Research News

Zika Surveillance Among Pregnant Women in India

India leads the world in dengue cases. CCGHE researchers are keeping an eye on Zika among pregnant women, which is transmitted by the same mosquito & can cause devastating birth defects.

Sepsis among newborns in the neonatal intensive care unit (NICU) is a big problem in India, and a complex one to untangle.

Clinical Research

We work with scientists and practitioners around the world to conduct clinical trials and observational studies that improve prevention and treatment of many grave health issues affecting resource-limited regions, including HIV and tuberculosis.
 
We have formal research partnerships with the following institutions:
 
 

Activism on rifapentine pricing: removing cost barriers to improve the uptake of tuberculosis research innovations

Post Date: 
2014-12-21
Publication: 
Public Health Action
As recent advances have been made in developing tools to fight tuberculosis (TB), there is also a trend towards increasing advocacy by the civil society for TB research and access. One recent successful effort to increase access to treatment options for TB involved a collaborative effort to...

Is CD4 monitoring needed among Ugandan clients achieving a virologic and immunologic response to treatment?

Post Date: 
2014-11-15
Publication: 
AIDS Patient Care and STDs
Country: 
It is unclear whether ongoing CD4 monitoring is needed following immunologic and virologic response to antiretroviral therapy (ART). We investigated the proportion of clients who achieved a virologic and immunologic response and then had a subsequent CD4 count <200 cells/μL despite continued...

Pre-antiretroviral therapy selenium status predicts WHO stages 3, 4 or death but not virologic failure post-antiretroviral therapy

Post Date: 
2014-11-13
Publication: 
Nutrients
A case-cohort study, within a multi-country trial of antiretroviral therapy (ART) efficacy (Prospective Evaluation of Antiretrovirals in Resource Limited Settings (PEARLS)), was conducted to determine if pre-ART serum selenium deficiency is independently associated with human immunodeficiency virus...

Complications of tuberculosis

Post Date: 
2014-10-15
Publication: 
Current Opinion in Infectious Diseases
Purpose of review : Diagnosis and management of tuberculosis (TB) remains challenging and complex because of the heterogeneity of disease presentations. Despite effective treatment, TB disease can lead to significant short-and long-term health consequences. We review potential acute and chronic...

High proportion of indeterminate QuantiFERON-TB Gold In-Tube results in an inpatient population are related to host factors and pre-analytical steps

Post Date: 
2014-09-19
Publication: 
Open Forum Infectious Diseases
Country: 
Background: QuantiFERON-TB Gold In-Tube test (QFT-GIT) can be used as an alternative to tuberculin skin testing (TST) for the targeted testing of latent tuberculosis. Due to many shortcomings with TST, QFT-GIT usage is increasing. QFT-GIT implementation in the inpatient setting remains unclear...

Source case investigation for children with TB disease in Pune, India

Post Date: 
2014-08-27
Publication: 
Tuberculosis Research and Treatment
Country: 
Setting. Contact tracing is broadly encouraged for tuberculosis (TB) control. In many high-burden countries, however, little effort is made to identify contacts of newly diagnosed TB patients. This failure puts children, many of whom live in poor crowded communities, at special risk. Objectives. To...

Economic challenges associated with tuberculosis diagnostic development

Post Date: 
2014-08-15
Publication: 
Expert Review of Pharmacoeconomics and Outcomes Research
Tuberculosis remains a global health crisis in part due to underdiagnosis. Technological innovations are needed to improve diagnostic test accuracy and reduce the reliance on expensive laboratory infrastructure. However, there are significant economic challenges impeding the development and...

Editorial commentary: Xpert MTB/RIF testing for individuals with presumed tuberculosis: implications for infection control and rapid tuberculosis detection in the United States.

Post Date: 
2014-08-04
Publication: 
Clinical Infectious Diseases
Country: 
Despite recent declines in incidence, tuberculosis remains a significant public health problem in the United States, with almost 10 000 new cases each year. As the disease becomes less common in the United States, diagnostic delays occur because of diverse clinical presentations and suboptimal...

Cell phone utilization among foreign-born latinos: a promising tool for dissemination of health and HIV information

Post Date: 
2014-08-01
Publication: 
Journal of Immigrant and Minority Health
Country: 
Latinos in the U.S. are disproportionately affected by HIV and are at risk for late presentation to care. Between June 2011 and January 2012, we conducted a cross-sectional survey of 209 Baltimore Latinos at community-based venues to evaluate the feasibility of using communication technology (ICT)-...

Impact of maternal hepatitis B virus coinfection on mother-to-child transmission of HIV

Post Date: 
2014-07-15
Publication: 
HIV Medicine
Country: 
Objectives: Despite high hepatitis B virus (HBV) endemicity in various resource-limited settings (RLSs), the impact of maternal HIV/HBV coinfection on infant health outcomes has not been defined. We aimed to assess the prevalence of HBV coinfection among HIV-infected pregnant women and its impact...

25-Hydroxyvitamin D insufficiency and deficiency is associated with HIV disease progression and virological failure post-antiretroviral therapy initiation in diverse multinational settings

Post Date: 
2014-07-15
Publication: 
The Journal of Infectious Diseases
Background: Low 25-hydroxyvitamin D (25(OH)D) has been associated with increased HIV mortality, but prospective studies assessing treatment outcomes after combination antiretroviral therapy (cART) initiation in resource-limited settings are lacking. Methods: A case-cohort study (N = 411) was nested...

Blood stream infections

Post Date: 
2014-07-01
Publication: 
BioMed Research International
Blood stream infection (BSI) is one of the most devastating preventable complications in Critical Care Units. It has far-reaching consequences resulting in prolonged length of hospital-stay, high costs to the individual and exchequer, and, in many instances, loss of life. Although exact rates of...

Diagnostic accuracy of a rapid urine lipoarabinomannan test for tuberculosis in HIV-infected adults

Post Date: 
2014-07-01
Publication: 
Journal of Acquired Immune Deficiency Syndromes
Objective : In settings of high HIV prevalence, tuberculosis control and patient management are hindered by lack of accurate, rapid tuberculosis diagnostic tests that can be performed at point-of-care. The Determine TB LAM Ag (TB LAM) test is a lateral flow immunochromatographic test for detection...

Optimisation of the Medical Education Partnership Initiative to address African health-care challenges

Post Date: 
2014-06-25
Publication: 
The Lancet Global Health
Country: 
The Medical Education Partnership Initiative (MEPI) is an innovative and potentially transformative 5-year programme, established by the US Government in 2010, to increase the number of doctors to meet crucial human resource needs in sub-Saharan Africa.1 MEPI allows African institutions that are...

Challenges to disclosure of HIV status to perinatally infected children: a study of caregiver perspectives in Pune, India

Post Date: 
2014-06-15
Publication: 
Journal of Pediatric Infectious Diseases
Country: 
Effective guidelines around disclosure of HIV status are lacking and limited data from India reveal low rates of HIV disclosure to perinatally infected children. This study, conducted in Pune, India, attempts to understand the experiences of caregivers of perinatally infected children around the...

Comparative performance of urinary lipoarabinomannan assays and Xpert MTB/RIF in HIV-infected individuals

Post Date: 
2014-06-01
Publication: 
AIDS
Country: 
Background : Xpert MTB/RIF ('Xpert') and urinary lipoarabinomannan (LAM) assays offer rapid tuberculosis (TB) diagnosis, but have suboptimal sensitivity when used individually in HIV-positive patients. The yield of these tests used in combination for the diagnosis of active TB among HIV-infected TB...

Taking the long view on CREATE studies' finding

Post Date: 
2014-05-15
Publication: 
The Lancet Infectious Disease
In the past 10 years, the Consortium to Respond Effectively to the AIDS TB Epidemic (CREATE) has done three large trials exploring new strategies to control HIV-related tuberculosis. Recognising that the global strategy for tuberculosis control of a decade ago (mainly directly observed short-course...

Socioeconomic determinants of mortality in HIV: evidence from a clinical cohort in Uganda

Post Date: 
2014-05-15
Publication: 
Journal of Acquired Immune Deficiency Syndromes
Country: 
Objective: To delineate the association between baseline socioeconomic status (SES) indicators and mortality and lost to follow-up (LTFU) in a cohort of HIV-infected individuals enrolled in antiretroviral therapy (ART) in urban Uganda. Design: Retrospective cohort study nested in an antiretroviral...

Gender-related barriers and delays in accessing tuberculosis diagnostic and treatment services - Part 2: a systematic review of qualitative studies

Post Date: 
2014-05-11
Publication: 
Tuberculosis Research and Treatment
Background: Tuberculosis (TB) remains a significant global public health problem with known gender-related (male versus female) disparities. We reviewed the qualitative evidence (written/spoken narrative) for gender-related differences limiting TB service access from symptom onset to treatment...

Barriers and delays in tuberculosis diagnosis and treatment services: does gender matter

Post Date: 
2014-04-28
Publication: 
Tuberculosis Research and Treatment
Background: Tuberculosis (TB) remains a global public health problem with known gender-related disparities. We reviewed the quantitative evidence for gender-related differences in accessing TB services from symptom onset to treatment initiation. Methods: Following a systematic review process, we:...

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Risk Factors for Unfavorable Treatment Outcomes in DOTs-treated Pediatric TB Patients

Post Date: 
2015-12-04
Presentation Location: 
Cape Town, South Africa
Country: 
Event & Convener: 
The 46th Union World Conference on Lung Health
Poster Discussion. Session: TB in Children: Epidemiology–I. Authors: Shelke S, Bollinger R, Chandanwale A, DeLuca A, Gupta A, Gupte N, Adhav PS, Kadam DB.

Utility of GeneXpert for Diagnosis of Rifampicin-resistant Extra-pulmonary TB—A Retrospective Review of 70 Cases, SGH, Pune, India

Post Date: 
2015-12-04
Presentation Location: 
Cape Town, South Africa
Country: 
Event & Convener: 
The 46th Union World Conference on Lung Health
Poster Session. TB Diagnostic Challenges: Molecular and Other Techniques. Authors: Girish S, Dharmashle S, Desai S, Kagal A, Bharadwaj R, Chandanwale A, Lokhande R, Kadam DB, DeLuca A, Gupte N, Jain D, Gupta A, Bollinger R, Mave V.

Maternal and Infant TB: Advancing Our Understanding of Pathogenesis, Treatment and Prevention

Post Date: 
2015-12-04
Presentation Location: 
Cape Town, South Africa
Event & Convener: 
The 46th Union World Conference on Lung Health
Symposium: Maternal and Infant TB: Advancing Our Understanding of Pathogenesis, Treatment and Prevention. Session Coordinators: Mathad J, Bekker A.

TB/HIV Treatment during Pregnancy: Does Drug Metabolism Change?

Post Date: 
2015-12-04
Presentation Location: 
Cape Town, South Africa
Event & Convener: 
The 46th Union World Conference on Lung Health
Symposium. Maternal and Infant TB: Advancing Our Understanding of Pathogenesis, Treatment and Prevention. Dooley K, Savic R.

Current Research on the Pathophysiology, Immunology, Prevention and Treatment of TB in Pregnant Women

Post Date: 
2015-12-04
Presentation Location: 
Cape Town, South Africa
Event & Convener: 
The 46th Union World Conference on Lung Health
Symposium. Maternal and Infant TB: Advancing Our Understanding of Pathogenesis, Treatment and Prevention. Moderators: Gupta A, Mathad J.

Applied HIV Epidemiology and Implementation Science: a multidisciplinary approach to understanding and controlling an evolving epidemic

Post Date: 
2015-11-20
Presentation Location: 
Bethesda, MD
Event & Convener: 
National Institutes of Health
Invited speaker

Isoniazid Concentration in Hair among Children with Tuberculosis

Post Date: 
2015-11-15
Presentation Location: 
Seattle, WA
Event & Convener: 
Annual Meeting, Center for AIDS Research
Presentation

BJMC-JHU Research Program

Post Date: 
2015-10-31
Presentation Location: 
Bangkok, Thailand
Event & Convener: 
TreatAsia Network Meeting
Presentation

Rakai Health Sciences Program: Social, Behavioral, and Biomedical Research in HIV Dynamics, Prevention, and Care

Post Date: 
2015-10-30
Presentation Location: 
Baltimore, MD
Country: 
Event & Convener: 
CFAR National Social and Behavioral Sciences Research Network Annual Meeting
Presentation

mHealth

Post Date: 
2015-10-29
Presentation Location: 
Baltimore, MD
Event & Convener: 
CFAR National Social and Behavioral Sciences Research Network Annual Meeting
Presentation

Operational Challenges Undermine WHO TB Symptom Screen in Pregnant Women

Post Date: 
2015-10-11
Presentation Location: 
San Diego, CA
Event & Convener: 
ID Week 2015
Poster Session: Latent TB Infection: Diagnosis and Treatment. Vaidya A , Tambe S, Bhosale R, Mave V, Elf J, Pradhan N, Nevrekar N, Patil S, Kagal A, Joshi S, Chandanwale A, Gupta A, Mathad J.

Developing a Validated Tool to Assess Internal Medicine and Infectious Disease Trainees’ Ability to Obtain and Interpret TB Diagnostics

Post Date: 
2015-10-11
Presentation Location: 
San Diego, CA
Event & Convener: 
ID Week 2015
Presentation. Chida N, Gupta A, Bollinger B, Melia M.

Dengue and Malaria are Common Infections among Adults and Adolescents Hospitalized with Acute Febrile Illness in Western India

Post Date: 
2015-10-09
Presentation Location: 
San Diego, CA
Country: 
Event & Convener: 
Infectious Diseases Society of America. ID Week 2015.
Poster Session: Student and Resident Poster Gallery during Posters in the Park. Mave V, Kadam D, Bharadwaj R, Kagal A, Sachs J, Raichur P, Kanade S, Gupte N, Joshi S, Chandanwale A, Zenilman JM, Bollinger R, Gupta A.

A Man from Central America with Progressive Shortness of Breath

Post Date: 
2015-10-07
Presentation Location: 
San Diego, CA
Event & Convener: 
ID Week 2015
Case Report. Fellows' Day Workshop.

TB and Women

Post Date: 
2015-09-29
Presentation Location: 
Rehoboth, DE
Event & Convener: 
Mid Atlantic TB Intensive Workshop
Presentation

Conducting HIV and TB Research in India: Challenges and Opportunities

Post Date: 
2015-08-27
Presentation Location: 
Atlanta, GA
Country: 
Event & Convener: 
Emory University
Presentation

Tuberculosis in Pregnant Women and Infants

Post Date: 
2015-08-26
Presentation Location: 
Atlanta, GA
Event & Convener: 
International Conference on Emerging Infectious Diseases
Presentation

Tuberculosis in Peripartum Women and Infants

Post Date: 
2015-08-26
Presentation Location: 
Atlanta, GA
Event & Convener: 
International Conference on Emerging Infectious Diseases
Presentation

Tuberculosis in Pregnant Women and Infants

Post Date: 
2015-08-25
Presentation Location: 
Atlanta, GA
Event & Convener: 
US Centers for Disease Control and Prevention
Presentation

Global Teaching of Global Health Competencies for Medical Students in Uganda

Post Date: 
2015-07-15
Presentation Location: 
Harare, Zimbabwe
Country: 
Event & Convener: 
Medical Education Partnership Initiative (MEPI) Innovation Session
Presentation

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