Research News

Annals of Internal Medicine
September 22, 2020

Risk factors for progression of coronavirus 2019 (COVID-19) to severe disease or death are underexplored in U.S. cohorts.

Clinical Research

Leadership
While we conduct research all over the world, the majority of our work is in India. Our Indo-JHU Clinical Research Partnership is located in Pune and is directed by Dr. Amita Gupta (Baltimore, MD), with onsite direction from Dr. Vidya Mave, Dr. Nishi Suryavanshi, and Dr. Nikhil Gupte (Pune). The Indo-JHU Partnership employs more than 200 people and in addition to our memberships in cosortia with many esteemed Indian research institutions, we have formal agreements with:

 
 

Tuberculosis (TB) Aftermath

Post Date: 
2020-06-05
   |   
Countries: 
   |   
Clinical Sites: 
Dr. Jonathan Golub is PI for this study. TB Aftermath seeks to provide evidence for an effective and scalable strategy targeting HHs of treated TB cases, a high priority of the NTEP. Purpose To compare the effectiveness, cost-effectiveness and feasibility of two Active Case Finding (ACF) strategies...

Mental Health Outcomes among Health Care Professionals Involved in the Treatment and Care of COVID 19 Patients in India

Post Date: 
2020-06-01
   |   
Countries: 
   |   
Clinical Sites: 
Drs. Nikhil Gupta and Nishi Suryavanshi are leading this survey project. This study is investigating the immediate impact of the COVID-19 pandemic on mental health outcomes and overall quality of life and what are the factors associated with it among Indian Health care workers. Among health care...

Prevalence of Risk Factors for Lung Cancer and Facilitators and Barriers for Tobacco Cessation among People Living with HIV

Post Date: 
2020-04-01
   |   
Countries: 
   |   
Clinical Sites: 
India has the world’s third largest HIV epidemic, with 2.1 million people currently living with HIV and an additional 90,000 new infections each year.[29] At the same time, expansion of the HIV response under India’s premier governmental agency - the National AIDS Control Organization (NACO), has...

The Sentinel Research Network of IeDEA: A Prospective Cohort among People Living with HIV

Post Date: 
2020-03-12
   |   
Clinical Sites: 
This study is nested within the TREAT Asia HIV Observational Database initiative. The global scale up of antiretroviral therapy (ART) has significantly improved the immune recovery and life expectancy of people living with HIV (PLHIV). However, PLHIV on long-term ART now face health challenges...

Hybrid Trial for Alcohol Reduction among People with TB and HIV in India

Post Date: 
2020-02-12
   |   
Countries: 
   |   
Clinical Sites: 
The highest incidence of tuberculosis disease (TB) in the world is in India, accounting for 27% of all new cases globally, with approximately 86,000 among persons with HIV (PWH). Unhealthy alcohol use triples the risk of TB in the general population, increasing susceptibility to primary infection...

Increasing Market and Public Health Outcomes Through Scaling Up Affordable Access Models of Short Course Preventive Therapy for TB (IMPAACT4TB)

Post Date: 
2019-12-17
   |   
Countries: 
   |   
Clinical Sites: 
Primary Objective: This study is being conducted in Brazil, Cambodia, China, Ethiopia, Ghana, Haiti, India, Indonesia, Kenya, Malawi, Mozambique, South Africa, Tanzania, and Zimbabwe. The overall goal is to reduce TB incidence among (1) people living with HIV who are on antiretroviral therapy, and...

Markers of Lung Impairment in HIV-TB Coinfected Indian Adults

Post Date: 
2019-12-11
   |   
Countries: 
   |   
Clinical Sites: 
Objectives/Aims We will compare the degree of lung impairment between HIV-TB co-infected adults (HIV-TB group) and TB cases without HIV co-infection (TB group) who successfully complete TB therapy. We hypothesize that the HIV-TB group will have a greater degree of lung impairment compared to the TB...

Inflammasome Genetics and Tuberculosis Treatment Outcomes

Post Date: 
2019-11-07
   |   
Countries: 
   |   
Clinical Sites: 
Dr. Amita Gupta is a Co-PI on this study. STUDY DESIGN We will conduct a retrospective case-cohort study nested within the CTRIUMPH and EDOTS cohorts to address our study objectives. This will enable us to measure the association of polymorphisms with multiple clinical outcomes simultaneously and...

A Phase 2a, Double-Blind, Placebo-Controlled, Randomized Clinical Trial to Evaluate the Safety and Immunogenicity of ID93 + GLA-SE Vaccine Administered to HIV-Negative Patients at 3 Time Points During Multidrug Therapy for Drug Susceptible Pulmonary TB

Post Date: 
2019-10-28
   |   
Clinical Sites: 
This study was terminated in April 2020. Vidya Mave was PI of this HIV vaccine trial. BACKGOUND: Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis (Mtb). TB is one of the leading causes of morbidity and mortality around the world with an estimated 10...

Utility of Multiplexed Rapid Fever Panel Kit among Hospitalized Febrile Patients in India and Its Impact on Antimicrobial Use and Diagnosis

Post Date: 
2019-10-24
   |   
Clinical Sites: 
Introduction Easy to use and multiplex diagnostic tools are needed to identify common causes of fever caused by vector-borne infectious diseases. Chembio has developed dual path platform (DPP) technology which differs from traditional lateral flow rapid diagnostic tests (RDT) by separating the...

Evaluation of a Urinary Biomarker Assay for Diagnosis and Test of Cure for Tuberculosis

Post Date: 
2019-09-09
   |   
Countries: 
   |   
Clinical Sites: 
Dr. Jeff Tornheim is PI of this study. METHODS This study will make use of biorepository samples from the Cohort for TB Research by the Indo-US Medical Partnership (CTRIUMPh). CTRIUMPh, funded by the US NIH and Indian Department of Biotechnology, is an academic collaboration between Johns Hopkins...

A5300B/I2003B: Protecting Households On Exposure to Newly Diagnosed Index Multidrug-Resistant Tuberculosis Patients (PHOENIx)

Post Date: 
2019-08-19
   |   
Countries: 
   |   
Clinical Sites: 
Dr. Amita Gupta is Protocol Co-chair for this multinational clinical trial. BACKGROUND The World Health Organization (WHO) estimates that there were 480,000 incident cases of MDR-TB globally in 2015. MDR-TB has been shown to be almost twice as common in TB patients living with HIV compared with TB...

A5300B/I2003B: Protecting Households On Exposure to Newly Diagnosed Index Multidrug-Resistant Tuberculosis Patients (PHOENIx)

Post Date: 
2019-08-19
   |   
Countries: 
   |   
Clinical Sites: 
Dr. Amita Gupta is Protocol Co-chair for this multinational clinical trial. BACKGROUND The World Health Organization (WHO) estimates that there were 480,000 incident cases of MDR-TB globally in 2015. MDR-TB has been shown to be almost twice as common in TB patients living with HIV compared with TB...

Management of Multidrug-resistant Tuberculosis among ART Programs in Low- and Middle-income Countries within the Global IeDEA Network

Post Date: 
2019-07-22
Purpose The purpose of the IeDEA MDR-TB survey is to study the clinical management of HIV patients co-infected with MDR-TB or XDR-TB from the perspective of healthcare workers in ART programs participating in the IeDEA global cohort consortium. Specifically, we aim: to describe diagnostic, referral...

Visual Field Loss in HIV-Positive Patients of Non-Infectious HIV Retinopathy

Post Date: 
2019-06-02
   |   
Countries: 
   |   
Clinical Sites: 
New study will assess HIV+ patients and determine the prevalence of visual field loss due to noninfectious HIV retinopathy

Immune Correlates of LTBI in HIV-exposed Infants

Post Date: 
2019-04-29
   |   
Countries: 
About 2 billion people worldwide harbor asymptomatic latent TB infection (LTBI), activation of which results in progression to TB disease. In areas of high tuberculosis (TB) prevalence, infants and young children have a 3-fold higher risk of progression and death from TB at age < 5 years...

P2010: Phase III Study of the Virologic Efficacy and Safety of Dolutegravir-Containing versus Efavirenz-Containing Antiretroviral Therapy Regimens in HIV-1-Infected Pregnant Women and their Infants “VESTED”

Post Date: 
2019-02-06
   |   
Countries: 
   |   
Clinical Sites: 
Full Title: P2010: Phase III Study of the Virologic Efficacy and Safety of Dolutegravir-Containing versus Efavirenz-Containing Antiretroviral Therapy Regimens in HIV-1-Infected Pregnant Women and their Infants “VESTED”: V irologic E fficacy and S afety of ART Combinations with T AF/TDF, E FV, and D...

Prevalence of Tuberculosis in Severely Malnourished Indian Children

Post Date: 
2018-12-18
   |   
Countries: 
   |   
Clinical Sites: 
This study is funded and conducted under the U.S. National Institutes of Health, Fogarty International Center. PIs are Robert Bollinger, MD, MPH; Dr. Muralidhar Tambe, BJGMC Severely malnourished children are vulnerable population for communicable and non-communicable disease. Diagnosis of TB among...

Host RNA Expression for Diagnosis and Monitoring of Pediatric TB in Africa and India

Post Date: 
2018-12-13
   |   
Countries: 
   |   
Clinical Sites: 
We are leveraging the RePORT platform by including a cohort of Indian children together with South African children in a large validation study to study on changes in gene expression profiles during treatment for TB

Characterization of Genomics and Metabolomics among Individuals Highly-Exposed, but Resistant to MTB Infection

Post Date: 
2018-12-13
   |   
Countries: 
   |   
Clinical Sites: 
New study launched in India & South Africa to identify functional relationships between genomics & metabolomics, & to characterize fundamental biological systems underlying resistance to Mtb infection.

Pages

The burden of anxiety among people living with HIV during the COVID-19 pandemic in Pune, India

Post Date: 
2020-10-23
   |   
Countries: 
Publication: 
BMC Public Health
Introduction: Globally, India has the third largest population of people living with HIV (PLHIV) and the second highest number of COVID-19 cases. Anxiety is associated with antiretroviral therapy (ART) nonadherence. It is crucial to understand the burden of anxiety and its sources among Asian...

Patient Trajectories Among Persons Hospitalized for COVID-19: A Cohort Study

Post Date: 
2020-09-22
   |   
Countries: 
Publication: 
Annals of Internals Medicine
Risk factors for progression of coronavirus 2019 (COVID-19) to severe disease or death are underexplored in U.S. cohorts.

Mental health and quality of life among healthcare professionals during the COVID-19 pandemic in India

Post Date: 
2020-09-11
   |   
Countries: 
Publication: 
Brain and Behavior
Background: The COVID-19 pandemic has placed healthcare professionals (HCP) in stressful circumstances with increased patient loads and a high risk of exposure. We sought to assess the mental health and quality of life (QoL) of Indian HCPs, the fourth highest-burden country for COVID-19. Method:...

Pharmacokinetics and drug-drug interactions of isoniazid and efavirenz in pregnant women living with HIV in high TB incidence settings: importance of genotyping

Post Date: 
2020-09-09
   |   
Countries: 
Publication: 
Clinical Pharmacology and Therapeutics
World Health Organization guidelines recommend that individuals living with HIV receive ≥6 months of isoniazid preventive therapy, including pregnant women.

An Evaluation of Baseline Kidney Function in the REPRIEVE Trial of Pitavastatin in Human Immunodeficiency Virus

Post Date: 
2020-08-01
Publication: 
The Journal of Infectious Diseases
Background Chronic kidney disease is a common comorbid condition among persons living with human immunodeficiency virus (PWH). We characterized baseline kidney function in the REPRIEVE (Randomized Trial to Prevent Vascular Events in HIV) trial cohort. Methods REPRIEVE enrolled PWH with low to...

Tuberculosis preventive treatment should be considered for all household contacts of pulmonary tuberculosis patients in India

Post Date: 
2020-07-29
   |   
Countries: 
   |   
Clinical Sites: 
Publication: 
PLoS One
PLoS One: Dr. Mandar Paradkar and colleagues conducted a CTRIUMPH study that supports TB preventive therapy for all household contacts of pulmonary TB patients in India

Effects of Pregnancy and Isoniazid Preventive Therapy on M. tuberculosis Interferon Gamma Response Assays in Women with HIV

Post Date: 
2020-07-28
   |   
Countries: 
Publication: 
Clinical Infectious Diseases
944 women with HIV participating in a randomized, double-blind, placebo-controlled study comparing 28 weeks of IPT antepartum versus postpartum, were tested by QuantiFERON-gold-in-tube (QGIT) antepartum and by QGIT and tuberculin skin test (TST) at delivery and postpartum.

Impact of the Fogarty Training Program on Trainee and Institutional Research Capacity Building at a Government Medical College in India

Post Date: 
2020-07-28
   |   
Countries: 
   |   
Clinical Sites: 
Publication: 
Annals of Global Health
Gauri Dumal and colleagues assess the impact of the 5-year HIV-TB research training program on building individual research capacity at BJGMC.

Clinical features associated with linezolid resistance among multidrug resistant tuberculosis patients at a tertiary care hospital in Mumbai, India

Post Date: 
2020-07-24
   |   
Countries: 
Publication: 
Journal of Clinical Tuberculosis and other Mycobacterial Diseases
Background: Multidrug-resistant tuberculosis (MDR-TB) is an increasing problem worldwide, and 24% occurs in India. Linezolid is associated with improved MDR-TB treatment outcomes but causes significant side-effects and drug susceptibility testing (DST) is rarely available. This study assessed...

A mobile health-facilitated behavioral intervention for community health workers improves exclusive breastfeeding and early infant HIV diagnosis in India: A cluster randomized trial

Post Date: 
2020-07-03
   |   
Countries: 
   |   
Clinical Sites: 
Publication: 
Journal of the International AIDS Society
When community health workers used a mobile health intervention with HIV+ women to deliver care, there was a higher uptake of exclusive breastfeeding at two months and early infant HIV diagnosis at six weeks

SARS-CoV-2 Positivity Rate for Latinos in the Baltimore-Washington, DC Region

Post Date: 
2020-06-18
   |   
Countries: 
Publication: 
JAMA
This study characterizes the trends in rates of SARS-CoV-2 positive test results among individuals in the Baltimore-Washington, DC area by self-reported race/ethnicity.

Once-weekly Rifapentine and Isoniazid for Tuberculosis Prevention in Patients With HIV Taking Dolutegravir-Based Antiretroviral Therapy: A Phase 1/2 Trial

Post Date: 
2020-03-30
Publication: 
Lancet HIV
Short-course preventive therapy with 12 doses of once-weekly rifapentine (900 mg) plus isoniazid (900 mg) could greatly improve tuberculosis control, especially in areas with high co-endemicity with HIV.

Venezuela’s health care crisis now poses a global threat

Post Date: 
2020-03-26
   |   
Countries: 
Publication: 
Foreign Policy
Foreign Policy: Dr. Kathleen Page argues that Venezuela's weak healthcare infrastructure leaves its people defenseless and presents a serious threat to global health, and she advocates for the global community to act now.

New Strategies in Clinical Guideline Delivery: Randomized trial of online, interactive decision-support versus guidelines for HIV treatment selection by trainees

Post Date: 
2020-03-25
Publication: 
Clinical Infectious Diseases
CID: Trainees using HIV-ASSIST were significantly more likely to choose appropriate ART regimens compared to those using guidelines alone.

TB prevention strategies and unanswered questions for pregnant and postpartum women living with HIV: the need for improved evidence

Post Date: 
2020-03-23
Publication: 
Journal of the International AIDS Society
World TB Day viewpoint on the need for more data about TB treatment for pregnant and postpartum women in J Int AIDS Soc by Drs. Jyoti Mathad and Amita Gupta.

Quantifying HIV transmission flow between high-prevalence hotspots and surrounding communities: a population-based study in Rakai, Uganda

Post Date: 
2020-03-17
   |   
Countries: 
Publication: 
The Lancet HIV
BACKGROUND: International and global organisations advocate targeting interventions to areas of high HIV prevalence (ie, hotspots). To better understand the potential benefits of geo-targeted control, we assessed the extent to which HIV hotspots along Lake Victoria sustain transmission...

Tuberculosis in children, adolescents, and women

Post Date: 
2020-02-27
Publication: 
Lancet Respiratory Medicine
In this Lancet Respiratory Medicine commentary, Dr. Amita Gupta and colleagues note that TB prevalence among children, adolescents, and women isn't well documented. This poses big challenges for the goal of TB elimination.

Migration, hotspots, and dispersal of HIV infection in Rakai, Uganda

Post Date: 
2020-02-20
   |   
Countries: 
Publication: 
Nature Communications
Abstract HIV prevalence varies markedly throughout Africa, and it is often presumed areas of higher HIV prevalence (i.e., hotspots) serve as sources of infection to neighboring areas of lower prevalence. However, the small-scale geography of migration networks and movement of HIV-...

High prevalence of late presentation of ART-naïve perinatally infected children for care in Pune, India

Post Date: 
2020-02-19
   |   
Countries: 
   |   
Clinical Sites: 
Publication: 
AIDS Care
AIDS Care : There is an urgent need to identify strategies that improve linkage of perinatally infected ART-naïve children to care, and earlier than what is currently observed.

Compliance of private pharmacies in Uganda with controlled prescription drugs regulations: A mixed-methods study

Post Date: 
2020-02-08
   |   
Countries: 
Publication: 
Substance Abuse Treatment, Prevention, and Policy
Background: Controlled prescription drug use disorders are a growing global health challenge in Sub-Saharan Africa. Effective supply chain regulations on dispensing and stock control are important for controlling this epidemic. Since compliance with these regulations in resource-limited countries...

Pages

Prevalence and Incidence of Tuberculosis Infection and Disease Among Household Contacts Exposed to Rifampin-resistant/Multidrug resistant Tuberculosis (RR/MDR-TB)

Post Date: 
2020-07-08
Gupta A, Wu X, Kim S, Naini L, Hughes M, Dawson R, Gaikwad S, Sanchez J, Mendoza A, Smith B, Shah S, Hesseling A, Churchyard G, Swindells S for the ACTG/IMPAACT PHOENIx feasibility study team. Prevalence and Incidence of Tuberculosis Infection and Disease Among Household Contacts Exposed to...

Predictors of tuberculosis infection in MDR-TB household contacts ≥15 years old.

Post Date: 
2020-03-11
   |   
Countries: 
Kim S , Gupta A, Wu X, Hughes M, Dawson R, Mave V, Kumarasamy, Smith B, Rustomgee R, Shah NS, Hesseling A, Swindells S, Churchyard G for the ACTG/IMPAACT A5300/I2003 PHOENIx Feasibility Study Team. Predictors of tuberculosis infection in MDR-TB household contacts ≥15 years old. Presented at: CROI...

Rifapentine pharmacokinetics and safety in pregnant women with and without HIV on 3HP

Post Date: 
2020-03-11
   |   
Countries: 
Mathad JS , Savic RM, Britto P, Wiesner L, Townley E, Chakhtoura N, Bradford S, Patil S, Vhembo T, Lespinasse D, Langat D, Werarak P, Kamthunzi P, Gupta A, Dooley KE. Rifapentine pharmacokinetics and safety in pregnant women with and without HIV on 3HP. Presented at: CROI 2020. Boston, MA; March 8-...

Effect of rifamycins on pretomanid exposure in patients with pulmonary TB

Post Date: 
2020-03-10
   |   
Countries: 
Abdelwahab MT , Ignatius E, Denti P, Dooley KE, Gupte N, Dawson R, Barnes G, Narunsky K, Hendricks B. Effect of rifamycins on pretomanid exposure in patients with pulmonary TB. (ID 3688). Presented at: CROI 2020. Boston, Massachusetts. March 8-11, 2020.

“Stylish Man” cluster RCT to increase male circumcision for adult men ≥ 19, Uganda

Post Date: 
2020-03-10
   |   
Countries: 
Wawer M , Kigozi G, Mugamba S, Zikusooka A, Kagaayi J, Serwadda D, Ndyanabo A, Ssekubugu R, Sseasanvu J, Chang LW, Gray RH. “Stylish Man” cluster RCT to increase male circumcision for adult men ≥ 19, Uganda. Presented at: CROI 2020. Boston, MA; March 8-11, 2020.

Randomized trial of HIV-ASSIST versus guidelines for ART selection by trainees

Post Date: 
2020-03-10
   |   
Countries: 
Ramirez J, Maddali M, Nematollahi S, Li JZ, Shah M. Randomized trial of HIV-ASSIST versus guidelines for ART selection by trainees. Presented at: CROI 2020. Boston, MA: March 8-11, 2020.

An mHealth CHW intervention trials in an HIV hyperendemic community in Rakai, Uganda

Post Date: 
2020-03-09
   |   
Countries: 
Chang LW , Mbabali I, Kong X, Amico R, Kennedy CE, Nalugoda F, Anok A, Serwadda D, Ssekasanvu J, Quinn TC, Reynolds SJ, Gray RH, Wawer M, Hutton H, Nakigozi G. An mHealth CHW intervention trials in an HIV hyperendemic community in Rakai, Uganda. Presented at: CROI 2020. Boston, MA; March 8-11, 2020.

Geographic and Individual Risk Factors for TB or Death in the Brief-TB Trial (A5279)

Post Date: 
2020-03-09
   |   
Countries: 
   |   
Clinical Sites: 
Riviere C , Juste MAJ, Ramchandani R, Gupta A, Benson CA, Masheto G, Supparatpinyo K, Mohapi L, da Silva Escada RO, Mngqibisa R, Kanyama C, Langat D, Swindells S, Chaisson RE, for the A5279/BRIEF TB Study Team. Geographic and Individual Risk Factors for TB or Death in the Brief-TB Trial (A5279)...

Population-level HIV viral load varies by gender, age, and location in Rakai, Uganda

Post Date: 
2020-03-09
   |   
Countries: 
Kyle I , Kagaagi J, Kigozi G, Nakigozi G, Ssekbugu R, Nalugoda F, Grabowski MK, Chang LW, Wawer M, Serwadda D, Gray RH, Quinn T, Reynolds SJ, Rattman O for the Rakai Health Sciences Program. Population-level HIV viral load varies by gender, age, and location in Rakai, Uganda. Presented at: CROI...

Waxing and waning HIV risk: Dynamics of PrEP eligibility in Rakai, Uganda

Post Date: 
2020-03-09
   |   
Countries: 
Ssempijja V, Ssekubugu R, Kigozi G, Kakigozi G, Kagaayi J, Lutalo T, Ndyanabo A, Ekstrom AM, Serwadda D, Quinn TC, Gray RH, Wawer M, Chang LW, Reynolds SJ. Waxing and waning HIV risk: Dynamics of PrEP eligibility in Rakai, Uganda. Presented at: CROI 2020. Boston, MA; March 8-11, 2020.

Factors associated with gestational diabetes in HIV+ and HIV- women in Pune, India

Post Date: 
2020-03-09
   |   
Countries: 
   |   
Clinical Sites: 
Chebrolu P , Alexander M, Bhosale R, Naik S, Patil N, Gupta A, Mathad J. Factors associated with gestational diabetes in HIV+ and HIV- women in Pune, India. Presented at: CROI 2020. Boston, Massachusetts. March 8-11, 2020.

Tuberculosis preventive therapy should be considered for all household contacts of pulmonary TB patients in India

Post Date: 
2020-02-07
   |   
Countries: 
   |   
Clinical Sites: 
Paradkar M, Chandrasekara P, Jain D, Shivakumar SVBY, Thiruvengadan K, Gupte AN, Thomas B, Kinikar A, Sekar K, Bharadwaj R, Dolla CK, Gaikwad S, Elilarasi S, Lokhande R, Reddy D, Murali L, Kulkarni V, Pradhan N, Hanna LE, Pattabiraman S, Kohli R, Nayagam R, Suryavanshi N, Shrinivasa BM, Cox SR,...

Female tuberculosis (TB) patients with stigma are at increased risk of persistent depression: time to integrate mental health screening into TB care

Post Date: 
2019-11-20
   |   
Clinical Sites: 
Suryavanshi N . Female tuberculosis (TB) patients with stigma are at increased risk of persistent depression: time to integrate mental health screening into TB care. Poster presentation. 50th Union World Conference on Lung Health. Hyderabad, India. October 30-November 2, 2019.

Confronting the crisis: emerging research in maternal-child TB

Post Date: 
2019-11-02
Mathad J . Symposium Chair. Confronting the crisis: emerging research in maternal-child TB. 50th Union World Conference on Lung Health. Hyderabad, India. October 30-November 2, 2019.

Is there a connection between gestational diabetes and TB?

Post Date: 
2019-11-02
   |   
Countries: 
   |   
Clinical Sites: 
Alexander M . Is there a connection between gestational diabetes and TB? Speaker. Confronting the crisis: emerging research in maternal-child TB Symposium.50th Union World Conference on Lung Health. Hyderabad, India. October 30-November 2, 2019.

Increased moxifloxacin dosing among MDR-TB patients with low-level resistance to moxifloxacin did not improve treatment outcomes in a tertiary care centre in Mumbai, India

Post Date: 
2019-11-02
   |   
Countries: 
   |   
Clinical Sites: 
Tornheim JA , Gajjar I, Shivakumar SVBY, Gupte AN, Kishore G, Karane M, Rodrigues C, Gupta A, Udwadia ZF. Increased moxifloxacin dosing among MDR-TB patients with low-level resistance to moxifloxacin did not improve treatment outcomes in a tertiary care centre in Mumbai, India. 50th Union World...

Six-week culture conversion predicts tuberculosis treatment outcomes

Post Date: 
2019-11-01
   |   
Countries: 
   |   
Clinical Sites: 
Pradhan N , Kagal A, Gupte N, Gaikwad S, Barthwa M, Gupta A, Golub JE, Mave V. Six-week culture conversion predicts tuberculosis treatment outcomes. Poster presentation. 50th Union World Conference on Lung Health. Hyderabad, India. October 30-November 2, 2019.

Association of latent TB infection in pregnancy with perinatal health outcomes in an Indian cohort

Post Date: 
2019-11-01
   |   
Clinical Sites: 
Graham H , Bhosale R, Alexander M, Kinikar A, Khwaja S, Patil N, Mathad J, Shivakoti S, Gupta A. Association of latent TB infection in pregnancy with perinatal health outcomes in an Indian cohort. Poster presentation. 50th Union World Conference on Lung Health. Hyderabad, India. October 30-November...

Inappropriate postpartum weight loss may predict development of active TB: Findings from a cohort study in Pune, India

Post Date: 
2019-11-01
   |   
Countries: 
   |   
Clinical Sites: 
Alexander M , Bhosale R, Naik S, Gupte N, Jain D, Patil N, Pradhan N, Mave V, Gupta A, Mathad J. Inappropriate postpartum weight loss may predict development of active TB: Findings from a cohort study in Pune, India. Poster presentation. 50th Union World Conference on Lung Health. Hyderabad, India...

Does treatment of infertile women with probable genital tuberculosis improve fertility outcome?

Post Date: 
2019-11-01
   |   
Countries: 
   |   
Clinical Sites: 
Naik SN , Chandanwale A, Kadam D, Sambarey PW, Dhumal G, DeLuca A, Jain D, Gupta A, Bollinger R, Mave V. Does treatment of infertile women with probable genital tuberculosis improve fertility outcome? Poster presentation. 50th Union World Conference on Lung Health. Hyderabad, India. October 30-...

Pages

Is It a Cold, the Flu, or COVID-19?

Post Date: 
2020-10-12
Source: 
Everyday Health
Dr. Natasha Chida
Dr. Natasha Chida: "...80 percent of people who get COVID-19 develop mild symptoms that resemble those of a cold.”

Leslie Marshall interviews Dr. Bob Bollinger on Latest COVID-19 News, Including Vaccines

Post Date: 
2020-10-07
Source: 
The Leslie Marshall Show
Dr. Robert Bollinger
CCGHE's Bob Bollinger talks with Leslie Marshall about the latest COVID-19 news, including vaccines.

Study Shows Extent, Danger of TB Exposure: Part I

Post Date: 
2020-08-24
Source: 
Medical Daily
Dr. Amita Gupta
Medical Daily: Amita Gupta and Mandar Paradkar are quoted in this report about TB preventive therapy for household contacts of confirmed cases in India

Research Story Tip: International Johns Hopkins Study Says Broad Measures Needed to Prevent TB Spread in India

Post Date: 
2020-08-06
Dr. Mandar Paradkar
Johns Hopkins News Release: News release highlights study findings published in PLOS One by Dr. Mandar Paradkar and colleagues.

Broad measures needed to check spread of TB in India: Study

Post Date: 
2020-08-05
Source: 
daijiworld.com
daijiworld.com (India): Dr. Mandar Paradkar is quoted about his recent study on TB preventive therapy for household contact of TB cases.

Study Shows Mobile Health, Video Technology, Influence Behavior of Affected Populations

Post Date: 
2020-07-09
Dr. Nishi Suryavanshi
Johns Hopkins News Release: Dr. Suryavanshi discusses her study on mobile health and technology training for improving care among HIV+ pregnant and post-partum women and their babies

NIH Awards Johns Hopkins Baltimore-Washington-India Trials Group $460,679 in Supplemental COVID-19 Funding

Post Date: 
2020-06-30
NIH
The supplement is leveraging existing HIV research infrastructure and personnel for DAIDS-sponsored COVID research

Latinx people more vulnerable to COVID-19 infection, US study finds

Post Date: 
2020-06-30
Source: 
Medical News Today
Dr. Kathleen Page
Medical News Today : "The need to work, lack of occupational protections, and crowded living conditions have led to high transmission in this community."

Latinx health crisis: 42% of sampled Johns Hopkins patients test positive for coronavirus

Post Date: 
2020-06-30
Source: 
BaltimoreBrew
Another study finding was that the hospital admission rate for Latinix patients was 29.1%, lower than than for White patients (40.1%) or Black patients (41.7%).

New research confirms higher rates of new coronavirus in Latinx populations

Post Date: 
2020-06-23
Source: 
Medical Xpress
Kathleen Page
Medical XPress: Kathleen Page: "...we must engage with communities early & provide language & culturally appropriate information & services, removing as many barriers to care as possible."

ACTG Site Spotlight: BJGMC-JHU Clinical Research Site, Pune, India

Post Date: 
2020-05-05
Source: 
ACTG Network Newsletter
ACTG Logo
The BJGMC-JHU Clinical Research site in Pune, India, is highlighted in this article.

Pandemic Planning in Pune: Distributing Study Medication during COVID-19

Post Date: 
2020-04-23
Dr. Sandesh Patil
Dr. Sandesh Patil reports how the team in India ensured study participants received medication during the COVID-19 pandemic.

Want to end state lockdowns? Send in the coronavirus detectives.

Post Date: 
2020-04-21
Source: 
The Christian Science Monitor
Contact Tracing
CSM: Bob Bollinger discusses limitations in US capacity for tracing contacts of confirmed COVID-19 cases.

US needs more testing to ‘transfer the economy ahead,’ says Johns Hopkins infectious disease expert

Post Date: 
2020-04-09
Source: 
Gruntstuff
Dr. Robert Bollinger, CCGHE Director, was interviewed for this report on the COVID-19 pandemic. Particularly, the U.S. needs more speedy testing and a greater system of contact tracing to decide who has been contaminated by COVID-19 and who has not, Bollinger mentioned on “Energy...

‘Every part of the country’ still at risk — ex-FDA chief urges US to stay united in coronavirus fight

Post Date: 
2020-04-09
Source: 
CNBC
Additional testing and contact tracing efforts are critical in obtaining the information needed to “move the economy forward,” Dr. Robert Bollinger of Johns Hopkins University told CNBC earlier this week. He pointed to contact tracing programs in Massachusetts and Maryland as examples that need to...

We need to expand access to rapid coronavirus testing and contact tracing: Johns Hopkins’ Dr. Bollinger

Post Date: 
2020-04-08
Source: 
CNBC
Bollinger-CNBC
Dr. Bob Bollinger appeared on CNBC's ‘Power Lunch’ to discuss coronavirus response.

New York has 12 TIMES more deaths than California because the state was slow to react to the pandemic, late on lockdown rules and advised residents to 'go on with' their lives, experts say

Post Date: 
2020-04-08
Source: 
Daily Mail
Dr. Robert Bollinger, CCGHE Director, was interviewed for this report on the COVID-19 pandemic. New York has more than 12 times the number of coronavirus deaths than California because the state was slow to react to the pandemic, late on lockdown rules and had advised residents to 'go on with'...

EMA Panel Backs Pretomanid for Drug-Resistant TB

Post Date: 
2020-03-31
Source: 
Medscape
Amita Gupta is mentioned in this article.

HIV-ASSIST Uses Algorithms in Appropriate ART-Regimen Selection

Post Date: 
2020-03-31
Source: 
Contagion, Infectious Diseases Today
Dr. Maunank Shah
Contagion highlights a randomized study of HIV-ASSIST recently published in Clinical Infectious Diseases by Maunank Shah and colleagues.

Rifapentine demonstrates efficacy for pregnant women, including those with HIV

Post Date: 
2020-03-14
Source: 
Infectious Disease News via Healio
Dr. Jyoti Mathad
Infectious Disease News via Healio: Jyoti Mathad discusses findings from the IMPAACT 2001 clinical trial.

Pages