Research News

Drs. Jeffrey Tornheim and Mandar Paradkar
December 4, 2019

Journal of Infectious Diseases: Gene expression profiles among Indian children with confirmed TB were distinct from those of adults, highlighting the importance of including distinct populations in differential gene expression models

Clinical Research

Leadership
While we conduct research all over the world, the majority of our work is in India. Our Indo-JHU Clinical Research Partnership is located in Pune and is directed by Dr. Amita Gupta (Baltimore, MD), with onsite direction from Dr. Vidya Mave, Dr. Nishi Suryavanshi, and Dr. Nikhil Gupte (Pune). The Indo-JHU Partnership employs more than 200 people and in addition to our memberships in cosortia with many esteemed Indian research institutions, we have formal agreements with:

 
 

Analysis of Data Collected from the Evaluation of Community-Based Education, Research and Service (COBERS)

Post Date: 
2012-06-12
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This effort ended in June 2015. Makerere University College of Health Sciences (MakCHS), the Medical Schools at Gulu University (GU), Mbarara University of Science and Technology (MUST), Kampala International University (KIU) and Busitema University (BU) came together with Johns Hopkins University...

C-TRIUMPH Pilot Study: Burden and Risk Factors for Drug-resistant Tuberculosis in Pune, India

Post Date: 
2012-05-29
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This pilot study ended in April 2015. Drug resistant TB (MDR-TB and XDR-TB) is increasing worldwide. Although 20% of all global TB cases occur in India, current estimates of the burden of MDR-TB in India are limited. A well-characterized TB clinical cohort, household cohort and control cohort would...

DOmestic Violence Enhanced Home Visitation and Smart Phones (DOVE)

Post Date: 
2012-01-01
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This effort ended in 2017. The major challenge of early prenatal nurse home visitation programs is to accurately identify abused women. The DOVE study aims to improve maternal health and increase the use of a safety plan and community resources by using an emocha ® application to assist home...

Sexually Transmitted Infections among Women in the Reproductive Age Group in Shevgaon, Ahmednagar District, Maharashtra, India

Post Date: 
2011-05-15
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Countries: 
This study was conducted in 2011. Sexually transmitted infections (STIs) constitute a significant epidemiological burden all over the world especially in middle and low income countries. Women are more vulnerable to STIs due to several biological and socio-economic reasons. Although transmission of...

A5273: Multicenter Study of Options for Second-Line Effective Combination Therapy (SELECT)

Post Date: 
2011-05-12
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This study was terminated May 2, 2017; it was conducted under the AIDS Clinical Trials Group (ACTG) and funded by the U.S. National Institutes of Health. This was a multinational clinical trial conducted in Brazil, India, Kenya, Malawi, Peru, South Africa, Tanzania, Thailand, and Zimbabwe. The...

Predictors of Perinatal HBV Transmission in an HIV/HBV Infected Cohort

Post Date: 
2011-04-22
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Countries: 
This study ended in 2014. Hepatitis B virus (HBV) coinfection is common; affecting greater than 10% of HIV-infected individuals in resource-limited settings(1-3). Although the impact of HIV disease on HBV coinfection has been studied in non-pregnant adults, little is known about the effects of HIV...

A5282: A Randomized, Phase II Trial to Compare an HPV Test-and-Treat Strategy to a Cytology-Based Strategy for Prevention of CIN 2+ in HIV-Infected Women

Post Date: 
2011-03-15
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Countries: 
Indo-JHU partnership work on this trial was officially terminated September 10, 2018; it was conducted under the AIDS Clinical Trials Group (ACTG) and funded by the U.S. National Institutes of Health. This multi-country trial is being conducted in Botswana, Haiti, India, Malawi, Peru, South Africa...

Course Evaluation of a Continuing Medical Education Program for Nurses and Midwives in Uganda

Post Date: 
2011-02-15
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Countries: 
This course evaluation was conducted in 2011. Hypertension presents a substantial burden on the world and Uganda is not immune to this disease. In a recent study, adults in the Rukungiri district in southwestern Uganda were shown to have a 30.5% prevalence of hypertension. (1) Hypertension needs to...

A Prospective Study Evaluating the Role of Cryptococcal Antigen Screening among HIV-infected Adults with Low CD4 Counts

Post Date: 
2011-01-01
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This prospective observational study aimed to evaluate the burden of cryptococcal disease among approximately 200 HIV-infected adults with low CD4 cell counts in Pune, India to determine whether a Cryptococcal screening strategy should be the standard of care among patients with advanced HIV...

Brief Venue Survey of HIV Risk Places and Use of Technology in the Baltimore Latino Population

Post Date: 
2010-12-14
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Countries: 
This study ended December 13, 2011. In the last ten years, Baltimore City has seen a doubling in the AIDS incidence rate among Latinos. This has been paralleled by a doubling of the Baltimore Latino population over the last five years. At the Baltimore City Health Department (BCHD), Latino patients...

P1073: Study of Immune Reconstitution Inflammatory Syndrome (IRIS) for International Sites Initiating Highly Active Antiretroviral Therapy (HAART) in Infants and Children < 72 Months of Age

Post Date: 
2010-11-15
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This study was terminated April 23, 2015. This was a multi-national study conducted in India, South Africa, and Tanzania under the International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) Network and funded by the U.S. National Institutes of Health. P1073 is a case controlled...

PreventionRx Study: Home-based Counseling and Testing in Uganda

Post Date: 
2010-10-21
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Countries: 
This study was terminated August 29, 2014. A ‘platform’ for evaluating combination HIV prevention & care-HIV counseling & testing is essential to optimize HIV services. In collaboration with the University of Washington and the Integrated Community Based Initiatives (ICOBI) NGO in Uganda,...

Hospitalized Pediatric Patients with Pandemic 2009 H1N1 Influenza in India (August-November 2009)

Post Date: 
2010-04-10
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This study ended in April 2013. This was a review and collection of data from the medical records of pediatric patients who were admitted to the BJMC/Sassoon General Hospitals with H1N1 influenza during August-November 2009.

P1077BF: Breastfeeding Version of the PROMISE Study (Promoting Maternal and Infant Survival Everywhere)

Post Date: 
2010-02-02
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Countries: 
This trial was terminated November 6, 2019. This multi-country trial is being conducted in India, Malawi, South Africa, Tanzania, Uganda, Zambia, and Zimbabwe, conducted under the International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) Network and funded by the U.S. National...

P1077FF: Formula Feeding Version of the PROMISE Study (Promoting Maternal and Infant Survival Everywhere)

Post Date: 
2010-02-02
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Countries: 
This trial was terminated November 6, 2019. This multi-country trial is being conducted in India, Malawi, South Africa, Tanzania, Uganda, Zambia, and Zimbabwe, under the International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) Network and funded by the U.S. National Institutes of...

A5225: Phase I/II Dose-Finding Study of High-Dose Fluconazole Treatment in AIDS-Associated Cryptococcal Meningitis

Post Date: 
2009-04-22
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Countries: 
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Clinical Sites: 
This trial was terminated in March 2015; it was conducted under the AIDS Clinical Trials Group (ACTG) and funded by the U.S. National Institutes of Health. This multi-country study was conducted in India, Kenyam Peru, South Africa, Thailand, Uganda, United States, and Zimbabwe. A5225/HiFLAC is a...

Impact of Malnutrition on HIV Treatment Failure in Resource-limited Settings

Post Date: 
2009-04-02
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This study, NWCS 319, was terminated August 20, 2019. Highly active antiretroviral therapy (HAART) has reduced morbidity and mortality among HIV-infected persons worldwide. However, early treatment failure (i.e. WHO stage 3 or 4 illnesses or death during the first 24 months of HAART) is more than 3...

Evaluation of the Impact of Distance Learning For Expanding Capacity for Clinical Research in India

Post Date: 
2009-02-13
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Countries: 
This study ended in March 2012. The Office of AIDS Research has initiated a comprehensive program to expand clinical research capacity in India. This program has utilized a number of platforms for providing research training, including intensive in-country workshops and conferences. These programs...

P1070: Dose-Finding and Pharmacogenetic Study of Efavirenz in HIV-Infected and HIV/TB Co-Infected Infants and Children ≥ 3 Months to < 36 Months of Age

Post Date: 
2008-12-05
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Clinical Sites: 
This study ended March 10, 2015. This multi-country trial was conducted in India, South Africa, Tanzania, Uganda, Zambia, and Zimbabwe, under the International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) Network and funded by the U.S. National Institutes of Health. Efavirenz (EFV)...

The Presentation and Disease Progression of HIV Infection Among Indian Children

Post Date: 
2008-09-22
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Countries: 
This study was terminated July 24, 2010.

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Global, regional, and national under-5 mortality, adult mortality, age-specific mortality, and life expectancy, 1970-2016: a systematic analysis for the Global Burden of Disease Study 2016

Post Date: 
2017-09-16
Publication: 
The Lancet
Abstract Background: Detailed assessments of mortality patterns, particularly age-specific mortality, represent a crucial input that enables health systems to target interventions to specific populations. Understanding how all-cause mortality has changed with respect to development status can...

Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016

Post Date: 
2017-09-16
Publication: 
The Lancet
Abstract Background: As mortality rates decline, life expectancy increases, and populations age, non-fatal outcomes of diseases and injuries are becoming a larger component of the global burden of disease. The Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) provides a...

Measuring progress and projecting attainment on the basis of past trends of the health-related Sustainable Development Goals in 188 countries: an analysis from the Global Burden of Disease Study 2016

Post Date: 
2017-09-12
Publication: 
The Lancet
Abstract Background: The UN's Sustainable Development Goals (SDGs) are grounded in the global ambition of "leaving no one behind". Understanding today's gains and gaps for the health-related SDGs is essential for decision makers as they aim to improve the health of populations. As part of the...

Healthcare Access and Quality Index based on mortality from causes amenable to personal health care in 195 countries and territories, 1990-2015: a novel analysis from the Global Burden of Disease Study 2015

Post Date: 
2017-07-15
Publication: 
The Lancet
Abstract Background: National levels of personal health-care access and quality can be approximated by measuring mortality rates from causes that should not be fatal in the presence of effective medical care (ie, amenable mortality). Previous analyses of mortality amenable to health care only...

A qualitative study exploring factors influencing clinical decision-making for influenza-like illness in Solapur city, Maharashtra, India

Post Date: 
2017-07-03
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Countries: 
Publication: 
Anthropology and Medicine
Abstract The co-existence of different types of medical systems (medical pluralism) is a typical feature of India's healthcare system. For conditions such as influenza-like illness (ILI), where non-specific disease signs/symptoms exist, clinical reasoning in the context of medical pluralism becomes...

Cardiovascular risk in an HIV-infected population in India

Post Date: 
2017-07-03
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Publication: 
Heart Asia
Findings: HIV+ Indian patients who had cardiovascular disease at a younger age appear to be at imminent risk for morbidity.

Household food insecurity is associated with low interferon-gamma levels in pregnant Indian women

Post Date: 
2017-07-01
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Publication: 
International Journal of Tuberculosis and Lung Disease
Objective: To determine the association between household food insecurity and interferon-gamma (IFN-γ) levels in pregnancy. Design: Pregnant women in India were administered the Household Food Insecurity Access Scale (HFIAS) questionnaire and underwent an IFN-γ release assay. Logistic regression...

Vitamin A and D deficiencies associated with incident tuberculosis in HIV-infected patients initiating antiretroviral therapy in multinational case-cohort study

Post Date: 
2017-07-01
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Publication: 
Journal of Acquired Immune Deficiency Syndromes
Introduction: Numerous micronutrients have immunomodulatory roles that may influence risk of tuberculosis (TB), but the association between baseline micronutrient deficiencies and incident TB after antiretroviral therapy (ART) initiation in HIV-infected individuals is not well characterized...

Maternal syphilis: An independent risk factor for mother to infant human immunodeficiency virus transmission

Post Date: 
2017-06-15
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Publication: 
Sexually Transmitted Diseases
Abstract Syphilis is associated with increased human immunodeficiency virus acquisition and sexual transmission; we examined impact on human immunodeficiency virus mother-to-child transmission among mother-infant pairs enrolled in the India Six-Week Extended-Dose Nevirapine study. Maternal syphilis...

Presence of human hepegivirus-1 in a cohort of people who inject drugs

Post Date: 
2017-06-07
Publication: 
Annals of Internal Medicine
Findings on the sensitivity of next-generation metagenomic sequencing for discovery of new viral infections.

Tuberculosis screening among persons with diabetes mellitus in Pune, India

Post Date: 
2017-06-02
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Publication: 
BMC Infectious Diseases
Background: Diabetes mellitus (DM) increases tuberculosis (TB) risk, and there is increasing concern over the public health implications of the convergence of these two epidemics. Screening for TB among people with DM is now recommended in India. Methods: People with DM seeking care at a large...

The impact of preexposure prophylaxis among men who have sex with men: An individual-based model

Post Date: 
2017-06-01
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Countries: 
Publication: 
Journal of Acquired Immune Deficiency Syndromes
Objectives Preexposure prophylaxis (PrEP) is recommended for preventing HIV infection among individuals at high risk, including men who have sex with men (MSM). Although its individual-level efficacy is proven, questions remain regarding population-level impact of PrEP implementation. Design We...

Pulmonary infections in pregnancy

Post Date: 
2017-06-01
Publication: 
Seminars in Respiratory and Critical Care Medicine
Clinical review from Drs. Amita Gupta & Jyoti Mathad on improving tuberculosis treatment outcomes for pregnant women.

Design and implementation of a community health worker HIV treatment and prevention intervention in an HIV hot spot fishing community in Rakai, Uganda

Post Date: 
2017-05-22
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Countries: 
Publication: 
Journal of the International Association of Providers of AIDS Care
Abstract Innovative approaches are needed to increase engagement in HIV treatment and prevention services, particularly in HIV hot spots. Here, we detail our design, training approach, and early implementation experiences of a community-based HIV intervention called "health scouts." The...

Treatment of pulmonary tuberculosis

Post Date: 
2017-04-27
Publication: 
Handbook of Tuberculosis
This chapter addresses the treatment of pulmonary tuberculosis highlighting drug classes, recommended regimens, adverse drug reactions, drug-drug interactions, and practical aspects of monitoring, The principles of treatment of latent tuberculosis are also addressed including whom to treat, what...

Clinical features and diagnosis of tuberculosis: primary infection and progressive pulmonary tuberculosis

Post Date: 
2017-04-27
Publication: 
Handbook of Tuberculosis
In this chapter, we will review the clinical manifestations of intrathoracic tuberculosis (TB), including pathophysiology and clinical features of primary and secondary or reactivation TB. Specific topics discussed are the physical examination, and microbiological, radiological, and immunological...

Extrapulmonary tuberculosis

Post Date: 
2017-04-27
Publication: 
Handbook of Tuberculosis
M. tuberculosis (MTB) can cause disease in almost any organ of the body. Extrapulmonary tuberculosis (EPTB) is defined as tuberculosis (TB) disease outside of the lung parenchyma [1]. Much like pulmonary TB, EPTB can occur as a primary infection or as reactivation of a latent focus with subsequent...

Resident doctors' attitudes toward tuberculosis patients

Post Date: 
2017-04-15
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Publication: 
Indian Journal of Tuberculosis
Background: The attitude of the resident doctors toward tuberculosis (TB) patients can affect their treatment seeking behavior, compliance to treatment as well as reinforce the stigma attached to the disease by the society at large. Aims: To assess the attitudes of resident medical doctors toward...

High burden of antimicrobial resistance and mortality among adults and children with community-onset bacterial infections in India

Post Date: 
2017-04-15
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Publication: 
Journal of Infectious Diseases
Of 133 isolates from 115 patients, 50% were multi-drug resistant; of 33 isolates tested for carbapenem susceptibility, 36% were resistant.

Novel interferon-gamma assays for diagnosing tuberculosis in young children in India

Post Date: 
2017-04-01
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Publication: 
International Journal of Tuberculosis and Lung Disease
Setting: The tuberculin skin test (TST) and interferon-gamma release assays (IGRAs) are used as supportive evidence to diagnose active tuberculosis (TB). Novel IGRAs could improve diagnosis, but data are lacking in young children. Design: Children (age 5 years or...

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TB and Diabetes in Pregnancy: Current Knowledge and Research Gaps

Post Date: 
2016-10-24
Gupta, A. TB and Diabetes in Pregnancy: Current Knowledge and Research Gaps. 47th Union World Conference on Lung Health. International Union for Tuberculosis and Lung Disease. Liverpool, England.

Sub-Therapeutic Concentrations of Anti-Tuberculosis Drugs in Children when Treated According to Indian Dosing Recommendation

Post Date: 
2016-10-24
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Guiastrennec B, Ramachandran G, Karlsson MO, Kumar H, Bhavani PK, Gangadevi NP, Swaminathan S, Gupta A, Dooley KE, Savic RM. Sub-Therapeutic Concentrations of Anti-Tuberculosis Drugs in Children when Treated According to Indian Dosing Recommendation. 9th Annual International Workshop on Clinical...

Vancomycin-resistant Enterococcal Bacteraemia: Is Daptomycin as Effective as Linezolid?

Post Date: 
2016-10-04
Mave, V. Vancomycin-resistant Enterococcal Bacteraemia: Is Daptomycin as Effective as Linezolid? Infectious Diseases Society of America. 2007 Annual Meeting. San Diego, CA. 2007.

Outreach Workers in the Prevention of Mother to Child Transmission of HIV (PMTCT) Programme in India: Challenges and Opportunities

Post Date: 
2016-07-21
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Clinical Sites: 
Suryavanshi N , Mave V, Kadam A, Kanade S, Sivalenka S, Sampath K, Harve P, Gupta RS, Hegde A, McKenzie-White J, Gupte N, Gupta A, Bollinger RC, Shankar AV. Outreach Workers in the Prevention of Mother to Child Transmission of HIV (PMTCT) Programme in India: Challenges and Opportunities. 21st...

A Cluster-Randomized Trial to Promote Combination HIV Prevention Using M-health-Supported CHWs in a High-Prevalence Fishing Community: Design and Baseline Characteristics of the mLAKE Trial in Rakai, Uganda

Post Date: 
2016-07-21
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Countries: 
Chang L, Mbabali I, Kong X, Hutton H, Long A, Thomas A, Bugos E, Ssekasanvu J, Kennedy C, Amico R, Nalugoda F, Reynolds S, Quinn T, Serwadda D, Wawer M, Gray R, Nakigozi G. A Cluster-Randomized Trial to Promote Combination HIV Prevention Using M-health-Supported CHWs in a High-Prevalence Fishing...

Rapid Diagnosis, Linkage and Treatment Initiation of Patients with Drug-resistant Tuberculosis in South Africa: The miLINC Solution to Improve Access to Care

Post Date: 
2016-07-20
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Countries: 
Farley JE , Seiguer S, Naicker M, McKenzie-White J, Greg C, Elmi M, Stevens W, Stewart-Isherwood L. Rapid Diagnosis, Linkage and Treatment Initiation of Patients with Drug-resistant Tuberculosis in South Africa: The miLINC Solution to Improve Access to Care. 21st International AIDS Conference...

High Risk for Loss to Follow-Up among Adolescents Living with HIV in Pune, India

Post Date: 
2016-07-19
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Clinical Sites: 
Nimkar S , Valvi C, Khadse S, Kadam D, Kinikar A, Marbaniang I, Rewari BB, Chandanwale A, Suryavanshi N, Patil S, Nevrekar N, Raichur P, Gupta A, Mave V. High Risk for Loss to Follow-Up among Adolescents Living with HIV in Pune, India. 21st International AIDS Conference. International AIDS Society...

Host Factors Associated with Poor Respiratory Health-related Quality of Life in Pulmonary Tuberculosis

Post Date: 
2016-07-17
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Clinical Sites: 
Gupte A , Meshram S, Selvaraju S, Gupte N, Shivakumar SVBY, Paradkar M, Kohli R, Theruvengadam K, Suryavanshi N, Chandrasekaran P, Mave V, Swaminathan S, Salvi S, Checkley, W, Golub J, Gupta A. Host Factors Associated with Poor Respiratory Health-related Quality of Life in Pulmonary Tuberculosis...

A5300/I2003: Feasibility of Identifying, Recruiting, and Characterizing Adult MDR TB Index Cases and their Adult and Child Household Contacts on Four Continents

Post Date: 
2016-07-17
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Clinical Sites: 
Swindells S , Kim S, Gupta A, Hesseling AC, Shah S, Johnson D, Harrington M, Suryavanshi N, Sanchez J, Dawson R, Naini L, Jones L, Hughes M, Churchyard G, for ACTG/IMPAACT. A5300/I2003: Feasibility of Identifying, Recruiting, and Characterizing Adult MDR TB Index Cases and their Adult and Child...

Prevalence of and Risk Factors for Diabetes mellitus among Pulmonary Tuberculosis Patients in Pune, India.

Post Date: 
2016-07-16
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Golub, J., Gupta, A. Prevalence of and Risk Factors for Diabetes mellitus among Pulmonary Tuberculosis Patients in Pune, India. TB2016. International AIDS Society. Durban, South Africa. 2016.

The Association of Household Air Pollution and Tuberculosis in Women and Children in Pune, India

Post Date: 
2016-06-21
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Elf, J. The Association of Household Air Pollution and Tuberculosis in Women and Children in Pune, India. 2016 Annual Meeting. Johns Hopkins Center for Tuberculosis Research. Baltimore, MD. 2016.

High Proportion of Extrapulmonary Tuberculosis in Baltimore City

Post Date: 
2016-06-21
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Countries: 
Chida, N. High Proportion of Extrapulmonary Tuberculosis in Baltimore City. 2016 Annual Meeting. Johns Hopkins Center for Tuberculosis Research. Baltimore, MD. 2016.

Host Factors Associated with Poor Respiratory Health-Related Quality of Life in Pulmonary TB

Post Date: 
2016-06-21
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Clinical Sites: 
Gupte, A. Host Factors Associated with Poor Respiratory Health-Related Quality of Life in Pulmonary TB. 2016 Annual Meeting. Johns Hopkins Center for Tuberculosis Research. Baltimore, MD. 2016.

Inflammation in HIV-infected Pregnant Women: Relationship with Diet, Gut Microbiome, and Preterm Birth

Post Date: 
2016-06-10
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Shivakoti, R. Inflammation in HIV-infected Pregnant Women: Relationship with Diet, Gut Microbiome, and Preterm Birth. JHU Center for AIDS Research Annual Meeting. Baltimore, MD.

Medicine as a Bridge Between the US and India

Post Date: 
2016-05-21
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Countries: 
Gupta, A. Medicine as a Bridge Between the US and India. Indiaspora. Philadelphia, PA.

An Overview of Protecting Households on Exposure to Newly Diagnosed Index (PHOENIx) Trial

Post Date: 
2016-05-19
Gupta, A. An Overview of Protecting Households on Exposure to Newly Diagnosed Index (PHOENIx) Trial. Johns Hopkins Center for Tuberculosis Research. Baltimore, MD.

Double Trouble: Managing and Preventing TB and HIV

Post Date: 
2016-04-20
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Countries: 
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Clinical Sites: 
Gupta, A. Double Trouble: Managing and Preventing TB and HIV. DY Patil University. Pune, India.

Conducting ID Research in India and Beyond

Post Date: 
2016-03-14
Gupta, A. Conducting ID Research in India and Beyond. ID Didactic Research Forum, Johns Hopkins School of Medicine. Baltimore, MD.

Clinical, Social, and Meteorological Factors Associated with Dengue and Malaria Diagnosis in Adults in Pune, India

Post Date: 
2016-03-03
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Countries: 
Kadam D, Raichur P, Chandanwale A, Joshi S, Robinson M, Marbaniang I, Kagal A, Bharadwaj, Mave V. Clinical, Social, and Meteorological Factors Associated with Dengue and Malaria Diagnosis in Adults in Pune, India. 17th International Congress on Infectious Diseases. Hyderabad, India.

Frequent Resistant Gram Negative Rod Stool Colonization among Patients Admitted with Acute Febrile Illness in Pune, India

Post Date: 
2016-03-03
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Countries: 
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Clinical Sites: 
Bharadwaj RS, Robinson M, Marbaniang I, Kagal A, Raichur PA, Kulkami V, Balasubramanian U, Onawale P, Kanade S, Nelson G, Gupta A, Mave V. Frequent Resistant Gram Negative Rod Stool Colonization among Patients Admitted with Acute Febrile Illness in Pune, India. 17th International Congress on...

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