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Study shows success with TB therapy observation conducted via video instead of via in-person clinic visits.

Children in Maharashtra India

Trials: Evidence for TB treatment in kids is largely based on adult studies. The SHINE study aims to fix this

Clinical Research

Leadership
Dr. Amita Gupta of Johns Hopkins is Principal Investigator for the Indo-JHU Clinical Research Partnership based out of CCGHE. Research is directed locally in India out of the BJGMC-JHU Clinical Research Site by Dr. Vidya Mave, a Hopkins faculty member who lives in Pune. Dr. Nikhil Gupte is the Lead Biostatistician and Deputy Director and Dr. Nishi Suryavanshi is Clinical Site Coordinator and Deputy Director. Research is conducted in collaboration with the following institutions:
 
 

Mortality and clinical characteristics of hospitalized adult patients with HIV in Pune, India

Post Date: 
2007-08-01
Publication: 
Indian Journal of Medical Research
Country: 
Background and Objective: In India, data regarding mortality and clinical characteristics of hospitalized HIV-infected patients are sparse, which may limit the effectiveness of new hospital-based HIV programmes providing antiretroviral therapy (ART). The objective of our study was to determine...

Post-partum TB incidence and mortality among HIV-infected women and their infants in Pune, India 2002-2005

Post Date: 
2007-07-15
Country: 
Background: In contrast with many other countries, isoniazid preventative therapy is not recommended in clinical care guidelines for human immunodeficiency virus (HIV)-infected persons with latent tuberculosis (TB) in India. Methods: Seven hundred fifteen HIV-infected mothers and their infants were...

Hematogenous osteomyelitis mimicking osteosarcoma due to Community Associated Methicillin-Resistant Staphylococcus aureus

Post Date: 
2007-06-15
Publication: 
Infection
Community Associated Methicillin - Resistant Staphylococcus aureus (CA-MRSA) is an emerging pathogen with increasing clinical significance. Initially recognized as a cause of skin and soft tissue infections, it has soon been shown to cause life threatening illnesses. We describe two cases of...

Clinically significant anemia in HIV-infected pregnant women in India is not a major barrier to zidovudine use for prevention of maternal-to-child transmission

Post Date: 
2007-06-01
Publication: 
Journal of Acquired Immune Deficiency Syndromes
Country: 
Objectives: To determine the prevalence of anemia (serum hemoglobin <10 g/dL) and assess zidovudine use and toxicity in HIV-positive pregnant women in India. Methods: From 2002 through 2006, 24,105 pregnant women in Pune were screened for HIV and anemia. As part of an infant prevention of mother...

Adherence to antiretroviral therapy and virologic suppression among HIV-infected persons receiving care in private clinics in Mumbai, India

Post Date: 
2007-05-01
Publication: 
Clinical Infectious Diseases
Country: 
Background: Adherence to antiretroviral therapy (ART) and correlates of adherence and virologic suppression among human immunodeficiency virus (HIV)-infected persons receiving ART in private, outpatient clinics in India is unknown. Methods: Between December 2004 and April 2005, persons receiving...

Impact of maternal HIV co-infection on the vertical transmission of Hepatitis C virus: a meta-analysis.

Post Date: 
2007-04-15
Publication: 
Clinical Infectious Diseases
Background: Observational studies suggest that maternal human immunodeficiency virus (HIV)-hepatitis C virus (HCV) coinfection is associated with increased odds of vertical HCV transmission. We performed a meta-analysis to summarize current evidence. Methods: We systematically searched for relevant...

Knowledge, attitudes and practices of antiretroviral therapy among adults attending private and public clinics in India

Post Date: 
2007-02-15
Publication: 
AIDS Patient Care and STDs
Country: 
India has approximately 5.2 million persons infected with HIV. Although antiretroviral therapy (ART) is being widely introduced in public clinics, many HIV-infected persons still seek care via the private sector. A cross-sectional survey was conducted in 2004 at six public and private sites to...

The traveling farm wife

Post Date: 
2007-01-15
Publication: 
American Journal of Medicine
In late summer, a 77-year-old woman was hospitalized after 9 days of chills, low-grade fever, fatigue, and generalized weakness. She did not have abdominal pain, coughing, diarrhea, dyspnea, jaundice, nausea, rashes, sore throat, vomiting, or weight loss. Her medical history was significant for...

Same-sex behavior and high rates of HIV among men attending sexually transmitted infection clinics in Pune, India (1993-2002)

Post Date: 
2006-12-01
Publication: 
Journal of Acquired Immune Deficiency Syndromes
Country: 
Objectives: To determine HIV/sexually transmitted infection (STI) prevalence, trends, and risk behaviors of men who have sex with men (MSM) and compare these with those of non-MSM attending STI clinics in Pune, India over a 10-year period. Methods: From 1993 through 2002, men attending 3 STI...

Community preparedness for HIV vaccine trials in the Democratic Republic of Congo

Post Date: 
2006-11-30
Publication: 
Culture, Health, and Sexuality
This paper reports on an assessment of community preparedness for HIV vaccine trials in the Democratic Republic of Congo. Formative research was conducted in the capital city of Kinshasa during the period October 2003 to March 2004 to answer questions pertinent to planning trials of a preventive...

Improved adherence and less toxicity with rifampin vs isoniazid for treatment of latent tuberculosis: a retrospective study

Post Date: 
2006-09-25
Publication: 
Archives of Internal Medicine
Country: 
Background: Treatment of latent tuberculosis infection (LTBI) is an important aspect of tuberculosis control in the United States, but the effectiveness of this strategy is compromised by poor adherence to the recommended 9-month isoniazid regimen. In this study, we compared treatment completion...

Evaluation of serologic screening for identification of chronic Salmonella typhi carriers in Vietnam

Post Date: 
2006-07-10
Publication: 
International Journal of Infectious Diseases
Objectives: To determine the utility of screening anti-Vi antibodies to detect chronic Salmonella Typhi carriers in an endemic community. Methods: We conducted a community-based serologic survey for anti-Vi antibodies to identify chronic Salmonella Typhi carriers in a typhoid endemic region in...

High rates of syphilis among STI patients are contributing to the spread of HIV-1 in India

Post Date: 
2006-04-15
Publication: 
Sexually Transmitted Infections
Country: 
Background: Recent syphilis outbreaks have raised concern regarding the potential enhancement of HIV transmission. The incidence of syphilis and its association with HIV‐1 infection rates among a cohort of sexually transmitted infection (STI) clinic attendees was investigated. Methods: 2732 HIV‐1...

Low HIV-1 incidence among married serodiscordant couples in Pune, India

Post Date: 
2006-03-15
Publication: 
Journal of Acquired Immune Deficiency Syndromes
Country: 
Unlike commercial sex workers and patients attending sexually transmitted infection (STI) clinics, married couples are not typically targeted for HIV risk reduction programs in India. Thus, married partners of HIV-infected persons are at particularly high risk for HIV infection. Between September...

The expanding realm of heterologous immunity: friend or foe?

Post Date: 
2006-02-15
Publication: 
Cellular Microbiology
Antecedent or current infections can alter the immunopathologic outcome of a subsequent unrelated infection. Immunomodulation by co-infecting pathogens has been referred to as 'heterologous immunity' and has been postulated to play a role in host susceptibility to disease, tolerance to organ...

Screening for HIV dementia in an HIV, clade C-infected population in India

Post Date: 
2006-02-12
Publication: 
Journal of Neurovirology
Country: 
Although human immunodeficiency virus (HIV) clade C virus infects the largest populations worldwide, to date there are no prospective studies reported thus far to determine the incidence or prevalence of HIV dementia in this population. HIV clade C virus is a CCR5-tropic virus and thus...

Rate of hospitalization and inpatient care costs for HIV-1 infected in Pune, India

Post Date: 
2006-02-01
Publication: 
National Medical Journal of India
Country: 
Background: The transition of human immunodeficiency virus (HIV) infection to acquired immune deficiency syndrome (AIDS) has begun in India, and an increase in AIDS-related hospitalizations and deaths is an anticipated challenge. We estimated the rates of hospitalization and inpatient care costs...

High HIV prevalence among a high-risk subgroup of women attending sexually transmitted infection clinics in Pune, India

Post Date: 
2006-01-01
Publication: 
Journal of Acquired Immune Deficiency Syndromes
Country: 
Objectives: To investigate changes over a decade in prevalence and correlates of HIV among high-risk women attending sexually transmitted infection (STI) clinics in Pune, India, who deny a history of commercial sex work (CSW). Methods: From 1993 to 2002, 2376 women attending 3 STI clinics in Pune...

Correlates and trend of HIV prevalence among female sex workers attending sexually transmitted disease clinics in Pune, India (1993-2002)

Post Date: 
2006-01-01
Publication: 
Journal of Acquired Immune Deficiency Syndromes
Country: 
In India, substantial efforts have been made to increase awareness about HIV/AIDS among female sex workers (FSWs). We assessed the impact of awareness regarding safe sex in a cohort of FSWs by studying trends in HIV prevalence, sexually transmitted diseases (STDs), and risk behaviors measured from...

Mycobacterial-induced potentiation of type 1 immune responses and protection against malaria is host-specific

Post Date: 
2005-12-15
Publication: 
Infection and Immunity
Malaria and tuberculosis are endemic in many regions of the world, and coinfection with the two pathogens is common. In this study, we examined the effects of long- and short-term infection with Mycobacterium tuberculosis on the course of a lethal form of murine malaria in resistant (C57BL/6) and...

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Conduct of international clinical trials

Post Date: 
2009-12-02
Presentation Location: 
Baltimore, MD
Event & Convener: 
Seminars in Clinical Investigations Course. Johns Hopkins Bloomberg School of Public Health
Presentation

World Health Organization (WHO) HIV Treatment Guidelines for Adults and Adolescents: Update and Insights on the 2009 Revision

Post Date: 
2009-11-30
Presentation Location: 
Baltimore, MD
Event & Convener: 
Infectious Diseases Conference. Johns Hopkins
Presentation

Conducting HIV clinical research: How to pose a relevant research question

Post Date: 
2009-11-13
Presentation Location: 
Pune, India
Event & Convener: 
National AIDS Research Institute
Presentation

The HIV epidemic among Latinos living in the U.S.

Post Date: 
2009-10-31
Presentation Location: 
Baltimore, MD
Country: 
Event & Convener: 
Medicine Grand Rounds. Johns Hopkins Department of Medicine
Presentation

WHO stop mother to child transmission of TB: What we do and do not know

Post Date: 
2009-07-19
Presentation Location: 
Cape Town, South Africa
Event & Convener: 
5th IAS Conference on HIV Pathogenesis, Treatment and Prevention
Presentation

Malnutrition, HIV and antiretroviral treatment outcomes: Current knowledge and controversies

Post Date: 
2009-07-08
Presentation Location: 
New York, NY
Event & Convener: 
Cornell Medical School, Division of Infectious Diseases
Presentation

HIV in India

Post Date: 
2009-05-22
Presentation Location: 
New York, NY
Country: 
Event & Convener: 
CIDER Seminar. Columbia Mailman School of Public Health
Presentation

HIV in India

Post Date: 
2009-05-04
Presentation Location: 
Baltimore, MD
Country: 
Event & Convener: 
Johns Hopkins University AIDS Alliance
Presentation

HIV pathogenesis and implications for acquired resistance

Post Date: 
2009-04-30
Presentation Location: 
Montevideo, Uruguay
Event & Convener: 
Facultad de Ciencias (University of Biological Sciences)
Facultad de Ciencias

TB in pregnancy and novel TB diagnostics

Post Date: 
2009-04-28
Presentation Location: 
Pune, India
Event & Convener: 
BJ Medical College Grand Rounds. BJ Medical College
Presentation

Collaborative Leadership through Effective Networks

Post Date: 
2009-04-21
Presentation Location: 
Kampala, Uganda
Event & Convener: 
Infectious Disease Summit
Presentation

Information Technology and Distance Learning and UbuntuNet and Broadband Connectivity in Four African Countries

Post Date: 
2009-04-17
Presentation Location: 
Nairobi, Kenya
Event & Convener: 
Consortium Workshop: Training Future Leaders in Global Health
Presentation

Global Health Education - Where in the world are we?

Post Date: 
2009-04-03
Presentation Location: 
Seattle, WA
Event & Convener: 
Annual GHEC Conference
Presentation

Update on HIV Resistance

Post Date: 
2009-03-31
Presentation Location: 
San Salvador, El Salvador
Event & Convener: 
COMISCA (Consejos de Ministerios de Salud de Centroamerica- Counsel of Central American Ministries of Health). Renaissance Hotel
Presentationi

PMTCT, infant feeding and response to ART treatment and resistance in women and children

Post Date: 
2009-03-26
Presentation Location: 
Maseru, Lesotho
Event & Convener: 
US State Department Workshop. Baylor Center for Excellence Pediatric Hospital
Presentation

Global HIV: Top Ten Developments of the Past Year and Prevention and Treatment of HIV in South Asia: Challenges and Opportunities

Post Date: 
2009-01-30
Presentation Location: 
Tampa, FL
Event & Convener: 
University of South Florida
Presentation

WHISC presentation of P1078

Post Date: 
2008-12-07
Presentation Location: 
Baltimore, MD
Event & Convener: 
IMPAACT Meeting
Presentation

Early mortality in HIV treatment and TB empiric therapy: Weighing the risks and benefits of an empiric TB strategy

Post Date: 
2008-12-05
Presentation Location: 
Baltimore, MD
Event & Convener: 
ACTG Meeting
Presentation

Update on opportunistic infections and IRIS

Post Date: 
2008-12-03
Presentation Location: 
Wilmington, DE
Event & Convener: 
Mid-Atlantic AIDS Education Training. Wilmington Hospital
Presentation

World AIDS day for African students

Post Date: 
2008-12-02
Presentation Location: 
Washington, DC
Event & Convener: 
US State Department Live Webcast
Presentation

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