Research News

Indian mother and child

Use of kerosene cooking fuel is positively associated with TB in women and children in our analysis using reported sources of exposure.

Group Photo, BJGMC Clinical Research Site, 2016, Pune, India

The Indo-JHU Clinical Research partnership at BJGMC in Pune, India, is now one of the top enrollers among all ACTG research sites internationally.

Clinical Research

Leadership
Dr. Amita Gupta of Johns Hopkins is Principal Investigator for the Indo-JHU Clinical Research Partnership based out of CCGHE. Research is directed locally in India out of the BJGMC-JHU Clinical Research Site by Dr. Vidya Mave, a Hopkins faculty member who lives in Pune. Dr. Nikhil Gupte is the Lead Biostatistician and Deputy Director and Dr. Nishi Suryavanshi is Clinical Site Coordinator and Deputy Director. Research is conducted in collaboration with the following institutions:
 
 

Activism on rifapentine pricing: removing cost barriers to improve the uptake of tuberculosis research innovations

Post Date: 
2014-12-21
Publication: 
Public Health Action
As recent advances have been made in developing tools to fight tuberculosis (TB), there is also a trend towards increasing advocacy by the civil society for TB research and access. One recent successful effort to increase access to treatment options for TB involved a collaborative effort to...

Inequalities in institutional delivery uptake and maternal mortality reduction in the context of cash incentive program, Janani Suraksha Yojana: Results from nine states in India

Post Date: 
2014-12-15
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Countries: 
Publication: 
Social Science and Medicine
Abstract Proportion of women giving birth in health institutions has increased sharply in India since the introduction of cash incentive program, Janani Suraksha Yojana (JSY) in 2005. JSY was intended to benefit disadvantaged population who had poor access to institutional care for childbirth and...

Is CD4 monitoring needed among Ugandan clients achieving a virologic and immunologic response to treatment?

Post Date: 
2014-11-15
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Countries: 
Publication: 
AIDS Patient Care and STDs
It is unclear whether ongoing CD4 monitoring is needed following immunologic and virologic response to antiretroviral therapy (ART). We investigated the proportion of clients who achieved a virologic and immunologic response and then had a subsequent CD4 count <200 cells/μL despite continued...

Pre-antiretroviral therapy selenium status predicts WHO stages 3, 4 or death but not virologic failure post-antiretroviral therapy

Post Date: 
2014-11-13
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Publication: 
Nutrients
A case-cohort study, within a multi-country trial of antiretroviral therapy (ART) efficacy (Prospective Evaluation of Antiretrovirals in Resource Limited Settings (PEARLS)), was conducted to determine if pre-ART serum selenium deficiency is independently associated with human immunodeficiency virus...

Complications of tuberculosis

Post Date: 
2014-10-15
Publication: 
Current Opinion in Infectious Diseases
Purpose of review : Diagnosis and management of tuberculosis (TB) remains challenging and complex because of the heterogeneity of disease presentations. Despite effective treatment, TB disease can lead to significant short-and long-term health consequences. We review potential acute and chronic...

High proportion of indeterminate QuantiFERON-TB Gold In-Tube results in an inpatient population are related to host factors and pre-analytical steps

Post Date: 
2014-09-19
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Publication: 
Open Forum Infectious Diseases
Background: QuantiFERON-TB Gold In-Tube test (QFT-GIT) can be used as an alternative to tuberculin skin testing (TST) for the targeted testing of latent tuberculosis. Due to many shortcomings with TST, QFT-GIT usage is increasing. QFT-GIT implementation in the inpatient setting remains unclear...

Source case investigation for children with TB disease in Pune, India

Post Date: 
2014-08-27
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Publication: 
Tuberculosis Research and Treatment
Setting. Contact tracing is broadly encouraged for tuberculosis (TB) control. In many high-burden countries, however, little effort is made to identify contacts of newly diagnosed TB patients. This failure puts children, many of whom live in poor crowded communities, at special risk. Objectives. To...

Economic challenges associated with tuberculosis diagnostic development

Post Date: 
2014-08-15
Publication: 
Expert Review of Pharmacoeconomics and Outcomes Research
Tuberculosis remains a global health crisis in part due to underdiagnosis. Technological innovations are needed to improve diagnostic test accuracy and reduce the reliance on expensive laboratory infrastructure. However, there are significant economic challenges impeding the development and...

Editorial commentary: Xpert MTB/RIF testing for individuals with presumed tuberculosis: implications for infection control and rapid tuberculosis detection in the United States.

Post Date: 
2014-08-04
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Publication: 
Clinical Infectious Diseases
Despite recent declines in incidence, tuberculosis remains a significant public health problem in the United States, with almost 10 000 new cases each year. As the disease becomes less common in the United States, diagnostic delays occur because of diverse clinical presentations and suboptimal...

Cell phone utilization among foreign-born latinos: a promising tool for dissemination of health and HIV information

Post Date: 
2014-08-01
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Countries: 
Publication: 
Journal of Immigrant and Minority Health
Latinos in the U.S. are disproportionately affected by HIV and are at risk for late presentation to care. Between June 2011 and January 2012, we conducted a cross-sectional survey of 209 Baltimore Latinos at community-based venues to evaluate the feasibility of using communication technology (ICT)-...

25-Hydroxyvitamin D insufficiency and deficiency is associated with HIV disease progression and virological failure post-antiretroviral therapy initiation in diverse multinational settings

Post Date: 
2014-07-15
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Clinical Sites: 
Publication: 
The Journal of Infectious Diseases
Background: Low 25-hydroxyvitamin D (25(OH)D) has been associated with increased HIV mortality, but prospective studies assessing treatment outcomes after combination antiretroviral therapy (cART) initiation in resource-limited settings are lacking. Methods: A case-cohort study (N = 411) was nested...

Impact of maternal hepatitis B virus coinfection on mother-to-child transmission of HIV

Post Date: 
2014-07-15
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Publication: 
HIV Medicine
Objectives: Despite high hepatitis B virus (HBV) endemicity in various resource-limited settings (RLSs), the impact of maternal HIV/HBV coinfection on infant health outcomes has not been defined. We aimed to assess the prevalence of HBV coinfection among HIV-infected pregnant women and its impact...

Blood stream infections

Post Date: 
2014-07-01
Publication: 
BioMed Research International
Blood stream infection (BSI) is one of the most devastating preventable complications in Critical Care Units. It has far-reaching consequences resulting in prolonged length of hospital-stay, high costs to the individual and exchequer, and, in many instances, loss of life. Although exact rates of...

Diagnostic accuracy of a rapid urine lipoarabinomannan test for tuberculosis in HIV-infected adults

Post Date: 
2014-07-01
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Publication: 
Journal of Acquired Immune Deficiency Syndromes
Objective : In settings of high HIV prevalence, tuberculosis control and patient management are hindered by lack of accurate, rapid tuberculosis diagnostic tests that can be performed at point-of-care. The Determine TB LAM Ag (TB LAM) test is a lateral flow immunochromatographic test for detection...

Optimisation of the Medical Education Partnership Initiative to address African health-care challenges

Post Date: 
2014-06-25
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Publication: 
The Lancet Global Health
The Medical Education Partnership Initiative (MEPI) is an innovative and potentially transformative 5-year programme, established by the US Government in 2010, to increase the number of doctors to meet crucial human resource needs in sub-Saharan Africa.1 MEPI allows African institutions that are...

Challenges to disclosure of HIV status to perinatally infected children: a study of caregiver perspectives in Pune, India

Post Date: 
2014-06-15
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Publication: 
Journal of Pediatric Infectious Diseases
Effective guidelines around disclosure of HIV status are lacking and limited data from India reveal low rates of HIV disclosure to perinatally infected children. This study, conducted in Pune, India, attempts to understand the experiences of caregivers of perinatally infected children around the...

Comparative performance of urinary lipoarabinomannan assays and Xpert MTB/RIF in HIV-infected individuals

Post Date: 
2014-06-01
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Countries: 
Publication: 
AIDS
Background : Xpert MTB/RIF ('Xpert') and urinary lipoarabinomannan (LAM) assays offer rapid tuberculosis (TB) diagnosis, but have suboptimal sensitivity when used individually in HIV-positive patients. The yield of these tests used in combination for the diagnosis of active TB among HIV-infected TB...

Socioeconomic determinants of mortality in HIV: evidence from a clinical cohort in Uganda

Post Date: 
2014-05-15
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Publication: 
Journal of Acquired Immune Deficiency Syndromes
Objective: To delineate the association between baseline socioeconomic status (SES) indicators and mortality and lost to follow-up (LTFU) in a cohort of HIV-infected individuals enrolled in antiretroviral therapy (ART) in urban Uganda. Design: Retrospective cohort study nested in an antiretroviral...

Taking the long view on CREATE studies' finding

Post Date: 
2014-05-15
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Publication: 
The Lancet Infectious Disease
In the past 10 years, the Consortium to Respond Effectively to the AIDS TB Epidemic (CREATE) has done three large trials exploring new strategies to control HIV-related tuberculosis. Recognising that the global strategy for tuberculosis control of a decade ago (mainly directly observed short-course...

Gender-related barriers and delays in accessing tuberculosis diagnostic and treatment services - Part 2: a systematic review of qualitative studies

Post Date: 
2014-05-11
Publication: 
Tuberculosis Research and Treatment
Background: Tuberculosis (TB) remains a significant global public health problem with known gender-related (male versus female) disparities. We reviewed the qualitative evidence (written/spoken narrative) for gender-related differences limiting TB service access from symptom onset to treatment...

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Conducting HIV/TB Research in India: Challenges and Opportunities

Post Date: 
2015-04-17
Gupta, A. Conducting HIV/TB Research in India: Challenges and Opportunities. Grand Rounds, Johns Hopkins School of Medicine. Baltimore, MD.

Conference on Vaccine Research, Closing Talk

Post Date: 
2015-04-15
Bollinger, R. Conference on Vaccine Research, Closing Talk. Annual Conference on Vaccine Research. National Foundation for Infectious Diseases. Bethesda, MD.

Grand Rounds

Post Date: 
2015-03-31
Page, K. Grand Rounds. Center for Child and Community Health Research. Johns Hopkins School of Medicine, Bayview Medical Center. Baltimore, MD.

TB and Diabetes Mellitus

Post Date: 
2015-03-30
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Clinical Sites: 
Mave, V. TB and Diabetes Mellitus. RePORT India TB Workshop. Pune, India.

Mobilizing Research for Global Health

Post Date: 
2015-03-25
Bollinger, R. Mobilizing Research for Global Health. Sixth Annual CUGH Conference. Consortium of Universities for Global Health. Boston, MA.

TB in Pregnancy

Post Date: 
2015-03-05
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Gupta, A. TB in Pregnancy. RePORT India TB Workshop. Mumbai, India.

Tuberculosis in Pregnancy

Post Date: 
2015-02-25
Gupta, A. Tuberculosis in Pregnancy. Conference on Retroviruses and Opportunistic Infections 2015. Seattle, WA. 2015.

Tuberculosis in Children

Post Date: 
2015-02-24
Gupta, A. Tuberculosis in Children. Conference on Retroviruses and Opportunistic Infections 2015. Seattle, WA. 2015.

Prevalence and Risk Factors of Multiple Micronutrient Deficiencies Pre- and Post-ART

Post Date: 
2015-02-24
Shivakoti R, Christian P, Gupte N, Kanyama C, Berendes S, Lama JR, Semba RD, Campbell TB, Gupta A for the NWCS 319 and PEARLS Study Team. Prevalence and Risk Factors of Multiple Micronutrient Deficiencies Pre- and Post-ART. Conference on Retroviruses and Opportunistic Infections 2015. Seattle, WA...

Obesity and Inflammation in Resource-Driven Settings of ART Initiation

Post Date: 
2015-02-24
Erlandson KM, Gupte N, Lama JR, Patcharaphan S, Mwelase T, Balagopal A, Asmuth D, Campbell TB, Gupta A. Obesity and Inflammation in Resource-Driven Settings of ART Initiation. Conference on Retroviruses and Opportunistic Infections 2015. Seattle, WA. 2015.

Cost-effectiveness of Isonaizid Preventive Therapy for HIV-Infected Pregnant Women in India

Post Date: 
2015-02-24
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Countries: 
Kapoor S, Chida N, Gupta A, Shah M. Cost-effectiveness of Isonaizid Preventive Therapy for HIV-Infected Pregnant Women in India. Conference on Retroviruses and Opportunistic Infections 2015. Seattle, WA. 2015.

Persistently High IL-18 and sCD14 are Independently Associated with Clinical Failure

Post Date: 
2015-02-24
Balagopal A, Gupte N, Hakim J, Hosseinipour M, Nagalingeswaran K, Cox A, Sanne I, Asmuth D, Campbell T, Gupta A. Persistently High IL-18 and sCD14 are Independently Associated with Clinical Failure. Conference on Retroviruses and Opportunistic Infections 2015. Seattle, WA. 2015.

Conducting Infectious Diseases Research in India

Post Date: 
2015-02-16
Gupta, A. Conducting Infectious Diseases Research in India. Johns Hopkins University School of Medicine. Baltimore, MD.

Empowering Women in Global Health: Lessons Learned and Strategies for Success

Post Date: 
2015-02-16
Gupta, A. Empowering Women in Global Health: Lessons Learned and Strategies for Success. Empowering Women in Global Health: Lessons Learned and Strategies for Success. New York, NY.

PMTCT: Current Recommendations

Post Date: 
2015-01-31
Mave, V. PMTCT: Current Recommendations. 5th National Conference on HIV/AIDS Therapy. Mumbai, India.

Global Health Panel Discussion

Post Date: 
2015-01-22
Gupta, A. Global Health Panel Discussion. Johns Hopkins University School of Medicine Global Health Webinar. Baltimore, MD.

Metabolic Complications/Inflammation

Post Date: 
2015-01-10
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Countries: 
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Clinical Sites: 
Gupta, A. Metabolic Complications/Inflammation. 5th National Conference on HIV/AIDS Therapy. Mumbai, India.

Metabolic Complications/Inflammation Lecture

Post Date: 
2015-01-10
Gupta A. Metabolic Complications/Inflammation Lecture. 5th National Conference on HIV/AIDS Therapy. Mumbai, India.

Intro to mHealth

Post Date: 
2014-12-17
Change, L. Intro to mHealth. JHU-GmI Seminar. Johns Hopkins School of Medicine. Baltimore, MD.

IMPAACT TB Scientific Committee 5 year Priorities and Plans

Post Date: 
2014-12-03
Gupta A. IMPAACT TB Scientific Committee 5 year Priorities and Plans. IMPAACT Network External Review. NIH. Washington, DC.

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