Research News

Tuberculosis bacteria
June 25, 2019

NIH Press Release: NIH announces a large international clinical trial to prevent multidrug-resistant TB in children, adolescents, and adults who live with someone who has MDR-TB. CCGHE's Dr. Amita Gupta is a protocol chair.

Clinical Research

Leadership
While we conduct research all over the world, the majority of our work is in India. Our Indo-JHU Clinical Research Partnership is located in Pune and is directed by Dr. Amita Gupta (Baltimore, MD), with onsite direction from Dr. Vidya Mave, Dr. Nishi Suryavanshi, and Dr. Nikhil Gupte (Pune). The Indo-JHU Partnership employs more than 200 people and in addition to our memberships in cosortia with many esteemed Indian research institutions, we have formal agreements with:

 
 

A5207: Maintaining Options for Mothers Study (MOMS): A Phase II Randomized Comparison of Three Antiretroviral Strategies Administered for 7 or 21 Days to Reduce the Emergence of Nevirapine Resistant HIV-1 Following a Single Intrapartum Dose of Nevirapine

Post Date: 
2004-12-20
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This study was terminated January 16, 2014; it was conducted under the AIDS Clinical Trials Group (ACTG) and funded by the U.S. National Institutes of Health. A major disadvantage of giving SD NVP is the potential for maternal development of NVP resistance and additional resistance to other...

A5175: PEARLS Evaluation of the Efficacy of Once-Daily Protease Inhibitor and Once-Daily Non-Nucleoside Reverse Transcriptase Inhibitor- Containing Therapy Combinations for Initial Treatment of HIV-1 Infected Individuals

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2004-07-27
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Full Title: A Phase IV, Prospective, Randomized, Open-Label Evaluation of the Efficacy of Once-Daily Protease Inhibitor and Once Daily Non-Nucleoside Reverse Transcriptase Inhibitor Containing Therapy Combinations for Initial Treatment of HIV-1 Infected Individuals from Resource-Limited Settings (...

Evaluation of Provider, Patient and Pharmacy Knowledge, Attitudes and Practices Regarding HIV Care and Use of Antiretroviral Therapy in Pune, India

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2004-03-29
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This study ended in 2007. Antiretroviral therapy (ART) has dramatically affected morbidity and mortality among HIV-infected persons in industrialized countries. In India, where approximately 4.3 million persons are estimated to be HIV-infected (NACO), the use of ART has been limited because of the...

A Study to Validate New Assays for Measuring HIV Seroincidence in Indian HIV Subtype C Seroconverters

Post Date: 
2003-08-05
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This study ended in July 2006.

Mother-to-Child Transmission (MTCT) of HIV: India SWEN Study

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2002-06-07
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This study was officially terminated August 2018. Primary and secondary analyses of the India SWEN study, an NIH-funded phase III randomized controlled trial of an extended nevirapine prophylaxis regimen among 783 HIV-infected pregnant women and their breastfed infants in Pune, India.

Technology-enhanced Peer Navigation to Improve Injection Drug User (IDU) Engagement in HIV Care

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2000-01-01
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This study is evaluating an mHealth-enhanced peer navigation intervention for improving retention-in-care and adherence to antiretroviral therapy (ART) for out-of-care, HIV-infected injection drug users (IDUs). The CCGHE-developed emocha® is assisting peer navigators (former IDUs successfully...

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Isoniazid hair concentrations in children with tuberculosis: a proof of concept study

Post Date: 
2016-06-01
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Publication: 
International Journal of Tuberculosis and Lung Disease
Assessing treatment adherence and quantifying exposure to anti-tuberculosis drugs among children is challenging. We undertook a 'proof of concept' study to assess the drug concentrations of isoniazid (INH) in hair as a therapeutic drug monitoring tool. Children aged <12 years initiated on...

The availability of emergency obstetric care in the context of the JSY cash transfer programme in Madhya Pradesh, India

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2016-05-18
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BMC Pregnancy and Childbirth
Abstract Background: Since 2005, India has implemented a national cash transfer programme, the Janani Suraksha Yojana (JSY), which provides women a cash transfer upon giving birth in an existing public facility. This has resulted in a steep rise in facility births across the country. The early...

Applying ethical principles to international community-based research; a case study from the Consortium to Respond Effectively to the AIDS/TB Epidemic

Post Date: 
2016-05-15
This paper describes how one set of HIV-TB prevention research studies put procedures in place to be responsive to these foundational ethical principles when interacting with communities in large population-based, global public health research.

Public health clinic-based hepatitis C testing and linkage to care in Baltimore

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2016-05-15
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Publication: 
Journal of Viral Hepatitis
Testing and linkage to care are important determinants of hepatitis C virus (HCV) treatment effectiveness. Public health clinics serve populations at high risk of HCV. We investigated their potential to serve as sites for HCV testing, initiation of and linkage to HCV care. Cross-sectional study of...

Management and control of multidrug-resistant tuberculosis (MDR-TB): addressing policy needs for India

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2016-05-06
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Journal of Public Health Policy
Multidrug-resistant tuberculosis (MDR-TB) challenges TB control efforts because of delays in diagnosis plus its long-term treatment which has toxic effects. Of TB high-incidence countries, India carries the highest burden of MDR-TB cases. We describe policy issues in India concerning MDR-TB...

High proportion of extrapulmonary tuberculosis in a low prevalence setting: a retrospective cohort study

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2016-04-29
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Public Health
Objectives: The proportion of extrapulmonary tuberculosis (EPTB) cases in the United States (US) has been rising due to a slower rate of decline in EPTB compared to pulmonary tuberculosis (PTB). The purpose of this study was to characterise the clinical and treatment differences between EPTB and...

Persistently elevated C-reactive protein level in the first year of antiretroviral therapy, despite virologic suppression, is associated with HIV disease progression in resource-constrained settings

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2016-04-01
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Publication: 
The Journal of Infectious Diseases
A case-cohort analysis of human immunodeficiency virus (HIV)-infected individuals receiving antiretroviral therapy (ART) was performed within a multicountry randomized trial (PEARLS) to assess the prevalence of persistently elevated C-reactive protein (CRP) levels, based on serial measurements of...

Inflammation and change in body weight with antiretroviral therapy initiation in a multinational cohort of HIV-infected adults

Post Date: 
2016-04-01
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The Journal of Infectious Diseases
Background: Both wasting and obesity are associated with inflammation, but the extent to which body weight changes influence inflammation during human immunodeficiency virus infection is unknown. Methods: Among a random virologically suppressed participants of the Prospective Evaluation of...

Tuberculosis risk among medical trainees, Pune, India

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2016-03-22
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Emerging Infectious Diseases
During 2012–2013, at a public hospital in Pune, India, 26 (3.9%) cases of tuberculosis were reported among 662 medical trainees, representing an estimated incidence of 3,279 cases/100,000 person-years. Three of these infections were isoniazid-resistant, 1 was multidrug-resistant, and 1 occurred in...

Empirical tuberculosis therapy versus isoniazid in adult outpatients with advanced HIV initiating antiretroviral therapy (REMEMBER): a multicountry open-label randomised controlled trial

Post Date: 
2016-03-19
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The Lancet
Background: Mortality within the first 6 months after initiating antiretroviral therapy is common in resource-limited settings and is often due to tuberculosis in patients with advanced HIV disease. Isoniazid preventive therapy is recommended in HIV-positive adults, but subclinical tuberculosis can...

Ecological momentary assessment of illicit drug use compared to biological and self-reported methods

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2016-03-15
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Journal of Medical Internet Research
Background: The use of mHealth methods for capturing illicit drug use and associated behaviors have become more widely used in research settings, yet there is little research as to how valid these methods are compared to known measures of capturing and quantifying drug use. Objective: We examined...

Infectious Diseases (ID) Learning Unit: How rapidly to evaluate for active tuberculosis disease in low-prevalence settings

Post Date: 
2016-03-11
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Open Forum Infectious Diseases
With declining tuberculosis (TB) incidence in low-prevalence settings, many clinicians are likely unaware that the approach to diagnosing active TB is evolving with newer technologies. Rapid molecular assays are commercially available, and more are likely to enter the market in the coming years...

Cohort for Tuberculosis Research by the Indo-US Medical Partnership (C-TRIUMPH): protocol for a multicentric prospective observational study

Post Date: 
2016-02-25
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BMJ Open
Introduction: Tuberculosis disease (TB) remains an important global health threat. An evidence-based response, tailored to local disease epidemiology in high-burden countries, is key to controlling the global TB epidemic. Reliable surrogate biomarkers that predict key active disease and latent TB...

Assessment of the quality of clinical documentation in India's JSY cash transfer program for facility births in Madhya Pradesh

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2016-02-15
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Publication: 
International Journal of Gynaecology and Obstetrics
Abstract Objective: To gain insight into the quality of care in facilities implementing the Janani Suraksha Yojana (JSY) cash transfer program in Madhya Pradesh, India, by reviewing the level of documentation in the clinical records of women who delivered. Methods: The present retrospective,...

Low Vitamin-D levels combined with PKP3-SIGIRR-TMEM16J host variants is strongly associated with tuberculosis and death in HIV-infected and -exposed infants

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2016-02-12
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PLOS One
Background: This study examined the associations of 25-hydroxyvitamin D and specific host genetic variants that affect vitamin D levels or its effects on immune function, with the risk of TB or mortality in children. Methods: A case-cohort sample of 466 South African infants enrolled in P1041 trial...

Prevalence and risk factors of micronutrient deficiencies pre- and post-antiretroviral therapy (ART) among a diverse multicountry cohort of HIV-infected adults

Post Date: 
2016-02-10
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Clinical Nutrition
Background & Aims: HIV-infected adults have increased risk of several individual micronutrient deficiencies. However, the prevalence and risk factors of concurrent and multiple micronutrient deficiencies and whether micronutrient concentrations change after antiretroviral therapy (ART)...

TLR2-modulating lipoproteins of the mycobacterium tuberculosis complex enhance the HIV infectivity of CD4+ T cells

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2016-01-25
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PLoS One
Abstract Co-infection with Mycobacterium tuberculosis accelerates progression from HIV to AIDS. Our previous studies showed that M. tuberculosis complex, unlike M. smegmatis, enhances TLR2-dependent susceptibility of CD4+ T cells to HIV. The M. tuberculosis complex produces multiple TLR2-...

Senior center-based hepatitis C screening in Baltimore

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2016-01-06
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Open Forum Infectious Diseases
Abstract Despite significant advancements in hepatitis C virus (HCV) treatments, the majority of individuals infected with HCV remain undiagnosed. We report on senior citizen center-based HCV testing in Baltimore, which revealed a 9.4% prevalence of infection. Our data suggest that community-based...

Toward earlier inclusion of pregnant and postpartum women in TB drug trials: consensus statements from an International Expert Panel

Post Date: 
2016-01-04
Publication: 
Clinical Infectious Diseases
Tuberculosis is a major cause of morbidity and mortality in women of childbearing age (15–44 years). Despite increased tuberculosis risk during pregnancy, optimal clinical treatment remains unclear: safety, tolerability, and pharmacokinetic data for many tuberculosis drugs are lacking, and trials...

Cost effectiveness of isoniazid preventive therapy for HIV-infected pregnant women in India

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2016-01-01
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International Journal of Tuberculosis and Lung Disease
Background: India has a high burden of active tuberculosis (TB) and human immunodeficiency virus (HIV) infection. Pregnancy increases the risks of developing TB in HIV-infected women. Isoniazid preventive therapy (IPT) reduces progression to TB, but may increase costs and hepatotoxicity. The cost-...

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Dengue and Malaria are Common Infections among Adults and Adolescents Hospitalized with Acute Febrile Illness in Western India

Post Date: 
2015-10-09
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Mave V, Kadam D, Bharadwaj R, Kagal A, Sachs J, Raichur P, Kanade S, Gupte N, Joshi S, Chandanwale A, Zenilman JM, Bollinger R, Gupta A. Dengue and Malaria are Common Infections among Adults and Adolescents Hospitalized with Acute Febrile Illness in Western India. Infectious Diseases Society of...

A Man from Central America with Progressive Shortness of Breath

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2015-10-07
Chida, N. A Man from Central America with Progressive Shortness of Breath. ID Week 2015. San Diego, CA. 2015.

TB and Women

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2015-09-29
Gupta, A. TB and Women. Mid Atlantic TB Intensive Workshop. Rehoboth, DE.

Conducting HIV and TB Research in India: Challenges and Opportunities

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2015-08-27
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Gupta, A. Conducting HIV and TB Research in India: Challenges and Opportunities. Emory University. Atlanta, GA.

Tuberculosis in Pregnant Women and Infants

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2015-08-26
Gupta, A. Tuberculosis in Pregnant Women and Infants. International Conference on Emerging Infectious Diseases. Atlanta, GA.

Tuberculosis in Peripartum Women and Infants

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2015-08-26
Gupta, A. Tuberculosis in Peripartum Women and Infants. International Conference on Emerging Infectious Diseases. Atlanta, GA.

Tuberculosis in Pregnant Women and Infants

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2015-08-25
Gupta, A. Tuberculosis in Pregnant Women and Infants. US Centers for Disease Control and Prevention. Atlanta, GA.

Global Teaching of Global Health Competencies for Medical Students in Uganda

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2015-07-15
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Bollinger, R. Global Teaching of Global Health Competencies for Medical Students in Uganda. Medical Education Partnership Initiative (MEPI) Innovation Session. Harare, Zimbabwe.

Hispanic-Serving Health Professions Schools (HSHPS) 2015 Workshop

Post Date: 
2015-06-30
Page, K. Hispanic-Serving Health Professions Schools (HSHPS) 2015 Workshop. Hispanic-Serving Health Professions Schools (HSHPS) 2015 Workshop. HSHPS and National Institutes of Health. Bethesda, MD. 2015.

Therapeutic Drug Monitoring (TDM) of TB in Young Children: The Role of Hair Assays

Post Date: 
2015-06-17
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Mave, V. Therapeutic Drug Monitoring (TDM) of TB in Young Children: The Role of Hair Assays. IMPAACT Annual Meeting. Washington, DC.

TB Research and Community Impact

Post Date: 
2015-05-27
Gupta, A. TB Research and Community Impact. Community Research Advisory Group (CRAG), Community Partners (CP). TB/HIV International Research & Community Engagement Webinar. N/A.

The Association of Exposure to Air Pollution from Biomass Fuels, Kerosene, and Secondhand Tobacco Smoke with TB in Adult Women and Children in Pune, India

Post Date: 
2015-05-01
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Elf JL , Kinikar A, Khadse S, Mave V, Gupte N, Kulkarni V, Patekar S, Raichur P, Breysse P, Gupta A, Golub J. The Association of Exposure to Air Pollution from Biomass Fuels, Kerosene, and Secondhand Tobacco Smoke with TB in Adult Women and Children in Pune, India. American Thoracic Society...

Conducting HIV/TB Research in India: Challenges and Opportunities

Post Date: 
2015-04-17
Gupta, A. Conducting HIV/TB Research in India: Challenges and Opportunities. Grand Rounds, Johns Hopkins School of Medicine. Baltimore, MD.

Conference on Vaccine Research, Closing Talk

Post Date: 
2015-04-15
Bollinger, R. Conference on Vaccine Research, Closing Talk. Annual Conference on Vaccine Research. National Foundation for Infectious Diseases. Bethesda, MD.

Grand Rounds

Post Date: 
2015-03-31
Page, K. Grand Rounds. Center for Child and Community Health Research. Johns Hopkins School of Medicine, Bayview Medical Center. Baltimore, MD.

TB and Diabetes Mellitus

Post Date: 
2015-03-30
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Mave, V. TB and Diabetes Mellitus. RePORT India TB Workshop. Pune, India.

Mobilizing Research for Global Health

Post Date: 
2015-03-25
Bollinger, R. Mobilizing Research for Global Health. Sixth Annual CUGH Conference. Consortium of Universities for Global Health. Boston, MA.

TB in Pregnancy

Post Date: 
2015-03-05
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Gupta, A. TB in Pregnancy. RePORT India TB Workshop. Mumbai, India.

Tuberculosis in Pregnancy

Post Date: 
2015-02-25
Gupta, A. Tuberculosis in Pregnancy. Conference on Retroviruses and Opportunistic Infections 2015. Seattle, WA. 2015.

Tuberculosis in Children

Post Date: 
2015-02-24
Gupta, A. Tuberculosis in Children. Conference on Retroviruses and Opportunistic Infections 2015. Seattle, WA. 2015.

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