Clinical Research

A retrospective study of health care workers (HCWs) was conducted by investigators of the Byramjee Jeejeebhoy Medical and Sassoon General Hospitals (BJMC-SGH) in Pune, India. The purpose of the study was to estimate TB prevalence and incidence and investigate frequency and treatment failure,...

Community Health Workers, mHealth, and Combination HIV Prevention in a Hotspot: A Randomized Trial (mLAKE)

Post Date:

2015-04-01

Country:

Led by Dr. Larry Chang, the mLAKE study in Uganda is examining whether community health workers equipped with cellphones and the emocha Mobile Health platform are able to successfully promote HIV treatment and prevention services in households in a fishing community in East Africa with a very high...

Salud al Dia

Post Date:

2014-11-01

Country:

This initiative is intended to address healthcare disparities among Latino children in Baltimore by increasing engagement of limited English proficiency (LEP) Latino parents in primary healthcare. Specifically, we are looking at whether using in-person and technology-based support interventions...

Predictive Value of TB-symptom Screen in HIV-infected and HIV-uninfected Pregnant Women in Pune, India

Post Date:

2014-10-28

Country:

This is a cross sectional observational study that will be conducted at BJGMC to establish what the predictive value of the WHO TB symptom screen is in pregnant women in India. We hypothesize that the WHO TB symptom screen will have a higher positive predictive value (PPV) in HIV-seronegative...

Predictive Val. of TB-symptom Screen in HIV-infected & -uninfected Pregnant Women in Pune, India. Substudy: Studying Molecular Mechanisms Leading to Suppressed Immunity in Pregnancy & Studying Relationship between Diet, Gut Microbiome, & Inflammation

Post Date:

2014-10-28

Country:

Pregnancy is a state of relative immunosuppression in order to protect the fetus from being rejected. It has also been shown that the Th-1 helper cell response, which is normally necessary for overcoming TB infection, is suppressed in pregnancy. Thus, pregnant women are especially vulnerable to TB...

miLINC: MDR-TB South Africa - Patient Linkage to and Retention in Care

Post Date:

2014-10-06

Country:

Mycobacterium tuberculosis (TB) remains the leading cause of death among persons living with human immunodeficiency virus and acquired immunodeficiency syndrome (HIV/AIDS) in southern Africa. Drug-resistant TB remains a growing threat to public health despite advances made in diagnosis and...

Diagnosis of Tuberculosis Infection and Th1 Immune Response in Pregnant Women in India

Post Date:

2014-09-01

Country:

Tuberculosis (TB) disease is a major cause of mortality among Indian women of reproductive age; approximately 20-50% of women in India are latently infected with Mycobacterium tuberculosis (MTB). Due to immune changes of pregnancy, women are particularly at risk of reactivation and progression to...

TB and Pregnancy Impact of Immune Changes of HIV and Stages of Pregnancy on Tuberculosis

Post Date:

2014-09-01

Country:

Purpose: TB is a leading cause of maternal mortality, especially among HIV-infected women. Women are most likely to develop active TB during and immediately after pregnancy. The immunologic conditions responsible for this phenomenon are not understood. Our recent research shows that pregnant women...

TBM Kids Substudy: Assessment of Neurocognitive Functions in Children with Tuberculosis Meningitis and Healthy Control Children Using the Mullen Scale of Early Learning Attending a Tertiary Care Public Hospital in Pune, India

Post Date:

2014-09-01

Country:

Objectives: The aim of the present study is to examine the neurological deficit in TBM kids and for that we need to assess, feasibility of the MSEL in our set up an Indian population of healthy children and children with meningitis in particular TB meningitis(TBM). The primary objective of the...

PreventionRx Study: Home-based Counseling and Testing in Uganda

Post Date:

2014-08-27

Country:

A ‘platform’ for evaluating combination HIV prevention & care-HIV counseling & testing is essential to optimize HIV services. In collaboration with the University of Washington and the Integrated Community Based Initiatives (ICOBI) NGO in Uganda, CCGHE has adapted the emocha ® platform to...

Evaluating Demand Generation (Stylish Man) for HIV/Family Planning Services, Rakai, Uganda

Post Date:

2014-08-01

Country:

Dr. Larry Chang is co-investigator of this effort to test a novel approach to promoting HIV services in Rakai, Uganda. The Stylish Man Program, attempts to “demedicalize” HIV prevention and care in a public health campaign designed to normalize HIV care as part of self care for African men. The...

Optimizing Treatment to Improve TBM Outcomes in Children

Post Date:

2014-05-01

Country:

This study is being conducted in India and Malawi. Primary Objectives To characterize the pharmacokinetics (PK) (plasma and cerebrospinal fluid (CSF)) of rifampicin given at model-derived optimal daily doses and levofloxacin in children ages 6 months to 12 years of age with TBM To assess the...

P1078: A Phase IV Randomized Double-Blind Placebo-Controlled Trial to Evaluate the Safety of Immediate (Antepartum-Initiated) Versus Deferred (Postpartum-Initiated) Isoniazid Preventive Therapy Among HIV-Infected Women in High TB Incidence Settings

Post Date:

2014-04-01

Country:

Dr. Amita Gupta is Protocol Chair for this multinational clinical trial being conducted in Botswana, Haiti, South Africa, Tanzania, Thailand, Uganda, and Zimbabwe, and in India by the Baltimore-Washington-India Clinical Trials Unit, of which CCGHE is a member. Background Tuberculosis (TB) is the...

Pulmonary and Functional Status of Patients with Pulmonary Mycobacterium Tuberculosis Post-treatment in Lima, Peru

Post Date:

2014-01-01

Country:

Peru

To conduct a longitudinal study evaluating the hypothesis that pulmonary function and functional status (functional capacity and quality of life) is reduced among individuals previously treated for pulmonary tuberculosis compared to those without a history of tuberculosis.

RePORT: C-TRIUMPH: Cohort for Tuberculosis Research by the Indo-US Medical Partnership

Post Date:

2013-09-28

Country:

Collaboratively funded by the US NIH, India’s Department of Biotechnology [DBT], and Indian Council of Medical Research, the Cohort for TB Research by the Indo-US Medical Partnership (C-TRIUMPH) is an Indo-US research consortium that is part of RePORT India, a countrywide consortium for TB research...

RePORT: C-TRIUMPH: Substudy on Assessing the Association of Indoor Air Pollution with Tuberculosis in Adult Women and Children under 5 Years of Age

Post Date:

2013-09-15

Country:

Addressing social and environmental risk factors contributing to TB disease is becoming increasingly important for national TB programs. We are leveraging the pediatric participants in 1,100 homes participating in the C-TRIUMPH study, enhancing data collection regarding household and individual...

Community Home Based India Prevention of Mother to Child Transmission of HIV

Post Date:

2013-09-02

Country:

CCGHE is assessing whether equipping Community Health Workers with mobile health technology and involving them in technology training and personal empowerment seminars can help prevent mother-to-child transmission of HIV. CHWs who care for HIV + pregnant and nursing women are using the emocha...

Impact of Diabetes on TB Treatment Outcomes

Post Date:

2013-02-01

Country:

CCGHE, the JHU Center for TB Research and BJGMC have been awarded a $2.5 million dollar NIH grant (2013-2018) to conduct a study to evaluate treatment outcomes among Indian patients with both diabetes mellitus and active TB. This study is assessing the prevalence of impaired glucose or frank...

Acute Febrile Illness and Antimicrobial Resistance Patterns in Pune, India

Post Date:

2013-01-10

Country:

Evaluate etiology of acute fever and bacterial drug resistance patterns among adults and children in India.

Feasibility and Acceptability of Smartphone-Based Ecological Momentary Assessment of Alcohol Use Among African American Men Who Have Sex With Men in Baltimore

Post Date:

2013-01-01

Country:

This study provides evidence to support the feasibility and acceptability of using Ecological Momentary Assessment (EMA ) methods for collecting data on alcohol use among African American men who have sex with men living in urban settings. These data provide the basis for future studies of EMA-...

Management and control of multidrug-resistant tuberculosis (MDR-TB): addressing policy needs for India

Post Date:

2016-05-06

Publication:

Journal of Public Health Policy

Country:

Multidrug-resistant tuberculosis (MDR-TB) challenges TB control efforts because of delays in diagnosis plus its long-term treatment which has toxic effects. Of TB high-incidence countries, India carries the highest burden of MDR-TB cases. We describe policy issues in India concerning MDR-TB...

High proportion of extrapulmonary tuberculosis in a low prevalence setting: a retrospective cohort study

Post Date:

2016-04-29

Publication:

Public Health

Country:

Objectives: The proportion of extrapulmonary tuberculosis (EPTB) cases in the United States (US) has been rising due to a slower rate of decline in EPTB compared to pulmonary tuberculosis (PTB). The purpose of this study was to characterise the clinical and treatment differences between EPTB and...

Persistently elevated C-reactive protein level in the first year of antiretroviral therapy, despite virologic suppression, is associated with HIV disease progression in resource-constrained settings

Post Date:

2016-04-01

Publication:

The Journal of Infectious Diseases

Country:

A case-cohort analysis of human immunodeficiency virus (HIV)-infected individuals receiving antiretroviral therapy (ART) was performed within a multicountry randomized trial (PEARLS) to assess the prevalence of persistently elevated C-reactive protein (CRP) levels, based on serial measurements of...

Inflammation and change in body weight with antiretroviral therapy initiation in a multinational cohort of HIV-infected adults

Post Date:

2016-04-01

Publication:

The Journal of Infectious Diseases

Country:

Background: Both wasting and obesity are associated with inflammation, but the extent to which body weight changes influence inflammation during human immunodeficiency virus infection is unknown. Methods: Among a random virologically suppressed participants of the Prospective Evaluation of...

High tuberculosis risk among medical trainees, Pune, India

Post Date:

2016-03-22

Publication:

Emerging Infectious Diseases

Country:

During 2012–2013, at a public hospital in Pune, India, 26 (3.9%) cases of tuberculosis were reported among 662 medical trainees, representing an estimated incidence of 3,279 cases/100,000 person-years. Three of these infections were isoniazid-resistant, 1 was multidrug-resistant, and 1 occurred in...

Empirical tuberculosis therapy versus isoniazid in adult outpatients with advanced HIV initiating antiretroviral therapy (REMEMBER): a multicountry open-label randomised controlled trial

Post Date:

2016-03-19

Publication:

The Lancet

Country:

Background: Mortality within the first 6 months after initiating antiretroviral therapy is common in resource-limited settings and is often due to tuberculosis in patients with advanced HIV disease. Isoniazid preventive therapy is recommended in HIV-positive adults, but subclinical tuberculosis can...

Ecological momentary assessment of illicit drug use compared to biological and self-reported methods

Post Date:

2016-03-15

Publication:

Journal of Medical Internet Research

Country:

Background: The use of mHealth methods for capturing illicit drug use and associated behaviors have become more widely used in research settings, yet there is little research as to how valid these methods are compared to known measures of capturing and quantifying drug use. Objective: We examined...

Infectious Diseases (ID) Learning Unit: How rapidly to evaluate for active tuberculosis disease in low-prevalence settings

Post Date:

2016-03-11

Publication:

Open Forum Infectious Diseases

Country:

With declining tuberculosis (TB) incidence in low-prevalence settings, many clinicians are likely unaware that the approach to diagnosing active TB is evolving with newer technologies. Rapid molecular assays are commercially available, and more are likely to enter the market in the coming years...

Cohort for Tuberculosis Research by the Indo-US Medical Partnership (C-TRIUMPH): protocol for a multicentric prospective observational study

Post Date:

2016-02-25

Publication:

BMJ Open

Country:

Introduction: Tuberculosis disease (TB) remains an important global health threat. An evidence-based response, tailored to local disease epidemiology in high-burden countries, is key to controlling the global TB epidemic. Reliable surrogate biomarkers that predict key active disease and latent TB...

Low Vitamin-D levels combined with PKP3-SIGIRR-TMEM16J host variants is strongly associated with tuberculosis and death in HIV-infected and -exposed infants

Post Date:

2016-02-12

Publication:

PLOS One

Country:

Background: This study examined the associations of 25-hydroxyvitamin D and specific host genetic variants that affect vitamin D levels or its effects on immune function, with the risk of TB or mortality in children. Methods: A case-cohort sample of 466 South African infants enrolled in P1041 trial...

Prevalence and risk factors of micronutrient deficiencies pre- and post-antiretroviral therapy (ART) among a diverse multicountry cohort of HIV-infected adults

Post Date:

2016-02-10

Publication:

Clinical Nutrition

Country:

Background & Aims: HIV-infected adults have increased risk of several individual micronutrient deficiencies. However, the prevalence and risk factors of concurrent and multiple micronutrient deficiencies and whether micronutrient concentrations change after antiretroviral therapy (ART)...

TLR2-modulating lipoproteins of the mycobacterium tuberculosis complex enhance the HIV infectivity of CD4+ T cells

Post Date:

2016-01-25

Publication:

PLoS One

Country:

Abstract Co-infection with Mycobacterium tuberculosis accelerates progression from HIV to AIDS. Our previous studies showed that M. tuberculosis complex, unlike M. smegmatis, enhances TLR2-dependent susceptibility of CD4+ T cells to HIV. The M. tuberculosis complex produces multiple TLR2-...

Quantitative IFN-y,IL-2 response and latent tuberculosis test discordance in HIV-infected pregnant women

Post Date:

2016-01-14

Publication:

American Journal of Respiratory and Critical Care Medicine

Country:

Rationale: Pregnant women with latent tuberculosis infection (LTBI) are at high risk for development of TB, especially if infected with HIV. Objectives: To assess the performance of LTBI tests in pregnant and postpartum women infected with HIV, investigate the immunology behind discordance in...

Senior center-based hepatitis C screening in Baltimore

Post Date:

2016-01-06

Publication:

Open Forum Infectious Diseases

Country:

Abstract Despite significant advancements in hepatitis C virus (HCV) treatments, the majority of individuals infected with HCV remain undiagnosed. We report on senior citizen center-based HCV testing in Baltimore, which revealed a 9.4% prevalence of infection. Our data suggest that community-based...

Toward earlier inclusion of pregnant and postpartum women in TB drug trials: consensus statements from an International Expert Panel

Post Date:

2016-01-04

Publication:

Clinical Infectious Diseases

Tuberculosis is a major cause of morbidity and mortality in women of childbearing age (15–44 years). Despite increased tuberculosis risk during pregnancy, optimal clinical treatment remains unclear: safety, tolerability, and pharmacokinetic data for many tuberculosis drugs are lacking, and trials...

Cost effectiveness of isoniazid preventive therapy for HIV-infected pregnant women in India

Post Date:

2016-01-01

Publication:

International Journal of Tuberculosis and Lung Disease

Country:

Background: India has a high burden of active tuberculosis (TB) and human immunodeficiency virus (HIV) infection. Pregnancy increases the risks of developing TB in HIV-infected women. Isoniazid preventive therapy (IPT) reduces progression to TB, but may increase costs and hepatotoxicity. The cost-...

Determinants of default from tuberculosis treatment among patients with drug-susceptible tuberculosis in Karachi, Pakistan: a mixed methods study

Post Date:

2015-11-12

Publication:

PLOS One

Country:

Pakistan

Purpose: Non-adherence to tuberculosis therapy can lead to drug resistance, prolonged infectiousness, and death; therefore, understanding what causes treatment default is important. Pakistan has one of the highest burdens of tuberculosis in the world, yet there have been no qualitative studies in...

Pediatric tuberculous meningitis: model-based approach to determining optimal doses of anti-tuberculosis drugs for children

Post Date:

2015-10-22

Publication:

Clinical Pharmacology and Therapeutics

Country:

Indonesia

Pediatric tuberculous meningitis (TBM) is a highly morbid, often fatal disease. Standard treatment includes isoniazid, rifampin, pyrazinamide, and ethambutol. Current rifampin dosing achieves low cerebrospinal fluid (CSF) concentrations, and CSF penetration of ethambutol is poor. In adult trials,...

RePORT International: advancing tuberculosis biomarker research through global collaboration

Post Date:

2015-10-15

Publication:

Clinical Infectious Diseases

Country:

Indonesia

Progress in tuberculosis clinical research is hampered by a lack of reliable biomarkers that predict progression from latent to active tuberculosis, and subsequent cure, relapse, or failure. Regional Prospective Observational Research for Tuberculosis (RePORT) International represents a consortium...

Soluble CD14: An independent biomarker for risk of HIV mother-to-child transmission in setting of pre- and post-exposure antiretroviral prophylaxis

Post Date:

2015-10-06

Publication:

The Journal of Infectious Diseases

Country:

Elevated soluble CD14 (sCD14) concentrations, a marker of monocyte activation, predicts adverse outcomes in human immunodeficiency virus (HIV)-infected adults. To examine the association of sCD14 concentrations with the risk of mother-to-child transmission (MTCT) of HIV, we nested a case-control...

Host Factors Associated with Poor Respiratory Health-Related Quality of Life in Pulmonary Tuberculosis

Post Date:

2016-10-27

Presentation Location:

New Orleans, LA

Country:

Event & Convener:

ID Week 2016

Poster Abstract Session: Tuberculosis Treatment and Outcome. Gupte A , Meshram S, Selvaraju S, Gupte N, Shivakumar SVBY, Paradkar M, Kohli R, Theruvengadam K, Suryavanshi N, Chandrasekaran P, Mave V, Swaminathan S, Salvi S, Checkley, W, Golub J, Gupta A

Impact of Drug Susceptibility Testing on Drug Choice in a Tuberculosis Cohort with High Rates of Drug Resistance from the Private Sector in Mumbai

Post Date:

2016-10-27

Presentation Location:

New Orleans, LA

Country:

Event & Convener:

ID Week 2016

Poster Abstract Session: Tuberculosis Treatment and Outcome. Udwadia ZF, Tornheim JA , Ganatra S, DeLuca A, Banka R, Gupta A

Etiology of Acute Febrile Illness among Hospitalized Adults and Children at a Public Tertiary-Care Center in Pune, India

Post Date:

2016-10-27

Presentation Location:

New Orleans, LA

Country:

Event & Convener:

ID Week 2016

Poster Abstract Session: Oh One World: Infections from Near and Far. Robinson M , Balasubramanian U, Raichur P, Kadam D, Khadse S, Marbaniang I, Kanade S, Sachs J, Basavaraj A, Bharadwaj R, Kinikar A, Kulkarni V, Kagal A, Gupta A, Mave V

Xpert® MTB/RIF Assay for Pulmonary Tuberculosis Diagnosis in Patients with Diabetes Mellitus

Post Date:

2016-10-27

Presentation Location:

Durban, South Africa

Event & Convener:

47th Union World Conference on Lung Health. International Union for Tuberculosis and Lung Disease.

Poster Presentation. Mave V , Gupte N, Meshram S, Kagal A, Gupta A, Bharadwaj R, Pradhan N, Deshmukh S, Atre S, Golub J

TB Infection Prevalence, Incidence and Risk Factors among Child and Adult Household Contacts of Adult TB Cases in India

Post Date:

2016-10-27

Presentation Location:

New Orleans, LA

Country:

Event & Convener:

ID Week 2016

Poster presentation. Shivakumar SVBY , Chandrasekaran P, Thiruvengadam K, Gupte N, Mave V, Hannah LE, Kulkarni V, Gupte A, Deluca A, Gomathy NS, Sathyamurthi P, Paradkar M, Kohli R, Meshram S, Kagal A, Suryavanshi N, Ramachandran G, Thomas B, Dolla CK, Subramanyam B, Golub J, Swaminathan S, Gupta A.

A Case-control Study of Household Air Pollution and Tuberculosis in Women and Children in Pune, India

Post Date:

2016-10-26

Presentation Location:

Liverpool, England

Country:

Event & Convener:

46th Union World Conference on Lung Health. International Union for Tuberculosis and Lung Disease

Oral Presentation. Elf JL , Kinikar A, Khadse S, Mave V, Gupte N, Kulkarni V, Patekar S, Raichur P, Breysse PN, Gupta A, Golub JE.

TB and Diabetes in Pregnancy: Current Knowledge and Research Gaps

Post Date:

2016-10-24

Presentation Location:

Liverpool, England

Event & Convener:

47th Union World Conference on Lung Health. International Union for Tuberculosis and Lung Disease.

Presentation. Workshop: Integrated Care and Research for Tuberculosis, Diabetes, and HIV/AIDS: Challenges, Strategies, and Clinical Solutions

Sub-Therapeutic Concentrations of Anti-Tuberculosis Drugs in Children when Treated According to Indian Dosing Recommendation

Post Date:

2016-10-24

Presentation Location:

Liverpool, England

Country:

Event & Convener:

9th Annual International Workshop on Clinical Pharmacology of Tuberculosis Drugs

Oral Presentation. Guiastrennec B , Ramachandran G, Karlsson MO, Kumar H, Bhavani PK, Gangadevi NP, Swaminathan S, Gupta A, Dooley KE, Savic RM.

Vancomycin-resistant Enterococcal Bacteraemia: Is Daptomycin as Effective as Linezolid?

Post Date:

2016-10-04

Presentation Location:

San Diego, CA

Event & Convener:

Infectious Diseases Society of America. 2007 Annual Meeting.

Presentation.

Outreach Workers in the Prevention of Mother to Child Transmission of HIV (PMTCT) Programme in India: Challenges and Opportunities

Post Date:

2016-07-21

Presentation Location:

Durban, South Africa

Country:

Event & Convener:

21st Annual International AIDS Conference (AIDS 2016)

Abstract Presentation. Suryavanshi N , Mave V, Kadam A, Kanade S, Sivalenka S, Sampath K, Harve P, Gupta RS, Hegde A, McKenzie-White J, Gupte N, Gupta A, Bollinger RC, Shankar AV.

A Cluster-Randomized Trial to Promote Combination HIV Prevention Using M-health-Supported CHWs in a High-Prevalence Fishing Community: Design and Baseline Characteristics of the mLAKE Trial in Rakai, Uganda

Post Date:

2016-07-21

Presentation Location:

Durban, South Africa

Country:

Event & Convener:

21st International AIDS Conference. International AIDS Society.

Abstract Presentation. Chang L, Mbabali I, Kong X, Hutton H, Long A, Thomas A, Bugos E, Ssekasanvu J, Kennedy C, Amico R, Nalugoda F, Reynolds S, Quinn T, Serwadda D, Wawer M, Gray R, Nakigozi G.

Rapid Diagnosis, Linkage and Treatment Initiation of Patients with Drug-resistant Tuberculosis in South Africa: The miLINC Solution to Improve Access to Care

Post Date:

2016-07-20

Presentation Location:

Durban, South Africa

Country:

Event & Convener:

21st International AIDS Conference. International AIDS Society.

Poster Presentation. Farley JE , Seiguer S, Naicker M, McKenzie-White J, Greg C, Elmi M, Stevens W, Stewart-Isherwood L

High Risk for Loss to Follow-Up among Adolescents Living with HIV in Pune, India

Post Date:

2016-07-19

Presentation Location:

Durban, South Africa

Country: