Research News

Annals of Internal Medicine
September 22, 2020

Risk factors for progression of coronavirus 2019 (COVID-19) to severe disease or death are underexplored in U.S. cohorts.

Clinical Research

Leadership
While we conduct research all over the world, the majority of our work is in India. Our Indo-JHU Clinical Research Partnership is located in Pune and is directed by Dr. Amita Gupta (Baltimore, MD), with onsite direction from Dr. Vidya Mave, Dr. Nishi Suryavanshi, and Dr. Nikhil Gupte (Pune). The Indo-JHU Partnership employs more than 200 people and in addition to our memberships in cosortia with many esteemed Indian research institutions, we have formal agreements with:

 
 

QuantiFERON-TB Gold In-Tube for the detection of Mycobacterium tuberculosis infection in children with household tuberculosis contact

Post Date: 
2011-05-05
Publication: 
International Journal of Tuberculosis and Lung Disease
Setting : Improved strategies are needed for detecting Mycobacterium tuberculosis infection in children in TB-endemic settings. Objective : To determine the prevalence of M. tuberculosis infection by tuberculin skin testing (TST) and by the QuantiFERON-TB Gold In-Tube (...

Mortality in HIV infected individuals in Pune, India

Post Date: 
2011-04-15
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Publication: 
Indian Journal of Medical Research
Background & Objectives: With the presence of HIV epidemic for more than two decades in India, rise in the number of HIV related deaths is expected. Data on mortality in HIV infected individuals from prospective studies are scanty in India. We report here data on mortality in a...

Twelve month follow-up of the SWEN randomized controlled trials: Differential impact of extended-dose nevirapine on mother-to-child transmission and infant death by maternal CD4 cell count

Post Date: 
2011-03-27
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Publication: 
AIDS Care
Objectives: We previously reported combined analysis of 6-week and 6-month endpoints of three randomized controlled trials [Six Week Extended Dose Nevirapine (SWEN) trials] that compared extended-dose nevirapine through 6 weeks of age to single-dose nevirapine to prevent HIV transmission via...

Predictors of retention among men attending STI clinics in HIV prevention programs and research: A case control study in Pune, India

Post Date: 
2011-03-11
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Publication: 
PLOS One
Background: Retention is critical in HIV prevention programs and clinical research. We studied retention in the three modeled scenarios of primary prevention programs, cohort studies and clinical trials to identify predictors of retention. Methodology/Principal Findings: Men attending Sexually...

Maternal tuberculosis: a risk factor for mother-to-child transmission of human immunodeficiency virus

Post Date: 
2011-02-01
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Publication: 
The Journal of Infectious Diseases
Background: Maternal human immunodeficiency virus (HIV) RNA load, CD4 cell count, breast-feeding, antiretroviral use, and malaria are well-established factors associated with mother-to-child transmission (MTCT) of HIV; the role of maternal tuberculosis (TB), however, has not been well...

Public private partnerships for emergency obstetric care: lessons from Maharashtra

Post Date: 
2011-01-15
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Publication: 
Indian Journal of Community Medicine
Abstract Background: The National Rural Health Mission of India advocates public private partnerships (PPPs) to meet its "service guarantee" of Emergency obstetric care (EmOC) provision. The Janani Suraksha Yojana (JSY) has a provision of Rs. 1500 for contracting in...

Unstimulated primary CD4+ T cells from HIV-1-positive elite suppressors are fully susceptible to HIV-1 entry and productive infection

Post Date: 
2011-01-15
Publication: 
Journal of Virology
Elite controllers or suppressors (ES) are a group of HIV-1-infected individuals who maintain viral loads below the limit of detection of commercial assays for many years. The mechanisms responsible for this remarkable control are under intense study, with the hope of developing therapeutic vaccines...

Tuberculosis in women and children

Post Date: 
2010-12-15
Publication: 
The Lancet
Apart from improvement of tuberculosis control, innovative strategies to advance tuberculosis prevention and treatment in women and children would contribute to the attainment of Millennium Development Goals 4 and 5 by reduction of the mortality rate in young children and women of...

Predictors of HIV testing among Latinos in Baltimore City

Post Date: 
2010-12-15
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Publication: 
Journal of Immigrant and Minority Health
To better understand access to HIV testing and prevention services experienced by Latinos, we evaluated data compiled through Baltimore City Health Department HIV outreach efforts in 2008. Of 6,443 clients served, Latinos were more likely male, young, and less-educated than non-Latinos. A...

Gonorrhoea and chlamydia testing rates of HIV-infected men: low despute guidelines

Post Date: 
2010-11-15
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Countries: 
Publication: 
Sexually Transmitted Infections
Objectives: Screening HIV-infected men for gonorrhea (GC) and Chlamydia (CT) may decrease HIV transmission and reduce the incidence of pelvic inflammatory disease in female partners. This study determined GC/CT testing rates in a clinical HIV cohort before and after 2003 when the U.S. Centers for...

Stigmatizing attitudes and low levels of knowledge but high willingness to participate in HIV management: A community based survey of pharmacies in Pune, India

Post Date: 
2010-08-27
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Publication: 
BMC Public Health
Background: The World Health Organization (WHO) recommends that the role of pharmacists in low-income settings be expanded to address the increasing complexity of HIV antiretroviral (ARV) and co-infection drug regimens. However, in many such settings including in India, many pharmacists and...

Unique aspects of the care of HIV-positive Latino patients living in the United States

Post Date: 
2010-08-15
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Publication: 
Current HIV/AIDS Reports
Latinos are disproportionately affected by HIV, with a higher risk of infection and a delayed presentation to care as compared to non-Hispanic whites. Over the last decade many Latinos, especially foreign-born migrants, have settled in regions of the country with historically low Latino...

Quantitative analysis of a urine-based assay for lipoarabinomannan in patients with tuberculosis

Post Date: 
2010-08-15
Publication: 
Journal of Clinical Microbiology
Abstract Urinary lipoarabinomannan (LAM) detection is a promising approach for rapid diagnosis of active tuberculosis (TB). In microbiologically confirmed TB patients, quantitative LAM detection results increased progressively with bacillary burden and immunosuppression. Patients with...

Antiretroviral regimens for patients with HIV who fail first-line antiretroviral therapy

Post Date: 
2010-06-16
Publication: 
Cochrane Database of Systematic Reviews
Background: Highly active antiretroviral therapy has reduced the morbidity and mortality of patients with HIV/AIDS. A common first-line ART regimen in low-resource settings includes a non-nucleoside reverse transcriptase inhibitor (NNRTI) and two nucleoside reverse transcriptase inhibitors (...

Effect of peer health workers on AIDS care in Rakai, Uganda: a cluster-randomized trial

Post Date: 
2010-06-02
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Publication: 
PLOS
Background: Human resource limitations are a challenge to the delivery of antiretroviral therapy (ART) in low-resource settings. We conducted a cluster randomized trial to assess the effect of community-based peer health workers (PHW) on AIDS care of adults in Rakai, Uganda. ...

Developing WHO guidelines with pragmatic, structured, evidence-based processes: a case study

Post Date: 
2010-05-15
Publication: 
Global Public Health
Many guidelines, including those produced by the World Health Organisation (WHO), have failed to adhere to rigorous methodological standards. Operational examples of guideline development processes may provide important lessons learned to improve the rigour and quality of future guidelines...

Optimal monitoring strategies for guiding when to switch first-line antiretroviral therapy regimens for treatment failure among adults and adolescents living with HIV in low-resource settings

Post Date: 
2010-04-14
Publication: 
Cochrane Database of Systematic Reviews
Background: One of the critical clinical decisions made in antiretroviral therapy (ART) is when to switch from an initial regimen to another due to treatment failure. This complex process requires consideration of multiple factors including: (1) what type of monitoring (e.g. clinical,...

Physician estimate of antiretroviral adherence: poor correlation with patient self-report and viral load

Post Date: 
2010-03-15
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Publication: 
AIDS Patient Care and STDs
Adherence to antiretroviral therapy (ART) is critical in maintaining viral suppression and minimizing resistance in HIV-infected patients. We compared physician estimates of their patients' ART adherence with participant's self-reported adherence to determine patient-provider agreement and identify...

Sexually transmitted infection prevalence and behavioral risk factors among Latino and non-Latino patients attending the Baltimore City STD clinics

Post Date: 
2010-03-15
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Publication: 
Sexually Transmitted Diseases
Background: Many studies have evaluated factors influencing STD/HIV disparities between African-American and white populations, but fewer have explicitly included Latinos for comparison. Methods: We analyzed demographic and behavioral data captured in electronic medical records of patients first...

One-, two-, and three-class resistance among HIV-infected patients on antiretroviral therapy in private care clinics: Mumbai, India

Post Date: 
2010-01-26
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Publication: 
AIDS Research and Human Retroviruses
HIV-infected patients receiving antiretroviral (ARV) therapy (ART) in India are not all adequately virally suppressed. We analyzed ARV drug resistance in adults receiving ART in three private clinics in Mumbai, India. HIV viral load was measured in 200 patients with the Roche AMPLICOR HIV-1 Monitor...

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Antibiotic Management Program

Post Date: 
2008-05-10
Bollinger, R. Antibiotic Management Program. Experience and Nococomial Pneumonia and Respiratory Tract Infections and C-difficile. Johns Hopkins Medicine International and Clinic of Condes. Santiago, Chile.

Update on opportunistic infections

Post Date: 
2008-04-04
Gupta, A. Update on opportunistic infections. Brazil-Hopkins AIDS Conference. Rio de Janeiro, Brazil.

The Need to Build a Culture and Capacity for Clinical Research within HIV Prevention, Care and Treatment Programs

Post Date: 
2008-04-04
Bollinger, R. The Need to Build a Culture and Capacity for Clinical Research within HIV Prevention, Care and Treatment Programs. VIII Brasil-Johns Hopkins University on HIV/AIDS. Hotel Sofitel. Rio de Janeiro, Brazil.

Priorities and Opportunities for Vaccine Development: A Global View

Post Date: 
2008-03-27
Bollinger, R. Priorities and Opportunities for Vaccine Development: A Global View. Jefferson Vaccine Center Yearly Retreat. Thomas Jefferson University. Philadelphia, PA.

Challenges in the Management of HIV in India

Post Date: 
2008-03-06
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Bollinger, R. Challenges in the Management of HIV in India. Center for Global Development, 1776 Massachusetts Avenue, NW, Third Floor. Washington, DC.

HIV-1 Genotype Testing: Clinical Applications and Novel Assays

Post Date: 
2007-10-31
Page, K. HIV-1 Genotype Testing: Clinical Applications and Novel Assays. COMISCA (Consejos de Ministerios de Salud de Centroamerica- Counsel of Central American Ministries of Health) Gorgas Memorial Institute. Panamá, Panama.

Barriers to Health Care for Latino Immigrants in Baltimore

Post Date: 
2007-09-30
Page, K. Barriers to Health Care for Latino Immigrants in Baltimore. Department of Hispanic Languages, Literature, and Culture. Goucher College. Baltimore, MD.

Global Health Education: What in the World Must We Do?

Post Date: 
2007-09-14
Bollinger, R. Global Health Education: What in the World Must We Do? Medical Education Grand Rounds. University of Pittsburgh School of Medicine. Pittsburgh, PA.

Improved Practice Through Networking and Knowledge Management

Post Date: 
2007-06-18
Bollinger, R. Improved Practice Through Networking and Knowledge Management. 2007 HIV/AIDS Implementers’ Meeting. Kigali, Rwanda. 2007.

Global Health Education. [Plenary I]

Post Date: 
2007-06-08
Bollinger, R. Global Health Education. [Plenary I]. Northeast Group on Educational Affairs. Stony Brook University School of Medicine. Stony Brook, NY.

Public Health Issues in South Asia

Post Date: 
2007-06-05
Bollinger, R. Public Health Issues in South Asia. South Asia Advanced Area Studies. Foreign Institute of the U.S. Department of State. Washington, DC.

Eosinophilia in a Patient from Latin America

Post Date: 
2007-05-31
Page, K. Eosinophilia in a Patient from Latin America. Medicine Grand Rounds. Bayview Department of Medicine. Baltimore, MD.

An update in opportunistic infections

Post Date: 
2007-05-21
Gupta, A. An update in opportunistic infections. Johns Hopkins HIV Clinical Care Conference. Baltimore, MD.

HIV Clinical Trials in the International Setting

Post Date: 
2007-04-30
Bollinger, R. HIV Clinical Trials in the International Setting. Cross-Cutting Issues in HIV Therapy and Management: Emerging Challenges. US Food and Drug Administration Center for Drug Evaluation and Research, and Committee for Advanced Scientific Education. Silver Spring, MD.

The Future of US Efforts to Fight the HIV/AIDS Pandemic

Post Date: 
2007-04-27
Bollinger, R. The Future of US Efforts to Fight the HIV/AIDS Pandemic. SAIS Global Health and Foreign Policy Initiative. The Paul H. Nitze School of Advanced International Studies (SAIS). Washington, DC.

Lessons Learned from bringing the National AIDS Institute of India and JHU researchers together: What was possible, and what wasn’t possible with the level of connection in place

Post Date: 
2007-04-25
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Bollinger, R. Lessons Learned from bringing the National AIDS Institute of India and JHU researchers together: What was possible, and what wasn’t possible with the level of connection in place. 2007 Internet2 Annual Meeting. Arlington, VA. 2007.

Careers in Global Health: Challenges and Opportunities

Post Date: 
2007-04-14
Bollinger, R. Careers in Global Health: Challenges and Opportunities. Leaders in Public Health Symposium. Haverford College. Haverford, PA.

ART and tuberculosis [Panelist], and Toxicities of protease inhibitors [Lecture]

Post Date: 
2007-01-12
Gupta, A. ART and tuberculosis [Panelist], and Toxicities of protease inhibitors [Lecture]. National HIV Conference CART 2007. Chennai, India. 2007.

Antiretroviral therapy during pregnancy and post-partum and ART resistance in India [Invited plenaries]

Post Date: 
2007-01-07
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Gupta, A. Antiretroviral therapy during pregnancy and post-partum and ART resistance in India [Invited plenaries]. HIV Current Treatment Options Conference. Mumbai, India.

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