Research News

Annals of Internal Medicine
September 22, 2020

Risk factors for progression of coronavirus 2019 (COVID-19) to severe disease or death are underexplored in U.S. cohorts.

Clinical Research

Leadership
While we conduct research all over the world, the majority of our work is in India. Our Indo-JHU Clinical Research Partnership is located in Pune and is directed by Dr. Amita Gupta (Baltimore, MD), with onsite direction from Dr. Vidya Mave, Dr. Nishi Suryavanshi, and Dr. Nikhil Gupte (Pune). The Indo-JHU Partnership employs more than 200 people and in addition to our memberships in cosortia with many esteemed Indian research institutions, we have formal agreements with:

 
 

A5225: Phase I/II Dose-Finding Study of High-Dose Fluconazole Treatment in AIDS-Associated Cryptococcal Meningitis

Post Date: 
2009-04-22
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Clinical Sites: 
This trial was terminated in March 2015; it was conducted under the AIDS Clinical Trials Group (ACTG) and funded by the U.S. National Institutes of Health. This multi-country study was conducted in India, Kenyam Peru, South Africa, Thailand, Uganda, United States, and Zimbabwe. A5225/HiFLAC is a...

Impact of Malnutrition on HIV Treatment Failure in Resource-limited Settings

Post Date: 
2009-04-02
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Clinical Sites: 
This study, NWCS 319, was terminated August 20, 2019. Highly active antiretroviral therapy (HAART) has reduced morbidity and mortality among HIV-infected persons worldwide. However, early treatment failure (i.e. WHO stage 3 or 4 illnesses or death during the first 24 months of HAART) is more than 3...

Evaluation of the Impact of Distance Learning For Expanding Capacity for Clinical Research in India

Post Date: 
2009-02-13
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Countries: 
This study ended in March 2012. The Office of AIDS Research has initiated a comprehensive program to expand clinical research capacity in India. This program has utilized a number of platforms for providing research training, including intensive in-country workshops and conferences. These programs...

P1070: Dose-Finding and Pharmacogenetic Study of Efavirenz in HIV-Infected and HIV/TB Co-Infected Infants and Children ≥ 3 Months to < 36 Months of Age

Post Date: 
2008-12-05
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Clinical Sites: 
This study ended March 10, 2015. This multi-country trial was conducted in India, South Africa, Tanzania, Uganda, Zambia, and Zimbabwe, under the International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) Network and funded by the U.S. National Institutes of Health. Efavirenz (EFV)...

The Presentation and Disease Progression of HIV Infection Among Indian Children

Post Date: 
2008-09-22
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Countries: 
This study was terminated July 24, 2010.

Immunomodulatory Properties of BCG: Implications for MTCT

Post Date: 
2008-06-01
To evaluate the immune activating properties of BCG vaccination in neonatal CD4 cells and test the hypothesis that neonatal BCG vaccination leads to activation of immune response that may increase the susceptibility to HIV infection in breast-fed infants of HIV-positive mothers.

HIV Latino Outreach Program, Baltimore City Health Department

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2008-01-01
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Dr. Kathleen Page founded and directs the Baltimore City Health Department’s HIV Latino Outreach Program, which provides more than 1000 HIV tests per year to Baltimore's Latino community, and provides linkages to care services for those testing positive.

Peer Community-based Assistant in REtention: Effect of Peer Health Workers on People Living with HIV Not on Antiretroviral Therapy—A Randomized Operations Research Trial

Post Date: 
2007-03-29
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Countries: 
Human resource limitations, long travel times, and a weak health care infrastructure pose significant challenges to the delivery of anti-retroviral therapy (ART) in rural settings such as the Rakai District in southwestern Uganda. HIV increases demand for health services and also impacts the health...

Calibration and Application of a Simple Sensitive/Less Sensitive Assay Applicable to Resource-Limited Countries for Determination of Recent HIV Infection and Incidence Estimates

Post Date: 
2007-03-22
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Countries: 
This study was terminated March 31, 2007. Sensitive/Less Sensitive assays (S/LS) to distinguish between recent and established HIV infections have been successfully applied to identify recently infected persons and determine HIV incidence. However, all currently used S/LS assays require laboratory...

BWI CTU: Baltimore-Washington-India Clinical Trials Unit

Post Date: 
2007-02-02
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Clinical Sites: 
Comprising clinical trial sites at Johns Hopkins Medicine in Baltimore, Whitman Walker Health in Washington, DC, and the BJGMC-CCGHE collaboration in Pune, India, the Baltimore-Washington-India Clinical Trials Unit (BWI-CTU) is one of only 25 international HIV/TB clinical trial sites funded by the...

Integration of HIV and Other Prevalent Relevant Infectious Disease Care into Primary Medical Care

Post Date: 
2007-01-01
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Countries: 
According to the Pan American Health Organization (PAHO), HIV is rapidly expanding in Latin America, and among the Latin American countries with highest HIV prevalence, four are located in Central America. Notably, AIDS is among the 10 leading causes of death in three of the six countries in...

BJGMC-JHU Fogarty HIV-TB Training Program

Post Date: 
2007-01-01
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Countries: 
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Clinical Sites: 
Funded by the Fogarty International Center at the National Institutes of Health, the JHU Fogarty program has nearly 20 years of success with providing training, professional development, and mentorship to clinicians and scientists in low and middle income countries. CCGHE's latest efforts in this...

P1060: Phase II, parallel, randomized, clinical trials comparing the responses to initiation of NNRTI-based antiretroviral therapy in HIV-infected infants who have not previously received Single dose Nevirapine for prevention of Mother-to-child HIV...

Post Date: 
2006-03-27
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Countries: 
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Clinical Sites: 
This study ended June 28, 2015. This multi-country trial was conducted in India, Malawi, South Africa, Tanzania, Uganda, Zambia, and Zimbabwe under the International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) Network and funded by the U.S. National Institutes of Health. Full Title...

A5207: Maintaining Options for Mothers Study (MOMS): A Phase II Randomized Comparison of Three Antiretroviral Strategies Administered for 7 or 21 Days to Reduce the Emergence of Nevirapine Resistant HIV-1 Following a Single Intrapartum Dose of Nevirapine

Post Date: 
2004-12-20
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This study was terminated January 16, 2014; it was conducted under the AIDS Clinical Trials Group (ACTG) and funded by the U.S. National Institutes of Health. A major disadvantage of giving SD NVP is the potential for maternal development of NVP resistance and additional resistance to other...

A5175: PEARLS Evaluation of the Efficacy of Once-Daily Protease Inhibitor and Once-Daily Non-Nucleoside Reverse Transcriptase Inhibitor- Containing Therapy Combinations for Initial Treatment of HIV-1 Infected Individuals

Post Date: 
2004-07-27
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Countries: 
Full Title: A Phase IV, Prospective, Randomized, Open-Label Evaluation of the Efficacy of Once-Daily Protease Inhibitor and Once Daily Non-Nucleoside Reverse Transcriptase Inhibitor Containing Therapy Combinations for Initial Treatment of HIV-1 Infected Individuals from Resource-Limited Settings (...

Evaluation of Provider, Patient and Pharmacy Knowledge, Attitudes and Practices Regarding HIV Care and Use of Antiretroviral Therapy in Pune, India

Post Date: 
2004-03-29
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Countries: 
This study ended in 2007. Antiretroviral therapy (ART) has dramatically affected morbidity and mortality among HIV-infected persons in industrialized countries. In India, where approximately 4.3 million persons are estimated to be HIV-infected (NACO), the use of ART has been limited because of the...

A Study to Validate New Assays for Measuring HIV Seroincidence in Indian HIV Subtype C Seroconverters

Post Date: 
2003-08-05
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Countries: 
This study ended in July 2006.

Mother-to-Child Transmission (MTCT) of HIV: India SWEN Study

Post Date: 
2002-06-07
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Countries: 
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Clinical Sites: 
This study was officially terminated August 2018. Primary and secondary analyses of the India SWEN study, an NIH-funded phase III randomized controlled trial of an extended nevirapine prophylaxis regimen among 783 HIV-infected pregnant women and their breastfed infants in Pune, India.

Technology-enhanced Peer Navigation to Improve Injection Drug User (IDU) Engagement in HIV Care

Post Date: 
2000-01-01
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Countries: 
This study is evaluating an mHealth-enhanced peer navigation intervention for improving retention-in-care and adherence to antiretroviral therapy (ART) for out-of-care, HIV-infected injection drug users (IDUs). The CCGHE-developed emocha® is assisting peer navigators (former IDUs successfully...

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Secondhand smoke exposure and validity of self-report in low-income women and children in India

Post Date: 
2018-01-10
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Countries: 
Publication: 
Pediatrics
Pediatrics: Dr. Jessica Elf and colleagues evaluated the validity of standard self-reported measures for secondhand smoke (SHS) exposure among women and children in urban India.

What will it take to reduce HIV incidence in the United States: A mathematical modeling analysis

Post Date: 
2018-01-06
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Countries: 
Publication: 
Open Forum Infectious Diseases
Modeling and simulations suggest that cutting HIV incidence in half by 2025 will require 95% of people living with HIV to be engaged in care.

How reliable and valid are the self-reports on sexual behavior among HIV discordant couples from Pune, India?

Post Date: 
2018-01-01
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Countries: 
Publication: 
Psychology, Health, and Medicine
Reliability of self-reported sexual and safe sex behavior among heterosexual HIV discordant couples was assessed by matching individual responses of couples to a common set of questions and validated by matching with pregnancy and seroconversion during study period. Demographic, clinical and...

Suboptimal antituberculosis drug concentrations and outcomes in small and HIV‐coinfected children in India: Recommendations for dose modifications

Post Date: 
2017-12-16
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Countries: 
Publication: 
Clinical Pharmacology and Therapeutics
This work aimed to evaluate the once-daily antituberculosis treatment as recommended by the new Indian pediatric guidelines. Isoniazid, rifampin, and pyrazinamide concentration-time profiles and treatment outcome were obtained from 161 Indian children with drug-sensitive tuberculosis...

Isoniazid concentrations in hair and plasma area-under-the-curve exposure among children with tuberculosis

Post Date: 
2017-12-07
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Countries: 
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Clinical Sites: 
Publication: 
PLOS One
PLOS One: Mave and colleagues compared TB drug exposure in plasma and hair samples among a small cohort of children.

The use of clinical decision support in reducing diagnosis of and treatment of asymptomatic bacteriuria

Post Date: 
2017-12-06
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Countries: 
Publication: 
Journal of Hospital Medicine
Clinical decision support embedded within the electronic health record is a potential antibiotic stewardship strategy for hospitalized patients.

Identifying models of HIV care and treatment service delivery in Tanzania, Uganda, and Zambia using cluster analysis and Delphi survey

Post Date: 
2017-12-06
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Countries: 
Publication: 
BMC Health Services Research
BACKGROUND: Organization of HIV care and treatment services, including clinic staffing and services, may shape clinical and financial outcomes, yet there has been little attempt to describe different models of HIV care in sub-Saharan Africa (SSA). Information about the relative benefits...

Suboptimal anti-tuberculosis drug concentrations and outcomes in small and HIV coinfected children in India: recommendations for dose modifications

Post Date: 
2017-12-01
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Countries: 
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Clinical Sites: 
Publication: 
Clinical Pharmacology and Therapeutics
This work aimed to evaluate the once-daily anti-tuberculosis treatment as recommended by the new Indian pediatric guidelines. Isoniazid, rifampin and pyrazinamide concentration-time profiles and treatment outcome were obtained from 161 Indian children with drug-sensitive tuberculosis...

HIV prevention efforts and incidence in HIV in Uganda

Post Date: 
2017-11-30
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Countries: 
Publication: 
New England Journal of Medicine
In a large study in Uganda, Dr. Larry Chang and colleagues found that combination HIV prevention has population level implications, reducing new infections by 42%.

People with tuberculosis falling through the cracks

Post Date: 
2017-11-01
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Countries: 
Publication: 
National Medical Journal of India
India accounts for approximately one-quarter of the estimated global burden of TB and MDR-TB. [4] Achieving the 2015 WHO End TB Strategy[5] and the latest Government of India target of TB elimination by 2025[6] will require substantial efforts and funding to continue to improve TB care in India...

Impact of a community health worker HIV treatment and prevention intervention in an HIV hotspot fishing community in Rakai, Uganda (mLAKE): study protocol for a randomized controlled trial

Post Date: 
2017-10-23
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Countries: 
Publication: 
Trials
Abstract Background: Effective yet practical strategies are needed to increase engagement in HIV treatment and prevention services, particularly in high-HIV-prevalence hotspots. We designed a community-based intervention called "Health Scouts" to promote uptake and adherence to...

Risk factors for early mortality on antiretroviral therapy in advanced HIV-infected adults

Post Date: 
2017-10-23
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Countries: 
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Clinical Sites: 
Publication: 
AIDS
Background: Many HIV-infected individuals present with advanced HIV disease. These patients are at high risk of death after antiretroviral therapy (ART) initiation, but risk factors for death in these patients are unclear. Methods: We used data from a multisite randomized trial...

Of testing and treatment: Implications of implementing new regimens for multidrug-resistant tuberculosis

Post Date: 
2017-10-01
Publication: 
Clinical Infectious Diseases
A novel, shorter-course regimen for treating multidrug-resistant (MDR) tuberculosis was recently recommended by the World Health Organization. However, the most appropriate use of drug susceptibility testing (DST) to support this regimen is less clear. Implementing countries must therefore...

Global, regional, and national under-5 mortality, adult mortality, age-specific mortality, and life expectancy, 1970-2016: a systematic analysis for the Global Burden of Disease Study 2016

Post Date: 
2017-09-16
Publication: 
The Lancet
Abstract Background: Detailed assessments of mortality patterns, particularly age-specific mortality, represent a crucial input that enables health systems to target interventions to specific populations. Understanding how all-cause mortality has changed with respect to...

Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016

Post Date: 
2017-09-16
Publication: 
The Lancet
Abstract Background: As mortality rates decline, life expectancy increases, and populations age, non-fatal outcomes of diseases and injuries are becoming a larger component of the global burden of disease. The Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD...

Measuring progress and projecting attainment on the basis of past trends of the health-related Sustainable Development Goals in 188 countries: an analysis from the Global Burden of Disease Study 2016

Post Date: 
2017-09-12
Publication: 
The Lancet
Abstract Background: The UN's Sustainable Development Goals (SDGs) are grounded in the global ambition of "leaving no one behind". Understanding today's gains and gaps for the health-related SDGs is essential for decision makers as they aim to improve the health of populations. As...

Healthcare Access and Quality Index based on mortality from causes amenable to personal health care in 195 countries and territories, 1990-2015: a novel analysis from the Global Burden of Disease Study 2015

Post Date: 
2017-07-15
Publication: 
The Lancet
Abstract Background: National levels of personal health-care access and quality can be approximated by measuring mortality rates from causes that should not be fatal in the presence of effective medical care (ie, amenable mortality). Previous analyses of mortality amenable to...

A qualitative study exploring factors influencing clinical decision-making for influenza-like illness in Solapur city, Maharashtra, India

Post Date: 
2017-07-03
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Countries: 
Publication: 
Anthropology and Medicine
Abstract The co-existence of different types of medical systems (medical pluralism) is a typical feature of India's healthcare system. For conditions such as influenza-like illness (ILI), where non-specific disease signs/symptoms exist, clinical reasoning in the context of medical...

Cardiovascular risk in an HIV-infected population in India

Post Date: 
2017-07-03
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Countries: 
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Clinical Sites: 
Publication: 
Heart Asia
Findings: HIV+ Indian patients who had cardiovascular disease at a younger age appear to be at imminent risk for morbidity.

Household food insecurity is associated with low interferon-gamma levels in pregnant Indian women

Post Date: 
2017-07-01
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Countries: 
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Clinical Sites: 
Publication: 
International Journal of Tuberculosis and Lung Disease
Objective: To determine the association between household food insecurity and interferon-gamma (IFN-γ) levels in pregnancy. Design: Pregnant women in India were administered the Household Food Insecurity Access Scale (HFIAS) questionnaire and underwent an IFN-γ release assay...

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The Association of Household Air Pollution and Tuberculosis in Women and Children in Pune, India

Post Date: 
2016-06-21
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Countries: 
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Clinical Sites: 
Elf, J. The Association of Household Air Pollution and Tuberculosis in Women and Children in Pune, India. 2016 Annual Meeting. Johns Hopkins Center for Tuberculosis Research. Baltimore, MD. 2016.

Inflammation in HIV-infected Pregnant Women: Relationship with Diet, Gut Microbiome, and Preterm Birth

Post Date: 
2016-06-10
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Countries: 
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Clinical Sites: 
Shivakoti, R. Inflammation in HIV-infected Pregnant Women: Relationship with Diet, Gut Microbiome, and Preterm Birth. JHU Center for AIDS Research Annual Meeting. Baltimore, MD.

Medicine as a Bridge Between the US and India

Post Date: 
2016-05-21
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Countries: 
Gupta, A. Medicine as a Bridge Between the US and India. Indiaspora. Philadelphia, PA.

An Overview of Protecting Households on Exposure to Newly Diagnosed Index (PHOENIx) Trial

Post Date: 
2016-05-19
Gupta, A. An Overview of Protecting Households on Exposure to Newly Diagnosed Index (PHOENIx) Trial. Johns Hopkins Center for Tuberculosis Research. Baltimore, MD.

Double Trouble: Managing and Preventing TB and HIV

Post Date: 
2016-04-20
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Countries: 
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Clinical Sites: 
Gupta, A. Double Trouble: Managing and Preventing TB and HIV. DY Patil University. Pune, India.

Conducting ID Research in India and Beyond

Post Date: 
2016-03-14
Gupta, A. Conducting ID Research in India and Beyond. ID Didactic Research Forum, Johns Hopkins School of Medicine. Baltimore, MD.

Clinical, Social, and Meteorological Factors Associated with Dengue and Malaria Diagnosis in Adults in Pune, India

Post Date: 
2016-03-03
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Countries: 
Kadam D, Raichur P, Chandanwale A, Joshi S, Robinson M, Marbaniang I, Kagal A, Bharadwaj, Mave V. Clinical, Social, and Meteorological Factors Associated with Dengue and Malaria Diagnosis in Adults in Pune, India. 17th International Congress on Infectious Diseases. Hyderabad, India.

Frequent Resistant Gram Negative Rod Stool Colonization among Patients Admitted with Acute Febrile Illness in Pune, India

Post Date: 
2016-03-03
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Countries: 
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Clinical Sites: 
Bharadwaj RS, Robinson M, Marbaniang I, Kagal A, Raichur PA, Kulkami V, Balasubramanian U, Onawale P, Kanade S, Nelson G, Gupta A, Mave V. Frequent Resistant Gram Negative Rod Stool Colonization among Patients Admitted with Acute Febrile Illness in Pune, India. 17th International Congress on...

High TB Risk in HIV-Positive Patients on Second line Antiretrovirals in Pune, India

Post Date: 
2016-02-24
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Countries: 
Mave V , Kadam D, Salvi S, Basavaraj A, Joshi S, Chandanwale A, Gupte N, Bollinger RC, Gupta A. High TB Risk in HIV-Positive Patients on Second line Antiretrovirals in Pune, India. Conference on Retroviruses and Opportunistic Infections 2016. Boston, MA. 2016.

Pregnancy Intensifies the IFN-gamma Suppression of HIV in TB-infected Indian Women

Post Date: 
2016-02-24
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Countries: 
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Clinical Sites: 
Mathad J, Bhosale R, Balasubramanian U, Deshpande P, Kanade S, Mave V, Gupta A. Pregnancy Intensifies the IFN-gamma Suppression of HIV in TB-infected Indian Women. Conference on Retroviruses and Opportunistic Infections 2016. Boston, MA. 2016.

Combination HIV Prevention and HIV Incidence in a Ugandan Hotspot Fishing Community

Post Date: 
2016-02-23
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Countries: 
Kagaayi J, Grabowski MK, Nakigozi G, Kigozi G, Nalugoda F, Ssekubugu R, Gray RH, Serwadda D, Wawer MJ, Chang L. Combination HIV Prevention and HIV Incidence in a Ugandan Hotspot Fishing Community. Conference on Retroviruses and Opportunistic Infections 2016. Boston, MA. 2016.

Primary Care Provider Interest in Treating HCV—A Mixed Methods Study

Post Date: 
2016-02-23
Falade-Nwulia O, McAdams-Mahmoud A, Irvin R, Niculescu A, Page K, Latkin C, Mix M, Thomas D, Sulkowski M, Mehta S. Primary Care Provider Interest in Treating HCV—A Mixed Methods Study. Conference on Retroviruses and Opportunistic Infections 2016. Boston, MA. 2016.

Migration, HIV Infection, and Combination HIV Prevention Access in Rakai, Uganda

Post Date: 
2016-02-23
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Countries: 
Grabowski MK, Lessler J, Bazaale JM, Chang L, Nabukalu D, Wawer M, Nalugoda F, Ssekubugu R, Nakigozi G, Gray RH. Migration, HIV Infection, and Combination HIV Prevention Access in Rakai, Uganda. Conference on Retroviruses and Opportunistic Infections 2016. Boston, MA. 2016.

Reducing Hepatitis C Viral Load and Genotype Ordering at Johns Hopkins Hospital

Post Date: 
2016-02-01
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Countries: 
Chida N, Greenbaum A, Tuddenham S, Kendall E, Ray S, Melia M. Reducing Hepatitis C Viral Load and Genotype Ordering at Johns Hopkins Hospital. JHMI High-Value Practice Research Symposium. Baltimore, MD.

TB Risk Perceptions Among Medical Residents at a Tertiary Care Center in India

Post Date: 
2015-12-06
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Countries: 
Pardeshi G , Parande M, Kadam D, Chandanwale A, Deluca A, Bollinger R, Farley J, Suryavanshi N. TB Risk Perceptions Among Medical Residents at a Tertiary Care Center in India. 46th Union World Conference on Lung Health. International Union for Tuberculosis and Lung Disease. Cape Town, South Africa.

Novel Package of Integrated Mobile Applications Reduces Time to Treatment Initiation for Patients with MDR-TB

Post Date: 
2015-12-05
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Countries: 
Farley J, McKenzie-White J, Seiguer S, Naicker M, Peters A, Isherwood L, Olsen F, Stevens W. Novel Package of Integrated Mobile Applications Reduces Time to Treatment Initiation for Patients with MDR-TB. The 46th Union World Conference on Lung Health. Cape Town, South Africa.

Incidence and Risk Factors for TB among HIV+ Children in India

Post Date: 
2015-12-05
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Countries: 
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Clinical Sites: 
Kinikar AA , DeLuca A, Gupte N, Kadam DB, Khadse S, Chandanwale A, Gupta A, Bollinger R. Incidence and Risk Factors for TB among HIV+ Children in India. The 46th Union World Conference on Lung Health. Cape Town, South Africa.

TB Outbreak among Health Care Workers and Trainees in a Tertiary-care Hospital in Pune, India

Post Date: 
2015-12-05
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Countries: 
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Clinical Sites: 
Basavaraj A , Patil A, Kadam DB, Chandanwale A, Jain D, DeLuca A, Mave V, Bollinger R. TB Outbreak among Health Care Workers and Trainees in a Tertiary-care Hospital in Pune, India. 46th Union World Conference on Lung Health. Cape Town, South Africa.

Isoniazid Hair Concentrations in Children with TB

Post Date: 
2015-12-05
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Countries: 
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Clinical Sites: 
Mave V, Kinikar AA, Gupte N, Nimkar S, Kagal A, Horng H, Ramachandran G, Dooley K, Gupta A. Isoniazid Hair Concentrations in Children with TB. 46th Union World Conference on Lung Health. International Union for Tuberculosis and Lung Disease. Cape Town, South Africa.

Utility of GeneXpert for Diagnosis of Rifampicin-resistant Extra-pulmonary TB—A Retrospective Review of 70 Cases, SGH, Pune, India

Post Date: 
2015-12-04
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Countries: 
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Clinical Sites: 
Girish S, Dharmashle S, Desai S, Kagal A, Bharadwaj R, Chandanwale A, Lokhande R, Kadam DB, DeLuca A, Gupte N, Jain D, Gupta A, Bollinger R, Mave V. Utility of GeneXpert for Diagnosis of Rifampicin-resistant Extra-pulmonary TB—A Retrospective Review of 70 Cases, SGH, Pune, India, The 46th Union...

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HIV, TB Co-infection Increases Postpartum Mother-child Mortality

Post Date: 
2007-06-28
Source: 
Reuters Health via MedScape
No link available

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