Research News

ClinInf

We assessed multidrug-resistant tuberculosis (MDR-TB) cases and their household contacts (HHCs) to inform the development of an interventional clinical trial.

Clinical Research

Leadership
Dr. Amita Gupta of Johns Hopkins is Principal Investigator for the Indo-JHU Clinical Research Partnership based out of CCGHE. Research is directed locally in India out of the BJGMC-JHU Clinical Research Site by Dr. Vidya Mave, a Hopkins faculty member who lives in Pune. Dr. Nikhil Gupte is the Lead Biostatistician and Deputy Director and Dr. Nishi Suryavanshi is Clinical Site Coordinator and Deputy Director. Research is conducted in collaboration with the following institutions:
 
 

Traditional Indian medicine and homeopathy for HIV/AIDS: a review of the literature

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2008-12-22
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AIDS Research and Therapy
Background: Allopathic practitioners in India are outnumbered by practitioners of traditional Indian medicine and homeopathy (TIMH), which is used by up to two-thirds of its population to help meet primary health care needs, particularly in rural areas. India has an estimated 2.5 million HIV...

Neutralizing antibody responses in recent seroconverters with HIV-1 subtype C infections in India

Post Date: 
2008-10-25
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AIDS Research and Human Retroviruses
The longitudinal heterologous neutralization response against two HIV-1 subtype C isolates was studied in 33 ART-naive individuals recently infected with HIV-1 subtype C from India. Seven of 33 (21%) seroconverters demonstrated a consistent response against both isolates (65-100% neutralization),...

High risk for occupational exposure to HIV and utilization of post-exposure prophylaxis in a teaching hospital in Pune, India

Post Date: 
2008-10-21
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BMC Infectious Diseases
Background: The risk for occupational exposure to HIV has been well characterized in the developed world, but limited information is available about this transmission risk in resource-constrained settings facing the largest burden of HIV infection. In addition, the feasibility and utilization of...

Neisseria gonorrhea and Chlamydia trachomatis among Human Immunodeficiency Virus-infected women

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2008-10-15
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Sexually Transmitted Diseases
In this study, we determine risk factors for CT and GC infection in women receiving HIV continuity care using data from the Johns Hopkins HIV Clinical Cohort. The Johns Hopkins HIV Clinical Cohort is a longitudinal observational study of adult patients (≥18 years old) in HIV care in the Johns...

Repeated pregnancy in HIV positive Indian women with known HIV status

Post Date: 
2008-09-29
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AIDS Care
HIV-positive women of reproductive age face challenges in decision making related to pregnancy. Understanding factors influencing repeat pregnancies in women with known HIV status are necessary to guide interventions and counseling strategies to better inform and support them. We compared three...

The Indian pediatric HIV epidemic: a systematic review

Post Date: 
2008-09-15
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Current HIV Research
Despite an estimated 70,000 Indian children living with HIV infection, little is known about India's pediatric HIV epidemic. Generalizations about epidemiology, natural history, and treatment outcomes from other resource-limited settings (RLS) may be inaccurate for several biologic and social...

Incidence of common opportunistic infections in HIV-infected individuals in Pune, India: analysis by stages of immunosuppression represented by CD4 counts

Post Date: 
2008-07-02
Publication: 
International Journal of Infectious Diseases
Background: Opportunistic infections (OIs) influence the morbidity and mortality due to HIV infections. Data from India on the incidence of OIs among HIV-infected individuals by stages of immunodeficiency are scarce. Methods: Between September 2002 and November 2004, HIV-infected individuals were...

Timing of therapy for latent tuberculosis infection among immigrants presenting to a U.S. public health clinic: a retrospective study

Post Date: 
2008-05-12
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BMC Public Health
Background: In the U.S. more than half of incident tuberculosis (TB) cases occur in immigrants. Current guidelines recommend screening and treatment for latent TB infection (LTBI) within 5 years of arrival to the U.S. This study evaluates the timing of LTBI therapy among immigrants presenting for...

Telecommunications and health care: An HIV/AIDS warmline for communication and consultation in Rakai, Uganda

Post Date: 
2008-04-25
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Journal of the International Association of Providers of AIDS Care
Hotlines and warmlines have been successfully used in the developed world to provide clinical advice; however, reports on their replicability in resource-limited settings are limited. A warmline was established in Rakai, Uganda, to support an antiretroviral therapy program. Over a 17-month period,...

Responding to the human resource crisis: Peer health workers, mobile phones, and HIV care in Rakai, Uganda.

Post Date: 
2008-03-15
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AIDS Patient Care and STDs
Dear Editor: Two challenges to successful antiretroviral therapy (ART) scale-up in resource-limited settings (RLS) are human resource and healthcare infrastructure limitations.1 We read with interest the modeling study by Bärnighausen et al. which describes the complexities of ensuring adequate...

Low utilization of HIV testing during pregnancy: what are the barriers to HIV testing for women in rural India?

Post Date: 
2008-02-01
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Journal of Acquired Immune Deficiency Syndromes
Introduction: Sixty percent of India's HIV cases occur in rural residents. Despite government policy to expand antenatal HIV screening and prevention of maternal-to-child transmission (PMTCT), little is known about HIV testing among rural women during pregnancy. Methods: Between January and March...

Modeling maternal infant HIV transmission in the presence of breast-feeding with an imperfect test

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2007-12-15
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Biometrics
An important public health question is to determine the probabilities of perinatal HIV transmission and when it occurs, whether antepartum, intrapartum, or postpartum through breastfeeding. However, this is a difficult problem because the presence of HIV infection in an infant can only be...

Selenium and HIV-1: Hope or hype?

Post Date: 
2007-12-10
Publication: 
Archives of Internal Medicine
We read with great interest the article by Hurwitz et al on the impact of selenium supplementation in patients infected with human immunodeficiency virus type 1 (HIV-1). Studies examining the association between micronutrients and HIV, particularly prospective studies, have been limited to date...

Nurses’ health education program in India increases HIV knowledge and reduces fear

Post Date: 
2007-11-30
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Journal of the Association of Nurses in AIDS Care
Few health care facilities are adequately prepared to manage and care for HIV/AIDS patients in India. Nurses play a critical role in patient care but are often ill-equipped to deal with their own fears of occupational risk and handle the clinical aspects of HIV/AIDS care, leading to stigma and...

Low sensitivity of total lymphocyte count as a surrogate marker to identify antepartum and postpartum Indian women who require antiretroviral therapy

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2007-11-01
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Journal of Acquired Immune Deficiency Syndromes
Background: Some studies support the use of total lymphocyte count (TLC) as a surrogate marker for CD4 cell count to guide antiretroviral therapy (ART) initiation. However, most of these studies have focused on nonpregnant adults. In light of expanding ART access through prevention of mother-to-...

Declining HIV Incidence among patients attending sexually transmitted infection clinics in Pune, India

Post Date: 
2007-08-15
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Journal of Acquired Immune Deficiency Syndromes
Objective: A recent report suggesting declining HIV transmission rates in southern India has been based on HIV seroprevalence data to estimate HIV incidence. We analyzed HIV incidence rates among 3 cohorts (male, female non-sex worker, female sex worker [FSW]) presenting to sexually transmitted...

Declining HIV infection rates among recently married, pregnant women in Pune, India

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2007-08-15
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Journal of Acquired Immune Deficiency Syndromes
Background: A single recent study has suggested a decrease in HIV risk for women attending antenatal clinics (ANCs) in southern India. Yet, some have questioned the validity of the Indian national surveillance data and analyses. Previous studies suggest that the only major HIV risk factor for...

Mother-to-child transmission of HIV among women who chose not to exclusively breastfeed their infants in Pune, India

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2007-08-15
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Indian Journal of Medical Research
Background and Objective: The percentage of HIV cases attributed to mother-to-child transmission (MTCT) has increased several fold in recent years. No reports are available on HIV MTCT rates among HIV-infected choosing not be exclusively breastfeed their infants in India. We examined HIV MTCT rates...

U.S. medical resident familiarity with national tuberculosis guidelines

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2007-08-02
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BMC Infectious Diseases
Background: The ability of medical residents training at U.S. urban medical centers to diagnose and manage tuberculosis cases has important public health implications. We assessed medical resident knowledge about tuberculosis diagnosis and early management based on American Thoracic Society...

Mortality and clinical characteristics of hospitalized adult patients with HIV in Pune, India

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2007-08-01
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Indian Journal of Medical Research
Background and Objective: In India, data regarding mortality and clinical characteristics of hospitalized HIV-infected patients are sparse, which may limit the effectiveness of new hospital-based HIV programmes providing antiretroviral therapy (ART). The objective of our study was to determine...

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Early mortality in HIV treatment and TB empiric therapy: Weighing the risks and benefits of an empiric TB strategy

Post Date: 
2008-12-05
Gupta, A. Early mortality in HIV treatment and TB empiric therapy: Weighing the risks and benefits of an empiric TB strategy. ACTG Meeting. Baltimore, MD.

Update on opportunistic infections and IRIS

Post Date: 
2008-12-03
Gupta, A. Update on opportunistic infections and IRIS. Mid-Atlantic AIDS Education Training. Wilmington Hospital. Wilmington, DE.

World AIDS day for African students

Post Date: 
2008-12-02
Gupta, A. World AIDS day for African students. US State Department Live Webcast. Washington, DC.

Global Perspective of HIV

Post Date: 
2008-12-01
Bollinger, R. Global Perspective of HIV. Caring for the City of HIV, World AIDS Day Celebration. Pastoral Care at the Johns Hopkins Hospital. The Johns Hopkins Hospital. Baltimore, MD.

Global epidemiology and its impact on the Macroeconomics of Countries

Post Date: 
2008-10-28
Bollinger, R. Global epidemiology and its impact on the Macroeconomics of Countries. University of Pennsylvania: Wharton School. Philadelphia, PA.

Perspectives on Health Care Delivery in Latin America

Post Date: 
2008-09-30
Page, K. Perspectives on Health Care Delivery in Latin America. Latin American Student Society. Johns Hopkins Bloomberg School of Public Health. Baltimore, MD.

Telemedicine in Resource Limited Countries

Post Date: 
2008-09-25
Bollinger, R. Telemedicine in Resource Limited Countries. Children’s National Medical Center. Washington, DC.

Community-based HIV Care

Post Date: 
2008-09-09
Chang, L. Community-based HIV Care. HIV Online Provider Education (H.O.P.E.) Conference. Harvard University Center for AIDS Research. Cambridge, MA.

Ceftriaxone-resistant Salmonella

Post Date: 
2008-06-21
Gupta, A. Ceftriaxone-resistant Salmonella. International Conference on Infectious Diseases. Kuala Lumpur, Malaysia.

Tuberculosis in Pregnancy

Post Date: 
2008-06-06
Thomas, A. Tuberculosis in Pregnancy. Workshop on Research Priorities for Pediatric Tuberculosis. NIAID/NICHD. Rockville, MD.

An update in opportunistic infections

Post Date: 
2008-05-16
Gupta, A. An update in opportunistic infections. Johns Hopkins HIV Clinical Care Conference. Baltimore, MD.

An Annual Checkup of South Asia’s Public Health

Post Date: 
2008-05-13
Bollinger, R. An Annual Checkup of South Asia’s Public Health. Foreign Service Institute. U.S. Department of State. Washington, DC.

Antibiotic Management Program

Post Date: 
2008-05-10
Bollinger, R. Antibiotic Management Program. Experience and Nococomial Pneumonia and Respiratory Tract Infections and C-difficile. Johns Hopkins Medicine International and Clinic of Condes. Santiago, Chile.

Update on opportunistic infections

Post Date: 
2008-04-04
Gupta, A. Update on opportunistic infections. Brazil-Hopkins AIDS Conference. Rio de Janeiro, Brazil.

The Need to Build a Culture and Capacity for Clinical Research within HIV Prevention, Care and Treatment Programs

Post Date: 
2008-04-04
Bollinger, R. The Need to Build a Culture and Capacity for Clinical Research within HIV Prevention, Care and Treatment Programs. VIII Brasil-Johns Hopkins University on HIV/AIDS. Hotel Sofitel. Rio de Janeiro, Brazil.

Priorities and Opportunities for Vaccine Development: A Global View

Post Date: 
2008-03-27
Bollinger, R. Priorities and Opportunities for Vaccine Development: A Global View. Jefferson Vaccine Center Yearly Retreat. Thomas Jefferson University. Philadelphia, PA.

Challenges in the Management of HIV in India

Post Date: 
2008-03-06
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Bollinger, R. Challenges in the Management of HIV in India. Center for Global Development, 1776 Massachusetts Avenue, NW, Third Floor. Washington, DC.

HIV-1 Genotype Testing: Clinical Applications and Novel Assays

Post Date: 
2007-10-31
Page, K. HIV-1 Genotype Testing: Clinical Applications and Novel Assays. COMISCA (Consejos de Ministerios de Salud de Centroamerica- Counsel of Central American Ministries of Health) Gorgas Memorial Institute. Panamá, Panama.

Barriers to Health Care for Latino Immigrants in Baltimore

Post Date: 
2007-09-30
Page, K. Barriers to Health Care for Latino Immigrants in Baltimore. Department of Hispanic Languages, Literature, and Culture. Goucher College. Baltimore, MD.

Global Health Education: What in the World Must We Do?

Post Date: 
2007-09-14
Bollinger, R. Global Health Education: What in the World Must We Do? Medical Education Grand Rounds. University of Pittsburgh School of Medicine. Pittsburgh, PA.

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