Research News

Venezuela flag
March 26, 2020

Foreign Policy: Dr. Kathleen Page argues that Venezuela's weak healthcare infrastructure leaves its people defenseless and presents a serious threat to global health, and she advocates for the global community to act now.

Clinical Research

Leadership
While we conduct research all over the world, the majority of our work is in India. Our Indo-JHU Clinical Research Partnership is located in Pune and is directed by Dr. Amita Gupta (Baltimore, MD), with onsite direction from Dr. Vidya Mave, Dr. Nishi Suryavanshi, and Dr. Nikhil Gupte (Pune). The Indo-JHU Partnership employs more than 200 people and in addition to our memberships in cosortia with many esteemed Indian research institutions, we have formal agreements with:

 
 

A5225: Phase I/II Dose-Finding Study of High-Dose Fluconazole Treatment in AIDS-Associated Cryptococcal Meningitis

Post Date: 
2009-04-22
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This trial was terminated in March 2015; it was conducted under the AIDS Clinical Trials Group (ACTG) and funded by the U.S. National Institutes of Health. This multi-country study was conducted in India, Kenyam Peru, South Africa, Thailand, Uganda, United States, and Zimbabwe. A5225/HiFLAC is a...

Impact of Malnutrition on HIV Treatment Failure in Resource-limited Settings

Post Date: 
2009-04-02
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This study, NWCS 319, was terminated August 20, 2019. Highly active antiretroviral therapy (HAART) has reduced morbidity and mortality among HIV-infected persons worldwide. However, early treatment failure (i.e. WHO stage 3 or 4 illnesses or death during the first 24 months of HAART) is more than 3...

Evaluation of the Impact of Distance Learning For Expanding Capacity for Clinical Research in India

Post Date: 
2009-02-13
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Countries: 
This study ended in March 2012. The Office of AIDS Research has initiated a comprehensive program to expand clinical research capacity in India. This program has utilized a number of platforms for providing research training, including intensive in-country workshops and conferences. These programs...

P1070: Dose-Finding and Pharmacogenetic Study of Efavirenz in HIV-Infected and HIV/TB Co-Infected Infants and Children ≥ 3 Months to < 36 Months of Age

Post Date: 
2008-12-05
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Clinical Sites: 
This study ended March 10, 2015. This multi-country trial was conducted in India, South Africa, Tanzania, Uganda, Zambia, and Zimbabwe, under the International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) Network and funded by the U.S. National Institutes of Health. Efavirenz (EFV)...

The Presentation and Disease Progression of HIV Infection Among Indian Children

Post Date: 
2008-09-22
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Countries: 
This study was terminated July 24, 2010.

Immunomodulatory Properties of BCG: Implications for MTCT

Post Date: 
2008-06-01
To evaluate the immune activating properties of BCG vaccination in neonatal CD4 cells and test the hypothesis that neonatal BCG vaccination leads to activation of immune response that may increase the susceptibility to HIV infection in breast-fed infants of HIV-positive mothers.

HIV Latino Outreach Program, Baltimore City Health Department

Post Date: 
2008-01-01
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Dr. Kathleen Page founded and directs the Baltimore City Health Department’s HIV Latino Outreach Program, which provides more than 1000 HIV tests per year to Baltimore's Latino community, and provides linkages to care services for those testing positive.

Peer Community-based Assistant in REtention: Effect of Peer Health Workers on People Living with HIV Not on Antiretroviral Therapy—A Randomized Operations Research Trial

Post Date: 
2007-03-29
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Countries: 
Human resource limitations, long travel times, and a weak health care infrastructure pose significant challenges to the delivery of anti-retroviral therapy (ART) in rural settings such as the Rakai District in southwestern Uganda. HIV increases demand for health services and also impacts the health...

Calibration and Application of a Simple Sensitive/Less Sensitive Assay Applicable to Resource-Limited Countries for Determination of Recent HIV Infection and Incidence Estimates

Post Date: 
2007-03-22
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Countries: 
This study was terminated March 31, 2007. Sensitive/Less Sensitive assays (S/LS) to distinguish between recent and established HIV infections have been successfully applied to identify recently infected persons and determine HIV incidence. However, all currently used S/LS assays require laboratory...

BWI CTU: Baltimore-Washington-India Clinical Trials Unit

Post Date: 
2007-02-02
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Comprising clinical trial sites at Johns Hopkins Medicine in Baltimore, Whitman Walker Health in Washington, DC, and the BJGMC-CCGHE collaboration in Pune, India, the Baltimore-Washington-India Clinical Trials Unit (BWI-CTU) is one of only 25 international HIV/TB clinical trial sites funded by the...

Integration of HIV and Other Prevalent Relevant Infectious Disease Care into Primary Medical Care

Post Date: 
2007-01-01
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Countries: 
According to the Pan American Health Organization (PAHO), HIV is rapidly expanding in Latin America, and among the Latin American countries with highest HIV prevalence, four are located in Central America. Notably, AIDS is among the 10 leading causes of death in three of the six countries in...

BJGMC-JHU Fogarty HIV-TB Training Program

Post Date: 
2007-01-01
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Funded by the Fogarty International Center at the National Institutes of Health, the JHU Fogarty program has nearly 20 years of success with providing training, professional development, and mentorship to clinicians and scientists in low and middle income countries. CCGHE's latest efforts in this...

P1060: Phase II, parallel, randomized, clinical trials comparing the responses to initiation of NNRTI-based antiretroviral therapy in HIV-infected infants who have not previously received Single dose Nevirapine for prevention of Mother-to-child HIV...

Post Date: 
2006-03-27
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Clinical Sites: 
This study ended June 28, 2015. This multi-country trial was conducted in India, Malawi, South Africa, Tanzania, Uganda, Zambia, and Zimbabwe under the International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) Network and funded by the U.S. National Institutes of Health. Full Title...

A5207: Maintaining Options for Mothers Study (MOMS): A Phase II Randomized Comparison of Three Antiretroviral Strategies Administered for 7 or 21 Days to Reduce the Emergence of Nevirapine Resistant HIV-1 Following a Single Intrapartum Dose of Nevirapine

Post Date: 
2004-12-20
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This study was terminated January 16, 2014; it was conducted under the AIDS Clinical Trials Group (ACTG) and funded by the U.S. National Institutes of Health. A major disadvantage of giving SD NVP is the potential for maternal development of NVP resistance and additional resistance to other...

A5175: PEARLS Evaluation of the Efficacy of Once-Daily Protease Inhibitor and Once-Daily Non-Nucleoside Reverse Transcriptase Inhibitor- Containing Therapy Combinations for Initial Treatment of HIV-1 Infected Individuals

Post Date: 
2004-07-27
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Countries: 
Full Title: A Phase IV, Prospective, Randomized, Open-Label Evaluation of the Efficacy of Once-Daily Protease Inhibitor and Once Daily Non-Nucleoside Reverse Transcriptase Inhibitor Containing Therapy Combinations for Initial Treatment of HIV-1 Infected Individuals from Resource-Limited Settings (...

Evaluation of Provider, Patient and Pharmacy Knowledge, Attitudes and Practices Regarding HIV Care and Use of Antiretroviral Therapy in Pune, India

Post Date: 
2004-03-29
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Countries: 
This study ended in 2007. Antiretroviral therapy (ART) has dramatically affected morbidity and mortality among HIV-infected persons in industrialized countries. In India, where approximately 4.3 million persons are estimated to be HIV-infected (NACO), the use of ART has been limited because of the...

A Study to Validate New Assays for Measuring HIV Seroincidence in Indian HIV Subtype C Seroconverters

Post Date: 
2003-08-05
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Countries: 
This study ended in July 2006.

Mother-to-Child Transmission (MTCT) of HIV: India SWEN Study

Post Date: 
2002-06-07
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This study was officially terminated August 2018. Primary and secondary analyses of the India SWEN study, an NIH-funded phase III randomized controlled trial of an extended nevirapine prophylaxis regimen among 783 HIV-infected pregnant women and their breastfed infants in Pune, India.

Technology-enhanced Peer Navigation to Improve Injection Drug User (IDU) Engagement in HIV Care

Post Date: 
2000-01-01
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Countries: 
This study is evaluating an mHealth-enhanced peer navigation intervention for improving retention-in-care and adherence to antiretroviral therapy (ART) for out-of-care, HIV-infected injection drug users (IDUs). The CCGHE-developed emocha® is assisting peer navigators (former IDUs successfully...

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Tuberculosis screening among persons with diabetes mellitus in Pune, India

Post Date: 
2017-06-02
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Publication: 
BMC Infectious Diseases
Background: Diabetes mellitus (DM) increases tuberculosis (TB) risk, and there is increasing concern over the public health implications of the convergence of these two epidemics. Screening for TB among people with DM is now recommended in India. Methods: People with DM seeking care at a large...

Pulmonary infections in pregnancy

Post Date: 
2017-06-01
Publication: 
Seminars in Respiratory and Critical Care Medicine
Clinical review from Drs. Amita Gupta & Jyoti Mathad on improving tuberculosis treatment outcomes for pregnant women.

The impact of preexposure prophylaxis among men who have sex with men: An individual-based model

Post Date: 
2017-06-01
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Countries: 
Publication: 
Journal of Acquired Immune Deficiency Syndromes
Objectives Preexposure prophylaxis (PrEP) is recommended for preventing HIV infection among individuals at high risk, including men who have sex with men (MSM). Although its individual-level efficacy is proven, questions remain regarding population-level impact of PrEP implementation...

Design and implementation of a community health worker HIV treatment and prevention intervention in an HIV hot spot fishing community in Rakai, Uganda

Post Date: 
2017-05-22
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Publication: 
Journal of the International Association of Providers of AIDS Care
Abstract Innovative approaches are needed to increase engagement in HIV treatment and prevention services, particularly in HIV hot spots. Here, we detail our design, training approach, and early implementation experiences of a community-based HIV intervention called "health scouts." The...

Treatment of pulmonary tuberculosis

Post Date: 
2017-04-27
Publication: 
Handbook of Tuberculosis
This chapter addresses the treatment of pulmonary tuberculosis highlighting drug classes, recommended regimens, adverse drug reactions, drug-drug interactions, and practical aspects of monitoring, The principles of treatment of latent tuberculosis are also addressed including whom to treat, what...

Clinical features and diagnosis of tuberculosis: primary infection and progressive pulmonary tuberculosis

Post Date: 
2017-04-27
Publication: 
Handbook of Tuberculosis
In this chapter, we will review the clinical manifestations of intrathoracic tuberculosis (TB), including pathophysiology and clinical features of primary and secondary or reactivation TB. Specific topics discussed are the physical examination, and microbiological, radiological, and immunological...

Extrapulmonary tuberculosis

Post Date: 
2017-04-27
Publication: 
Handbook of Tuberculosis
M. tuberculosis (MTB) can cause disease in almost any organ of the body. Extrapulmonary tuberculosis (EPTB) is defined as tuberculosis (TB) disease outside of the lung parenchyma [1]. Much like pulmonary TB, EPTB can occur as a primary infection or as reactivation of a latent focus with subsequent...

High burden of antimicrobial resistance and mortality among adults and children with community-onset bacterial infections in India

Post Date: 
2017-04-15
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Publication: 
Journal of Infectious Diseases
Of 133 isolates from 115 patients, 50% were multi-drug resistant; of 33 isolates tested for carbapenem susceptibility, 36% were resistant.

Resident doctors' attitudes toward tuberculosis patients

Post Date: 
2017-04-15
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Publication: 
Indian Journal of Tuberculosis
Background: The attitude of the resident doctors toward tuberculosis (TB) patients can affect their treatment seeking behavior, compliance to treatment as well as reinforce the stigma attached to the disease by the society at large. Aims: To assess the attitudes...

Novel interferon-gamma assays for diagnosing tuberculosis in young children in India

Post Date: 
2017-04-01
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Publication: 
International Journal of Tuberculosis and Lung Disease
Setting: The tuberculin skin test (TST) and interferon-gamma release assays (IGRAs) are used as supportive evidence to diagnose active tuberculosis (TB). Novel IGRAs could improve diagnosis, but data are lacking in young children. Design: Children (age 5 years or...

Prevalence of HIV testing provision at community organizations serving young people in a mid-Atlantic city, 2013-2014

Post Date: 
2017-03-31
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Countries: 
Publication: 
Public Health Reports
Objectives: Little is known about the prevalence of human immunodeficiency virus (HIV) testing at community organizations or the organizational characteristics associated with testing. The objective of this study was to describe (1) the prevalence of HIV testing at community organizations...

Reducing uncertainty for acute febrile illness in resource-limited settings: the current diagnostic landscape

Post Date: 
2017-03-27
Publication: 
The American Journal of Tropical Medicine and Hygiene
After decades of slow progress in diagnostics for acute febrile illness in resource-limited settings, a wave of converging advancements will enable clinicians in resource limited settings to reduce uncertainty for the diagnosis of acute febrile illness.

The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis

Post Date: 
2017-03-24
Publication: 
The Lancet Respiratory Medicine
Global tuberculosis incidence has declined marginally over the past decade, and tuberculosis remains out of control in several parts of the world including Africa and Asia. Although tuberculosis control has been effective in some regions of the world, these gains are threatened by the increasing...

High prevalence of cryptococcal antigenaemia amongst asymptomatic advanced HIV patients in Pune, India

Post Date: 
2017-03-21
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Publication: 
Indian Journal of Medical Microbiology
Methods : A prospective study was conducted in a large public sector ART centre and the inpatient wards of Sassoon Hospital, Pune, India. All consenting patients> 18 years of age with CD4 count <100 cells/mm3 were screened for CrAg by latex agglutination assay. Those with positive CrAg...

Drug-resistant tuberculosis in 2017: at a crossroads

Post Date: 
2017-03-15
Publication: 
Lancet Respiratory Medicine
In The Lancet Respiratory Medicine, Dheda and colleagues present one of the most comprehensive pictures to date of the global epidemic of drug-resistant tuberculosis. This comes at a time of increasing awareness of antimicrobial resistance as a global threat, and Mycobacterium tuberculosis...

Chilling effect? Post-election health care use by undocumented and mixed-status families

Post Date: 
2017-03-08
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Countries: 
Publication: 
New England Journal of Medicine
Perspective article from Dr. Kathleen Page in the New England Journal of Medicine

Vitamin A and D deficiencies associated with incident tuberculosis in HIV-infected patients initiating antiretroviral therapy in multinational case-cohort study

Post Date: 
2017-02-06
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Publication: 
Journal of Acquired Immune Deficiency Syndromes
Introduction: Numerous micronutrients have immunomodulatory roles that may influence risk of tuberculosis (TB), but the association between baseline micronutrient deficiencies and incident TB after antiretroviral (ART) initiation in HIV-infected individuals is not well characterized. ...

¡Sólo se vive una vez! (you only live once): a pilot evaluation of individually tailored video modules aiming to increase HIV testing among foreign-born Latino men

Post Date: 
2017-02-01
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Countries: 
Publication: 
Journal of Acquired Immune Deficiency Syndromes
BACKGROUND: Although Latinos living in the United States are disproportionately affected by HIV, the development, implementation, and evaluation of HIV prevention, testing, and linkage to care interventions lag behind efforts occurring in other communities. To address...

Tuberculosis associated with HIV infection

Post Date: 
2017-01-15
Publication: 
Microbiology Spectrum
Abstract Tuberculosis (TB) has recently surpassed HIV as the primary infectious disease killer worldwide, but the two diseases continue to display lethal synergy. The burden of TB is disproportionately borne by people living with HIV, particularly where HIV and poverty...

Qualitative insights into implementation, processes, and outcomes of a randomized trial on peer support and HIV care engagement in Rakai, Uganda

Post Date: 
2017-01-10
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Publication: 
BMC Infectious Diseases
BACKGROUND: People living with human immunodeficiency virus (HIV) who have not yet initiated antiretroviral therapy (ART) can benefit from being engaged in care and utilizing preventive interventions. Community-based peer support may be an effective approach to promote these...

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Frequent Resistant Gram Negative Rod Stool Colonization among Patients Admitted with Acute Febrile Illness in Pune, India

Post Date: 
2016-03-03
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Bharadwaj RS, Robinson M, Marbaniang I, Kagal A, Raichur PA, Kulkami V, Balasubramanian U, Onawale P, Kanade S, Nelson G, Gupta A, Mave V. Frequent Resistant Gram Negative Rod Stool Colonization among Patients Admitted with Acute Febrile Illness in Pune, India. 17th International Congress on...

High TB Risk in HIV-Positive Patients on Second line Antiretrovirals in Pune, India

Post Date: 
2016-02-24
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Countries: 
Mave V , Kadam D, Salvi S, Basavaraj A, Joshi S, Chandanwale A, Gupte N, Bollinger RC, Gupta A. High TB Risk in HIV-Positive Patients on Second line Antiretrovirals in Pune, India. Conference on Retroviruses and Opportunistic Infections 2016. Boston, MA. 2016.

Pregnancy Intensifies the IFN-gamma Suppression of HIV in TB-infected Indian Women

Post Date: 
2016-02-24
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Clinical Sites: 
Mathad J, Bhosale R, Balasubramanian U, Deshpande P, Kanade S, Mave V, Gupta A. Pregnancy Intensifies the IFN-gamma Suppression of HIV in TB-infected Indian Women. Conference on Retroviruses and Opportunistic Infections 2016. Boston, MA. 2016.

Combination HIV Prevention and HIV Incidence in a Ugandan Hotspot Fishing Community

Post Date: 
2016-02-23
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Countries: 
Kagaayi J, Grabowski MK, Nakigozi G, Kigozi G, Nalugoda F, Ssekubugu R, Gray RH, Serwadda D, Wawer MJ, Chang L. Combination HIV Prevention and HIV Incidence in a Ugandan Hotspot Fishing Community. Conference on Retroviruses and Opportunistic Infections 2016. Boston, MA. 2016.

Primary Care Provider Interest in Treating HCV—A Mixed Methods Study

Post Date: 
2016-02-23
Falade-Nwulia O, McAdams-Mahmoud A, Irvin R, Niculescu A, Page K, Latkin C, Mix M, Thomas D, Sulkowski M, Mehta S. Primary Care Provider Interest in Treating HCV—A Mixed Methods Study. Conference on Retroviruses and Opportunistic Infections 2016. Boston, MA. 2016.

Migration, HIV Infection, and Combination HIV Prevention Access in Rakai, Uganda

Post Date: 
2016-02-23
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Countries: 
Grabowski MK, Lessler J, Bazaale JM, Chang L, Nabukalu D, Wawer M, Nalugoda F, Ssekubugu R, Nakigozi G, Gray RH. Migration, HIV Infection, and Combination HIV Prevention Access in Rakai, Uganda. Conference on Retroviruses and Opportunistic Infections 2016. Boston, MA. 2016.

Reducing Hepatitis C Viral Load and Genotype Ordering at Johns Hopkins Hospital

Post Date: 
2016-02-01
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Chida N, Greenbaum A, Tuddenham S, Kendall E, Ray S, Melia M. Reducing Hepatitis C Viral Load and Genotype Ordering at Johns Hopkins Hospital. JHMI High-Value Practice Research Symposium. Baltimore, MD.

TB Risk Perceptions Among Medical Residents at a Tertiary Care Center in India

Post Date: 
2015-12-06
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Countries: 
Pardeshi G , Parande M, Kadam D, Chandanwale A, Deluca A, Bollinger R, Farley J, Suryavanshi N. TB Risk Perceptions Among Medical Residents at a Tertiary Care Center in India. 46th Union World Conference on Lung Health. International Union for Tuberculosis and Lung Disease. Cape Town, South Africa.

Novel Package of Integrated Mobile Applications Reduces Time to Treatment Initiation for Patients with MDR-TB

Post Date: 
2015-12-05
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Countries: 
Farley J, McKenzie-White J, Seiguer S, Naicker M, Peters A, Isherwood L, Olsen F, Stevens W. Novel Package of Integrated Mobile Applications Reduces Time to Treatment Initiation for Patients with MDR-TB. The 46th Union World Conference on Lung Health. Cape Town, South Africa.

Incidence and Risk Factors for TB among HIV+ Children in India

Post Date: 
2015-12-05
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Countries: 
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Clinical Sites: 
Kinikar AA , DeLuca A, Gupte N, Kadam DB, Khadse S, Chandanwale A, Gupta A, Bollinger R. Incidence and Risk Factors for TB among HIV+ Children in India. The 46th Union World Conference on Lung Health. Cape Town, South Africa.

TB Outbreak among Health Care Workers and Trainees in a Tertiary-care Hospital in Pune, India

Post Date: 
2015-12-05
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Countries: 
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Clinical Sites: 
Basavaraj A , Patil A, Kadam DB, Chandanwale A, Jain D, DeLuca A, Mave V, Bollinger R. TB Outbreak among Health Care Workers and Trainees in a Tertiary-care Hospital in Pune, India. 46th Union World Conference on Lung Health. Cape Town, South Africa.

Isoniazid Hair Concentrations in Children with TB

Post Date: 
2015-12-05
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Countries: 
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Clinical Sites: 
Mave V, Kinikar AA, Gupte N, Nimkar S, Kagal A, Horng H, Ramachandran G, Dooley K, Gupta A. Isoniazid Hair Concentrations in Children with TB. 46th Union World Conference on Lung Health. International Union for Tuberculosis and Lung Disease. Cape Town, South Africa.

Impact of Rifapentine Price Reduction on Utilization for TB Treatment in the United States

Post Date: 
2015-12-04
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Countries: 
Gupta, A. Impact of Rifapentine Price Reduction on Utilization for TB Treatment in the United States. The 46th Union World Conference on Lung Health. Cape Town, South Africa.

Characteristics Associated with Mobile Phone Access among TB Patients in Pune, India

Post Date: 
2015-12-04
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Countries: 
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Clinical Sites: 
Ogale YP, Elf J, Lokhande R, Mave V, Roy S, Gupta A, Golub J, Mathad J. Characteristics Associated with Mobile Phone Access among TB Patients in Pune, India. The 46th Union World Conference on Lung Health. Cape Town, South Africa.

Risk Factors for Unfavorable Treatment Outcomes in DOTs-treated Pediatric TB Patients

Post Date: 
2015-12-04
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Countries: 
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Clinical Sites: 
Shelke S, Bollinger R, Chandanwale A, DeLuca A, Gupta A, Gupte N, Adhav PS, Kadam DB. Risk Factors for Unfavorable Treatment Outcomes in DOTs-treated Pediatric TB Patients. The 46th Union World Conference on Lung Health. Cape Town, South Africa.

Utility of GeneXpert for Diagnosis of Rifampicin-resistant Extra-pulmonary TB—A Retrospective Review of 70 Cases, SGH, Pune, India

Post Date: 
2015-12-04
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Countries: 
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Clinical Sites: 
Girish S, Dharmashle S, Desai S, Kagal A, Bharadwaj R, Chandanwale A, Lokhande R, Kadam DB, DeLuca A, Gupte N, Jain D, Gupta A, Bollinger R, Mave V. Utility of GeneXpert for Diagnosis of Rifampicin-resistant Extra-pulmonary TB—A Retrospective Review of 70 Cases, SGH, Pune, India, The 46th Union...

Maternal and Infant TB: Advancing Our Understanding of Pathogenesis, Treatment and Prevention

Post Date: 
2015-12-04
Mathad J, Bekker A. Maternal and Infant TB: Advancing Our Understanding of Pathogenesis, Treatment and Prevention. The 46th Union World Conference on Lung Health. Cape Town, South Africa.

TB/HIV Treatment during Pregnancy: Does Drug Metabolism Change?

Post Date: 
2015-12-04
Dooley K, Savic R. TB/HIV Treatment during Pregnancy: Does Drug Metabolism Change? The 46th Union World Conference on Lung Health. Cape Town, South Africa.

Current Research on the Pathophysiology, Immunology, Prevention and Treatment of TB in Pregnant Women

Post Date: 
2015-12-04
Gupta A, Mathad J. Current Research on the Pathophysiology, Immunology, Prevention and Treatment of TB in Pregnant Women. The 46th Union World Conference on Lung Health. Cape Town, South Africa.

Current Research on the Pathophysiology, Immunology, Prevention and Treatment of TB in Pregnant Women

Post Date: 
2015-12-04
Gupta, A., Mathad, J. Current Research on the Pathophysiology, Immunology, Prevention and Treatment of TB in Pregnant Women. International Union for Tuberculosis and Lung Disease. 46th Union World Conference on Lung Health. Capetown, South Africa.

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