01-01
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Countries: 
This study was terminated September 30, 2018. Dr. Maunank Shah was the Project Leader for HIV modeling for this effort led by Emory University and funded by the U.S. Centers for Disease Control and Prevention.

Salud al Dia

Post Date: 
2014-11-01
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Countries: 
This initiative is intended to address healthcare disparities among Latino children in Baltimore by increasing engagement of limited English proficiency (LEP) Latino parents in primary healthcare. Specifically, we are looking at whether using in-person and technology-based support interventions...

TB Case Conference

Post Date: 
2013-02-25
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Countries: 
CCGHE broadcasts live TB Case Conferences and provides a global audience with open access to all live and archived webcasts via the CCGHE website. Hosted by Dr. Maunank Shah (Johns Hopkins), this case-based conference serves as a forum where clinicians caring for individuals with active TB can...

Feasibility and Acceptability of Smartphone-Based Ecological Momentary Assessment of Alcohol Use Among African American Men Who Have Sex With Men in Baltimore

Post Date: 
2013-01-01
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Countries: 
This study provides evidence to support the feasibility and acceptability of using Ecological Momentary Assessment (EMA ) methods for collecting data on alcohol use among African American men who have sex with men living in urban settings. These data provide the basis for future studies of EMA-...

Pages

Sex and gender differences in COVID testing, hospital admission, presentation, and drivers of severe outcomes in the DC/Maryland region

Post Date: 
2021-08-31
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Countries: 
Publication: 
medRxiv
Rates of severe illness and mortality from SARS-CoV-2 are greater for males, but the mechanisms for this difference are unclear.

Comparison of Time to Clinical Improvement With vs Without Remdesivir Treatment in Hospitalized Patients With COVID-19

Post Date: 
2021-03-24
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Publication: 
JAMA Network Open
Just Published in JAMA Network Open: In this retrospective analysis, remdesivir was associated with faster clinical improvement of COVID-19 in a cohort of predominantly non-White patients

Aspergillosis Complicating Severe Coronavirus Disease

Post Date: 
2021-01-01
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Publication: 
EID Journal
Aspergillosis complicating severe influenza infection has been increasingly detected worldwide. Recently, coronavirus disease–associated pulmonary aspergillosis (CAPA) has been detected through rapid reports, primarily from centers in Europe. We provide a case series of CAPA, adding 20 cases to the...

Tocilizumab for the Treatment of COVID-19 Among Hospitalized Patients: A Matched Retrospective Cohort Analysis

Post Date: 
2020-12-28
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Publication: 
Open Forum Infectious Diseases
Background: There is currently no single treatment that mitigates all harms caused by severe acute respiratory syndrome coronavirus 2 infection. Tocilizumab, an interleukin-6 antagonist, may have a role as an adjunctive immune-modulating therapy. Methods: This was an observational retrospective...

Nevirapine pharmacokinetics in HIV-infected persons receiving rifapentine and isoniazid for TB prevention

Post Date: 
2020-11-26
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Publication: 
The Journal of Antimicrobial Chemotherapy
Background: The use of rifamycin antibiotics for TB prevention carries a risk of detrimental drug-drug interactions with concomitantly used ART. Objectives: To evaluate the interaction of the antiretroviral drug nevirapine in combination with 4 weeks of daily rifapentine and isoniazid for TB...

Patient Trajectories Among Persons Hospitalized for COVID-19: A Cohort Study

Post Date: 
2020-09-22
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Publication: 
Annals of Internals Medicine
Risk factors for progression of coronavirus 2019 (COVID-19) to severe disease or death are underexplored in U.S. cohorts.

Pharmacokinetics and drug-drug interactions of isoniazid and efavirenz in pregnant women living with HIV in high TB incidence settings: importance of genotyping

Post Date: 
2020-09-09
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Countries: 
Publication: 
Clinical Pharmacology and Therapeutics
World Health Organization guidelines recommend that individuals living with HIV receive ≥6 months of isoniazid preventive therapy, including pregnant women.

Effects of Pregnancy and Isoniazid Preventive Therapy on M. tuberculosis Interferon Gamma Response Assays in Women with HIV

Post Date: 
2020-07-28
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Countries: 
Publication: 
Clinical Infectious Diseases
944 women with HIV participating in a randomized, double-blind, placebo-controlled study comparing 28 weeks of IPT antepartum versus postpartum, were tested by QuantiFERON-gold-in-tube (QGIT) antepartum and by QGIT and tuberculin skin test (TST) at delivery and postpartum.

SARS-CoV-2 Positivity Rate for Latinos in the Baltimore-Washington, DC Region

Post Date: 
2020-06-18
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Publication: 
JAMA
This study characterizes the trends in rates of SARS-CoV-2 positive test results among individuals in the Baltimore-Washington, DC area by self-reported race/ethnicity.

Undocumented U.S. Immigrants and Covid-19

Post Date: 
2020-03-27
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Countries: 
Publication: 
New England Journal of Medicine
NEJM: Kathleen Page and colleagues outline COVID-19 hardships faced by undocumented immigrants and strategies needed to ensure they have access to care.

Community-Driven Priorities in Smartphone Application Development: Leveraging Social Networks to Self-Manage Type 2 Diabetes in a Low-Income African American Neighborhood

Post Date: 
2019-07-30
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Countries: 
Publication: 
International Journal of Environmental Research and Public Health
Social networks have the potential to enhance Type 2 Diabetes Mellitus (T2DM) self-management. We used qualitative methods to study if and how mobile application (app) functions that mobilize social resources to improve T2DM management would be desired in a low-income African American community. Data were collected through community discussions and in-depth interviews with 78 participants in 2016–2018.

Advancing Patient-Centered Care in Tuberculosis Management: A Mixed-Methods Appraisal of Video Directly Observed Therapy

Post Date: 
2019-06-25
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Countries: 
Publication: 
Open Forum Infectious Diseases
OFID : Study compared directly-observed therapy with video-based observed therapy using the emocha mobile health platform

A population pharmacokinetic analysis shows that arylacetamide deacetylase (AADAC) gene polymorphism and HIV infection affect the exposure of rifapentine

Post Date: 
2019-03-29
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Countries: 
Publication: 
Antimicrobial Agents Chemotherapy
New analysis published in Antimicrobial Agents and Chemotherapy!

Evaluation of an adapted Project Connect community based intervention among professionals serving young minority men

Post Date: 
2019-03-15
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Countries: 
Publication: 
Sexually Transmitted Diseases
BACKGROUND: To address sexual and reproductive health (SRH) needs of young minority urban males, we developed and evaluated Project Connect Baltimore (Connect), which was adapted from a program with demonstrated effectiveness among young females. The objectives were to determine (1) the...

Impact of providing preexposure prophylaxis for human immunodeficiency virus at clinics for sexually transmitted infections in Baltimore City: An agent-based model

Post Date: 
2018-12-15
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Countries: 
Publication: 
Sexually Transmitted Diseases
BACKGROUND: Preexposure prophylaxis (PrEP) greatly reduces the risk of human immunodeficiency virus (HIV) acquisition, but its optimal delivery strategy remains uncertain. Clinics for sexually transmitted infections (STIs) can provide an efficient venue for PrEP delivery. ...

Immigration legal services as a structural HIV intervention for Latinx sexual and gender minorities

Post Date: 
2018-11-21
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Countries: 
Lack of legal immigration status is associated with poor HIV-related outcomes for immigrant Latinx sexual and gender minorities (LSGM). LSGM often meet eligibility criteria for legal immigration relief. A Medical-Legal Partnership (MLP) may thus be strategic to improve their health. We know...

The role of perceived friend depression and perceived stigma on self-reported depression among individuals who use drugs

Post Date: 
2018-11-15
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Countries: 
Publication: 
Journal of Community Psychology
Depression and substance use are highly comorbid, and stigmatized, mental health conditions influenced by social network factors. The objective of this study was to explore the role of perceived depression and perceived mental health stigma among friends on self-reported depression over time...

Missed opportunities to address pregnancy prevention with young men in primary care

Post Date: 
2018-11-15
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Countries: 
Publication: 
Clinical Pediatrics
Young men (aged 15-24 years) have pregnancy prevention needs, yet little is known about whether they perceive they learn about pregnancy prevention in primary care. A sample of 190 young men seen in primary care in one city from April 2014 to September 2016 were assessed on perceived learning...

Centro SOL: A community-academic partnership to care for undocumented immigrants in an emerging Latino area

Post Date: 
2018-10-30
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Countries: 
Publication: 
Academic Medicine
PROBLEM: From 2000 to 2014, the Latino population in Baltimore city, an emerging Latino settlement area, has experienced rapid growth. Many of these individuals are undocumented and not eligible for coverage. Academic medical centers often lead the way in addressing the health needs of...

Enhanced immigration enforcement in the USA and the transnational continuity of HIV care for Latinx migrants in deportation proceedings

Post Date: 
2018-10-15
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Countries: 
Publication: 
Lancet HIV
In our work as clinicians, researchers, and immigrant rights advocates, we have noted increased anxiety about the possibility of deportation and disruptions in care among immigrants with HIV. Before the 2016 US elections, patients rarely asked about HIV treatment in their home countries...

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Randomized trial of HIV-ASSIST versus guidelines for ART selection by trainees

Post Date: 
2020-03-09
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Countries: 
Ramirez J, Maddali M, Nematollahi S, Li JZ, Shah M. Randomized trial of HIV-ASSIST versus guidelines for ART selection by trainees. Presented at: CROI 2020. Boston, MA: March 8-11, 2020.

mobile Health (mHealth) strategies to strengthen CHW impact.

Post Date: 
2019-09-15
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Countries: 
Chang L. mobile Health (mHealth) strategies to strengthen CHW impact. Strengthening the Impact of Community Health Workers on HIV Care and Viral Suppression in the US. Bethesda, MD. September 16, 2019.

High Proportion of Extrapulmonary Tuberculosis in Baltimore City

Post Date: 
2016-06-21
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Countries: 
Chida, N. High Proportion of Extrapulmonary Tuberculosis in Baltimore City. 2016 Annual Meeting. Johns Hopkins Center for Tuberculosis Research. Baltimore, MD. 2016.

Reducing Hepatitis C Viral Load and Genotype Ordering at Johns Hopkins Hospital

Post Date: 
2016-02-01
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Countries: 
Chida N, Greenbaum A, Tuddenham S, Kendall E, Ray S, Melia M. Reducing Hepatitis C Viral Load and Genotype Ordering at Johns Hopkins Hospital. JHMI High-Value Practice Research Symposium. Baltimore, MD.

Impact of Rifapentine Price Reduction on Utilization for TB Treatment in the United States

Post Date: 
2015-12-04
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Countries: 
Gupta, A. Impact of Rifapentine Price Reduction on Utilization for TB Treatment in the United States. The 46th Union World Conference on Lung Health. Cape Town, South Africa.

Recognizing the Need for HIV Prevention and Care in Emerging Latino Communities

Post Date: 
2013-10-09
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Countries: 
Page, K. Recognizing the Need for HIV Prevention and Care in Emerging Latino Communities. Center for AIDS Research. Johns Hopkins Bloomberg School of Public Health. Baltimore, MD.

The HIV epidemic among Latinos living in the U.S.

Post Date: 
2009-10-31
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Countries: 
Page, K. The HIV epidemic among Latinos living in the U.S. Medicine Grand Rounds. Johns Hopkins Department of Medicine. Baltimore, MD.
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