Research News

Sepsis among newborns in the neonatal intensive care unit (NICU) is a big problem in India, and a complex one to untangle.

In a multi-country study, we are assessing the accuracy of the BD MAX rapid MDR-TB assay to detect rifampin and isoniazid resistance.

Clinical Research

We work with scientists and practitioners around the world to conduct clinical trials and observational studies that improve prevention and treatment of many grave health issues affecting resource-limited regions, including HIV and tuberculosis.
 
We have formal research partnerships with the following institutions:
 
 

miDOT (Directly Observed Therapy)

Post Date: 
2015-11-01
Designed by Dr. Maunank Shah, the miDOT mobile health application is a video-based Directly Observed Therapy interface that uses the emocha Mobile Health platform to remotely connect patients on long-term tuberculosis therapy with clinicians who are required to witness patients taking medication...

RePORT: C-TRIUMPH: Substudy on Residual Respiratory Impairment Following Pulmonary Tuberculosis

Post Date: 
2015-09-13
Country: 
Many TB patients have residual respiratory impairment despite treatment. Such individuals may be at increased risk of chronic lung diseases and disability in the future. Using respiratory questionnaires and lung function tests, the Lung Health Sub-study will evaluate 400 adult TB patients enrolled...

A5300/IMPAACT2003: Study of MDR TB Cases and Their Household Contacts: Operational Feasibility to Inform PHOENIx Trial Design

Post Date: 
2015-09-01
Country: 
Dr. Amita Gupta is Protocol Co-Chair for this multinational study being conducted in Haiti, South Africa, Uganda, and in India by the Baltimore-Washington-India Clinical Trials Unit, of which CCGHE is a member. This is a cross-sectional study of adult MDR TB index cases and their identified adult...

TREAT Asia: Prevalence Survey of Risk Factors for Tuberculosis and Non-communicable Diseases in an HIV-positive Population in Pune, India

Post Date: 
2015-08-17
Country: 
The primary objective of this study is to assess the prevalence of risk factors for tuberculosis and non-communicable diseases (NCDs)--coronary artery disease and diabetes mellitus--among HIV-positive patients. The study will also assess the development of NCDs at 12, 24, 48 months after study...

RePORT: C-TRIUMPH: Substudy on Understanding of Tuberculosis Infection and Preventive Therapy among Skin-Test Positive Household Contacts of Tuberculosis Cases

Post Date: 
2015-08-13
Country: 
It is both relevant and important to gauge awareness of IPT (Isoniazieas an option for preventing TB among those who are tuberculin skin test (TST) positive, given India’s vast TB-infected population pool that are at risk for progressing to active disease, in order to demonstrate demand. We...

Acute Febrile Illness and Antimicrobial Resistance Patterns in Pune, India: Substudy on Community Health-Seeking Behavior Among Patients Admitted with Acute Febrile Illness

Post Date: 
2015-05-28
Objectives: To describe the patterns of health-care seeking behavior and prior outpatient care among patients admitted with acute febrile illness to Sassoon Hospital To determine the effects of outpatient behaviors and prior treatments on the antimicrobial resistance patterns of stool colonizing...

Barriers for Intervention to Prevent Occupationally Acquired Tuberculosis in Healthcare Workers

Post Date: 
2015-05-21
Country: 
Observational study to assess the current status of implementation of interventions for preventing occupationally acquired TB in HCW. Identify the barriers to implementing these interventions

Risk of Tuberculosis among Health Care Workers and Trainees in a Tertiary-care Hospital in Pune, India

Post Date: 
2015-04-15
Country: 
A retrospective study of health care workers (HCWs) was conducted by investigators of the Byramjee Jeejeebhoy Medical and Sassoon General Hospitals (BJMC-SGH) in Pune, India. The purpose of the study was to estimate TB prevalence and incidence and investigate frequency and treatment failure,...

Community Health Workers, mHealth, and Combination HIV Prevention in a Hotspot: A Randomized Trial (mLAKE)

Post Date: 
2015-04-01
Country: 
Led by Dr. Larry Chang, the mLAKE study in Uganda is examining whether community health workers equipped with cellphones and the emocha Mobile Health platform are able to successfully promote HIV treatment and prevention services in households in a fishing community in East Africa with a very high...

Salud al Dia

Post Date: 
2014-11-01
Country: 
This initiative is intended to address healthcare disparities among Latino children in Baltimore by increasing engagement of limited English proficiency (LEP) Latino parents in primary healthcare. Specifically, we are looking at whether using in-person and technology-based support interventions...

Predictive Value of TB-symptom Screen in HIV-infected and HIV-uninfected Pregnant Women in Pune, India

Post Date: 
2014-10-28
Country: 
This is a cross sectional observational study that will be conducted at BJGMC to establish what the predictive value of the WHO TB symptom screen is in pregnant women in India. We hypothesize that the WHO TB symptom screen will have a higher positive predictive value (PPV) in HIV-seronegative...

miLINC: MDR-TB South Africa - Patient Linkage to and Retention in Care

Post Date: 
2014-10-06
Country: 
Mycobacterium tuberculosis (TB) remains the leading cause of death among persons living with human immunodeficiency virus and acquired immunodeficiency syndrome (HIV/AIDS) in southern Africa. Drug-resistant TB remains a growing threat to public health despite advances made in diagnosis and...

TBM Kids Substudy: Assessment of Neurocognitive Functions in Children with Tuberculosis Meningitis and Healthy Control Children Using the Mullen Scale of Early Learning Attending a Tertiary Care Public Hospital in Pune, India

Post Date: 
2014-09-01
Country: 
Objectives: The aim of the present study is to examine the neurological deficit in TBM kids and for that we need to assess, feasibility of the MSEL in our set up an Indian population of healthy children and children with meningitis in particular TB meningitis(TBM). The primary objective of the...

TB and Pregnancy Impact of Immune Changes of HIV and Stages of Pregnancy on Tuberculosis

Post Date: 
2014-09-01
Country: 
Purpose: TB is a leading cause of maternal mortality, especially among HIV-infected women. Women are most likely to develop active TB during and immediately after pregnancy. The immunologic conditions responsible for this phenomenon are not understood. Our recent research shows that pregnant women...

Diagnosis of Tuberculosis Infection and Th1 Immune Response in Pregnant Women in India

Post Date: 
2014-09-01
Country: 
Tuberculosis (TB) disease is a major cause of mortality among Indian women of reproductive age; approximately 20-50% of women in India are latently infected with Mycobacterium tuberculosis (MTB). Due to immune changes of pregnancy, women are particularly at risk of reactivation and progression to...

PreventionRx Study: Home-based Counseling and Testing in Uganda

Post Date: 
2014-08-27
Country: 
A ‘platform’ for evaluating combination HIV prevention & care-HIV counseling & testing is essential to optimize HIV services. In collaboration with the University of Washington and the Integrated Community Based Initiatives (ICOBI) NGO in Uganda, CCGHE has adapted the emocha ® platform to...

Evaluating Demand Generation (Stylish Man) for HIV/Family Planning Services, Rakai, Uganda

Post Date: 
2014-08-01
Country: 
Dr. Larry Chang is co-investigator of this effort to test a novel approach to promoting HIV services in Rakai, Uganda. The Stylish Man Program, attempts to “demedicalize” HIV prevention and care in a public health campaign designed to normalize HIV care as part of self care for African men. The...

Evaluation of Longitudinal Blood Culture Isolates from BJ Medical College in Pune, India

Post Date: 
2014-06-16
Country: 
Antibiotic resistance is a serious global problem and is caused by multiple factors which have led to difficulty in the management of life-threatening, multi-drug resistant (MDR) bacterial bloodstream infections. The knowledge of antibiotic resistance patterns and availability of appropriate...

Optimizing Treatment to Improve TBM Outcomes in Children

Post Date: 
2014-05-01
Country: 
This study is being conducted in India and Malawi. Primary Objectives To characterize the pharmacokinetics (PK) (plasma and cerebrospinal fluid (CSF)) of rifampicin given at model-derived optimal daily doses and levofloxacin in children ages 6 months to 12 years of age with TBM To assess the...

P1078: A Phase IV Randomized Double-Blind Placebo-Controlled Trial to Evaluate the Safety of Immediate (Antepartum-Initiated) Versus Deferred (Postpartum-Initiated) Isoniazid Preventive Therapy Among HIV-Infected Women in High TB Incidence Settings

Post Date: 
2014-04-01
Country: 
Dr. Amita Gupta is Protocol Chair for this multinational clinical trial being conducted in Botswana, Haiti, South Africa, Tanzania, Thailand, Uganda, and Zimbabwe, and in India by the Baltimore-Washington-India Clinical Trials Unit, of which CCGHE is a member. Background Tuberculosis (TB) is the...

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Epidemiological impact of achieving UNAIDS 90-90-90 targets for HIV care in India: a modelling study

Post Date: 
2016-07-07
Publication: 
BMJ Open
Country: 
Objective: Recent UNAIDS ‘90-90-90’ targets propose that to end the HIV epidemic by 2030, 90% of persons living with HIV (PLWH) worldwide should know their diagnosis, 90% of diagnosed PLWH should be on antiretroviral therapy (ART) and 90% of PLWH on ART should be virally suppressed by 2020. We...

Inflammation and change in body weight with antiretroviral therapy initiation in a multinational cohort of HIV-infected adults

Post Date: 
2016-07-01
Publication: 
Journal of Infectious Diseases
Country: 
Background: Both wasting and obesity are associated with inflammation, but the extent to which body weight changes influence inflammation during human immunodeficiency virus infection is unknown. Methods: Among a random virologically suppressed participants of the Prospective Evaluation of...

Defining clinical excellence in adult infectious disease practice

Post Date: 
2016-06-16
Publication: 
Open Forum Infectious Diseases
Country: 
Clinical excellence should be recognized, particularly in the current climate that appropriately prioritizes relationship-centered care. In order to develop a recognition model, a definition of clinical excellence must be created and agreed upon. A paradigm recently suggested by C. Christmas...

Isoniazid hair concentrations in children with tuberculosis: a proof of concept study

Post Date: 
2016-06-01
Publication: 
International Journal of Tuberculosis and Lung Disease
Country: 
Assessing treatment adherence and quantifying exposure to anti-tuberculosis drugs among children is challenging. We undertook a 'proof of concept' study to assess the drug concentrations of isoniazid (INH) in hair as a therapeutic drug monitoring tool. Children aged <12 years initiated on a...

Public health clinic-based hepatitis C testing and linkage to care in Baltimore

Post Date: 
2016-05-15
Publication: 
Journal of Viral Hepatitis
Country: 
Testing and linkage to care are important determinants of hepatitis C virus (HCV) treatment effectiveness. Public health clinics serve populations at high risk of HCV. We investigated their potential to serve as sites for HCV testing, initiation of and linkage to HCV care. Cross-sectional study of...

Applying ethical principles to international community-based research; a case study from the Consortium to Respond Effectively to the AIDS/TB Epidemic

Post Date: 
2016-05-15
This paper describes how one set of HIV-TB prevention research studies put procedures in place to be responsive to these foundational ethical principles when interacting with communities in large population-based, global public health research.

Management and control of multidrug-resistant tuberculosis (MDR-TB): addressing policy needs for India

Post Date: 
2016-05-06
Publication: 
Journal of Public Health Policy
Country: 
Multidrug-resistant tuberculosis (MDR-TB) challenges TB control efforts because of delays in diagnosis plus its long-term treatment which has toxic effects. Of TB high-incidence countries, India carries the highest burden of MDR-TB cases. We describe policy issues in India concerning MDR-TB...

High proportion of extrapulmonary tuberculosis in a low prevalence setting: a retrospective cohort study

Post Date: 
2016-04-29
Publication: 
Public Health
Country: 
Objectives: The proportion of extrapulmonary tuberculosis (EPTB) cases in the United States (US) has been rising due to a slower rate of decline in EPTB compared to pulmonary tuberculosis (PTB). The purpose of this study was to characterise the clinical and treatment differences between EPTB and...

Inflammation and change in body weight with antiretroviral therapy initiation in a multinational cohort of HIV-infected adults

Post Date: 
2016-04-01
Publication: 
The Journal of Infectious Diseases
Background: Both wasting and obesity are associated with inflammation, but the extent to which body weight changes influence inflammation during human immunodeficiency virus infection is unknown. Methods: Among a random virologically suppressed participants of the Prospective Evaluation of...

Persistently elevated C-reactive protein level in the first year of antiretroviral therapy, despite virologic suppression, is associated with HIV disease progression in resource-constrained settings

Post Date: 
2016-04-01
Publication: 
The Journal of Infectious Diseases
A case-cohort analysis of human immunodeficiency virus (HIV)-infected individuals receiving antiretroviral therapy (ART) was performed within a multicountry randomized trial (PEARLS) to assess the prevalence of persistently elevated C-reactive protein (CRP) levels, based on serial measurements of...

High tuberculosis risk among medical trainees, Pune, India

Post Date: 
2016-03-22
Publication: 
Emerging Infectious Diseases
Country: 
During 2012–2013, at a public hospital in Pune, India, 26 (3.9%) cases of tuberculosis were reported among 662 medical trainees, representing an estimated incidence of 3,279 cases/100,000 person-years. Three of these infections were isoniazid-resistant, 1 was multidrug-resistant, and 1 occurred in...

Empirical tuberculosis therapy versus isoniazid in adult outpatients with advanced HIV initiating antiretroviral therapy (REMEMBER): a multicountry open-label randomised controlled trial

Post Date: 
2016-03-19
Publication: 
The Lancet
Background: Mortality within the first 6 months after initiating antiretroviral therapy is common in resource-limited settings and is often due to tuberculosis in patients with advanced HIV disease. Isoniazid preventive therapy is recommended in HIV-positive adults, but subclinical tuberculosis can...

Ecological momentary assessment of illicit drug use compared to biological and self-reported methods

Post Date: 
2016-03-15
Publication: 
Journal of Medical Internet Research
Country: 
Background: The use of mHealth methods for capturing illicit drug use and associated behaviors have become more widely used in research settings, yet there is little research as to how valid these methods are compared to known measures of capturing and quantifying drug use. Objective: We examined...

Infectious Diseases (ID) Learning Unit: How rapidly to evaluate for active tuberculosis disease in low-prevalence settings

Post Date: 
2016-03-11
Publication: 
Open Forum Infectious Diseases
Country: 
With declining tuberculosis (TB) incidence in low-prevalence settings, many clinicians are likely unaware that the approach to diagnosing active TB is evolving with newer technologies. Rapid molecular assays are commercially available, and more are likely to enter the market in the coming years...

Cohort for Tuberculosis Research by the Indo-US Medical Partnership (C-TRIUMPH): protocol for a multicentric prospective observational study

Post Date: 
2016-02-25
Publication: 
BMJ Open
Country: 
Introduction: Tuberculosis disease (TB) remains an important global health threat. An evidence-based response, tailored to local disease epidemiology in high-burden countries, is key to controlling the global TB epidemic. Reliable surrogate biomarkers that predict key active disease and latent TB...

Low Vitamin-D levels combined with PKP3-SIGIRR-TMEM16J host variants is strongly associated with tuberculosis and death in HIV-infected and -exposed infants

Post Date: 
2016-02-12
Publication: 
PLOS One
Country: 
Background: This study examined the associations of 25-hydroxyvitamin D and specific host genetic variants that affect vitamin D levels or its effects on immune function, with the risk of TB or mortality in children. Methods: A case-cohort sample of 466 South African infants enrolled in P1041 trial...

Prevalence and risk factors of micronutrient deficiencies pre- and post-antiretroviral therapy (ART) among a diverse multicountry cohort of HIV-infected adults

Post Date: 
2016-02-10
Publication: 
Clinical Nutrition
Background & Aims: HIV-infected adults have increased risk of several individual micronutrient deficiencies. However, the prevalence and risk factors of concurrent and multiple micronutrient deficiencies and whether micronutrient concentrations change after antiretroviral therapy (ART)...

TLR2-modulating lipoproteins of the mycobacterium tuberculosis complex enhance the HIV infectivity of CD4+ T cells

Post Date: 
2016-01-25
Publication: 
PLoS One
Country: 
Abstract Co-infection with Mycobacterium tuberculosis accelerates progression from HIV to AIDS. Our previous studies showed that M. tuberculosis complex, unlike M. smegmatis, enhances TLR2-dependent susceptibility of CD4+ T cells to HIV. The M. tuberculosis complex produces multiple TLR2-...

Quantitative IFN-y,IL-2 response and latent tuberculosis test discordance in HIV-infected pregnant women

Post Date: 
2016-01-14
Publication: 
American Journal of Respiratory and Critical Care Medicine
Country: 
Rationale: Pregnant women with latent tuberculosis infection (LTBI) are at high risk for development of TB, especially if infected with HIV. Objectives: To assess the performance of LTBI tests in pregnant and postpartum women infected with HIV, investigate the immunology behind discordance in...

Senior center-based hepatitis C screening in Baltimore

Post Date: 
2016-01-06
Publication: 
Open Forum Infectious Diseases
Country: 
Abstract Despite significant advancements in hepatitis C virus (HCV) treatments, the majority of individuals infected with HCV remain undiagnosed. We report on senior citizen center-based HCV testing in Baltimore, which revealed a 9.4% prevalence of infection. Our data suggest that community-based...

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Descriptive Baseline Characteristics, Treatment Outcomes and Biorepository of Pediatric TB Cases in CTRIUMPh-RePORT India Prospective Cohort

Post Date: 
2017-02-03
Presentation Location: 
Hyderabad, India
Country: 
Event & Convener: 
6th Annual Regional Prospective Observational Research for Tuberculosis (RePORT) India Joint Leadership Meeting
Poster presentation. Paradkar M , Kavitha D, Shiva Kumar SVBY, Khadse S, Khwaja S, Hari K, Rani N, Thiruvengadam K, Gupte N, Raskar S, Jain D, Suryavanshi S, Kohli R, Kulkarni V, Pradhan N, Sathyamurthi B, Tornheim J, Gupte A, DeLuca A, Mave V, Chandrasekaran P, Gupta A for the CTRIUMPH Study Team

Household Contact Tracing of Adult Pulmonary TB Patients in India: Prevalence of TB Disease and Infection

Post Date: 
2017-02-03
Presentation Location: 
Hyderabad, India
Country: 
Event & Convener: 
6th Annual Regional Prospective Observational Research for Tuberculosis (RePORT) India Joint Leadership Meeting
Poster presentation. Chandrasekaran P , Thiruvengadam K, Gupte N, Luck EH, Mave M, Gupte A, Gupta A, Swaminathan S

Attrition among HIV-infected Adolescent Girls and Young Women in Pune, India

Post Date: 
2016-12-06
Presentation Location: 
Birmingham, AL
Country: 
Event & Convener: 
Center for AIDS Research. Women and HIV: Inter-CFAR Joint Symposium on HIV Research in Women
Poster presentation. Nimkar S , Kadam D, Marbaniang I, Suman R, Gupte N, Salvi S, Suryavanshi N, Gupta A, Mave V.

Characteristics of HIV-infected Transgender Women Registered under Programmatic Conditions in Pune, India

Post Date: 
2016-12-06
Presentation Location: 
Birmingham, AL
Country: 
Event & Convener: 
Center for AIDS Research. Women and HIV: Inter-CFAR Joint Symposium on HIV Research in Women
Oral presentation. Marbaniang I , Kadam D, Gupte N, Suman R, Salvi S, Nimkar S, Suryavanshi N, Gupta A, Mave V.

Spousal Serostatus Affects Retention in Care among Married HIV Infected Women in Pune, India

Post Date: 
2016-12-06
Presentation Location: 
Birmingham, AL
Country: 
Event & Convener: 
Center for AIDS Research. Women and HIV: Inter-CFAR Joint Symposium on HIV Research in Women
Poster presentation. Nimkar S , Kadam D, Marbaniang I< Suman R, Gupte N, Salvi S, Suryavanshi N, Gupta A, Mave V.

Characteristics Associated with Mobile Phone Access among Tuberculosis Patents in Pune, India

Post Date: 
2016-12-04
Presentation Location: 
Cape Town, South Africa
Country: 
Event & Convener: 
46th Union World Conference on Lung Health. International Union for Tuberculosis and Lung Disease.
Poster Presentation. Ogale YP , Elf JL, Lokhande R, Mave V, Roy S, Gupta A, Golub J, Mathad J.

Presentation, Etiology, and Outcome of Febrile Indian Patients Differs by HIV Status

Post Date: 
2016-11-16
Presentation Location: 
Atlanta, GA
Event & Convener: 
65th Annual Meeting, American Society of Tropical Medicine and Hygiene
Poster presentation. Kadam D, Robinson M , Kagal A, Bharadwaj R, Raichur P, Kanade S, Sachs J, Gupte N, Gupta A, Mave V.

Pharmacokinetic Aspects of 3HP in Special Populations

Post Date: 
2016-10-29
Presentation Location: 
Liverpool, England
Event & Convener: 
47th Union World Conference on Lung Health. International Union for Tuberculosis and Lung Disease.
Presentation. Mathad J.

IMPAACT P1078: Background, Design and Baseline Data

Post Date: 
2016-10-29
Presentation Location: 
Liverpool, England
Country: 
Event & Convener: 
47th Union World Conference on Lung Health. International Union for Tuberculosis and Lung Disease.
Presentation. Mathad J on behalf of Gupta A and P1078 Study Team TB APPRISE: Phase IV Randomized Double-blind Placebo-controlled Trial to Evaluate the Safety of Immediate (Antepartum-initiated) vs. Deferred (Postpartum-initiated) Isoniazid Preventive Therapy among HIV-infected Women in High TB...

The Impact of Health Seeking Behavior on Community-acquired Multi-drug Resistant Stool Colonization among Hospitalized Febrile Illness Patients in Pune, India

Post Date: 
2016-10-29
Presentation Location: 
New Orleans, LA
Country: 
Event & Convener: 
ID Week 2016
Poster Session: Antibiotic Stewardship: Outpatient and ED. Sachs J , Bharadwaj R, Khadse S, Kadam D, Kagal A, Shaikh N, Shingada K, Raichur P, Kanade S, Suryanvanshi N, Gupta A, Robinson M, Mave V.

Choosing an ID Fellowship

Post Date: 
2016-10-29
Presentation Location: 
New Orleans, LA
Event & Convener: 
ID Week 2016
Presenter, Symposium: Choosing a Career in Infectious Diseases

Xpert® MTB/RIF Assay for Pulmonary Tuberculosis Diagnosis in Patients with Diabetes Mellitus

Post Date: 
2016-10-27
Presentation Location: 
Durban, South Africa
Event & Convener: 
47th Union World Conference on Lung Health. International Union for Tuberculosis and Lung Disease.
Poster Presentation. Mave V , Gupte N, Meshram S, Kagal A, Gupta A, Bharadwaj R, Pradhan N, Deshmukh S, Atre S, Golub J

TB Infection Prevalence, Incidence and Risk Factors among Child and Adult Household Contacts of Adult TB Cases in India

Post Date: 
2016-10-27
Presentation Location: 
New Orleans, LA
Country: 
Event & Convener: 
ID Week 2016
Poster presentation. Shivakumar SVBY , Chandrasekaran P, Thiruvengadam K, Gupte N, Mave V, Hannah LE, Kulkarni V, Gupte A, Deluca A, Gomathy NS, Sathyamurthi P, Paradkar M, Kohli R, Meshram S, Kagal A, Suryavanshi N, Ramachandran G, Thomas B, Dolla CK, Subramanyam B, Golub J, Swaminathan S, Gupta A.

Household Contact Tracing of Adult Pulmonary TB Patients in India: Prevalence of TB Disease and Infection

Post Date: 
2016-10-27
Presentation Location: 
New Orleans, LA
Country: 
Event & Convener: 
ID Week 2016
Poster Abstract Session: Tuberculosis Epidemiology and Diagnosis. Chandrasekaran P , Thiruvengadam K, Gupte N, Luck EH, Mave M, Gupte A, Gupta A, Swaminathan S

Host Factors Associated with Poor Respiratory Health-Related Quality of Life in Pulmonary Tuberculosis

Post Date: 
2016-10-27
Presentation Location: 
New Orleans, LA
Country: 
Event & Convener: 
ID Week 2016
Poster Abstract Session: Tuberculosis Treatment and Outcome. Gupte A , Meshram S, Selvaraju S, Gupte N, Shivakumar SVBY, Paradkar M, Kohli R, Theruvengadam K, Suryavanshi N, Chandrasekaran P, Mave V, Swaminathan S, Salvi S, Checkley, W, Golub J, Gupta A

Impact of Drug Susceptibility Testing on Drug Choice in a Tuberculosis Cohort with High Rates of Drug Resistance from the Private Sector in Mumbai

Post Date: 
2016-10-27
Presentation Location: 
New Orleans, LA
Country: 
Event & Convener: 
ID Week 2016
Poster Abstract Session: Tuberculosis Treatment and Outcome. Udwadia ZF, Tornheim JA , Ganatra S, DeLuca A, Banka R, Gupta A

Etiology of Acute Febrile Illness among Hospitalized Adults and Children at a Public Tertiary-Care Center in Pune, India

Post Date: 
2016-10-27
Presentation Location: 
New Orleans, LA
Country: 
Event & Convener: 
ID Week 2016
Poster Abstract Session: Oh One World: Infections from Near and Far. Robinson M , Balasubramanian U, Raichur P, Kadam D, Khadse S, Marbaniang I, Kanade S, Sachs J, Basavaraj A, Bharadwaj R, Kinikar A, Kulkarni V, Kagal A, Gupta A, Mave V

A Case-control Study of Household Air Pollution and Tuberculosis in Women and Children in Pune, India

Post Date: 
2016-10-26
Presentation Location: 
Liverpool, England
Country: 
Event & Convener: 
46th Union World Conference on Lung Health. International Union for Tuberculosis and Lung Disease
Oral Presentation. Elf JL , Kinikar A, Khadse S, Mave V, Gupte N, Kulkarni V, Patekar S, Raichur P, Breysse PN, Gupta A, Golub JE.

Sub-Therapeutic Concentrations of Anti-Tuberculosis Drugs in Children when Treated According to Indian Dosing Recommendation

Post Date: 
2016-10-24
Presentation Location: 
Liverpool, England
Country: 
Event & Convener: 
9th Annual International Workshop on Clinical Pharmacology of Tuberculosis Drugs
Oral Presentation. Guiastrennec B , Ramachandran G, Karlsson MO, Kumar H, Bhavani PK, Gangadevi NP, Swaminathan S, Gupta A, Dooley KE, Savic RM.

TB and Diabetes in Pregnancy: Current Knowledge and Research Gaps

Post Date: 
2016-10-24
Presentation Location: 
Liverpool, England
Event & Convener: 
47th Union World Conference on Lung Health. International Union for Tuberculosis and Lung Disease.
Presentation. Workshop: Integrated Care and Research for Tuberculosis, Diabetes, and HIV/AIDS: Challenges, Strategies, and Clinical Solutions

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Multidrug TB prophylaxis not needed in advanced HIV

Post Date: 
2016-03-18
Source: 
MedPage Today
Patients with advanced HIV infection initiating anti-retroviral therapy who were treated with isoniazid alone to prevent tuberculosis had similar survival rates as patients treated with a standard four-drug anti-tuberculosis regimen in a multi-national, randomized, controlled trial.

Proactively treating HIV patients at risk for tuberculosis with multidrug TB therapy doesn’t save more lives

Post Date: 
2016-03-17
In what investigators say is a surprise finding, results of a new study appear to strongly affirm the effectiveness of prescribing the anti-tuberculosis drug isoniazid alone — in place of the standard four-drug regimen — to prevent TB and reduce death in people with advanced HIV/AIDS infections...

Common treatment of TB in advanced HIV patients doesn't save more lives

Post Date: 
2016-03-17
Source: 
Medical Xpress
In a report on the so-called REMEMBER (Reducing Early Mortality and Early Morbidity by Empiric Tuberculosis Treatment) study—a 10-nation, randomized clinical trial of adult outpatients—investigators concluded that there was no added benefit of using four drugs for TB over just using one drug,...

CCGHE at CROI 2016

Post Date: 
2016-02-29
JOHNS HOPKINS CENTER FOR CLINICAL GLOBAL HEALTH EDUCATION AT CROI 2016 FEBRUARY 22-25 2016 | BOSTON, MASSACHUSETTS TUESDAY, FEBRUARY 23 Combination HIV Prevention and HIV Incidence in a Ugandan Hotspot Fishing Community. Poster Presentation. Session: HIV Testing and Prevention. Authors: Kagaayi J,...

Now, docs to get TB leave as cases mount

Post Date: 
2016-02-24
Source: 
Pune Mirror
Too many cases of tuberculosis (TB) among medical trainees and resident doctors in the state have prompted the medical education department to sanction medical leaves exclusively for the malady. This is the first time any state has taken such a step in India. Unusual working hours; close contact...

VIDEO: Amita Gupta, MD, MHS, reviews TB prevention in patients with HIV

Post Date: 
2016-02-24
Source: 
Infectious Disease News, via Healio
In this video with Healio.com, Amita Gupta, MD, MHS, associate professor medicine and international health and deputy director of the Center for Clinical Global Health Education at Johns Hopkins University School of Medicine, discusses research related to the prevention of tuberculosis in patients...

LEAP Program a Resource for Investigators of New Antiretrovirals

Post Date: 
2016-02-03
February 3, 2016—Baltimore, MD—The Johns Hopkins Center for Clinical Global Health Education, the Johns Hopkins Departments of Medicine and Pharmacology and Molecular Sciences, and the University of Liverpool launched a new website for an NIH-funded drug development resource called the Long-Acting/...

Up Close: Matthew Robinson

Post Date: 
2016-02-01
Looking for Causes of Fever in India “The most common reason Indians go to the doctor is for fever. The list of potential causes for fever in India and other low and middle income countries in tropical settings is extensive.” Matt Robinson, MD, is a Clinical Fellow whose research in India aims to...

Tuberculosis test may underreport in pregnant women with HIV

Post Date: 
2016-01-28
Source: 
Infectious Disease Advisor
Pregnancy may confound tuberculosis (TB) tests results in women with HIV, according to research published in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine .

Tuberculosis scare in HIV positive pregnant women: most widely-used tuberculosis test fails to diagnose illness

Post Date: 
2016-01-28
Source: 
International Business Times
The most commonly-used tuberculosis (TB) test, TST, has failed to detect TB in HIV positive pregnant women. A research published online in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine has revealed that the TB test failed to accurately diagnose the...

Most commonly used TB test fails to accurately diagnose pregnant, HIV-positive women

Post Date: 
2016-01-25
Source: 
Infection Control Today
New research finds that the most commonly used test for tuberculosis fails to accurately diagnose TB in up to 50 percent of pregnant women who are HIV positive. The research published early online in the American Thoracic Society’s American Journal of Respiratory and Critical Care Medicine is...

BJGMC Clinical Research Site Observes World AIDS Day

Post Date: 
2015-12-14
Pune, India—To mark the struggle of those living with HIV and in commemoration of those who have lost their lives, the Clinical Research Site at Byramjee Jeejeebhoy Government Medical College (BJGMC CRS) participated in the National AIDS Trust’s World AIDS Day . Each year on December 1, events are...

CCGHE At The Union 2015

Post Date: 
2015-11-30
JOHNS HOPKINS CENTER FOR CLINICAL GLOBAL HEALTH EDUCATION AT THE UNION DECEMBER 2- 6 2015 | CAPE TOWN, SOUTH AFRICA Congratulations, Fogarty Fellows & Ujala Scholars! Dr. Anita Basavaraj, Ms. Jessica Elf, Dr. Sunita Girish, Dr. Nikhil Gupte, Dr. Aarti Kinikar, Dr. Rahul Lokhande, Dr. Jyoti...

Amid international growth, emocha gets grant to look at Maryland TB treatment

Post Date: 
2015-11-23
Source: 
Technical.ly Baltimore
emocha Mobile Health received a Small Business Innovation Research grant to further development of its mobile app that provides video-based healthcare observations in some cases where visits were previously required. The NIH grant, which is for about $200,000 over two years, will allow the Johns...

New cases of HIV in India could fall by 38% with early ART and better retention, finds study

Post Date: 
2015-10-23
Source: 
The BMJ
Starting antiretroviral therapy (ART) early in India could reduce new infections by 18% and AIDS mortality by 9%, a study has found. Better retention in care could reduce new cases by 38% over the next 20 years. The study used dynamic compartmental modelling to compare early ART initiation (at CD4...

CCGHE Faculty and Fogarty Scholars Meet with BJGMC Leadership

Post Date: 
2015-06-22
Baltimore, MD—Dr. Ajay S. Chandanwale, Dean, and other faculty leadership of Byramjee Jeejeebhoy Government Medical College (BJGMC) in Pune, India, arrived at the Johns Hopkins Medical Campus today to meet with CCGHE faculty and Fogarty Scholars who are in Baltimore attending the Hopkins Summer...

Mobile app developed by JHU grads helps monitor Ebola, tuberculosis patients

Post Date: 
2015-05-13
Source: 
The HUB at Johns Hopkins
Listening to Morad Elmi list off the recent developments at emocha Mobile Health Inc., the company he co-founded with fellow Johns Hopkins Carey Business School graduate Sebastian Seiguer, it's hard not to be impressed by the breadth and scope of the startup's work. In the past six months, the...

Ujala Foundation Recognized for Commitment to Hopkins Work in India

Post Date: 
2015-04-30
Back Row: Ashlyn Sowell, Kelly Dooley, Jessica Elf, Rupak Shivakoti, Natasha Chida, Akshay Gupte, Jyoti Mathad, Leslie Bernard. Front Row: Molly Bowen, Bob Bollinger, Kamla Gupta, Raj Gupta, Amita Gupta, Jane McKenzie-White Photography: Jon Cristofersen Baltimore, MD—On April 30, 2015, the Ujala...

Uniting mobile, education and pharma to combat HIV

Post Date: 
2015-04-07
Source: 
Healthcare Innovation
Health Innovation talks to Kris Sterkens, Company Group Chairman, Janssen Asia Pacific, about the TAMA project, as well as about some of the changes he has seen in the pharmaceutical industry because of IT and mobile.

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