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Study shows success with TB therapy observation conducted via video instead of via in-person clinic visits.

Children in Maharashtra India

Trials: Evidence for TB treatment in kids is largely based on adult studies. The SHINE study aims to fix this

Clinical Research

Leadership
Dr. Amita Gupta of Johns Hopkins is Principal Investigator for the Indo-JHU Clinical Research Partnership based out of CCGHE. Research is directed locally in India out of the BJGMC-JHU Clinical Research Site by Dr. Vidya Mave, a Hopkins faculty member who lives in Pune. Dr. Nikhil Gupte is the Lead Biostatistician and Deputy Director and Dr. Nishi Suryavanshi is Clinical Site Coordinator and Deputy Director. Research is conducted in collaboration with the following institutions:
 
 

Technology-enhanced Peer Navigation to Improve Injection Drug User (IDU) Engagement in HIV Care

Post Date: 
2000-01-01
Country: 
This study is evaluating an mHealth-enhanced peer navigation intervention for improving retention-in-care and adherence to antiretroviral therapy (ART) for out-of-care, HIV-infected injection drug users (IDUs). The CCGHE-developed emocha® is assisting peer navigators (former IDUs successfully...

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Efavirenz pharmacokinetics in HIV-infected persons receiving rifapentine and isoniazid for tuberculosis prevention

Post Date: 
2015-06-16
Publication: 
Clinical Infectious Diseases
Background: Concomitant use of rifamycins to treat or prevent tuberculosis can result in subtherapeutic concentrations of antiretroviral drugs. We studied the interaction of efavirenz with daily rifapentine and isoniazid in human immunodeficiency virus (HIV)-infected individuals receiving a 4-week...

Impact of patient-selected care buddies on adherence to HIV care, disease progression and conduct of daily life among pre-antiretroviral HIV-infected patients in Rakai, Uganda: a randomized controlled trial

Post Date: 
2015-06-01
Publication: 
Journal of Acquired Immune Deficiency Syndromes
Country: 
Background: Data are limited on effects of household or community support persons ("care buddies") on enrollment into and adherence to pre-antiretroviral HIV care. We assessed the impact of care buddies on adherence to HIV clinic appointments, HIV progression, and conduct of daily life among pre-...

Utilizing mHealth methods to identify patterns of high risk illicit drug use

Post Date: 
2015-06-01
Publication: 
Drug and Alcohol Dependence
Country: 
Introduction: We assessed patterns of illicit drug use using mobile health (mHealth) methods and subsequent health care indicators among drug users in Baltimore, MD. Methods: Participants of the EXposure Assessment in Current Time (EXACT) study were provided a mobile device for assessment of their...

Durable suppression of HIV-1 after virologic monitoring-based antiretroviral adherence counseling in Rakai, Uganda

Post Date: 
2015-05-26
Publication: 
PLOS One
Country: 
Objectives: HIV viral load is recommended for monitoring antiretroviral treatment and identifying treatment failure. We assessed the durability of viral suppression after viral load-triggered adherence counseling among patients with HIV viremia 6 months after ART initiation. Design: Observational...

Neisseria gonorrhoeae and Chlamydia trachomatis among women reporting extragenital exposures

Post Date: 
2015-05-15
Publication: 
Sexually Transmitted Diseases
Country: 
Background: The Centers for Disease Control and Prevention recommends pharyngeal screening of Neisseria gonorrhoeae (GC) and rectal screening of GC and Chlamydia trachomatis (CT) in HIV-infected and at-risk men who have sex with men (MSM). There are currently no recommendations to routinely screen...

Dengue and chikungunya co-infection associated with more severe clinical disease than mono-infection

Post Date: 
2015-04-15
Publication: 
International Journal of Healthcare and Biomedical Research
Country: 
Background: Dengue and chikungunya infections appear to be increasing in India. While Aedies aegypti is the transmitting vector for both viruses and co-infection occurs in the same communities, studies on the clinical significance of co-infection are limited. Materials and Methods: We conducted a...

Availability and distribution of safe abortion services in rural areas: a facility assessment study in Madhya Pradesh, India

Post Date: 
2015-03-20
Publication: 
Global Health Action
Country: 
Abstract Background: Unsafe abortion contributes to a significant portion of maternal mortality in India. Access to safe abortion care is known to reduce maternal mortality. Availability and distribution of abortion care facilities can influence women's access to these services, especially in rural...

Vitamin D deficiency and risk of postpartum tuberculosis among HIV-infected breastfeeding mothers in India

Post Date: 
2015-03-15
Publication: 
International Journal of Tuberculosis and Lung Disease
Country: 
Some studies have associated low vitamin D levels with the risk of tuberculosis (TB), but its association in human immunodeficiency virus (HIV) infected mothers in a TB-endemic region has not been well studied. We conducted a nested 1:2 case-control study among HIV-infected mothers in western India...

What tuberculosis means for maternal health

Post Date: 
2015-03-04
Mrs. Kumar [not her real name] was diagnosed with TB 18 years ago, during her first pregnancy, which ended in miscarriage. She then became depressed and side effects from the TB medications caused her difficulty eating. Three years later, during her second pregnancy, she and her husband were...

Capturing illicit drug use where and when it happens: an ecologic momentary assessment of the social, physical and activity environment of using versus craving illicit drugs

Post Date: 
2015-02-15
Publication: 
Addiction
Country: 
Aim: To understand the environmental and contextual influences of illicit cocaine and heroin use and craving using mobile health (mHealth) methods. Design: Interactive mHealth methods of ecological momentary assessment (EMA) were utilized in the Exposure Assessment in Current Time (EXACT) study to...

Analysis of latent tuberculosis infection treatment adherence among refugees and other patient groups referred to the Baltimore City Health Department TB clinic

Post Date: 
2015-02-15
Publication: 
Journal of Immigrant and Minority Health
Country: 
We sought to determine the proportion of refugee patients at the Baltimore City Health Department Tuberculosis program (BCHD-TB) successfully completing latent tuberculosis infection (LTBI) treatment, as compared to other referral groups, and to identify factors associated with treatment completion...

Predictors and outcomes of mycobacteremia among HIV-infected smear- negative presumptive tuberculosis patients in Uganda

Post Date: 
2015-02-15
Publication: 
BMC Infectious Diseases
Country: 
Background : Sputum smear microscopy for tuberculosis (TB) diagnosis lacks sensitivity in HIV-infected symptomatic patients and increases the likelihood that mycobacterial infections particularly disseminated TB will be missed; delays in diagnosis can be fatal. Given the duration for MTB growth in...

Implementing a large scale systematic tuberculosis screening program in correctional facilities in South Africa

Post Date: 
2015-01-08
Publication: 
Open Forum Infectious Diseases
Country: 
Background : Tuberculosis (TB) prevalence is high in correctional facilities in southern Africa. With support from local South African nongovernmental organizations, the South African Department of Correctional Services initiated a program of systematically screening newly admitted and current...

Activism on rifapentine pricing: removing cost barriers to improve the uptake of tuberculosis research innovations

Post Date: 
2014-12-21
Publication: 
Public Health Action
As recent advances have been made in developing tools to fight tuberculosis (TB), there is also a trend towards increasing advocacy by the civil society for TB research and access. One recent successful effort to increase access to treatment options for TB involved a collaborative effort to...

Inequalities in institutional delivery uptake and maternal mortality reduction in the context of cash incentive program, Janani Suraksha Yojana: Results from nine states in India

Post Date: 
2014-12-15
Publication: 
Social Science and Medicine
Country: 
Abstract Proportion of women giving birth in health institutions has increased sharply in India since the introduction of cash incentive program, Janani Suraksha Yojana (JSY) in 2005. JSY was intended to benefit disadvantaged population who had poor access to institutional care for childbirth and...

Is CD4 monitoring needed among Ugandan clients achieving a virologic and immunologic response to treatment?

Post Date: 
2014-11-15
Publication: 
AIDS Patient Care and STDs
Country: 
It is unclear whether ongoing CD4 monitoring is needed following immunologic and virologic response to antiretroviral therapy (ART). We investigated the proportion of clients who achieved a virologic and immunologic response and then had a subsequent CD4 count <200 cells/μL despite continued...

Pre-antiretroviral therapy selenium status predicts WHO stages 3, 4 or death but not virologic failure post-antiretroviral therapy

Post Date: 
2014-11-13
Publication: 
Nutrients
A case-cohort study, within a multi-country trial of antiretroviral therapy (ART) efficacy (Prospective Evaluation of Antiretrovirals in Resource Limited Settings (PEARLS)), was conducted to determine if pre-ART serum selenium deficiency is independently associated with human immunodeficiency virus...

Complications of tuberculosis

Post Date: 
2014-10-15
Publication: 
Current Opinion in Infectious Diseases
Purpose of review : Diagnosis and management of tuberculosis (TB) remains challenging and complex because of the heterogeneity of disease presentations. Despite effective treatment, TB disease can lead to significant short-and long-term health consequences. We review potential acute and chronic...

High proportion of indeterminate QuantiFERON-TB Gold In-Tube results in an inpatient population are related to host factors and pre-analytical steps

Post Date: 
2014-09-19
Publication: 
Open Forum Infectious Diseases
Country: 
Background: QuantiFERON-TB Gold In-Tube test (QFT-GIT) can be used as an alternative to tuberculin skin testing (TST) for the targeted testing of latent tuberculosis. Due to many shortcomings with TST, QFT-GIT usage is increasing. QFT-GIT implementation in the inpatient setting remains unclear...

Source case investigation for children with TB disease in Pune, India

Post Date: 
2014-08-27
Publication: 
Tuberculosis Research and Treatment
Country: 
Setting. Contact tracing is broadly encouraged for tuberculosis (TB) control. In many high-burden countries, however, little effort is made to identify contacts of newly diagnosed TB patients. This failure puts children, many of whom live in poor crowded communities, at special risk. Objectives. To...

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Utility of GeneXpert for Diagnosis of Rifampicin-resistant Extra-pulmonary TB—A Retrospective Review of 70 Cases, SGH, Pune, India

Post Date: 
2015-12-04
Presentation Location: 
Cape Town, South Africa
Country: 
Event & Convener: 
The 46th Union World Conference on Lung Health
Poster Session. TB Diagnostic Challenges: Molecular and Other Techniques. Authors: Girish S, Dharmashle S, Desai S, Kagal A, Bharadwaj R, Chandanwale A, Lokhande R, Kadam DB, DeLuca A, Gupte N, Jain D, Gupta A, Bollinger R, Mave V.

Maternal and Infant TB: Advancing Our Understanding of Pathogenesis, Treatment and Prevention

Post Date: 
2015-12-04
Presentation Location: 
Cape Town, South Africa
Event & Convener: 
The 46th Union World Conference on Lung Health
Symposium: Maternal and Infant TB: Advancing Our Understanding of Pathogenesis, Treatment and Prevention. Session Coordinators: Mathad J, Bekker A.

TB/HIV Treatment during Pregnancy: Does Drug Metabolism Change?

Post Date: 
2015-12-04
Presentation Location: 
Cape Town, South Africa
Event & Convener: 
The 46th Union World Conference on Lung Health
Symposium. Maternal and Infant TB: Advancing Our Understanding of Pathogenesis, Treatment and Prevention. Dooley K, Savic R.

Current Research on the Pathophysiology, Immunology, Prevention and Treatment of TB in Pregnant Women

Post Date: 
2015-12-04
Presentation Location: 
Cape Town, South Africa
Event & Convener: 
The 46th Union World Conference on Lung Health
Symposium. Maternal and Infant TB: Advancing Our Understanding of Pathogenesis, Treatment and Prevention. Moderators: Gupta A, Mathad J.

Current Research on the Pathophysiology, Immunology, Prevention and Treatment of TB in Pregnant Women

Post Date: 
2015-12-04
Presentation Location: 
Capetown, South Africa
Event & Convener: 
International Union for Tuberculosis and Lung Disease. 46th Union World Conference on Lung Health.
Symposium: Maternal and Infant TB: Advancing our Understanding of Pathogenesis, Treatment and Prevention.

Impact of Rifapentine Price Reduction on Utilization for TB Treatment in the United States

Post Date: 
2015-12-04
Presentation Location: 
Cape Town, South Africa
Country: 
Event & Convener: 
The 46th Union World Conference on Lung Health

Characteristics Associated with Mobile Phone Access among TB Patients in Pune, India

Post Date: 
2015-12-04
Presentation Location: 
Cape Town, South Africa
Country: 
Event & Convener: 
The 46th Union World Conference on Lung Health
Poster Discussion. Session: What's App Doc? Use of m-Health. Authors: Ogale YP, Elf J, Lokhande R, Mave V, Roy S, Gupta A, Golub J, Mathad J.

Risk Factors for Unfavorable Treatment Outcomes in DOTs-treated Pediatric TB Patients

Post Date: 
2015-12-04
Presentation Location: 
Cape Town, South Africa
Country: 
Event & Convener: 
The 46th Union World Conference on Lung Health
Poster Discussion. Session: TB in Children: Epidemiology–I. Authors: Shelke S, Bollinger R, Chandanwale A, DeLuca A, Gupta A, Gupte N, Adhav PS, Kadam DB.

Applied HIV Epidemiology and Implementation Science: a multidisciplinary approach to understanding and controlling an evolving epidemic

Post Date: 
2015-11-20
Presentation Location: 
Bethesda, MD
Event & Convener: 
National Institutes of Health
Invited speaker

Isoniazid Concentration in Hair among Children with Tuberculosis

Post Date: 
2015-11-15
Presentation Location: 
Seattle, WA
Event & Convener: 
Annual Meeting, Center for AIDS Research
Presentation

BJMC-JHU Research Program

Post Date: 
2015-10-31
Presentation Location: 
Bangkok, Thailand
Event & Convener: 
TreatAsia Network Meeting
Presentation

Rakai Health Sciences Program: Social, Behavioral, and Biomedical Research in HIV Dynamics, Prevention, and Care

Post Date: 
2015-10-30
Presentation Location: 
Baltimore, MD
Country: 
Event & Convener: 
CFAR National Social and Behavioral Sciences Research Network Annual Meeting
Presentation

mHealth

Post Date: 
2015-10-29
Presentation Location: 
Baltimore, MD
Event & Convener: 
CFAR National Social and Behavioral Sciences Research Network Annual Meeting
Presentation

Does Quality of Delivery Care Differ Between Public and Private Facilities in Madhya Pradesh, India?: An Exit Interview Study of Routine Delivery Care Practices

Post Date: 
2015-10-20
Presentation Location: 
Mexico City, Mexico
Country: 
Event & Convener: 
Global Maternal Newborn Health Conference 2015
Abstract Presentation. Chaturvedi C, Randive B , Sabde Y, Diwan V, Raven J, De Costa A.

Operational Challenges Undermine WHO TB Symptom Screen in Pregnant Women

Post Date: 
2015-10-11
Presentation Location: 
San Diego, CA
Event & Convener: 
ID Week 2015
Poster Session: Latent TB Infection: Diagnosis and Treatment. Vaidya A , Tambe S, Bhosale R, Mave V, Elf J, Pradhan N, Nevrekar N, Patil S, Kagal A, Joshi S, Chandanwale A, Gupta A, Mathad J.

Developing a Validated Tool to Assess Internal Medicine and Infectious Disease Trainees’ Ability to Obtain and Interpret TB Diagnostics

Post Date: 
2015-10-11
Presentation Location: 
San Diego, CA
Event & Convener: 
ID Week 2015
Presentation. Chida N, Gupta A, Bollinger B, Melia M.

Dengue and Malaria are Common Infections among Adults and Adolescents Hospitalized with Acute Febrile Illness in Western India

Post Date: 
2015-10-09
Presentation Location: 
San Diego, CA
Country: 
Event & Convener: 
Infectious Diseases Society of America. ID Week 2015.
Poster Session: Student and Resident Poster Gallery during Posters in the Park. Mave V, Kadam D, Bharadwaj R, Kagal A, Sachs J, Raichur P, Kanade S, Gupte N, Joshi S, Chandanwale A, Zenilman JM, Bollinger R, Gupta A.

A Man from Central America with Progressive Shortness of Breath

Post Date: 
2015-10-07
Presentation Location: 
San Diego, CA
Event & Convener: 
ID Week 2015
Case Report. Fellows' Day Workshop.

TB and Women

Post Date: 
2015-09-29
Presentation Location: 
Rehoboth, DE
Event & Convener: 
Mid Atlantic TB Intensive Workshop
Presentation

Conducting HIV and TB Research in India: Challenges and Opportunities

Post Date: 
2015-08-27
Presentation Location: 
Atlanta, GA
Country: 
Event & Convener: 
Emory University
Presentation

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