Research News

Mother and baby
October 3, 2019

New England Journal of Medicine: Dr. Amita Gupta and colleagues found that the current standard of care given to HIV+ pregnant women to prevent TB should wait until 12 weeks after delivery. The study underscores the need to include pregnant women in clinical trials.

Clinical Research

Leadership
While we conduct research all over the world, the majority of our work is in India. Our Indo-JHU Clinical Research Partnership is located in Pune and is directed by Dr. Amita Gupta (Baltimore, MD), with onsite direction from Dr. Vidya Mave, Dr. Nishi Suryavanshi, and Dr. Nikhil Gupte (Pune). The Indo-JHU Partnership employs more than 200 people and in addition to our memberships in cosortia with many esteemed Indian research institutions, we have formal agreements with:

 
 

Selenium and HIV-1: Hope or hype?

Post Date: 
2007-12-10
Publication: 
Archives of Internal Medicine
We read with great interest the article by Hurwitz et al on the impact of selenium supplementation in patients infected with human immunodeficiency virus type 1 (HIV-1). Studies examining the association between micronutrients and HIV, particularly prospective studies, have been limited to date...

Nurses’ health education program in India increases HIV knowledge and reduces fear

Post Date: 
2007-11-30
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Publication: 
Journal of the Association of Nurses in AIDS Care
Few health care facilities are adequately prepared to manage and care for HIV/AIDS patients in India. Nurses play a critical role in patient care but are often ill-equipped to deal with their own fears of occupational risk and handle the clinical aspects of HIV/AIDS care, leading to stigma and...

Low sensitivity of total lymphocyte count as a surrogate marker to identify antepartum and postpartum Indian women who require antiretroviral therapy

Post Date: 
2007-11-01
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Publication: 
Journal of Acquired Immune Deficiency Syndromes
Background: Some studies support the use of total lymphocyte count (TLC) as a surrogate marker for CD4 cell count to guide antiretroviral therapy (ART) initiation. However, most of these studies have focused on nonpregnant adults. In light of expanding ART access through prevention of mother-to-...

Declining HIV Incidence among patients attending sexually transmitted infection clinics in Pune, India

Post Date: 
2007-08-15
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Publication: 
Journal of Acquired Immune Deficiency Syndromes
Objective: A recent report suggesting declining HIV transmission rates in southern India has been based on HIV seroprevalence data to estimate HIV incidence. We analyzed HIV incidence rates among 3 cohorts (male, female non-sex worker, female sex worker [FSW]) presenting to sexually transmitted...

Declining HIV infection rates among recently married, pregnant women in Pune, India

Post Date: 
2007-08-15
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Publication: 
Journal of Acquired Immune Deficiency Syndromes
Background: A single recent study has suggested a decrease in HIV risk for women attending antenatal clinics (ANCs) in southern India. Yet, some have questioned the validity of the Indian national surveillance data and analyses. Previous studies suggest that the only major HIV risk factor for...

Mother-to-child transmission of HIV among women who chose not to exclusively breastfeed their infants in Pune, India

Post Date: 
2007-08-15
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Publication: 
Indian Journal of Medical Research
Background and Objective: The percentage of HIV cases attributed to mother-to-child transmission (MTCT) has increased several fold in recent years. No reports are available on HIV MTCT rates among HIV-infected choosing not be exclusively breastfeed their infants in India. We examined HIV MTCT rates...

U.S. medical resident familiarity with national tuberculosis guidelines

Post Date: 
2007-08-02
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BMC Infectious Diseases
Background: The ability of medical residents training at U.S. urban medical centers to diagnose and manage tuberculosis cases has important public health implications. We assessed medical resident knowledge about tuberculosis diagnosis and early management based on American Thoracic Society...

Mortality and clinical characteristics of hospitalized adult patients with HIV in Pune, India

Post Date: 
2007-08-01
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Publication: 
Indian Journal of Medical Research
Background and Objective: In India, data regarding mortality and clinical characteristics of hospitalized HIV-infected patients are sparse, which may limit the effectiveness of new hospital-based HIV programmes providing antiretroviral therapy (ART). The objective of our study was to determine...

Post-partum TB incidence and mortality among HIV-infected women and their infants in Pune, India 2002-2005

Post Date: 
2007-07-15
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Publication: 
Clinical Infectious Diseases
Background: In contrast with many other countries, isoniazid preventative therapy is not recommended in clinical care guidelines for human immunodeficiency virus (HIV)-infected persons with latent tuberculosis (TB) in India. Methods: Seven hundred fifteen HIV-infected mothers and their infants were...

Hematogenous osteomyelitis mimicking osteosarcoma due to Community Associated Methicillin-Resistant Staphylococcus aureus

Post Date: 
2007-06-15
Publication: 
Infection
Community Associated Methicillin - Resistant Staphylococcus aureus (CA-MRSA) is an emerging pathogen with increasing clinical significance. Initially recognized as a cause of skin and soft tissue infections, it has soon been shown to cause life threatening illnesses. We describe two cases of...

Clinically significant anemia in HIV-infected pregnant women in India is not a major barrier to zidovudine use for prevention of maternal-to-child transmission

Post Date: 
2007-06-01
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Publication: 
Journal of Acquired Immune Deficiency Syndromes
Objectives: To determine the prevalence of anemia (serum hemoglobin <10 g/dL) and assess zidovudine use and toxicity in HIV-positive pregnant women in India. Methods: From 2002 through 2006, 24,105 pregnant women in Pune were screened for HIV and anemia. As part of an infant prevention of mother...

Adherence to antiretroviral therapy and virologic suppression among HIV-infected persons receiving care in private clinics in Mumbai, India

Post Date: 
2007-05-01
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Publication: 
Clinical Infectious Diseases
Background: Adherence to antiretroviral therapy (ART) and correlates of adherence and virologic suppression among human immunodeficiency virus (HIV)-infected persons receiving ART in private, outpatient clinics in India is unknown. Methods: Between December 2004 and April 2005, persons receiving...

Impact of maternal HIV co-infection on the vertical transmission of Hepatitis C virus: a meta-analysis.

Post Date: 
2007-04-15
Publication: 
Clinical Infectious Diseases
Background: Observational studies suggest that maternal human immunodeficiency virus (HIV)-hepatitis C virus (HCV) coinfection is associated with increased odds of vertical HCV transmission. We performed a meta-analysis to summarize current evidence. Methods: We systematically searched for relevant...

Knowledge, attitudes and practices of antiretroviral therapy among adults attending private and public clinics in India

Post Date: 
2007-02-15
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AIDS Patient Care and STDs
India has approximately 5.2 million persons infected with HIV. Although antiretroviral therapy (ART) is being widely introduced in public clinics, many HIV-infected persons still seek care via the private sector. A cross-sectional survey was conducted in 2004 at six public and private sites to...

The traveling farm wife

Post Date: 
2007-01-15
Publication: 
American Journal of Medicine
In late summer, a 77-year-old woman was hospitalized after 9 days of chills, low-grade fever, fatigue, and generalized weakness. She did not have abdominal pain, coughing, diarrhea, dyspnea, jaundice, nausea, rashes, sore throat, vomiting, or weight loss. Her medical history was significant for...

Same-sex behavior and high rates of HIV among men attending sexually transmitted infection clinics in Pune, India (1993-2002)

Post Date: 
2006-12-01
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Publication: 
Journal of Acquired Immune Deficiency Syndromes
Objectives: To determine HIV/sexually transmitted infection (STI) prevalence, trends, and risk behaviors of men who have sex with men (MSM) and compare these with those of non-MSM attending STI clinics in Pune, India over a 10-year period. Methods: From 1993 through 2002, men attending 3 STI...

Community preparedness for HIV vaccine trials in the Democratic Republic of Congo

Post Date: 
2006-11-30
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Publication: 
Culture, Health, and Sexuality
This paper reports on an assessment of community preparedness for HIV vaccine trials in the Democratic Republic of Congo. Formative research was conducted in the capital city of Kinshasa during the period October 2003 to March 2004 to answer questions pertinent to planning trials of a preventive...

Improved adherence and less toxicity with rifampin vs isoniazid for treatment of latent tuberculosis: a retrospective study

Post Date: 
2006-09-25
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Publication: 
Archives of Internal Medicine
Background: Treatment of latent tuberculosis infection (LTBI) is an important aspect of tuberculosis control in the United States, but the effectiveness of this strategy is compromised by poor adherence to the recommended 9-month isoniazid regimen. In this study, we compared treatment completion...

Evaluation of serologic screening for identification of chronic Salmonella typhi carriers in Vietnam

Post Date: 
2006-07-10
Publication: 
International Journal of Infectious Diseases
Objectives: To determine the utility of screening anti-Vi antibodies to detect chronic Salmonella Typhi carriers in an endemic community. Methods: We conducted a community-based serologic survey for anti-Vi antibodies to identify chronic Salmonella Typhi carriers in a typhoid endemic region in...

High rates of syphilis among STI patients are contributing to the spread of HIV-1 in India

Post Date: 
2006-04-15
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Sexually Transmitted Infections
Background: Recent syphilis outbreaks have raised concern regarding the potential enhancement of HIV transmission. The incidence of syphilis and its association with HIV‐1 infection rates among a cohort of sexually transmitted infection (STI) clinic attendees was investigated. Methods: 2732 HIV‐1...

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Lessons Learned from bringing the National AIDS Institute of India and JHU researchers together: What was possible, and what wasn’t possible with the level of connection in place

Post Date: 
2007-04-25
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Bollinger, R. Lessons Learned from bringing the National AIDS Institute of India and JHU researchers together: What was possible, and what wasn’t possible with the level of connection in place. 2007 Internet2 Annual Meeting. Arlington, VA. 2007.

Careers in Global Health: Challenges and Opportunities

Post Date: 
2007-04-14
Bollinger, R. Careers in Global Health: Challenges and Opportunities. Leaders in Public Health Symposium. Haverford College. Haverford, PA.

ART and tuberculosis [Panelist], and Toxicities of protease inhibitors [Lecture]

Post Date: 
2007-01-12
Gupta, A. ART and tuberculosis [Panelist], and Toxicities of protease inhibitors [Lecture]. National HIV Conference CART 2007. Chennai, India. 2007.

Antiretroviral therapy during pregnancy and post-partum and ART resistance in India [Invited plenaries]

Post Date: 
2007-01-07
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Gupta, A. Antiretroviral therapy during pregnancy and post-partum and ART resistance in India [Invited plenaries]. HIV Current Treatment Options Conference. Mumbai, India.

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