Research News

Sepsis among newborns in the neonatal intensive care unit (NICU) is a big problem in India, and a complex one to untangle.

In a multi-country study, we are assessing the accuracy of the BD MAX rapid MDR-TB assay to detect rifampin and isoniazid resistance.

Clinical Research

We work with scientists and practitioners around the world to conduct clinical trials and observational studies that improve prevention and treatment of many grave health issues affecting resource-limited regions, including HIV and tuberculosis.
 
We have formal research partnerships with the following institutions:
 
 

TREAT Asia: Prevalence and Risk Factors for Oral Cancer among HIV-Infected Adults

Post Date: 
2016-12-13
Country: 
The study is designed as a cross-sectional, single time point study for opportunistic oral cancer screening of HIV-infected and non- HIV adults 21 years or older in an urban hospital. All participants will undergo screening for oral cancer and oral potentially malignant disorders (OPMD) by visual...

Cost-effectiveness of Xpert MTB/RIF for Diagnosing Pulmonary Tuberculosis in HIV-positive Patients

Post Date: 
2016-12-01
Country: 
This is a prospective cross-sectional study which will be conducted at BJGMC in Pune, India. The aim of this study is to see whether Xpert MTB/RIF is useful for early detection of pulmonary tuberculosis, and therefore cost-effective, as compared with sputum microscopy and the gold standard tests...

The Evaluation of Clinical Profile and Mortality of Children Admitted with Tuberculosis in Pediatric Intensive-Care Unit at Sassoon General Hospitals, Pune

Post Date: 
2016-10-27
Country: 
Tuberculosis (TB) is one of the most common causes of infection-related death globally. TB was declared global public health emergency in 1993 by World HealthOrganization (WHO). Mortality due to TB is increasing due to emergence of multidrug resistant (MDR) strains and HIV-TB co-infection,...

The Evaluation of Clinical Profile and Mortality of Children Admitted with Tuberculosis in Pediatric Intensive Care Unit at Sassoon General Hospitals, Pune

Post Date: 
2016-10-27
Country: 
This retrospective descriptive analytical study reviews the clinical profile and outcome of children with pulmonary tuberculosis (TB) and extra-pulmonary tuberculosis admitted to a Pediatric Intensive Care Unit (PICU) in a tertiary care hospital. The study will evaluate the clinical profile and...

ART Study 1: Database: Epidemiology of HIV/AIDS and Associated Comorbidities in a Public Antiretroviral Treatment (ART) Clinic at BJGMC in Pune

Post Date: 
2016-09-19
Country: 
Since 2004, the National AIDS Control Program of India has been rolling out free antiretroviral therapy. Byramjee Jeejeebhoy Government Medical College (BJGMC), located in Pune, India, is now the largest HIV clinic in India, with over 26,000 adult and pediatric patients registered since 2005. We...

RePORT: C-TRIUMPH: Substudy on Transcriptomic and Metabolomic Analysis of Microbiologically Confirmed Pediatric Tuberculosis Patients and Uninfected Household Contacts

Post Date: 
2016-09-01
Country: 
The objectives for this study are to: Assess the RNAseq, microRNA, and metabolic signature differences between confirmed pediatric TB patients and age- and sex-matched controls who are all household contacts of known cases but have remained TST and IGRA negative. Determine which of the published...

Establishing an Observational Cohort Database for Patient Care and Research at the Hinduja Hospital Chest Clinic

Post Date: 
2016-08-30
Country: 
India has the largest burden of global tuberculosis (TB), accounting for one quarter of the total number of cases reported. Together with South Africa, India sees one-third of the total number of deaths from TB. Drug-resistant strains of the disease are also on the rise, with India having one of...

Measuring TB Drugs in Hair as a Tool to Monitor Adherence, Exposure and Response in Patients with HIV

Post Date: 
2016-08-16
Country: 
Our study will examine whether hair levels of two key first line tuberculosis drugs will be useful markers to identify individuals at highest risk of treatment failure in active tuberculosis. Our study aims to provide a lowcost clinical tool using hair that can be noninvasively collected to monitor...

mHealth-enhanced Peer Navigation Intervention for PrEP Delivery among MSM at STD Clinics

Post Date: 
2016-08-01
Country: 
Using mixed methodology (quantitative surveys, qualitative interviews, and administrative data), this study will assess acceptability and feasibility of an mHealth-enhanced peer navigation to promote PrEP initiation, retention and adherence among men who have sex with men (MSM) in the Baltimore...

Adherence to Indian National Guidelines for Isoniazid Chemoprophylaxis among Pediatric Contacts of Pulmonary Tuberculosis Cases

Post Date: 
2016-07-06
Country: 
The primary objective of the study was to assess the implementation of the Indian Revised National Tuberculosis Programme's (RNTCP) guidelines regarding isoniazid preventive treatment (IPT) for children under 6 years of age who had been in contact with adults diagnosed with sputum positive...

TB and Pregnancy Impact of Immune Changes of HIV and Stages of Pregnancy on Tuberculosis: Nested Study on Temporal Dynamics of Gut Microbiota in HIV Infected Pregnant Women

Post Date: 
2016-07-05
Country: 
This is a nested prospective longitudinal cohort study of 35 HIV-infected and 35 HIV-noninfected pregnant women who are part of the parent study “Impact of Immune Changes of HIV and Stages of Pregnancy on Tuberculosis." The objectives are to: Determine the association of gestational age with...

Maternal Inflammation, Diet and Gut Microbiome in HIV: Impact on Infant Outcomes

Post Date: 
2016-07-01
Country: 
The primary objective of this study is to determine the feasibility and operational logistics of collecting stool for microbiome analysis, detailed nutritional assessment using a food-frequency questionnaire for dietary intake and serum for inflammatory markers in order to determine factors that...

A Randomized Therapeutic Interventional Comparative Study between Three Different Modalities of Paediatric Antitubercular Treatment

Post Date: 
2016-06-13
This study, conducted and concluded in 2013, evaluated three different TB treatment regimens in children attending Sassoon General Hospital in Pune, India. A convenience sample size of n=100 children were enrolled in the study. The study investigators in India have asked the JHU faculty listed on...

Optimal Algorithmic Diagnosis of Genital TB among HIV-infected and Uninfected Infertile Women

Post Date: 
2016-05-26
There is a lack of a set protocol universally for diagnosis of genital TB, and for Indian hospitals, India's Revised National Tuberculosis Control Program (RNTCP) also does not give guidelines on diagnosis of Genital TB. Detection of Genital TB in the early stages has a good outcome with return of...

Whole Genome Sequencing and Trek Sensititre Testing of Stored Isolates of Drug-resistant Tuberculosis from a Clinical Cohort at Hinduja Hospital, Mumbai

Post Date: 
2016-05-02
Country: 
Among HIV-positive TB patients presenting to Médecins San Frontières (MSF) clinics in Mumbai, 78% carried MDR-TB strains, with nearly half also found to have additional drug resistance. A previously published cohort of 202 patients cared for at these MSF clinics have enrolled in a cross-sectional...

RePORT: C-TRIUMPH: Substudy on Comparison of Available Purified-protein Derivative (PPD) Tuberculin Skin Test (TST) Antigen Solutions in Detecting Latent Tuberculosis Infection in India

Post Date: 
2016-04-21
Country: 
Given the worldwide shortage of PPD TST antigen solutions, it is important to establish the sensitivity of the commercially available SPAN diagnostic TST when compared products used in international settings. This study aims to establish whether the SPAN diagnostic product is bioequivalent to PPDs...

Barriers to Early Treatment Initiation in Childhood Tuberculosis in High Incidence Setting

Post Date: 
2016-04-21
Country: 
Funded by the Fogarty International Center and led by PI Dr. Chhaya Tukaram Valvi, the aim of this study is to evaluate the time to treatment initiation and barriers to early treatment initiation in childhood tuberculosis. TB diagnosis in children is challenging, often overlooked or missed, because...

Barriers to Implementation of Isoniazid Preventive Treatment (IPT) in Pediatric Contacts of Sputum Positive Adults with Tuberculosis

Post Date: 
2016-03-24
Country: 
Young children infected with M.tuberculosis can rapidly progress to pulmonary and extrapulmonary disease with high rates of mortality and morbidity. Studies worldwide have demonstrated that IPT not only prevents latent and asymptomatic TB from progression to clinical disease, it also effectively...

Acute Febrile Illness and Antimicrobial Resistance Patterns in Pune, India: Substudy on the Characterization of the Human Virome

Post Date: 
2016-02-21
Country: 
Objective 1: To use novel molecular techniques to characterize the human virome in the circulating blood of patients in clinical settings who presented to an acute care setting with an acute febrile illness and in whom a diagnosis cannot be achieved by conventional methods. Healthy controls will be...

Whole Genome Sequencing of Clinical Isolates from Patients with Multidrug Resistant Tuberculosis in India 

Post Date: 
2015-11-12
Country: 
Comparative genomic analysis using whole genome sequencing (WGS) offers an opportunity to understand the specific mutations associated with drug resistance and the phenotypic behavior of TB. As treatment programs incorporate more molecular diagnostics such as Xpert MTB/RIF and line probe assays, it...

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High prevalence of cryptococcal antigenaemia amongst asymptomatic advanced HIV patients in Pune, India

Post Date: 
2017-03-21
Publication: 
Indian Journal of Medical Microbiology
Country: 
Methods : A prospective study was conducted in a large public sector ART centre and the inpatient wards of Sassoon Hospital, Pune, India. All consenting patients> 18 years of age with CD4 count <100 cells/mm3 were screened for CrAg by latex agglutination assay. Those with positive CrAg...

Chilling effect? Post-election health care use by undocumented and mixed-status families

Post Date: 
2017-03-08
Publication: 
New England Journal of Medicine
Country: 
Perspective article from Dr. Kathleen Page in the New England Journal of Medicine

Vitamin A and D deficiencies associated with incident tuberculosis in HIV-infected patients initiating antiretroviral therapy in multinational case-cohort study

Post Date: 
2017-02-06
Publication: 
Journal of Acquired Immune Deficiency Syndromes
Introduction: Numerous micronutrients have immunomodulatory roles that may influence risk of tuberculosis (TB), but the association between baseline micronutrient deficiencies and incident TB after antiretroviral (ART) initiation in HIV-infected individuals is not well characterized. Methods: We...

¡Sólo se vive una vez! (you only live once): a pilot evaluation of individually tailored video modules aiming to increase HIV testing among foreign-born Latino men

Post Date: 
2017-02-01
Publication: 
Journal of Acquired Immune Deficiency Syndromes
Country: 
BACKGROUND: Although Latinos living in the United States are disproportionately affected by HIV, the development, implementation, and evaluation of HIV prevention, testing, and linkage to care interventions lag behind efforts occurring in other communities. To address sociocultural barriers to...

Tuberculosis associated with HIV infection

Post Date: 
2017-01-15
Publication: 
Microbiology Spectrum
Abstract Tuberculosis (TB) has recently surpassed HIV as the primary infectious disease killer worldwide, but the two diseases continue to display lethal synergy. The burden of TB is disproportionately borne by people living with HIV, particularly where HIV and poverty coexist. The impact of these...

Qualitative insights into implementation, processes, and outcomes of a randomized trial on peer support and HIV care engagement in Rakai, Uganda

Post Date: 
2017-01-10
Publication: 
BMC Infectious Diseases
Country: 
BACKGROUND: People living with human immunodeficiency virus (HIV) who have not yet initiated antiretroviral therapy (ART) can benefit from being engaged in care and utilizing preventive interventions. Community-based peer support may be an effective approach to promote these important HIV services...

The socioecology of sexual and reproductive health care use among young urban minority males

Post Date: 
2017-01-05
Publication: 
Journal of Adolescent Health
Country: 
Purpose: To explore perceptions of facilitators/barriers to sexual and reproductive health (SRH) care use among an urban sample of African-American and Hispanic young men aged 15-24 years, including sexual minorities. Methods: Focus groups were conducted between April 2013 and May 2014 in one mid-...

Carbapenems against Mycobacterium tuberculosis: a review of the evidence

Post Date: 
2016-11-15
Publication: 
International Journal of Tuberculosis and Lung Disease
Carbapenems, a more recent β-lactam class, represent a unique anti-tuberculosis option, as emerging evidence demonstrates that they target the Mycobacterium tuberculosis cell wall and β-lactamase. This provides a potentially new agent against M. tuberculosis, in particular for multidrug-resistant (...

Tuberculosis burden in India's private sector

Post Date: 
2016-11-15
Publication: 
The Lancet Infectious Disease
Country: 
Reply to author's reply

Primary care providers knowledge, attitude and practices related to hepatitis C screening and treatment in the oral direct acting antiviral agents era

Post Date: 
2016-10-28
Publication: 
Journal of Community Medicine and Health Education
Country: 
Background: There are over 3 million Americans infected with hepatitis C virus (HCV). Despite recent advances in HCV treatment, a major barrier to care remains a limited number of treaters. HCV therapy provision by primary care providers (PCPs) could expand access by increasing the pool of HCV...

Mandatory tuberculosis case notification in high tuberculosis-incidence countries: policy and practice

Post Date: 
2016-10-20
Publication: 
European Respiratory Journal
Mandatory tuberculosis (TB) notification is an important policy under the End TB Strategy, but little is known about its enforcement especially in high TB incidence countries. We undertook a literature search for selected high-incidence countries, followed by a questionnaire-based survey among key...

Sex-related differences in inflammatory and immune activation markers before and after combined antiretroviral therapy initiation

Post Date: 
2016-10-01
Publication: 
Journal of Acquired Immune Deficiency Syndromes
Background: Women progress to death at the same rate as men despite lower plasma HIV RNA (viral load). We investigated sex-specific differences in immune activation and inflammation as a potential explanation. Methods: Inflammatory and immune activation markers [interferon γ, tumor necrosis factor...

Efficacy of six-week extended-dose nevirapine varies by infant birth weight with greatest relative efficacy in low birth weight infants

Post Date: 
2016-09-30
Publication: 
PLOS One
Country: 
Low birth weight (LBW), defined by the World Health Organization (WHO) as birth weight less than 2500 g, is a significant public health issue in resource-limited settings, particularly in Sub Saharan Africa and South Asia where the estimated annual incidence is 14% and 28–31%, respectively, and the...

HIV-related stigma among Spanish speaking Latinos in an emerging immigrant receiving city

Post Date: 
2016-09-27
Publication: 
Journal of Immigrant and Minority Health
Country: 
HIV-related stigma has been associated with a reluctance to test for HIV among Latinos . This study assessed community HIV-related stigma within an emerging Latino immigrant receiving city . We conducted a brief survey among a convenience sample of 312 Spanish - speaking Latinos in Baltimore,...

Continued importance of sexually transmitted disease clinics in the era of the Affordable Care Act

Post Date: 
2016-09-15
Publication: 
American Journal of Preventive Medicine
Country: 
Introduction: Following the 2014 expansions of Medicaid and private health insurance through the Affordable Care Act, municipal sexually transmitted disease (STD) clinics-which have historically served predominantly uninsured patients-have been threatened with budget cuts nationwide. This study was...

Lateral flow urine lipoarabinomannan assay for detecting active tuberculosis in HIV-positive adults

Post Date: 
2016-08-16
Publication: 
Cochrane Database of Systematic Reviews
Country: 
Background: Rapid detection of tuberculosis (TB) among people living with human immunodeficiency virus (HIV) is a global health priority. HIV-associated TB may have different clinical presentations and is challenging to diagnose. Conventional sputum tests have reduced sensitivity in HIV-positive...

Heterogeneity of the HIV epidemic in agrarian, trading, and fishing communities in Rakai, Uganda: an observational epidemiological study

Post Date: 
2016-08-15
Publication: 
The Lancet HIV
Country: 
Background : Understanding the extent to which HIV burden differs across communities and the drivers of local disparities is crucial for an effective and targeted HIV response. We assessed community-level variations in HIV prevalence, risk factors, and treatment and prevention service uptake in...

Community-based interventions to improve and sustain antiretroviral therapy adherence, retention in HIV care and clinical outcomes in low- and middle-income countries for achieving the UNAIDS 90-90-90 targets

Post Date: 
2016-07-30
Publication: 
Current HIV/AIDS Reports
Country: 
Little is known about the effect of community versus health facility-based interventions to improve and sustain antiretroviral therapy (ART) adherence, virologic suppression, and retention in care among HIV-infected individuals in low- and middle-income countries (LMICs). We systematically searched...

Continued elevation of interleukin-18 and interferon-γ after initiation of antiretroviral therapy and clinical failure in a diverse multicountry human immunodeficiency virus cohort

Post Date: 
2016-07-27
Publication: 
Open Forum Infectious Diseases
Country: 
Background: We assessed immune activation after antiretroviral therapy (ART) initiation to understand clinical failure in diverse settings. Methods: We performed a case-control study in ACTG Prospective Evaluation of Antiretrovirals in Resource-Limited Settings (PEARLS). Cases were defined as...

Association of medical male circumcision and antiretroviral therapy scale-up with community HIV incidence in Rakai, Uganda

Post Date: 
2016-07-12
Publication: 
JAMA
Country: 
IMPORTANCE: Medical male circumcision (MMC) and antiretroviral therapy (ART) are proven HIV prevention interventions, but there are limited data on the population-level effect of scale-up of these interventions in sub-Saharan Africa. Such evaluation is important for planning and resource allocation...

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IMPAACT 2001: Trial of the Pharmacokinetics, Tolerability, and Safety of Once-Weekly Rifapentine and Isoniazid in HIV-infected and HIV-1-uninfected Pregnant and Postpartum Women with Latent Tuberculosis Infection

Post Date: 
2017-05-30
Presentation Location: 
Washington, DC
Event & Convener: 
2017 IMPAACT Annual Meeting
Invited presenter. Tuberculosis Scientific Committee.

CTRIUMPh Pediatric Biomarker Substudy

Post Date: 
2017-05-30
Presentation Location: 
Washington, DC
Country: 
Event & Convener: 
2017 IMPAACT Annual Meeting
Tornheim J . Paradkar M. Invited presenter. Session: The Future of MDR-TB Treatment in Children.

A5300/I2003/PHOENIx Preparatory Study of MDR TB Cases and Their Household Contacts: Operational Feasibility to Inform PHOENIx Trial

Post Date: 
2017-05-29
Presentation Location: 
Washington, DC
Country: 
Event & Convener: 
2017 IMPAACT Annual Meeting
Invited presenter. MDR-TB Training Session.

How Americans Benefit from Global Health Research

Post Date: 
2017-05-25
Presentation Location: 
Washington, DC
Country: 
Event & Convener: 
The Fogarty International Center: How Americans Benefit from Global Health Research Webinar, Research!America
Invited presenter. Live webinar with NIH Fogarty Director Roger Glass, and Johns Hopkins Desmond M. Tutu Professor of Public Health and Human Rights Chris Beyrer.

Knowledge, Attitudes and Practices About Multidrug-Resistant Tuberculosis (MDR-TB) and Preventive Therapy Among Adult and Adolescent Household Contacts of MDR-TB Index Cases

Post Date: 
2017-05-22
Presentation Location: 
Washington, DC
Country: 
Event & Convener: 
American Thoracic Society 2017 International Conference
Poster Presentation. Suryavanshi N, Shah S, Murrill M , Gupta A.

It Simply Won’t Work Here – Few Eligible for the Newly Recommended Short Course MDR-TB Regimen in a Mumbai Private Clinic

Post Date: 
2017-05-21
Presentation Location: 
Washington, DC
Country: 
Event & Convener: 
American Thoracic Society 2017 International Conference
Poster Presentation. Tornheim J , DeLuca A, Ganatra S, Radhika B, Gupta A, Udwadia Z.

Communicating Whole Genome Sequencing Results for Tuberculosis: What Does It Mean and Who Needs to Know?

Post Date: 
2017-04-25
Presentation Location: 
Mumbai, India
Country: 
Event & Convener: 
Foundation for Medical Research
Invited lecture.

What are We Trying to Say Here? Standardizing Next Generation Sequencing Reports for Tuberculosis

Post Date: 
2017-03-30
Presentation Location: 
Washington, DC
Event & Convener: 
2017 Critical Path to TB Drug Regimens Annual Workshop.
Invited speaker

Validity of Reported Measures of Secondhand Smoke Exposure in Indian Households: Mishri Preparation a Potentially Overlooked Source in Low-Income Indian Communities

Post Date: 
2017-03-10
Presentation Location: 
Florence, Italy
Event & Convener: 
23rd Annual Meeting of the Society for Research on Nicotine & Tobacco (SRNT)
Oral presentation. Elf JL , Kinikar AA, Khadse S, Mave V, Gupte N, Kulkarni V, Patekar S, Raichur P, Cohen J, Breysse PN, Gupta A, Golub JE.

mHealth in medicine: A Hopkins-Focused Perspective

Post Date: 
2017-02-24
Presentation Location: 
Baltimore, MD
Event & Convener: 
Digital Health Day. Johns Hopkins University
Invited speaker

HIV Testing Uptake Among Household Contacts of MDR-TB Index Cases in Eight Countries

Post Date: 
2017-02-14
Presentation Location: 
Seattle, Washington
Event & Convener: 
CROI 2017
Poster Presentation. Opollo VS, Wu X, Lando R, Swindells S, Gupta A, Hesseling A, Dawson R, Hughes MD, Shah S

Impact of INH Adherence on TB Incidence and Mortality by Week 96 in ACTG 5274 Trial 

Post Date: 
2017-02-14
Presentation Location: 
Seattle, Washington
Country: 
Event & Convener: 
CROI 2017
Poster Presentation. Gupta A , Sun X, Miyahara S, Matoga M, Langat D, Riviere C, Bisson C, Kumwenda J, Hosseinipour MC, for the ACTG A5274/REMEMBER Study Team

Inflammation Biomarkers Predict Clinical Treatment Failure in HIV-infected Adults

Post Date: 
2017-02-14
Presentation Location: 
Seattle, Washington
Country: 
Event & Convener: 
CROI 2017
Poster Presentation. Shivakoti R , Gupte N, Pillay S, Riviere C, Cardoso SW, Balagopal A, Semba R, Campbell T, Gupta A

Risk Factors for Death in Advanced HIV-Infected Adults in an Empiric TB Therapy Trial

Post Date: 
2017-02-14
Presentation Location: 
Seattle, Washington
Country: 
Event & Convener: 
CROI 2017
Poster Presentation. Bisson G, Ramchandani R , Miyahara S, Sun X, Bao J, Gupta A, Hosseinipour MC, Kumwenda J

Hepatotoxicity in People with Advanced Immunosuppression taking Isoniazid Preventive Therapy and Antiretroviral Therapy

Post Date: 
2017-02-14
Presentation Location: 
Seattle, Washington
Event & Convener: 
CROI 2017
Poster Presentation. Ngongondo M , Miyahara S, Hughes MD, Sun X, Gupta A, Kumwenda J, Torres TS, Bisson G, Hosseinipour MC

Factors Associated with Pulmonary Impairment in HIV-infected South African Adults

Post Date: 
2017-02-14
Presentation Location: 
Seattle, Washington
Country: 
Event & Convener: 
CROI 2017
Poster Presentation. Gupte A , Wong M, Msandiwa R, Barnes G, Golub J, Chaisson R, Hoffmann C, Martinson N

Impact of Drug Susceptibility Testing on Drug Choice in a Tuberculosis Cohort with High Rates of Drug Resistance from the Private Sector in Mumbai

Post Date: 
2017-02-03
Presentation Location: 
Hyderabad, India
Country: 
Event & Convener: 
6th Annual Regional Prospective Observational Research for Tuberculosis (RePORT) India Joint Leadership Meeting
Poster presentation. Tornheim JA , Ganatra S, DeLuca A, Banka R, Gupta A, Udwadia ZF

Alcohol Use Among Adult Pulmonary and Extra-pulmonary TB Cases in the C-TRIUMPH India Cohort

Post Date: 
2017-02-03
Presentation Location: 
Hyderabad, India
Country: 
Event & Convener: 
6th Annual Regional Prospective Observational Research for Tuberculosis (RePORT) India Joint Leadership Meeting
Poster presentation. John S , DeLuca A, Paradkar M, Nayagam R, Shivakumar SVBY, Gupte A, Gupte N, Thomas B, Suryavanshi N, Kolhi R, Golub J, Kulkarni V, Pradhan N, Mave V, Chandrasekaran P, Gupta A

Impact of Immune Changes of Pregnancy and HIV Infection on Tuberculosis

Post Date: 
2017-02-03
Presentation Location: 
Hyderabad, India
Country: 
Event & Convener: 
6th Annual Regional Prospective Observational Research for Tuberculosis (RePORT) India Joint Leadership Meeting
Poster presentation. Mathad J, Alexander M , Bhosale R, Naik S, Shivakoti R, Mave V, Suryavanshi N, Gupte N, Kulkarni V, Pradan N, Patil N, Gupta A

Host Factors Associated with Poor Respiratory Health-Related Quality of Life in Pulmonary Tuberculosis

Post Date: 
2017-02-03
Presentation Location: 
Hyderabad, India
Country: 
Event & Convener: 
6th Annual Regional Prospective Observational Research for Tuberculosis (RePORT) India Joint Leadership Meeting
Poster presentation. Gupte A , Meshram S, Selvaraju S, Gupte N, Shivakumar SVBY, Paradkar M, Kohli R, Theruvengadam K, Suryavanshi N, Chandrasekaran P, Mave V, Swaminathan S, Salvi S, Checkley, W, Golub J, Gupta A

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Imec’s miDiagnostics joint venture does blood tests from blood-drop

Post Date: 
2016-08-09
Source: 
Electronics Weekly
miDiagnostics, the joint venture between Imec and Johns Hopkins University, aims to develop IC-based diagnostic tests which use drops of blood to detect cells, proteins, nucleic acids, and/or small molecules.

emocha’s public health apps are heading to California

Post Date: 
2016-08-02
Source: 
Technical.ly Baltimore
Three counties in California signed on to use emocha’s apps for managing tuberculosis. The Johns Hopkins spinout is implementing miDOT in Fresno, Merced and Contra Costa counties.

Emocha brings TB adherence tech to California as part of national expansion

Post Date: 
2016-08-02
Source: 
MedCity News
Emocha, a digital health startup seeking to create more flexibility for tuberculosis patients to meet the requirements for Directly Observed Therapy, or DOT, has added a new set of customers in California as part of a national expansion.

Help on wheels to screen TB in rural areas

Post Date: 
2016-07-26
Source: 
The Times of India
A state-of the art health services bus would provide medical care to rural populace at their doorsteps. Designed through a donation of US$100,000 from philanthropists Raj and Bharati Shah of the US-based Capital Technology Information Services (CTIS), the mobile health and wellness clinic launched...

Mobile Health and Wellness Clinic Debuts in Pune for Clinical Research and Community-Based Care

Post Date: 
2016-07-25
The Maryland-based health care informatics company CTIS and its founders, Raj and Bharti Shah, have collaborated with the Johns Hopkins Center for Clinical Global Health Education and Byramjee Jeejeebhoy Government Medical College to equip and dispatch a custom-designed mobile health care services...

CCGHE at AIDS 2016

Post Date: 
2016-07-20
CCGHE efforts presented at AIDS 2016 in Durban, South Africa

2016 Global Health Established Field Placement Awardees

Post Date: 
2016-06-28
The following Johns Hopkins students received Global Health Established Field Placement Awards to work on CCGHE research studies in India and Uganda. Each student is spending a minimum of 6 weeks in the field, and each has been awarded $3500 from the Johns Hopkins Center for Global Health for...

Confronting Gender Based Violence 2016 Course

Post Date: 
2016-06-16
2016-06-16—The Johns Hopkins Center for Clinical Global Health Education (CCGHE) is pleased to launch the free online course Confronting Gender-based Violence: Global Lessons for Healthcare Workers. Registration is now open for the course, which is being offered through Coursera. It is scheduled to...

Up Close: Jessica Elf

Post Date: 
2016-05-31
The quality of air is an ethical imperative.

Lateral flow urine lipoarabinomannan assay for detecting active tuberculosis in HIV-positive adults

Post Date: 
2016-05-11
Source: 
Science Daily
An international review team has prepared a systematic review to assess the accuracy of a point-of-care urine test for diagnosing and screening tuberculosis (TB) in people living with human immunodeficiency virus (HIV).

Amita Gupta Appointed US Chair for India TB Research Consortium

Post Date: 
2016-05-11
“After more than 40 years of little discovery, interest, or funding for TB research, we are at a nexus of advancement."

Can Technology & Training Promote Retention in Care & Prevent HIV Transmission?

Post Date: 
2016-05-10
When HIV+ mothers are actively engaged in care, they are far less likely to transmit the disease to their babies. And while HIV+ women in India generally seek initial care, maintaining continuity of care can be challenging. One study in India seeks to answer the question: Can a focused empowerment...

Mobile Technology Developed at Hopkins Medicine Transforming TB Care in Texas

Post Date: 
2016-04-19
Harris County Public Health Environmental Services Hailed TB Elimination Champion by CDC The US Centers for Disease Control and Prevention recently named Harris County Public Health Environmental Services among its 2016 TB Elimination Champions for improving tuberculosis (TB) patient outcomes in...

Study evaluates four-drug TB treatment for HIV/AIDS patients

Post Date: 
2016-04-04
Source: 
Vaccine News Daily
"Our results even suggest the four-drug strategy is actually doing more harm than isoniazid-alone therapy because study participants found it less tolerable and stopped using it," Dr. Amita Gupta, senior study author and associate professor of medicine and deputy director of the Johns Hopkins...

Feasibility Study Complete on Preventive Therapy for Household Contacts of MDR-TB Patients in Pune, India

Post Date: 
2016-03-31
March 31, 2016—Pune, India—The Baltimore-Washington-India Clinical Trials Unit is pleased to announce that the BJGMC Clinical Research Site (BJGMC-CRS) in Pune, India, just finished the feasibility study titled A5300/IMPAACT2003: Study of MDR-TB Cases and their Household Contacts: Operational...

In Many Regions, World Tuberculosis Day is Every Day

Post Date: 
2016-03-24
India Assumes the Greatest Burden Each year on March 24, the world pauses to reflect on the devastation that tuberculosis causes globally. TB is preventable and treatable, and it disproportionately and gravely affects resource-limited regions of the world. The World Health Organization reports that...

Proactively treating HIV patients at risk for tuberculosis with multi-drug TB regimens doesn't save more lives

Post Date: 
2016-03-20
Source: 
Health Canal
The number one killer of HIV patients in resource-limited areas, including parts of Africa and India, is tuberculosis (TB), underscoring the need for optimal treatments and effective strategies to address this deadly co-infection. But TB is harder to detect in HIV-infected patients and diagnostic...

Proactively treating HIV patients at risk for tuberculosis with multi-drug TB regimens doesn't save more lives

Post Date: 
2016-03-18
Source: 
Infection Control Today
In what investigators say is a surprise finding, results of a new study appear to strongly affirm the effectiveness of prescribing the anti-tuberculosis drug isoniazid alone — in place of the standard four-drug regimen — to prevent TB and reduce death in

Common TB treatment in HIV: no added benefit?

Post Date: 
2016-03-18
Source: 
Pharmaceutical Processing Online
In a report on the REMEMBER (Reducing Early Mortality and Early Morbidity by Empiric Tuberculosis Treatment) study—a 10-nation, randomized clinical trial of adult outpatients—investigators concluded that there was no added benefit of using four drugs for TB over just using one drug, isoniazid, to...

4-drug tuberculosis treatment among HIV/AIDS patients does not save more lives

Post Date: 
2016-03-18
Source: 
MedIndia
There was no added benefit of using four drugs for tuberculosis over using just one drug, isoniazid, to save lives in people with advanced HIV/AIDS, revealed a report on the so-called REMEMBER (Reducing Early Mortality and Early Morbidity by Empiric Tuberculosis Treatment) study—a 10 nation,...

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