Research News

Remdesivir vials
March 24, 2021

Just Published in JAMA Network Open: In this retrospective analysis, remdesivir was associated with faster clinical improvement of COVID-19 in a cohort of predominantly non-White patients

Clinical Research

Leadership
While we conduct research all over the world, the majority of our work is in India. Our Indo-JHU Clinical Research Partnership is located in Pune and is directed by Dr. Amita Gupta (Baltimore, MD), with onsite direction from Dr. Vidya Mave, Dr. Nishi Suryavanshi, and Dr. Nikhil Gupte (Pune). The Indo-JHU Partnership employs more than 200 people and in addition to our memberships in cosortia with many esteemed Indian research institutions, we have formal agreements with:

 
 

Tuberculosis (TB) Aftermath

Post Date: 
2020-06-05
   |   
Countries: 
   |   
Clinical Sites: 
Drs. Vidya Mave and Jonathan Golub are co-PIs for this study. TB Aftermath seeks to provide evidence for an effective and scalable strategy targeting HHs of treated TB cases, a high priority of the NTEP. Purpose To compare the effectiveness, cost-effectiveness and feasibility of two Active Case...

Mental Health Outcomes among Health Care Professionals Involved in the Treatment and Care of COVID 19 Patients in India

Post Date: 
2020-06-01
   |   
Countries: 
   |   
Clinical Sites: 
Drs. Nikhil Gupta and Nishi Suryavanshi are leading this survey project. This study is investigating the immediate impact of the COVID-19 pandemic on mental health outcomes and overall quality of life and what are the factors associated with it among Indian Health care workers. Among health care...

Prevalence of Risk Factors for Lung Cancer and Facilitators and Barriers for Tobacco Cessation among People Living with HIV

Post Date: 
2020-04-01
   |   
Countries: 
   |   
Clinical Sites: 
India has the world’s third largest HIV epidemic, with 2.1 million people currently living with HIV and an additional 90,000 new infections each year.[29] At the same time, expansion of the HIV response under India’s premier governmental agency - the National AIDS Control Organization (NACO), has...

The Sentinel Research Network of IeDEA: A Prospective Cohort among People Living with HIV

Post Date: 
2020-03-12
   |   
Clinical Sites: 
This study is nested within the TREAT Asia HIV Observational Database initiative. The global scale up of antiretroviral therapy (ART) has significantly improved the immune recovery and life expectancy of people living with HIV (PLHIV). However, PLHIV on long-term ART now face health challenges...

Hybrid Trial for Alcohol Reduction among People with TB and HIV in India

Post Date: 
2020-02-12
   |   
Countries: 
   |   
Clinical Sites: 
The highest incidence of tuberculosis disease (TB) in the world is in India, accounting for 27% of all new cases globally, with approximately 86,000 among persons with HIV (PWH). Unhealthy alcohol use triples the risk of TB in the general population, increasing susceptibility to primary infection...

Increasing Market and Public Health Outcomes Through Scaling Up Affordable Access Models of Short Course Preventive Therapy for TB (IMPAACT4TB)

Post Date: 
2019-12-17
   |   
Countries: 
   |   
Clinical Sites: 
Primary Objective: This study is being conducted in Brazil, Cambodia, China, Ethiopia, Ghana, Haiti, India, Indonesia, Kenya, Malawi, Mozambique, South Africa, Tanzania, and Zimbabwe. The overall goal is to reduce TB incidence among (1) people living with HIV who are on antiretroviral therapy, and...

Markers of Lung Impairment in HIV-TB Coinfected Indian Adults

Post Date: 
2019-12-11
   |   
Countries: 
   |   
Clinical Sites: 
Objectives/Aims We will compare the degree of lung impairment between HIV-TB co-infected adults (HIV-TB group) and TB cases without HIV co-infection (TB group) who successfully complete TB therapy. We hypothesize that the HIV-TB group will have a greater degree of lung impairment compared to the TB...

Inflammasome Genetics and Tuberculosis Treatment Outcomes

Post Date: 
2019-11-07
   |   
Countries: 
   |   
Clinical Sites: 
Dr. Amita Gupta is a Co-PI on this study. STUDY DESIGN We will conduct a retrospective case-cohort study nested within the CTRIUMPH and EDOTS cohorts to address our study objectives. This will enable us to measure the association of polymorphisms with multiple clinical outcomes simultaneously and...

A Phase 2a, Double-Blind, Placebo-Controlled, Randomized Clinical Trial to Evaluate the Safety and Immunogenicity of ID93 + GLA-SE Vaccine Administered to HIV-Negative Patients at 3 Time Points During Multidrug Therapy for Drug Susceptible Pulmonary TB

Post Date: 
2019-10-28
   |   
Clinical Sites: 
This study was terminated in April 2020. Vidya Mave was PI of this HIV vaccine trial. BACKGOUND: Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis (Mtb). TB is one of the leading causes of morbidity and mortality around the world with an estimated 10...

Utility of Multiplexed Rapid Fever Panel Kit among Hospitalized Febrile Patients in India and Its Impact on Antimicrobial Use and Diagnosis

Post Date: 
2019-10-24
   |   
Clinical Sites: 
Introduction Easy to use and multiplex diagnostic tools are needed to identify common causes of fever caused by vector-borne infectious diseases. Chembio has developed dual path platform (DPP) technology which differs from traditional lateral flow rapid diagnostic tests (RDT) by separating the...

Evaluation of a Urinary Biomarker Assay for Diagnosis and Test of Cure for Tuberculosis

Post Date: 
2019-09-09
   |   
Countries: 
   |   
Clinical Sites: 
Dr. Jeff Tornheim is PI of this study. METHODS This study will make use of biorepository samples from the Cohort for TB Research by the Indo-US Medical Partnership (CTRIUMPh). CTRIUMPh, funded by the US NIH and Indian Department of Biotechnology, is an academic collaboration between Johns Hopkins...

A5300B/I2003B: Protecting Households On Exposure to Newly Diagnosed Index Multidrug-Resistant Tuberculosis Patients (PHOENIx)

Post Date: 
2019-08-19
   |   
Countries: 
   |   
Clinical Sites: 
Dr. Amita Gupta is Protocol Co-chair for this multinational clinical trial. BACKGROUND The World Health Organization (WHO) estimates that there were 480,000 incident cases of MDR-TB globally in 2015. MDR-TB has been shown to be almost twice as common in TB patients living with HIV compared with TB...

A5300B/I2003B: Protecting Households On Exposure to Newly Diagnosed Index Multidrug-Resistant Tuberculosis Patients (PHOENIx)

Post Date: 
2019-08-19
   |   
Countries: 
   |   
Clinical Sites: 
Dr. Amita Gupta is Protocol Co-chair for this multinational clinical trial. BACKGROUND The World Health Organization (WHO) estimates that there were 480,000 incident cases of MDR-TB globally in 2015. MDR-TB has been shown to be almost twice as common in TB patients living with HIV compared with TB...

Management of Multidrug-resistant Tuberculosis among ART Programs in Low- and Middle-income Countries within the Global IeDEA Network

Post Date: 
2019-07-22
Purpose The purpose of the IeDEA MDR-TB survey is to study the clinical management of HIV patients co-infected with MDR-TB or XDR-TB from the perspective of healthcare workers in ART programs participating in the IeDEA global cohort consortium. Specifically, we aim: to describe diagnostic, referral...

Visual Field Loss in HIV-Positive Patients of Non-Infectious HIV Retinopathy

Post Date: 
2019-06-02
   |   
Countries: 
   |   
Clinical Sites: 
New study will assess HIV+ patients and determine the prevalence of visual field loss due to noninfectious HIV retinopathy

Immune Correlates of LTBI in HIV-exposed Infants

Post Date: 
2019-04-29
   |   
Countries: 
About 2 billion people worldwide harbor asymptomatic latent TB infection (LTBI), activation of which results in progression to TB disease. In areas of high tuberculosis (TB) prevalence, infants and young children have a 3-fold higher risk of progression and death from TB at age < 5 years...

P2010: Phase III Study of the Virologic Efficacy and Safety of Dolutegravir-Containing versus Efavirenz-Containing Antiretroviral Therapy Regimens in HIV-1-Infected Pregnant Women and their Infants “VESTED”

Post Date: 
2019-02-06
   |   
Countries: 
   |   
Clinical Sites: 
Full Title: P2010: Phase III Study of the Virologic Efficacy and Safety of Dolutegravir-Containing versus Efavirenz-Containing Antiretroviral Therapy Regimens in HIV-1-Infected Pregnant Women and their Infants “VESTED”: V irologic E fficacy and S afety of ART Combinations with T AF/TDF, E FV...

Prevalence of Tuberculosis in Severely Malnourished Indian Children

Post Date: 
2018-12-18
   |   
Countries: 
   |   
Clinical Sites: 
This study is funded and conducted under the U.S. National Institutes of Health, Fogarty International Center. PIs are Robert Bollinger, MD, MPH; Dr. Muralidhar Tambe, BJGMC Severely malnourished children are vulnerable population for communicable and non-communicable disease. Diagnosis of TB among...

Characterization of Genomics and Metabolomics among Individuals Highly-Exposed, but Resistant to MTB Infection

Post Date: 
2018-12-13
   |   
Countries: 
   |   
Clinical Sites: 
New study launched in India & South Africa to identify functional relationships between genomics & metabolomics, & to characterize fundamental biological systems underlying resistance to Mtb infection.

Host RNA Expression for Diagnosis and Monitoring of Pediatric TB in Africa and India

Post Date: 
2018-12-13
   |   
Countries: 
   |   
Clinical Sites: 
We are leveraging the RePORT platform by including a cohort of Indian children together with South African children in a large validation study to study on changes in gene expression profiles during treatment for TB

Pages

Comparison of Time to Clinical Improvement With vs Without Remdesivir Treatment in Hospitalized Patients With COVID-19

Post Date: 
2021-03-24
   |   
Countries: 
Publication: 
JAMA Network Open
Just Published in JAMA Network Open: In this retrospective analysis, remdesivir was associated with faster clinical improvement of COVID-19 in a cohort of predominantly non-White patients

Unhealthy alcohol use independently associated with unfavorable TB treatment outcomes among Indian men

Post Date: 
2021-03-10
   |   
Countries: 
   |   
Clinical Sites: 
Publication: 
International Journal of Tuberculosis and Lung Disease
This study by Samyra Cox and colleagues highlights the need for integrating effective alcohol interventions into TB care.

Development of Severe COVID-19 Adaptive Risk Predictor (SCARP), a Calculator to Predict Severe Disease or Death in Hospitalized Patients With COVID-19

Post Date: 
2021-03-02
Publication: 
Annals of Internal Medicine
Dr. Matt Robinson and colleagues developed a real-time tool that can predict severe disease or death among COVID patients

Systemic Inflammation in Pregnant Women With Latent Tuberculosis Infection

Post Date: 
2021-01-27
   |   
Countries: 
Publication: 
Frontiers in Immunology
Background: Recent studies in adults have characterized differences in systemic inflammation between adults with and without latent tuberculosis infection (LTBI+ vs. LTBI-). Potential differences in systemic inflammation by LTBI status has not been assess in pregnant women. Methods: We conducted a...

Higher interleukin-6 levels and changes in transforming growth factor-β are associated with lung impairment in pulmonary tuberculosis

Post Date: 
2021-01-18
   |   
Countries: 
Publication: 
ERJ Open Resource
Higher levels of IL-6 and slow-to-resolve TGF-β are associated with lung impairment in treated tuberculosis. These results have important implications for clinical trials of immunomodulatory therapies to prevent tuberculosis-associated lung disease. http://openres.ersjournals.com/lookup/doi/...

Detection of genital tuberculosis among women with infertility using best clinical practices in India: An implementation study

Post Date: 
2021-01-15
   |   
Countries: 
   |   
Clinical Sites: 
Publication: 
Indian Journal of Tuberculosis
Background Diagnosis of genital tuberculosis (TB) as a cause of infertility still remains a diagnostic dilemma for clinicians, as no standard guidelines exist. The recently proposed best practices for genital TB diagnosis have not been evaluated yet in India. Objectives To implement best practices...

Higher IL-6 Levels and Changes in TGF-β are Associated with Lung Impairment in Pulmonary Tuberculosis

Post Date: 
2021-01-08
   |   
Countries: 
Publication: 
ERJ
Pulmonary tuberculosis (PTB) is associated with granuloma formation, necrosis and cavitation in lung tissue. Lung injury in PTB can persist despite microbiological cure and is associated with chronic obstructive pulmonary disease (COPD) independent of smoking exposure[1]. Furthermore, pulmonary...

Validation of NINA-DISH food frequency questionnaire with multiple 24-hour dietary recalls among pregnant women in Pune, India

Post Date: 
2021-01-06
   |   
Countries: 
Publication: 
The British Journal of Nutrition
Adequate dietary intake is critical to prevent adverse pregnancy outcomes. India has a high burden of maternal and child morbidity and mortality, but there is a lack of adequate tools to assess dietary intake. We validate a food frequency questionnaire (FFQ), New-Interactive Nutrition Assistant-...

Novel community health worker strategy for HIV service engagement in a hyperendemic community in Rakai, Uganda: A pragmatic, cluster-randomized trial

Post Date: 
2021-01-06
   |   
Countries: 
Publication: 
PLOS Medicine
Effective implementation strategies are needed to increase engagement in HIV services in hyperendemic settings. We conducted a pragmatic cluster-randomized trial...

Measuring TB drug levels in the hair in adults and children to monitor drug exposure and outcomes

Post Date: 
2021-01-01
   |   
Countries: 
Publication: 
International Journal of Tuberculosis and Lung Disease
INTRODUCTION: Testing for anti-TB drugs in small hair samples may serve as a non-invasive tool to measure cumulative drug exposure and/or adherence, as these determine treatment success. We aimed to assess how well hair assays of TB drugs predict TB treatment outcomes.METHODS: A small thatch of...

Tocilizumab for the Treatment of COVID-19 Among Hospitalized Patients: A Matched Retrospective Cohort Analysis

Post Date: 
2020-12-28
   |   
Countries: 
Publication: 
Open Forum Infectious Diseases
Background: There is currently no single treatment that mitigates all harms caused by severe acute respiratory syndrome coronavirus 2 infection. Tocilizumab, an interleukin-6 antagonist, may have a role as an adjunctive immune-modulating therapy. Methods: This was an observational retrospective...

Association of Vegetable and Animal Flesh Intake with Inflammation in Pregnant Women from India

Post Date: 
2020-12-08
   |   
Countries: 
Publication: 
MDPI
In pregnant women, studies are lacking on the relationship of vegetable and animal flesh (poultry, red meat and seafood) intake with inflammation...

Nevirapine pharmacokinetics in HIV-infected persons receiving rifapentine and isoniazid for TB prevention

Post Date: 
2020-11-26
   |   
Countries: 
Publication: 
The Journal of Antimicrobial Chemotherapy
Background: The use of rifamycin antibiotics for TB prevention carries a risk of detrimental drug-drug interactions with concomitantly used ART. Objectives: To evaluate the interaction of the antiretroviral drug nevirapine in combination with 4 weeks of daily rifapentine and isoniazid for TB...

Xpert MTB/RIF Ultra for the Diagnosis of Tuberculous Meningitis: A Small Step Forward

Post Date: 
2020-11-05
   |   
Countries: 
Publication: 
Clinical Infectious Diseases
The delayed diagnosis of tuberculous meningitis (TBM) leads to poor outcomes, yet the current diagnostic methods for identifying Mycobacterium tuberculosis in cerebrospinal fluid (CSF) are inadequate. The first comparative study of the new GeneXpert MTB/RIF Ultra (Xpert Ultra) for TBM diagnosis...

Using a composite maternal-infant outcome measure in tuberculosis prevention studies among pregnant women

Post Date: 
2020-11-04
   |   
Countries: 
Publication: 
Clinical Infectious Diseases
Background: Tuberculosis (TB) preventive therapy (TPT) among pregnant women reduces the risk of TB in mothers and infants, but the timing of initiation should consider potential adverse effects. We propose an analytical approach to evaluate the risk-benefit of interventions. Methods: A novel...

Assessment of persistent depression among TB patients

Post Date: 
2020-11-01
   |   
Countries: 
Publication: 
International Journal of Tuberculosis and Lung Disease
(No abstract available)

The burden of anxiety among people living with HIV during the COVID-19 pandemic in Pune, India

Post Date: 
2020-10-22
   |   
Countries: 
Publication: 
BMC Public Health
Introduction: Globally, India has the third largest population of people living with HIV (PLHIV) and the second highest number of COVID-19 cases. Anxiety is associated with antiretroviral therapy (ART) nonadherence. It is crucial to understand the burden of anxiety and its sources among Asian...

The Impact of Hypertension and Use of Calcium Channel Blockers on Tuberculosis Treatment Outcomes

Post Date: 
2020-09-24
   |   
Countries: 
Publication: 
Clinical Infectious Diseases
Background: Hypertension induces systemic inflammation, but its impact on the outcome of infectious diseases like tuberculosis (TB) is unknown. Calcium channel blockers (CCB) improve TB treatment outcomes in pre-clinical models, but their effect in patients with TB remain unclear. Methods: This...

Patient Trajectories Among Persons Hospitalized for COVID-19: A Cohort Study

Post Date: 
2020-09-22
   |   
Countries: 
Publication: 
Annals of Internals Medicine
Risk factors for progression of coronavirus 2019 (COVID-19) to severe disease or death are underexplored in U.S. cohorts.

Mental health and quality of life among healthcare professionals during the COVID-19 pandemic in India

Post Date: 
2020-09-10
   |   
Countries: 
Publication: 
Brain and Behavior
Background: The COVID-19 pandemic has placed healthcare professionals (HCP) in stressful circumstances with increased patient loads and a high risk of exposure. We sought to assess the mental health and quality of life (QoL) of Indian HCPs, the fourth highest-burden country for COVID-19. Method:...

Pages

COVID-19 Lessons Learned

Post Date: 
2021-04-27
   |   
Clinical Sites: 
Bollinger R. Speaker. COVIS-19 Lessons Learned. 47th Annual Annual Conference of Research Society, BJGMC and Sassoon General Hospital. Virtual confernece, based in Pune, India. Apri 28-29, 2021.

Reservoirs of transmission of resistant Gram-negative pathogens responsible for neonatal sepsis among hospitalized neonates in Pune, India

Post Date: 
2020-10-21
   |   
Countries: 
   |   
Clinical Sites: 
Johnson J, Robinson ML, Naik S, Patil S, Kulkarni R, Kinikar A, Dohe V, Mudshinkar S, Kagal A, Smith RM, Westercamp M, Randive B, Kadam A, Kulkarni V, Mave V, Gupta A, Milstone AM, Manabe YC, for the CDC SHEPheRD India Study Team. Reservoirs of transmission of resistant Gram-negative pathogens...

Screening for Tuberculosis (TB) in pregnant and non-pregnant women of reproductive age: Findings from an observational study in Pune, India

Post Date: 
2020-10-20
   |   
Countries: 
   |   
Clinical Sites: 
Alexander M, Bhosale R, Naik S, Kulkarni V, Mave V, Suryavanshi N, Gupte N, Gupta A, Mathad J. Screening for Tuberculosis (TB) in pregnant and non-pregnant women of reproductive age: Findings from an observational study in Pune, India. Poster Presentation. 51st Union World Conference on Lung Health...

An RNA signature for TB risk in pregnant women: A prospective cohort study from India

Post Date: 
2020-10-20
   |   
Countries: 
   |   
Clinical Sites: 
Mathad J, Bhosale R, Barreto-Duarte B, Alexander M, Kulkarni V, Nathella PK, Andrade B, Gupta A. Polyfunctional T-cells and IL-2 production decrease in pregnant women with latent TB. TB Science 2020. Virtual. October 20, 2020.

Systemic inflammation in pregnant women with and without latent tuberculosis infection

Post Date: 
2020-10-20
   |   
Countries: 
   |   
Clinical Sites: 
Naik S, Alexander M, Kumar P, Kulkarni V, Yadana S, Bhosale R, Babu S, Gupta A, Mathad J and Shivakoti R. Systemic inflammation in pregnant women with and without latent tuberculosis infection. Poster Presentation. 51st Union World Conference on Lung Health. Virtual Conference. October 20-24, 2020.

Polyfunctional T-cells and IL-2 production decrease in pregnant women with latent TB

Post Date: 
2020-10-20
   |   
Countries: 
   |   
Clinical Sites: 
Mathad J, Bhosale R, Barreto-Duarte B, Alexander M, Kulkarni V, Nathella PK, Andrade B, Gupta A. Polyfunctional T-cells and IL-2 production decrease in pregnant women with latent TB. TB Science 2020. Virtual. October 20, 2020.

Comparison of neurocognitive assessment in children with TB Meningitis and healthy controls in Pune, India

Post Date: 
2020-10-20
   |   
Countries: 
   |   
Clinical Sites: 
Nimkar S, Joshi S, Kinikar A, Valvi C, Gupte N, Thakur KT, Suryavanshi N, Mave V, Dooley KE, Arenivas A. Comparison of neurocognitive assessment in children with TB Meningitis and healthy controls in Pune, India. Poster Presentation. 51st Union World Conference on Lung Health. Virtual Conference...

Blood-based biomarkers of tuberculosis in children integrating metabolomic and transcriptomic data

Post Date: 
2020-10-20
   |   
Countries: 
   |   
Clinical Sites: 
Tornheim JA, Paradkar M, Fukutani KF, Kinikar A, Mave V, Andrade BB, Gupta A, Karakousis PC. Blood-based biomarkers of tuberculosis in children integrating metabolomic and transcriptomic data. TB Science 2020. Virtual. October 20, 2020.

Prevalence and Incidence of Tuberculosis Infection and Disease Among Household Contacts Exposed to Rifampin-resistant/Multidrug resistant Tuberculosis (RR/MDR-TB)

Post Date: 
2020-07-08
Gupta A, Wu X, Kim S, Naini L, Hughes M, Dawson R, Gaikwad S, Sanchez J, Mendoza A, Smith B, Shah S, Hesseling A, Churchyard G, Swindells S for the ACTG/IMPAACT PHOENIx feasibility study team. Prevalence and Incidence of Tuberculosis Infection and Disease Among Household Contacts Exposed to...

Predictors of tuberculosis infection in MDR-TB household contacts ≥15 years old.

Post Date: 
2020-03-11
   |   
Countries: 
Kim S , Gupta A, Wu X, Hughes M, Dawson R, Mave V, Kumarasamy, Smith B, Rustomgee R, Shah NS, Hesseling A, Swindells S, Churchyard G for the ACTG/IMPAACT A5300/I2003 PHOENIx Feasibility Study Team. Predictors of tuberculosis infection in MDR-TB household contacts ≥15 years old. Presented at: CROI...

Rifapentine pharmacokinetics and safety in pregnant women with and without HIV on 3HP

Post Date: 
2020-03-11
   |   
Countries: 
Mathad JS , Savic RM, Britto P, Wiesner L, Townley E, Chakhtoura N, Bradford S, Patil S, Vhembo T, Lespinasse D, Langat D, Werarak P, Kamthunzi P, Gupta A, Dooley KE. Rifapentine pharmacokinetics and safety in pregnant women with and without HIV on 3HP. Presented at: CROI 2020. Boston, MA; March 8-...

Effect of rifamycins on pretomanid exposure in patients with pulmonary TB

Post Date: 
2020-03-10
   |   
Countries: 
Abdelwahab MT , Ignatius E, Denti P, Dooley KE, Gupte N, Dawson R, Barnes G, Narunsky K, Hendricks B. Effect of rifamycins on pretomanid exposure in patients with pulmonary TB. (ID 3688). Presented at: CROI 2020. Boston, Massachusetts. March 8-11, 2020.

“Stylish Man” cluster RCT to increase male circumcision for adult men ≥ 19, Uganda

Post Date: 
2020-03-10
   |   
Countries: 
Wawer M , Kigozi G, Mugamba S, Zikusooka A, Kagaayi J, Serwadda D, Ndyanabo A, Ssekubugu R, Sseasanvu J, Chang LW, Gray RH. “Stylish Man” cluster RCT to increase male circumcision for adult men ≥ 19, Uganda. Presented at: CROI 2020. Boston, MA; March 8-11, 2020.

Randomized trial of HIV-ASSIST versus guidelines for ART selection by trainees

Post Date: 
2020-03-09
   |   
Countries: 
Ramirez J, Maddali M, Nematollahi S, Li JZ, Shah M. Randomized trial of HIV-ASSIST versus guidelines for ART selection by trainees. Presented at: CROI 2020. Boston, MA: March 8-11, 2020.

Factors associated with gestational diabetes in HIV+ and HIV- women in Pune, India

Post Date: 
2020-03-09
   |   
Countries: 
   |   
Clinical Sites: 
Chebrolu P , Alexander M, Bhosale R, Naik S, Patil N, Gupta A, Mathad J. Factors associated with gestational diabetes in HIV+ and HIV- women in Pune, India. Presented at: CROI 2020. Boston, Massachusetts. March 8-11, 2020.

An mHealth CHW intervention trials in an HIV hyperendemic community in Rakai, Uganda

Post Date: 
2020-03-08
   |   
Countries: 
Chang LW , Mbabali I, Kong X, Amico R, Kennedy CE, Nalugoda F, Anok A, Serwadda D, Ssekasanvu J, Quinn TC, Reynolds SJ, Gray RH, Wawer M, Hutton H, Nakigozi G. An mHealth CHW intervention trials in an HIV hyperendemic community in Rakai, Uganda. Presented at: CROI 2020. Boston, MA; March 8-11, 2020.

Geographic and Individual Risk Factors for TB or Death in the Brief-TB Trial (A5279)

Post Date: 
2020-03-09
   |   
Countries: 
   |   
Clinical Sites: 
Riviere C , Juste MAJ, Ramchandani R, Gupta A, Benson CA, Masheto G, Supparatpinyo K, Mohapi L, da Silva Escada RO, Mngqibisa R, Kanyama C, Langat D, Swindells S, Chaisson RE, for the A5279/BRIEF TB Study Team. Geographic and Individual Risk Factors for TB or Death in the Brief-TB Trial (A5279)...

Population-level HIV viral load varies by gender, age, and location in Rakai, Uganda

Post Date: 
2020-03-09
   |   
Countries: 
Kyle I , Kagaagi J, Kigozi G, Nakigozi G, Ssekbugu R, Nalugoda F, Grabowski MK, Chang LW, Wawer M, Serwadda D, Gray RH, Quinn T, Reynolds SJ, Rattman O for the Rakai Health Sciences Program. Population-level HIV viral load varies by gender, age, and location in Rakai, Uganda. Presented at: CROI...

Waxing and waning HIV risk: Dynamics of PrEP eligibility in Rakai, Uganda

Post Date: 
2020-03-09
   |   
Countries: 
Ssempijja V, Ssekubugu R, Kigozi G, Kakigozi G, Kagaayi J, Lutalo T, Ndyanabo A, Ekstrom AM, Serwadda D, Quinn TC, Gray RH, Wawer M, Chang LW, Reynolds SJ. Waxing and waning HIV risk: Dynamics of PrEP eligibility in Rakai, Uganda. Presented at: CROI 2020. Boston, MA; March 8-11, 2020.

Tuberculosis preventive therapy should be considered for all household contacts of pulmonary TB patients in India

Post Date: 
2020-02-07
   |   
Countries: 
   |   
Clinical Sites: 
Paradkar M, Chandrasekara P, Jain D, Shivakumar SVBY, Thiruvengadan K, Gupte AN, Thomas B, Kinikar A, Sekar K, Bharadwaj R, Dolla CK, Gaikwad S, Elilarasi S, Lokhande R, Reddy D, Murali L, Kulkarni V, Pradhan N, Hanna LE, Pattabiraman S, Kohli R, Nayagam R, Suryavanshi N, Shrinivasa BM, Cox SR,...

Pages

Experts say COVID-19 mutations are normal

Post Date: 
2021-01-15
Dr. Robert Bollinger: “... As with any virus, changes are something to be watched, to ensure that testing and vaccines are still effective.

CURE ID Moves to Automated Data Collection in Light of COVID Pandemic

Post Date: 
2021-07-13
Dr. Matt Robinson
Drs. Matt Robinson is leading JHU efforts in this FDA program, and Robert Bollinger and Jane McKenzie-White helped launch it before COVID.

Hopkins Tool Predicts How Hospitalized COVID Patients Will Fare

Post Date: 
2021-03-31
Source: 
Fox 45 News (Baltimore)
Dr. Matthew Robinson
Fox New 45 (Baltimore): Dr. Matt Robinson discusses the SCARP tool, which can predict patients' risk of severe COVID disease and death.

Innovation During Times of Change  |  2020 Annual Report

Post Date: 
2021-03-29
2020 Annual Report
2020 was a year like no other. Learn what CCGHE discovered in our Annual Report.

Experts concerned over pockets of covid among unvaccinated minorities

Post Date: 
2021-03-03
Source: 
Sierra Leone Times
Dr. Kathleen Page
Dr. Page: "If Latinos and Blacks are not receiving vaccinations, the consequences could be troubling for public health."

Will the New COVID-19 Variants Increase Reinfection Rates?

Post Date: 
2021-02-15
Source: 
VeryWellHealth
Dr. Robert Bollinger
"While the mutations don’t mean much in terms of how the virus functions, if the mutations lead to a change in how the virus works, then we pay more attention to it."

World Renowned Infectious Disease Expert on CDC's New School Guidelines.

Post Date: 
2021-02-15
Source: 
Leslie Marshall Show
Dr. Robert Bollinger
Leslie Marshall interviews Dr. Robert Bollinger on CDC's New School Guidelines.

State of Maryland Launches Public Outreach and Equity Campaign to Promote Vaccine Confidence

Post Date: 
2021-02-05
Source: 
The Southern Maryland Chronicle
Dr. Kathleen Page
The State of Maryland today launched its grassroots public outreach and equity campaign to promote vaccine confidence. GoVAX encourages all Marylanders to protect themselves...

COVID-19 Strain Variants, Ramping Up Vaccinations to Get to Herd Immunity

Post Date: 
2021-01-27
Source: 
Leslie Marshall Show
Dr. Robert Bollinger
Leslie and Dr. Bollinger discuss the latest news surrounding COVID-19, including: Moderna announcing that its COVID-19 vaccine is effective against new...

Doctors Explain The Risks If You Miss Your Second Vaccine Appointment

Post Date: 
2021-01-27
Source: 
Bustle
Dr. Robert Bollinger
Dr. Robert Bollinger: "You could be less protected against COVID, for a shorter period, or it could also give the virus time and space to mutate."

New strains of COVID swiftly moving through the US need careful watch, scientists say

Post Date: 
2021-01-25
Source: 
USATODAY
Dr. Robert Bollinger
Instead of perfectly copying its 29,811 bases, the four-letter alphabet used to describe its genetic code, a wrong letter sneaks in.

VERIFY: What do we know about the coronavirus strain in South Africa?

Post Date: 
2021-01-25
Source: 
Radio Health Journal
Dr. Robert Bollinger
Here’s what we know about the strain found in South Africa. According to Dr. Bollinger, it looks to be more contagious than the original. “That's true, not just about the South African variant...

Covid Vaccination Incentives: The Risks And Rewards For Employers

Post Date: 
2021-01-16
Source: 
Forbes
Dr. Robert Bollinger
Dr. Bob Bollinger: “To stop this epidemic and get us all back to a new normal as soon as possible, we will need all segments of society to increase community uptake of vaccination[s]."

Experts say COVID-19 mutations are normal

Post Date: 
2021-01-15
Source: 
messenger-inquirer.com
Dr. Robert Bollinger
Dr. Robert Bollinger: “... As with any virus, changes are something to be watched, to ensure that testing and vaccines are still effective.

A New Strain of Coronavirus: What You Should Know

Post Date: 
2021-01-06
Source: 
hopkinsmedicine.org
Dr. Robert Bollinger
Dr. Bollinger: "All viruses mutate over time, some more than others. For example, flu viruses change often, which is why doctors recommend that you get a flu shot every year."

Research Story Tip: Grants, Management Roles Keep Johns Hopkins A Leader In Hiv/Aids Clinical Trial Research

Post Date: 
2020-12-08
Research Story Tip
Researchers at Johns Hopkins Medicine learned that they now have an enhanced opportunity to help move the world toward a day when that observance is rendered obsolete.

Research Update: TB Trials Conducted by JHU-India Team Will Shorten Drug-Susceptible TB Treatment for Children and Adults

Post Date: 
2020-12-07
Research Updated
Reporting from the virtual 51st Union Conference on Lung Health, the World Health Organization (WHO) and the U.S. Centers for Disease Control and Prevention (CDC) announced promising findings from 2 TB trials

Is It a Cold, the Flu, or COVID-19?

Post Date: 
2020-10-11
Source: 
Everyday Health
Dr. Natasha Chida
Everydat Health: Dr. Natasha Chida: "...80 percent of people who get COVID-19 develop mild symptoms that resemble those of a cold.”

Leslie Marshall interviews Dr. Bob Bollinger on Latest COVID-19 News, Including Vaccines

Post Date: 
2020-10-06
Source: 
The Leslie Marshall Show
Dr. Robert Bollinger
CCGHE's Bob Bollinger talks with Leslie Marshall about the latest COVID-19 news, including vaccines.

Study Shows Extent, Danger of TB Exposure: Part I

Post Date: 
2020-08-24
Source: 
Medical Daily
Dr. Amita Gupta
Medical Daily: Amita Gupta and Mandar Paradkar are quoted in this report about TB preventive therapy for household contacts of confirmed cases in India

Research Story Tip: International Johns Hopkins Study Says Broad Measures Needed to Prevent TB Spread in India

Post Date: 
2020-08-06
Dr. Mandar Paradkar
Johns Hopkins News Release: News release highlights study findings published in PLOS One by Dr. Mandar Paradkar and colleagues.

Pages