Research News

Indian mother and child

Use of kerosene cooking fuel is positively associated with TB in women and children in our analysis using reported sources of exposure.

Home visit in India

PLoS One: Prevention of Mother-to-Child Transmission of HIV program in India is one of the largest in the world, and it relies on outreach workers. Our study looked at challenges and opportunities for outreach workers.

Clinical Research

Leadership
Dr. Amita Gupta of Johns Hopkins is Principal Investigator for the Indo-JHU Clinical Research Partnership based out of CCGHE. Research is directed locally in India out of the BJGMC-JHU Clinical Research Site by Dr. Vidya Mave, a Hopkins faculty member who lives in Pune. Dr. Nikhil Gupte is the Lead Biostatistician and Deputy Director and Dr. Nishi Suryavanshi is Clinical Site Coordinator and Deputy Director. Research is conducted in collaboration with the following institutions:
 
 

The traveling farm wife

Post Date: 
2007-01-15
Publication: 
American Journal of Medicine
In late summer, a 77-year-old woman was hospitalized after 9 days of chills, low-grade fever, fatigue, and generalized weakness. She did not have abdominal pain, coughing, diarrhea, dyspnea, jaundice, nausea, rashes, sore throat, vomiting, or weight loss. Her medical history was significant for...

Same-sex behavior and high rates of HIV among men attending sexually transmitted infection clinics in Pune, India (1993-2002)

Post Date: 
2006-12-01
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Countries: 
Publication: 
Journal of Acquired Immune Deficiency Syndromes
Objectives: To determine HIV/sexually transmitted infection (STI) prevalence, trends, and risk behaviors of men who have sex with men (MSM) and compare these with those of non-MSM attending STI clinics in Pune, India over a 10-year period. Methods: From 1993 through 2002, men attending 3 STI...

Community preparedness for HIV vaccine trials in the Democratic Republic of Congo

Post Date: 
2006-11-30
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Publication: 
Culture, Health, and Sexuality
This paper reports on an assessment of community preparedness for HIV vaccine trials in the Democratic Republic of Congo. Formative research was conducted in the capital city of Kinshasa during the period October 2003 to March 2004 to answer questions pertinent to planning trials of a preventive...

Improved adherence and less toxicity with rifampin vs isoniazid for treatment of latent tuberculosis: a retrospective study

Post Date: 
2006-09-25
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Countries: 
Publication: 
Archives of Internal Medicine
Background: Treatment of latent tuberculosis infection (LTBI) is an important aspect of tuberculosis control in the United States, but the effectiveness of this strategy is compromised by poor adherence to the recommended 9-month isoniazid regimen. In this study, we compared treatment completion...

Evaluation of serologic screening for identification of chronic Salmonella typhi carriers in Vietnam

Post Date: 
2006-07-10
Publication: 
International Journal of Infectious Diseases
Objectives: To determine the utility of screening anti-Vi antibodies to detect chronic Salmonella Typhi carriers in an endemic community. Methods: We conducted a community-based serologic survey for anti-Vi antibodies to identify chronic Salmonella Typhi carriers in a typhoid endemic region in...

High rates of syphilis among STI patients are contributing to the spread of HIV-1 in India

Post Date: 
2006-04-15
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Publication: 
Sexually Transmitted Infections
Background: Recent syphilis outbreaks have raised concern regarding the potential enhancement of HIV transmission. The incidence of syphilis and its association with HIV‐1 infection rates among a cohort of sexually transmitted infection (STI) clinic attendees was investigated. Methods: 2732 HIV‐1...

Low HIV-1 incidence among married serodiscordant couples in Pune, India

Post Date: 
2006-03-15
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Publication: 
Journal of Acquired Immune Deficiency Syndromes
Unlike commercial sex workers and patients attending sexually transmitted infection (STI) clinics, married couples are not typically targeted for HIV risk reduction programs in India. Thus, married partners of HIV-infected persons are at particularly high risk for HIV infection. Between September...

The expanding realm of heterologous immunity: friend or foe?

Post Date: 
2006-02-15
Publication: 
Cellular Microbiology
Antecedent or current infections can alter the immunopathologic outcome of a subsequent unrelated infection. Immunomodulation by co-infecting pathogens has been referred to as 'heterologous immunity' and has been postulated to play a role in host susceptibility to disease, tolerance to organ...

Screening for HIV dementia in an HIV, clade C-infected population in India

Post Date: 
2006-02-12
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Countries: 
Publication: 
Journal of Neurovirology
Although human immunodeficiency virus (HIV) clade C virus infects the largest populations worldwide, to date there are no prospective studies reported thus far to determine the incidence or prevalence of HIV dementia in this population. HIV clade C virus is a CCR5-tropic virus and thus...

Rate of hospitalization and inpatient care costs for HIV-1 infected in Pune, India

Post Date: 
2006-02-01
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Publication: 
National Medical Journal of India
Background: The transition of human immunodeficiency virus (HIV) infection to acquired immune deficiency syndrome (AIDS) has begun in India, and an increase in AIDS-related hospitalizations and deaths is an anticipated challenge. We estimated the rates of hospitalization and inpatient care costs...

High HIV prevalence among a high-risk subgroup of women attending sexually transmitted infection clinics in Pune, India

Post Date: 
2006-01-01
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Countries: 
Publication: 
Journal of Acquired Immune Deficiency Syndromes
Objectives: To investigate changes over a decade in prevalence and correlates of HIV among high-risk women attending sexually transmitted infection (STI) clinics in Pune, India, who deny a history of commercial sex work (CSW). Methods: From 1993 to 2002, 2376 women attending 3 STI clinics in Pune...

Correlates and trend of HIV prevalence among female sex workers attending sexually transmitted disease clinics in Pune, India (1993-2002)

Post Date: 
2006-01-01
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Countries: 
Publication: 
Journal of Acquired Immune Deficiency Syndromes
In India, substantial efforts have been made to increase awareness about HIV/AIDS among female sex workers (FSWs). We assessed the impact of awareness regarding safe sex in a cohort of FSWs by studying trends in HIV prevalence, sexually transmitted diseases (STDs), and risk behaviors measured from...

Mycobacterial-induced potentiation of type 1 immune responses and protection against malaria is host-specific

Post Date: 
2005-12-15
Publication: 
Infection and Immunity
Malaria and tuberculosis are endemic in many regions of the world, and coinfection with the two pathogens is common. In this study, we examined the effects of long- and short-term infection with Mycobacterium tuberculosis on the course of a lethal form of murine malaria in resistant (C57BL/6) and...

Adult botulism type F in the United States, 1981-2002

Post Date: 
2005-12-13
Publication: 
Neurology
Background: Clostridium botulinum neurotoxin types A, B, and E cause most cases of the paralytic disease botulism. Little is known about the epidemiology, clinical features, or microbiology of botulism type F. Methods: Cases of adult type F botulism were identified by review of data collected by...

Antifungal interventions for the primary prevention of cryptococcal disease in adults with HIV

Post Date: 
2005-07-20
Publication: 
Cochrane Database of Systematic Reviews
Infection with the human immunodeficiency virus (HIV) leads to progressive destruction and weakening of the body's immune system. Patients with advanced HIV disease are vulnerable to various diseases, called opportunistic infections (OIs), which most people with normal immune systems are protected...

Necrotizing enterocolitis associated with Clostridium perfringens type A in previously healthy North-American adults

Post Date: 
2005-07-15
Publication: 
Journal of the American College of Surgeons
Background: Necrotizing enteritis associated with Clostridium perfringens type C ("pigbel") is a well-known syndrome in severely protein-deprived populations in the Pacific. It is exceedingly rare in the developed world. C perfringens type A is a common cause of acute gastroenteritis and, in a...

Genetic diversification and recombination of HIV type 1 group M in Kinshasa, Democratic Republic of Congo

Post Date: 
2005-07-15
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Publication: 
AIDS Research and Human Retroviruses
As the HIV-1 pandemic becomes increasingly complex, the genetic characterization of HIV strains bears important implications for vaccine research. To better understand the molecular evolution of HIV-1 viral diversity, we performed a comparative molecular analysis of HIV strains collected from high-...

Antimicrobial-resistant Shigella sonnei: Limited antimicrobial treatment options for children and challenges of interpreting in vitro azithromycin susceptibility

Post Date: 
2005-06-15
Publication: 
Journal of Pediatric Infectious Diseases
Background: Antimicrobial-resistant Shigella sonnei is a growing problem in the United States and poses treatment challenges particularly among children. Azithromycin is recommended as an alternative oral agent for shigellosis. Methods: All isolates of Shigella submitted to Johns Hopkins clinical...

IJMR Special Issue on HIV/AIDS: Editorial overview

Post Date: 
2005-04-15
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Countries: 
Publication: 
Indian Journal of Medical Research
No summary available online

High-risk behaviour in young men attending sexually transmitted disease clinics in Pune, India.

Post Date: 
2005-04-15
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Countries: 
Publication: 
AIDS Care
The present study reports sexual risk factors associated with HIV infection among men attending two sexually transmitted disease (STD) clinicsin Pune, India and compares these behaviours between young and older men. Between April 1998 and May 2000, 1872 STD patients were screened for HIV infection...

Pages

Eosinophilia in a Patient from Latin America

Post Date: 
2007-05-31
Page, K. Eosinophilia in a Patient from Latin America. Medicine Grand Rounds. Bayview Department of Medicine. Baltimore, MD.

An update in opportunistic infections

Post Date: 
2007-05-21
Gupta, A. An update in opportunistic infections. Johns Hopkins HIV Clinical Care Conference. Baltimore, MD.

HIV Clinical Trials in the International Setting

Post Date: 
2007-04-30
Bollinger, R. HIV Clinical Trials in the International Setting. Cross-Cutting Issues in HIV Therapy and Management: Emerging Challenges. US Food and Drug Administration Center for Drug Evaluation and Research, and Committee for Advanced Scientific Education. Silver Spring, MD.

The Future of US Efforts to Fight the HIV/AIDS Pandemic

Post Date: 
2007-04-27
Bollinger, R. The Future of US Efforts to Fight the HIV/AIDS Pandemic. SAIS Global Health and Foreign Policy Initiative. The Paul H. Nitze School of Advanced International Studies (SAIS). Washington, DC.

Lessons Learned from bringing the National AIDS Institute of India and JHU researchers together: What was possible, and what wasn’t possible with the level of connection in place

Post Date: 
2007-04-25
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Countries: 
Bollinger, R. Lessons Learned from bringing the National AIDS Institute of India and JHU researchers together: What was possible, and what wasn’t possible with the level of connection in place. 2007 Internet2 Annual Meeting. Arlington, VA. 2007.

Careers in Global Health: Challenges and Opportunities

Post Date: 
2007-04-14
Bollinger, R. Careers in Global Health: Challenges and Opportunities. Leaders in Public Health Symposium. Haverford College. Haverford, PA.

ART and tuberculosis [Panelist], and Toxicities of protease inhibitors [Lecture]

Post Date: 
2007-01-12
Gupta, A. ART and tuberculosis [Panelist], and Toxicities of protease inhibitors [Lecture]. National HIV Conference CART 2007. Chennai, India. 2007.

Antiretroviral therapy during pregnancy and post-partum and ART resistance in India [Invited plenaries]

Post Date: 
2007-01-07
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Countries: 
Gupta, A. Antiretroviral therapy during pregnancy and post-partum and ART resistance in India [Invited plenaries]. HIV Current Treatment Options Conference. Mumbai, India.

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