Research News

ClinInf

We assessed multidrug-resistant tuberculosis (MDR-TB) cases and their household contacts (HHCs) to inform the development of an interventional clinical trial.

Tuberculosis, Gestational Diabetes, and HIV graphic

IJTLD article reviews the epidemiology and immunology of gestational diabetes and finds there's a lot we don't know about interactions between diabetes, pregnancy, and tuberculosis in both HIV+/- women

Clinical Research

Leadership
Dr. Amita Gupta of Johns Hopkins is Principal Investigator for the Indo-JHU Clinical Research Partnership based out of CCGHE. Research is directed locally in India out of the BJGMC-JHU Clinical Research Site by Dr. Vidya Mave, a Hopkins faculty member who lives in Pune. Dr. Nikhil Gupte is the Lead Biostatistician and Deputy Director and Dr. Nishi Suryavanshi is Clinical Site Coordinator and Deputy Director. Research is conducted in collaboration with the following institutions:
 
 

Community Home Based India Prevention of Mother to Child Transmission of HIV (COMBIND)

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2013-09-02
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CCGHE is assessing whether equipping Community Health Workers with mobile health technology and involving them in technology training and personal empowerment seminars can help prevent mother-to-child transmission of HIV. CHWs who care for HIV + pregnant and nursing women are using the emocha...

Impact of Diabetes on TB Treatment Outcomes

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2013-02-01
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CCGHE, the JHU Center for TB Research and BJGMC have been awarded a $2.5 million dollar NIH grant (2013-2018) to conduct a study to evaluate treatment outcomes among Indian patients with both diabetes mellitus and active TB. This study is assessing the prevalence of impaired glucose or frank...

Bacterial Antimicrobial Resistance Patterns in Pune, India

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2013-01-10
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Evaluate etiology of acute fever and bacterial drug resistance patterns among adults and children in India.

Feasibility and Acceptability of Smartphone-Based Ecological Momentary Assessment of Alcohol Use Among African American Men Who Have Sex With Men in Baltimore

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2013-01-01
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This study provides evidence to support the feasibility and acceptability of using Ecological Momentary Assessment (EMA ) methods for collecting data on alcohol use among African American men who have sex with men living in urban settings. These data provide the basis for future studies of EMA-...

ONCOGRID: An mHealth Approach to Prevention and Early Diagnosis of Oral Cancer in Rural South India

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2012-11-01
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This study ended February 7, 2017. The Indian sub-continent is burdened with 80% of the world’s patients with oral cancer, and delay in oral cancer diagnosis is one of the major problems that leads to poor treatment outcomes (V. Shanta, R. Swaminathan, R. Rama. Cancer Control 2013). Current...

Project Connect Baltimore: Connecting Young Males to Sexual/Reproductive Healthcare

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2012-10-01
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To design, implement and evaluate a male-friendly and culturally appropriate guide for increasing access to and use of human immunodeficiency virus (HIV)/sexually transmitted disease (STD) testing and sexual/reproductive healthcare (SRHC) among African American and Latino males.

Diagnosis of Active Tuberculosis in HIV-infected and Uninfected Young Children in India

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2012-07-24
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Tuberculosis (TB) is the most common cause of morbidity/mortality in HIV-infected individuals in India. India has the world's highest burden of HIV and TB, and since children acquire HIV/TB from their caregivers, active TB is highly prevalent (14-67.5%) among HIV-infected young children in India...

A5288: MULTIOCTAVE, Management Using the Latest Technologies in Resource-limited Settings to Optimize Combination Therapy After Viral Failure

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2012-07-16
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This is a mult-country clinical trial being conducted in Brazil, Haiti, India, Kenya, Malawi, Peru, South Africa, Thailand, Uganda, and Zambia under the AIDS Clinical Trials Group (ACTG) and funded by the U.S. National Institutes of Health. A5288 is a multi-step, open-label phase IV, prospective,...

RePORT India

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2012-06-30
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RePORT India is a joint venture between the Indian and US governments. The Indo-US Vaccine Action Program, a collaboration between the Indian Department of Biotechnology (DBT), the Indian Council of Medical Research (ICMR), and the US NIH, is co-funding six teams of India- and US-based...

Analysis of Data Collected from the Evaluation of Community-Based Education, Research and Service (COBERS)

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2012-06-12
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This effort ended in June 2015. Makerere University College of Health Sciences (MakCHS), the Medical Schools at Gulu University (GU), Mbarara University of Science and Technology (MUST), Kampala International University (KIU) and Busitema University (BU) came together with Johns Hopkins University...

C-TRIUMPH Pilot Study: Burden and Risk Factors for Drug-resistant Tuberculosis in Pune, India

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2012-05-29
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This pilot study ended in April 2015. Drug resistant TB (MDR-TB and XDR-TB) is increasing worldwide. Although 20% of all global TB cases occur in India, current estimates of the burden of MDR-TB in India are limited. A well-characterized TB clinical cohort, household cohort and control cohort would...

DOmestic Violence Enhanced Home Visitation and Smart Phones (DOVE)

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2012-01-01
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This effort ended in 2017. The major challenge of early prenatal nurse home visitation programs is to accurately identify abused women. The DOVE study aims to improve maternal health and increase the use of a safety plan and community resources by using an emocha ® application to assist home...

Sexually Transmitted Infections among Women in the Reproductive Age Group in Shevgaon, Ahmednagar District, Maharashtra, India

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2011-05-15
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This study was conducted in 2011. Sexually transmitted infections (STIs) constitute a significant epidemiological burden all over the world especially in middle and low income countries. Women are more vulnerable to STIs due to several biological and socio-economic reasons. Although transmission of...

A5273: Multicenter Study of Options for Second-Line Effective Combination Therapy (SELECT)

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2011-05-12
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This study was terminated May 2, 2017; it was conducted under the AIDS Clinical Trials Group (ACTG) and funded by the U.S. National Institutes of Health. This was a multinational clinical trial conducted in Brazil, India, Kenya, Malawi, Peru, South Africa, Tanzania, Thailand, and Zimbabwe. The...

Predictors of Perinatal HBV Transmission in an HIV/HBV Infected Cohort

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2011-04-22
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This study ended in 2014. Hepatitis B virus (HBV) coinfection is common; affecting greater than 10% of HIV-infected individuals in resource-limited settings(1-3). Although the impact of HIV disease on HBV coinfection has been studied in non-pregnant adults, little is known about the effects of HIV...

A5282: A Randomized, Phase II Trial to Compare an HPV Test-and-Treat Strategy to a Cytology-Based Strategy for Prevention of CIN 2+ in HIV-Infected Women

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2011-03-15
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Indo-JHU partnership work on this trial was officially terminated September 10, 2018; it was conducted under the AIDS Clinical Trials Group (ACTG) and funded by the U.S. National Institutes of Health. This multi-country trial is being conducted in Botswana, Haiti, India, Malawi, Peru, South Africa...

Course Evaluation of a Continuing Medical Education Program for Nurses and Midwives in Uganda

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2011-02-15
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This course evaluation was conducted in 2011. Hypertension presents a substantial burden on the world and Uganda is not immune to this disease. In a recent study, adults in the Rukungiri district in southwestern Uganda were shown to have a 30.5% prevalence of hypertension. (1) Hypertension needs to...

A Prospective Study Evaluating the Role of Cryptococcal Antigen Screening among HIV-infected Adults with Low CD4 Counts

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2011-01-01
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This prospective observational study aimed to evaluate the burden of cryptococcal disease among approximately 200 HIV-infected adults with low CD4 cell counts in Pune, India to determine whether a Cryptococcal screening strategy should be the standard of care among patients with advanced HIV...

Brief Venue Survey of HIV Risk Places and Use of Technology in the Baltimore Latino Population

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2010-12-14
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This study ended December 13, 2011. In the last ten years, Baltimore City has seen a doubling in the AIDS incidence rate among Latinos. This has been paralleled by a doubling of the Baltimore Latino population over the last five years. At the Baltimore City Health Department (BCHD), Latino patients...

P1073: Study of Immune Reconstitution Inflammatory Syndrome (IRIS) for International Sites Initiating Highly Active Antiretroviral Therapy (HAART) in Infants and Children < 72 Months of Age

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2010-11-15
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This study was terminated April 23, 2015. This was a multi-national study conducted in India, South Africa, and Tanzania under the International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) Network and funded by the U.S. National Institutes of Health. P1073 is a case controlled...

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Drug-resistant tuberculosis in 2017: at a crossroads

Post Date: 
2017-03-15
Publication: 
Lancet Respiratory Medicine
In The Lancet Respiratory Medicine, Dheda and colleagues present one of the most comprehensive pictures to date of the global epidemic of drug-resistant tuberculosis. This comes at a time of increasing awareness of antimicrobial resistance as a global threat, and Mycobacterium tuberculosis has had...

Chilling effect? Post-election health care use by undocumented and mixed-status families

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2017-03-08
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New England Journal of Medicine
Perspective article from Dr. Kathleen Page in the New England Journal of Medicine

Vitamin A and D deficiencies associated with incident tuberculosis in HIV-infected patients initiating antiretroviral therapy in multinational case-cohort study

Post Date: 
2017-02-06
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Journal of Acquired Immune Deficiency Syndromes
Introduction: Numerous micronutrients have immunomodulatory roles that may influence risk of tuberculosis (TB), but the association between baseline micronutrient deficiencies and incident TB after antiretroviral (ART) initiation in HIV-infected individuals is not well characterized. Methods: We...

¡Sólo se vive una vez! (you only live once): a pilot evaluation of individually tailored video modules aiming to increase HIV testing among foreign-born Latino men

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2017-02-01
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Journal of Acquired Immune Deficiency Syndromes
BACKGROUND: Although Latinos living in the United States are disproportionately affected by HIV, the development, implementation, and evaluation of HIV prevention, testing, and linkage to care interventions lag behind efforts occurring in other communities. To address sociocultural barriers to...

Tuberculosis associated with HIV infection

Post Date: 
2017-01-15
Publication: 
Microbiology Spectrum
Abstract Tuberculosis (TB) has recently surpassed HIV as the primary infectious disease killer worldwide, but the two diseases continue to display lethal synergy. The burden of TB is disproportionately borne by people living with HIV, particularly where HIV and poverty coexist. The impact of these...

Qualitative insights into implementation, processes, and outcomes of a randomized trial on peer support and HIV care engagement in Rakai, Uganda

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2017-01-10
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BMC Infectious Diseases
BACKGROUND: People living with human immunodeficiency virus (HIV) who have not yet initiated antiretroviral therapy (ART) can benefit from being engaged in care and utilizing preventive interventions. Community-based peer support may be an effective approach to promote these important HIV services...

The socioecology of sexual and reproductive health care use among young urban minority males

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2017-01-05
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Journal of Adolescent Health
Purpose: To explore perceptions of facilitators/barriers to sexual and reproductive health (SRH) care use among an urban sample of African-American and Hispanic young men aged 15-24 years, including sexual minorities. Methods: Focus groups were conducted between April 2013 and May 2014 in one mid-...

Bedaquiline

Post Date: 
2017-01-01
Publication: 
Kucers’ the Use of Antibiotics: A Clinical Review of Antibacterial, Antifungal, and Antiviral Drugs, 7th Edition
Section II, Antibiotics: Part 12 Anti-tuberculosis drugs.

Carbapenems against Mycobacterium tuberculosis: a review of the evidence

Post Date: 
2016-11-15
Publication: 
International Journal of Tuberculosis and Lung Disease
Carbapenems, a more recent β-lactam class, represent a unique anti-tuberculosis option, as emerging evidence demonstrates that they target the Mycobacterium tuberculosis cell wall and β-lactamase. This provides a potentially new agent against M. tuberculosis, in particular for multidrug-resistant (...

Tuberculosis burden in India's private sector

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2016-11-15
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The Lancet Infectious Disease
Reply to author's reply

Primary care providers knowledge, attitude and practices related to hepatitis C screening and treatment in the oral direct acting antiviral agents era

Post Date: 
2016-10-28
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Journal of Community Medicine and Health Education
Background: There are over 3 million Americans infected with hepatitis C virus (HCV). Despite recent advances in HCV treatment, a major barrier to care remains a limited number of treaters. HCV therapy provision by primary care providers (PCPs) could expand access by increasing the pool of...

Mandatory tuberculosis case notification in high tuberculosis-incidence countries: policy and practice

Post Date: 
2016-10-20
Publication: 
European Respiratory Journal
Mandatory tuberculosis (TB) notification is an important policy under the End TB Strategy, but little is known about its enforcement especially in high TB incidence countries. We undertook a literature search for selected high-incidence countries, followed by a questionnaire-based survey...

Sex-related differences in inflammatory and immune activation markers before and after combined antiretroviral therapy initiation

Post Date: 
2016-10-01
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Publication: 
Journal of Acquired Immune Deficiency Syndromes
Background: Women progress to death at the same rate as men despite lower plasma HIV RNA (viral load). We investigated sex-specific differences in immune activation and inflammation as a potential explanation. Methods: Inflammatory and immune activation markers [interferon γ, tumor necrosis factor...

Efficacy of six-week extended-dose nevirapine varies by infant birth weight with greatest relative efficacy in low birth weight infants

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2016-09-30
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PLOS One
Low birth weight (LBW), defined by the World Health Organization (WHO) as birth weight less than 2500 g, is a significant public health issue in resource-limited settings, particularly in Sub Saharan Africa and South Asia where the estimated annual incidence is 14% and 28–31%, respectively,...

HIV-related stigma among Spanish speaking Latinos in an emerging immigrant receiving city

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2016-09-27
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Journal of Immigrant and Minority Health
HIV-related stigma has been associated with a reluctance to test for HIV among Latinos . This study assessed community HIV-related stigma within an emerging Latino immigrant receiving city . We conducted a brief survey among a convenience sample of 312 Spanish - speaking Latinos in Baltimore,...

Continued importance of sexually transmitted disease clinics in the era of the Affordable Care Act

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2016-09-15
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American Journal of Preventive Medicine
Introduction: Following the 2014 expansions of Medicaid and private health insurance through the Affordable Care Act, municipal sexually transmitted disease (STD) clinics-which have historically served predominantly uninsured patients-have been threatened with budget cuts nationwide. This study was...

Lateral flow urine lipoarabinomannan assay for detecting active tuberculosis in HIV-positive adults

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2016-08-16
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Cochrane Database of Systematic Reviews
Background: Rapid detection of tuberculosis (TB) among people living with human immunodeficiency virus (HIV) is a global health priority. HIV-associated TB may have different clinical presentations and is challenging to diagnose. Conventional sputum tests have reduced sensitivity in HIV-positive...

Heterogeneity of the HIV epidemic in agrarian, trading, and fishing communities in Rakai, Uganda: an observational epidemiological study

Post Date: 
2016-08-15
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Publication: 
The Lancet HIV
Background : Understanding the extent to which HIV burden differs across communities and the drivers of local disparities is crucial for an effective and targeted HIV response. We assessed community-level variations in HIV prevalence, risk factors, and treatment and prevention service uptake in...

Community-based interventions to improve and sustain antiretroviral therapy adherence, retention in HIV care and clinical outcomes in low- and middle-income countries for achieving the UNAIDS 90-90-90 targets

Post Date: 
2016-07-30
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Publication: 
Current HIV/AIDS Reports
Little is known about the effect of community versus health facility-based interventions to improve and sustain antiretroviral therapy (ART) adherence, virologic suppression, and retention in care among HIV-infected individuals in low- and middle-income countries (LMICs). We systematically searched...

Continued elevation of interleukin-18 and interferon-γ after initiation of antiretroviral therapy and clinical failure in a diverse multicountry human immunodeficiency virus cohort

Post Date: 
2016-07-27
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Publication: 
Open Forum Infectious Diseases
Background: We assessed immune activation after antiretroviral therapy (ART) initiation to understand clinical failure in diverse settings. Methods: We performed a case-control study in ACTG Prospective Evaluation of Antiretrovirals in Resource-Limited Settings (PEARLS). Cases were defined as...

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Host Factors Associated with Poor Respiratory Health-related Quality of Life in Pulmonary Tuberculosis

Post Date: 
2016-07-17
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Gupte A , Meshram S, Selvaraju S, Gupte N, Shivakumar SVBY, Paradkar M, Kohli R, Theruvengadam K, Suryavanshi N, Chandrasekaran P, Mave V, Swaminathan S, Salvi S, Checkley, W, Golub J, Gupta A. Host Factors Associated with Poor Respiratory Health-related Quality of Life in Pulmonary Tuberculosis...

A5300/I2003: Feasibility of Identifying, Recruiting, and Characterizing Adult MDR TB Index Cases and their Adult and Child Household Contacts on Four Continents

Post Date: 
2016-07-17
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Swindells S , Kim S, Gupta A, Hesseling AC, Shah S, Johnson D, Harrington M, Suryavanshi N, Sanchez J, Dawson R, Naini L, Jones L, Hughes M, Churchyard G, for ACTG/IMPAACT. A5300/I2003: Feasibility of Identifying, Recruiting, and Characterizing Adult MDR TB Index Cases and their Adult and Child...

Prevalence of and Risk Factors for Diabetes mellitus among Pulmonary Tuberculosis Patients in Pune, India.

Post Date: 
2016-07-16
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Golub, J., Gupta, A. Prevalence of and Risk Factors for Diabetes mellitus among Pulmonary Tuberculosis Patients in Pune, India. TB2016. International AIDS Society. Durban, South Africa. 2016.

The Association of Household Air Pollution and Tuberculosis in Women and Children in Pune, India

Post Date: 
2016-06-21
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Elf, J. The Association of Household Air Pollution and Tuberculosis in Women and Children in Pune, India. 2016 Annual Meeting. Johns Hopkins Center for Tuberculosis Research. Baltimore, MD. 2016.

High Proportion of Extrapulmonary Tuberculosis in Baltimore City

Post Date: 
2016-06-21
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Chida, N. High Proportion of Extrapulmonary Tuberculosis in Baltimore City. 2016 Annual Meeting. Johns Hopkins Center for Tuberculosis Research. Baltimore, MD. 2016.

Host Factors Associated with Poor Respiratory Health-Related Quality of Life in Pulmonary TB

Post Date: 
2016-06-21
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Clinical Sites: 
Gupte, A. Host Factors Associated with Poor Respiratory Health-Related Quality of Life in Pulmonary TB. 2016 Annual Meeting. Johns Hopkins Center for Tuberculosis Research. Baltimore, MD. 2016.

Inflammation in HIV-infected Pregnant Women: Relationship with Diet, Gut Microbiome, and Preterm Birth

Post Date: 
2016-06-10
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Shivakoti, R. Inflammation in HIV-infected Pregnant Women: Relationship with Diet, Gut Microbiome, and Preterm Birth. JHU Center for AIDS Research Annual Meeting. Baltimore, MD.

Medicine as a Bridge Between the US and India

Post Date: 
2016-05-21
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Gupta, A. Medicine as a Bridge Between the US and India. Indiaspora. Philadelphia, PA.

An Overview of Protecting Households on Exposure to Newly Diagnosed Index (PHOENIx) Trial

Post Date: 
2016-05-19
Gupta, A. An Overview of Protecting Households on Exposure to Newly Diagnosed Index (PHOENIx) Trial. Johns Hopkins Center for Tuberculosis Research. Baltimore, MD.

Double Trouble: Managing and Preventing TB and HIV

Post Date: 
2016-04-20
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Gupta, A. Double Trouble: Managing and Preventing TB and HIV. DY Patil University. Pune, India.

Conducting ID Research in India and Beyond

Post Date: 
2016-03-14
Gupta, A. Conducting ID Research in India and Beyond. ID Didactic Research Forum, Johns Hopkins School of Medicine. Baltimore, MD.

Clinical, Social, and Meteorological Factors Associated with Dengue and Malaria Diagnosis in Adults in Pune, India

Post Date: 
2016-03-03
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Countries: 
Kadam D, Raichur P, Chandanwale A, Joshi S, Robinson M, Marbaniang I, Kagal A, Bharadwaj, Mave V. Clinical, Social, and Meteorological Factors Associated with Dengue and Malaria Diagnosis in Adults in Pune, India. 17th International Congress on Infectious Diseases. Hyderabad, India.

Frequent Resistant Gram Negative Rod Stool Colonization among Patients Admitted with Acute Febrile Illness in Pune, India

Post Date: 
2016-03-03
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Bharadwaj RS, Robinson M, Marbaniang I, Kagal A, Raichur PA, Kulkami V, Balasubramanian U, Onawale P, Kanade S, Nelson G, Gupta A, Mave V. Frequent Resistant Gram Negative Rod Stool Colonization among Patients Admitted with Acute Febrile Illness in Pune, India. 17th International Congress on...

High TB Risk in HIV-Positive Patients on Second line Antiretrovirals in Pune, India

Post Date: 
2016-02-24
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Countries: 
Mave V , Kadam D, Salvi S, Basavaraj A, Joshi S, Chandanwale A, Gupte N, Bollinger RC, Gupta A. High TB Risk in HIV-Positive Patients on Second line Antiretrovirals in Pune, India. Conference on Retroviruses and Opportunistic Infections 2016. Boston, MA. 2016.

Pregnancy Intensifies the IFN-gamma Suppression of HIV in TB-infected Indian Women

Post Date: 
2016-02-24
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Mathad J, Bhosale R, Balasubramanian U, Deshpande P, Kanade S, Mave V, Gupta A. Pregnancy Intensifies the IFN-gamma Suppression of HIV in TB-infected Indian Women. Conference on Retroviruses and Opportunistic Infections 2016. Boston, MA. 2016.

Combination HIV Prevention and HIV Incidence in a Ugandan Hotspot Fishing Community

Post Date: 
2016-02-23
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Countries: 
Kagaayi J, Grabowski MK, Nakigozi G, Kigozi G, Nalugoda F, Ssekubugu R, Gray RH, Serwadda D, Wawer MJ, Chang L. Combination HIV Prevention and HIV Incidence in a Ugandan Hotspot Fishing Community. Conference on Retroviruses and Opportunistic Infections 2016. Boston, MA. 2016.

Primary Care Provider Interest in Treating HCV—A Mixed Methods Study

Post Date: 
2016-02-23
Falade-Nwulia O, McAdams-Mahmoud A, Irvin R, Niculescu A, Page K, Latkin C, Mix M, Thomas D, Sulkowski M, Mehta S. Primary Care Provider Interest in Treating HCV—A Mixed Methods Study. Conference on Retroviruses and Opportunistic Infections 2016. Boston, MA. 2016.

Migration, HIV Infection, and Combination HIV Prevention Access in Rakai, Uganda

Post Date: 
2016-02-23
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Countries: 
Grabowski MK, Lessler J, Bazaale JM, Chang L, Nabukalu D, Wawer M, Nalugoda F, Ssekubugu R, Nakigozi G, Gray RH. Migration, HIV Infection, and Combination HIV Prevention Access in Rakai, Uganda. Conference on Retroviruses and Opportunistic Infections 2016. Boston, MA. 2016.

Reducing Hepatitis C Viral Load and Genotype Ordering at Johns Hopkins Hospital

Post Date: 
2016-02-01
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Countries: 
Chida N, Greenbaum A, Tuddenham S, Kendall E, Ray S, Melia M. Reducing Hepatitis C Viral Load and Genotype Ordering at Johns Hopkins Hospital. JHMI High-Value Practice Research Symposium. Baltimore, MD.

TB Risk Perceptions Among Medical Residents at a Tertiary Care Center in India

Post Date: 
2015-12-06
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Countries: 
Pardeshi G , Parande M, Kadam D, Chandanwale A, Deluca A, Bollinger R, Farley J, Suryavanshi N. TB Risk Perceptions Among Medical Residents at a Tertiary Care Center in India. 46th Union World Conference on Lung Health. International Union for Tuberculosis and Lung Disease. Cape Town, South Africa.

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New guidelines on treating those with HIV developed

Post Date: 
2012-03-06
Source: 
The Baltimore Sun
“Clearly, there is lots of room for improvement in how we, as care providers, can get new patients into treatment and help them adhere to the often strict drug regimens needed to suppress the viral disease and prevent drug resistance,” Dr. Larry W. Chang, a guidelines co-author and an...

HIV, TB Co-infection Increases Postpartum Mother-child Mortality

Post Date: 
2007-06-28
Source: 
Reuters Health via MedScape
No link available

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