Clinical Research

Leadership
Dr. Amita Gupta of Johns Hopkins is Principal Investigator for the Indo-JHU Clinical Research Partnership based out of CCGHE. Research is directed locally in India out of the BJGMC-JHU Clinical Research Site by Dr. Vidya Mave, a Hopkins faculty member who lives in Pune. Dr. Nikhil Gupte is the Lead Biostatistician and Deputy Director and Dr. Nishi Suryavanshi is Clinical Site Coordinator and Deputy Director. Research is conducted in collaboration with the following institutions:

Byramjee Jeejeebhoy Government Medical College, and Sassoon General Hospital (BJGMC). Pune, India
DY Patil Medical College, Hospital and Research Center. Pune, India
National Institute for Research in Tuberculosis. Chennai, India
PD Hinduja Hospital and Medical Group. Mumbai, India

Publications
Presentations

Low HIV-1 incidence among married serodiscordant couples in Pune, India

Post Date:

2006-03-15

Countries:

India

Publication:

Journal of Acquired Immune Deficiency Syndromes

Unlike commercial sex workers and patients attending sexually transmitted infection (STI) clinics, married couples are not typically targeted for HIV risk reduction programs in India. Thus, married partners of HIV-infected persons are at particularly high risk for HIV infection. Between September...

The expanding realm of heterologous immunity: friend or foe?

Post Date:

2006-02-15

Publication:

Cellular Microbiology

Antecedent or current infections can alter the immunopathologic outcome of a subsequent unrelated infection. Immunomodulation by co-infecting pathogens has been referred to as 'heterologous immunity' and has been postulated to play a role in host susceptibility to disease, tolerance to organ...

Screening for HIV dementia in an HIV, clade C-infected population in India

Post Date:

2006-02-12

Countries:

India

Publication:

Journal of Neurovirology

Although human immunodeficiency virus (HIV) clade C virus infects the largest populations worldwide, to date there are no prospective studies reported thus far to determine the incidence or prevalence of HIV dementia in this population. HIV clade C virus is a CCR5-tropic virus and thus...

Rate of hospitalization and inpatient care costs for HIV-1 infected in Pune, India

Post Date:

2006-02-01

Countries:

India

Publication:

National Medical Journal of India

Background: The transition of human immunodeficiency virus (HIV) infection to acquired immune deficiency syndrome (AIDS) has begun in India, and an increase in AIDS-related hospitalizations and deaths is an anticipated challenge. We estimated the rates of hospitalization and inpatient care costs...

High HIV prevalence among a high-risk subgroup of women attending sexually transmitted infection clinics in Pune, India

Post Date:

2006-01-01

Countries:

India

Publication:

Journal of Acquired Immune Deficiency Syndromes

Objectives: To investigate changes over a decade in prevalence and correlates of HIV among high-risk women attending sexually transmitted infection (STI) clinics in Pune, India, who deny a history of commercial sex work (CSW). Methods: From 1993 to 2002, 2376 women attending 3 STI clinics in Pune...

Correlates and trend of HIV prevalence among female sex workers attending sexually transmitted disease clinics in Pune, India (1993-2002)

Post Date:

2006-01-01

Countries:

India

Publication:

Journal of Acquired Immune Deficiency Syndromes

In India, substantial efforts have been made to increase awareness about HIV/AIDS among female sex workers (FSWs). We assessed the impact of awareness regarding safe sex in a cohort of FSWs by studying trends in HIV prevalence, sexually transmitted diseases (STDs), and risk behaviors measured from...

Mycobacterial-induced potentiation of type 1 immune responses and protection against malaria is host-specific

Post Date:

2005-12-15

Publication:

Infection and Immunity

Malaria and tuberculosis are endemic in many regions of the world, and coinfection with the two pathogens is common. In this study, we examined the effects of long- and short-term infection with Mycobacterium tuberculosis on the course of a lethal form of murine malaria in resistant (C57BL/6) and...

Adult botulism type F in the United States, 1981-2002

Post Date:

2005-12-13

Publication:

Neurology

Background: Clostridium botulinum neurotoxin types A, B, and E cause most cases of the paralytic disease botulism. Little is known about the epidemiology, clinical features, or microbiology of botulism type F. Methods: Cases of adult type F botulism were identified by review of data collected by...

Antifungal interventions for the primary prevention of cryptococcal disease in adults with HIV

Post Date:

2005-07-20

Publication:

Cochrane Database of Systematic Reviews

Infection with the human immunodeficiency virus (HIV) leads to progressive destruction and weakening of the body's immune system. Patients with advanced HIV disease are vulnerable to various diseases, called opportunistic infections (OIs), which most people with normal immune systems are protected...

Genetic diversification and recombination of HIV type 1 group M in Kinshasa, Democratic Republic of Congo

Post Date:

2005-07-15

Countries:

Democratic Republic of Congo

Publication:

AIDS Research and Human Retroviruses

As the HIV-1 pandemic becomes increasingly complex, the genetic characterization of HIV strains bears important implications for vaccine research. To better understand the molecular evolution of HIV-1 viral diversity, we performed a comparative molecular analysis of HIV strains collected from high-...

Necrotizing enterocolitis associated with Clostridium perfringens type A in previously healthy North-American adults

Post Date:

2005-07-15

Publication:

Journal of the American College of Surgeons

Background: Necrotizing enteritis associated with Clostridium perfringens type C ("pigbel") is a well-known syndrome in severely protein-deprived populations in the Pacific. It is exceedingly rare in the developed world. C perfringens type A is a common cause of acute gastroenteritis and, in a...

Antimicrobial-resistant Shigella sonnei: Limited antimicrobial treatment options for children and challenges of interpreting in vitro azithromycin susceptibility

Post Date:

2005-06-15

Publication:

Journal of Pediatric Infectious Diseases

Background: Antimicrobial-resistant Shigella sonnei is a growing problem in the United States and poses treatment challenges particularly among children. Azithromycin is recommended as an alternative oral agent for shigellosis. Methods: All isolates of Shigella submitted to Johns Hopkins clinical...

IJMR Special Issue on HIV/AIDS: Editorial overview

Post Date:

2005-04-15

Countries:

India

Publication:

Indian Journal of Medical Research

No summary available online

High-risk behaviour in young men attending sexually transmitted disease clinics in Pune, India.

Post Date:

2005-04-15

Countries:

India

Publication:

AIDS Care

The present study reports sexual risk factors associated with HIV infection among men attending two sexually transmitted disease (STD) clinicsin Pune, India and compares these behaviours between young and older men. Between April 1998 and May 2000, 1872 STD patients were screened for HIV infection...

Making the choice: the translation of global HIV and infant feeding policy to local practice among mothers in Pune, India

Post Date:

2005-04-15

Countries:

India

Clinical Sites:

BJGMC

Publication:

The Journal of Nutrition

In 2003, India had over 5.1 million infected individuals living with HIV/AIDS. The percentage of all HIV cases attributed to perinatal transmission has been increasing steadily from 0.33% of total cases in 1999 to 2.80% in 2004. Recent statistics indicate that over 130,000 infants have been...

Sex-based differences in T lymphocyte responses in HIV-1-seropositive individuals

Post Date:

2005-03-15

Publication:

Journal of Infectious Diseases

Sex-based differences in the levels of human immunodeficiency virus 1 (HIV-1) RNA in plasma could be associated with differences in the strength of HIV-1-specific CD8(+) T cell responses. CD8(+) effector responses in 18 men and 15 women were measured 0-2 years (time A) and 5-7 years (time B) after...

Correlates of HIV vaccine trial participation: an Indian perspective

Post Date:

2005-02-03

Countries:

India

Publication:

Vaccine

Successful conduct of HIV vaccine trials in a population of great cultural diversity like India could be a challenge. Concerns, knowledge gaps and willingness to participate in future HIV vaccine trials were studied among 349 patients attending three sexually transmitted infections clinics and one...

Profile of bone marrow examination in HIV/AIDS patients to detect opportunistic infections, especially tuberculosis

Post Date:

2005-01-15

Countries:

India

Clinical Sites:

BJGMC

Publication:

Indian Journal of Pathology and Microbiology

Morphological evaluation of 140 bone marrow aspirations received in haematopathology laboratory with serologically established HIV infection, along with other relevant special haematological tests, was done during 1st Jan 1999 - 31st Dec 2002 at state government run tertiary care General Hospital...

Profile of bone marrow examination in HIV/AIDS patients to detect opportunistic infections, especially tuberculosis

Post Date:

2005-01-15

Countries:

India

Clinical Sites:

BJGMC

Publication:

iIndian Journal of Pathology and Microbiology

An international outbreak of salmonellosis associated with raw almonds contaminated with a rare phage type of Salmonella enteriditis

Post Date:

2005-01-15

Countries:

United States

Publication:

Journal of Food Protection

During the winter of 2000 to 2001, an outbreak due to Salmonella Enteritidis (SE) phage type 30 (PT30), a rare strain, was detected in Canada. The ensuing investigation involved Canadian and American public health and food regulatory agencies and an academic research laboratory. Enhanced laboratory...

Antibiotic Management Program

Post Date:

2008-05-10

Bollinger, R. Antibiotic Management Program. Experience and Nococomial Pneumonia and Respiratory Tract Infections and C-difficile. Johns Hopkins Medicine International and Clinic of Condes. Santiago, Chile.

Update on opportunistic infections

Post Date:

2008-04-04

Gupta, A. Update on opportunistic infections. Brazil-Hopkins AIDS Conference. Rio de Janeiro, Brazil.

The Need to Build a Culture and Capacity for Clinical Research within HIV Prevention, Care and Treatment Programs

Post Date:

2008-04-04

Bollinger, R. The Need to Build a Culture and Capacity for Clinical Research within HIV Prevention, Care and Treatment Programs. VIII Brasil-Johns Hopkins University on HIV/AIDS. Hotel Sofitel. Rio de Janeiro, Brazil.

Priorities and Opportunities for Vaccine Development: A Global View

Post Date:

2008-03-27

Bollinger, R. Priorities and Opportunities for Vaccine Development: A Global View. Jefferson Vaccine Center Yearly Retreat. Thomas Jefferson University. Philadelphia, PA.

Challenges in the Management of HIV in India

Post Date:

2008-03-06

Countries:

India

Bollinger, R. Challenges in the Management of HIV in India. Center for Global Development, 1776 Massachusetts Avenue, NW, Third Floor. Washington, DC.

HIV-1 Genotype Testing: Clinical Applications and Novel Assays

Post Date:

2007-10-31

Page, K. HIV-1 Genotype Testing: Clinical Applications and Novel Assays. COMISCA (Consejos de Ministerios de Salud de Centroamerica- Counsel of Central American Ministries of Health) Gorgas Memorial Institute. Panamá, Panama.

Barriers to Health Care for Latino Immigrants in Baltimore

Post Date:

2007-09-30

Page, K. Barriers to Health Care for Latino Immigrants in Baltimore. Department of Hispanic Languages, Literature, and Culture. Goucher College. Baltimore, MD.

Global Health Education: What in the World Must We Do?

Post Date:

2007-09-14

Bollinger, R. Global Health Education: What in the World Must We Do? Medical Education Grand Rounds. University of Pittsburgh School of Medicine. Pittsburgh, PA.

Improved Practice Through Networking and Knowledge Management

Post Date:

2007-06-18

Bollinger, R. Improved Practice Through Networking and Knowledge Management. 2007 HIV/AIDS Implementers’ Meeting. Kigali, Rwanda. 2007.

Global Health Education. [Plenary I]

Post Date:

2007-06-08

Bollinger, R. Global Health Education. [Plenary I]. Northeast Group on Educational Affairs. Stony Brook University School of Medicine. Stony Brook, NY.

Public Health Issues in South Asia

Post Date:

2007-06-05

Bollinger, R. Public Health Issues in South Asia. South Asia Advanced Area Studies. Foreign Institute of the U.S. Department of State. Washington, DC.

Eosinophilia in a Patient from Latin America

Post Date:

2007-05-31

Page, K. Eosinophilia in a Patient from Latin America. Medicine Grand Rounds. Bayview Department of Medicine. Baltimore, MD.

An update in opportunistic infections

Post Date:

2007-05-21

Gupta, A. An update in opportunistic infections. Johns Hopkins HIV Clinical Care Conference. Baltimore, MD.

HIV Clinical Trials in the International Setting

Post Date:

2007-04-30

Bollinger, R. HIV Clinical Trials in the International Setting. Cross-Cutting Issues in HIV Therapy and Management: Emerging Challenges. US Food and Drug Administration Center for Drug Evaluation and Research, and Committee for Advanced Scientific Education. Silver Spring, MD.

The Future of US Efforts to Fight the HIV/AIDS Pandemic

Post Date:

2007-04-27

Bollinger, R. The Future of US Efforts to Fight the HIV/AIDS Pandemic. SAIS Global Health and Foreign Policy Initiative. The Paul H. Nitze School of Advanced International Studies (SAIS). Washington, DC.

Lessons Learned from bringing the National AIDS Institute of India and JHU researchers together: What was possible, and what wasn’t possible with the level of connection in place

Post Date:

2007-04-25

Countries:

India

Bollinger, R. Lessons Learned from bringing the National AIDS Institute of India and JHU researchers together: What was possible, and what wasn’t possible with the level of connection in place. 2007 Internet2 Annual Meeting. Arlington, VA. 2007.

Careers in Global Health: Challenges and Opportunities

Post Date:

2007-04-14

Bollinger, R. Careers in Global Health: Challenges and Opportunities. Leaders in Public Health Symposium. Haverford College. Haverford, PA.

ART and tuberculosis [Panelist], and Toxicities of protease inhibitors [Lecture]

Post Date:

2007-01-12

Gupta, A. ART and tuberculosis [Panelist], and Toxicities of protease inhibitors [Lecture]. National HIV Conference CART 2007. Chennai, India. 2007.

Antiretroviral therapy during pregnancy and post-partum and ART resistance in India [Invited plenaries]

Post Date:

2007-01-07

Countries:

India

Gupta, A. Antiretroviral therapy during pregnancy and post-partum and ART resistance in India [Invited plenaries]. HIV Current Treatment Options Conference. Mumbai, India.

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