Research News

Zika Surveillance Among Pregnant Women in India

India leads the world in dengue cases. CCGHE researchers are keeping an eye on Zika among pregnant women, which is transmitted by the same mosquito & can cause devastating birth defects.

Sepsis among newborns in the neonatal intensive care unit (NICU) is a big problem in India, and a complex one to untangle.

Clinical Research

We work with scientists and practitioners around the world to conduct clinical trials and observational studies that improve prevention and treatment of many grave health issues affecting resource-limited regions, including HIV and tuberculosis.
 
We have formal research partnerships with the following institutions:
 
 

Low tuberculosis knowledge among HIV-infected patients in a high HIV prevalence region within Southeast India

Post Date: 
2013-03-21
Publication: 
Journal of the International Association of Providers of AIDS Care
Country: 
Setting: A private multispecialty hospital in Kakinada, Andhra Pradesh, India. Methods: A survey of knowledge, attitudes, and perceptions adapted from a pretested questionnaire was administered to 128 HIV-infected adults, from July to August 2008.

Correlates of lower comprehension of informed consent among participants enrolled in a cohort study in Pune, India

Post Date: 
2013-03-15
Publication: 
International Health
Country: 
Background: Optimum comprehension of informed consent by research participants is essential yet challenging. This study explored correlates of lower comprehension of informed consent among 1334 participants of a cohort study aimed at estimating HIV incidence in Pune, India. Methods: As part of the...

Combination implementation for HIV prevention: moving from evidence to population-level impact

Post Date: 
2013-01-15
Publication: 
The Lancet Infectious Disease
The promise of combination HIV prevention-the application of multiple HIV prevention interventions to maximise population-level effects-has never been greater. However, to succeed in achieving significant reductions in HIV incidence, an additional concept needs to be considered: combination...

Assessing the evolving definition of underrepresented minority and its application in academic medicine

Post Date: 
2013-01-15
Publication: 
Academic Medicine
Country: 
Purpose: To assess how U.S. academic health centers (AHCs) define the term underrepresented minority (URM) and apply it to their diversity programs, following the 2003 revision of the Association of American Medical Colleges' (AAMC's) definition of URM. Method: In 2010, the authors developed and...

Tuberculosis in pregnant and postpartum women: Epidemiology, management, and research gaps

Post Date: 
2012-12-15
Publication: 
Clinical Infectious Diseases
Tuberculosis is most common during a woman's reproductive years and is a major cause of maternal-child mortality. National guidelines for screening and management vary widely owing to insufficient data. In this article, we review the available data on (1) the global burden of tuberculosis in women...

Household-based HIV counseling and testing as a platform for referral to HIV care and medical male circumcision in Uganda: a pilot evaluation

Post Date: 
2012-12-13
Publication: 
PLOS One
Country: 
Background: Combination HIV prevention initiatives incorporate evidence-based, biomedical and behavioral interventions appropriate and acceptable to specific populations, aiming to significantly reduce population-level HIV incidence. Knowledge of HIV serostatus is key to linkages to HIV care and...

Growth patterns among HIV-exposed infants receiving nevirapine prophylaxis in Pune, India

Post Date: 
2012-10-31
Publication: 
BMC Infectious Diseases
Country: 
Background: India has among the highest rates of infant malnutrition. Few studies investigating the growth patterns of HIV-exposed infants in India or the impact of timing of HIV infection on growth in settings such as India exist. Methods: We used data from the Six Week Extended Nevirapine (SWEN)...

A novel educational strategy targeting health care workers in underserved communities in Central America to integrate HIV into primary medical care

Post Date: 
2012-10-24
Publication: 
PLOS
Background: Current educational strategies to integrate HIV care into primary medical care in Central America have traditionally targeted managers or higher-level officials, rather than local health care workers (HCWs). We developed a complementary online and on-site interactive training program to...

Pooled individual data analysis of five randomized trials of infant nevirapine prophylaxis to prevent breast-milk HIV-1 transmission

Post Date: 
2012-10-19
Publication: 
Clinical Infectious Diseases
Background: In resource-limited settings, mothers infected with human immunodeficiency virus type 1 (HIV-1) face a difficult choice: breastfeed their infants but risk transmitting HIV-1 or not breastfeed their infants and risk the infants dying of other infectious diseases or malnutrition. Recent...

Vitamin D deficiency is common among HIV-infected breastfeeding mothers in Pune, India, but not associated with mother-to-child HIV transmission

Post Date: 
2012-10-01
Publication: 
HIV Clinical Trials
Country: 
A recent report from Tanzania demonstrated an increased risk of being HIV infected or of dying at birth among children born to breastfeeding mothers with low baseline vitamin D levels. We conducted a nested case-control study among HIV-infected pregnant women in western India to confirm the...

Research capacity-building program for clinicians and staff at a community-based HIV clinic in Uganda: A pre/post evaluation

Post Date: 
2012-10-01
Publication: 
Journal of the Association of Nurses in AIDS Care
Country: 
Developing capacity for HIV research and clinical practice is critically needed in resource-limited countries. The purpose of this study was to evaluate a research capacity building program for community-based participants in preparation and conduct of mHealth interventions. A descriptive, cross-...

Evaluation of a multimodal, distance learning HIV management course for clinical care providers in India

Post Date: 
2012-10-01
Publication: 
Journal of the International Association of Providers of AIDS Care
Country: 
Distance learning is an important tool for training HIV health workers. However, there is limited evidence on design and evaluation of distance learning HIV curricula and tools. We therefore designed, implemented, and evaluated a distance learning course on HIV management for clinical care...

Cost analyses of peer health worker and mHealth support interventions for improving AIDS care in Rakai, Uganda

Post Date: 
2012-09-12
Publication: 
AIDS Care
Country: 
A cost analysis study calculates resources needed to deliver an intervention and can provide useful information on affordability for service providers and policy-makers. We conducted cost analyses of both a peer health worker (PHW) and a mHealth (mobile phone) support intervention. Excluding...

HIV testing behaviors among Latinos in Baltimore City

Post Date: 
2012-08-14
Publication: 
Journal of Immigrant and Minority Health
Country: 
In the US, HIV disproportionately affects Latinos who often present late in the disease. Baltimore has seen a recent rapid growth in its Latino population paralleled by an increasing impact of HIV/AIDS among Latinos. From 2009 to 2010, we performed a cross-sectional survey of Latinos accessing the...

Detection of microbial translocation in HIV and SIV infection using the limulus amebocyte lysate assay is masked by serum and plasma

Post Date: 
2012-08-01
Publication: 
PLOS One
Objective: Microbial translocation (MT) is thought to be a major contributor to the pathogenesis of HIV-related immune activation, and circulating lipopolysaccharide (LPS) from Gram-negative bacteria is the principle measurement of this process. However, related research has been impeded by...

Mycobacterium tuberculosis complex enhances susceptibility of CD4 T Cells to HIV through a TLR2-mediated pathway

Post Date: 
2012-07-23
Publication: 
PLOS One
Among HIV-infected individuals, co-infection with Mycobacterium tuberculosis is associated with faster progression to AIDS. We investigated the hypothesis that M. bovis BCG and M. tuberculosis (Mtb complex) could enhance susceptibility of CD4+ cells to HIV infection. Peripheral blood mononuclear...

Guidelines for improving entry into and retention in care and antiretroviral adherence for persons with HIV: evidence-based recommendations from an International Association of Physicians in AIDS Care panel

Post Date: 
2012-06-05
Publication: 
Annals of Internal Medicine
Description: After HIV diagnosis, timely entry into HIV medical care and retention in that care are essential to the provision of effective antiretroviral therapy (ART). ART adherence is among the key determinants of successful HIV treatment outcome and is essential to minimize the emergence of...

Authors’ response to Hanrahan et al CID article

Post Date: 
2012-05-15
Publication: 
Clinical Infectious Diseases
Country: 
Reply to letter

Programmatic impact of QuantiFERON-TB Gold In-Tube implementation on latent tuberculosis diagnosis and treatment in a public health clinic

Post Date: 
2012-05-07
Publication: 
PLoS One
Country: 
Background : QuantiFERON-TB Gold In-Tube (QFT-GIT) is considered an alternative to the tuberculin skin test (TST) for the diagnosis of tuberculosis (TB) infection, but the programmatic impact of QFT-GIT implementation is largely unknown. In March, 2010, the Baltimore City Health Department (BCHD)...

Safety, tolerability, and pharmacokinetic interactions between single-dose TMC207 and steady-state efavirenz in healthy volunteers: AIDS Clinical Trials Group (ACTG) Study.

Post Date: 
2012-04-15
Publication: 
Journal of Acquired Immune Deficiency Syndromes
Country: 
Background: Drug-drug interactions complicate management of coinfection with HIV-1 and Mycobacterium tuberculosis. Bedaquiline (formerly TMC207), an investigational agent for the treatment of tuberculosis, is metabolized by cytochrome P450 (CYP) 3A which may be induced by the antiretroviral drug...

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Global Health Panel Discussion

Post Date: 
2015-01-22
Presentation Location: 
Baltimore, MD
Event & Convener: 
Johns Hopkins University School of Medicine Global Health Webinar
Panel participant

Metabolic Complications/Inflammation Lecture

Post Date: 
2015-01-10
Presentation Location: 
Mumbai, India
Event & Convener: 
5th National Conference on HIV/AIDS Therapy
TB and HIV Co-Morbidities & IRIS Panel Discussion. Gupta A

Metabolic Complications/Inflammation

Post Date: 
2015-01-10
Presentation Location: 
Mumbai, India
Country: 
Event & Convener: 
5th National Conference on HIV/AIDS Therapy
Panel Discussion: TB and HIV Co-Morbidities & IRIS.

Intro to mHealth

Post Date: 
2014-12-17
Presentation Location: 
Baltimore, MD
Event & Convener: 
JHU-GmI Seminar. Johns Hopkins School of Medicine
Presentation

IMPAACT TB Scientific Committee 5 year Priorities and Plans

Post Date: 
2014-12-03
Presentation Location: 
Washington, DC
Event & Convener: 
IMPAACT Network External Review. NIH
Presenter. Gupta A

Conducting International Clinical Trials: Some Important Considerations

Post Date: 
2014-11-19
Presentation Location: 
Baltimore, MD
Event & Convener: 
Johns Hopkins Clinical Investigation Course
Lecture. Gupta A

Barriers and Delays in TB Diagnosis and Treatment: Does Gender Matter?

Post Date: 
2014-11-17
Presentation Location: 
Washington, DC
Event & Convener: 
PATH Gender & TB Experts Meeting
Presentation

GETHealth Summit to Bridge Health Workforce Gap in Developing Countries

Post Date: 
2014-11-10
Presentation Location: 
Dublin, Ireland
Event & Convener: 
GETHealth Summit
Opening Ceremony Speaker

Developing a Roadmap for Integration of TB/HIV Activities in Maternal and Child Health Setting

Post Date: 
2014-10-26
Presentation Location: 
Barcelona, Spain
Event & Convener: 
International Union for Tuberculosis and Lung Disease. 45th Union World Conference on Lung Health.
Speaker: Symposium “Empirical treatment for TB among HIV-positive people: who when, how?”

Global Health Opportunities: Conducting International Health Work from the US

Post Date: 
2014-10-14
Presentation Location: 
Baltimore, MD
Event & Convener: 
Johns Hopkins Medical Student Global Health Elective
Lecture

Advancing Public Reporting and Surveillance of Healthcare-associated Infections

Post Date: 
2014-10-06
Presentation Location: 
Philadelphia, PA
Event & Convener: 
ID Week 2014
Presentation

Metabolic Complications over a Lifetime

Post Date: 
2014-09-27
Presentation Location: 
Cape Town, South Africa
Event & Convener: 
2014 Southern African HIV Clinician Society Conference
Invited Plenary Talk

Complex Cases in HIV/Metabolic Complications Management

Post Date: 
2014-09-25
Presentation Location: 
Cape Town, South Africa
Event & Convener: 
2014 Southern African HIV Clinician Society Conference
Case-based Discussion

TB in Pregnancy

Post Date: 
2014-09-08
Presentation Location: 
Washington, DC
Event & Convener: 
Interscience Conference on Antimicrobial Agents and Chemotherapy
Presentation. Conundrums in TB Symposium

Update on TB and OIs

Post Date: 
2014-09-04
Presentation Location: 
Rio de Janeiro, Brazil
Event & Convener: 
Brazil-Hopkins AIDS Conference
Presentation

Body Mass Index (BMI) and Change in Levels of Immune Activation Post- ART Initiation in Diverse Low- and Middle-Income Settings

Post Date: 
2014-07-20
Presentation Location: 
Melbourne, Australia
Event & Convener: 
International AIDS Conference. AIDS 2014
Presentation.

Prevalence of Asymtpomatic Cryptococcemia and its Implications in Pune, India

Post Date: 
2014-07-20
Presentation Location: 
Melbourne, Australia
Event & Convener: 
International AIDS Conference. AIDS 2014
Presentation.

Vitamin D and TMEM16J Host Variants Associated with TB and Death in HIV Infected and Exposed Infants

Post Date: 
2014-06-13
Presentation Location: 
Baltimore, MD
Event & Convener: 
Johns Hopkins Center for TB Research Annual Scientific Meeting
Presentation

Conducting HIV Research through the US and India HIV Clinical Trials Units

Post Date: 
2014-06-11
Presentation Location: 
Baltimore, MD
Event & Convener: 
ICOHRTA-Fogarty Training Program
Presentation

Finding Your Passion to Do Your Best Work and Have Fun

Post Date: 
2014-05-31
Presentation Location: 
Baltimore, MD
Event & Convener: 
Research Initiatives for Student Enhancement. Kennedy Krieger Institute
Lecture

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