Research News

Mother and baby
October 3, 2019

New England Journal of Medicine: Dr. Amita Gupta and colleagues found that the current standard of care given to HIV+ pregnant women to prevent TB should wait until 12 weeks after delivery. The study underscores the need to include pregnant women in clinical trials.

Clinical Research

Leadership
While we conduct research all over the world, the majority of our work is in India. Our Indo-JHU Clinical Research Partnership is located in Pune and is directed by Dr. Amita Gupta (Baltimore, MD), with onsite direction from Dr. Vidya Mave, Dr. Nishi Suryavanshi, and Dr. Nikhil Gupte (Pune). The Indo-JHU Partnership employs more than 200 people and in addition to our memberships in cosortia with many esteemed Indian research institutions, we have formal agreements with:

 
 

Calibration and Application of a Simple Sensitive/Less Sensitive Assay Applicable to Resource-Limited Countries for Determination of Recent HIV Infection and Incidence Estimates

Post Date: 
2007-03-22
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This study was terminated March 31, 2007. Sensitive/Less Sensitive assays (S/LS) to distinguish between recent and established HIV infections have been successfully applied to identify recently infected persons and determine HIV incidence. However, all currently used S/LS assays require laboratory...

BWI CTU: Baltimore-Washington-India Clinical Trials Unit

Post Date: 
2007-02-02
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Comprising clinical trial sites at Johns Hopkins Medicine in Baltimore, Whitman Walker Health in Washington, DC, and the BJGMC-CCGHE collaboration in Pune, India, the Baltimore-Washington-India Clinical Trials Unit (BWI-CTU) is one of only 25 international HIV/TB clinical trial sites funded by the...

Integration of HIV and Other Prevalent Relevant Infectious Disease Care into Primary Medical Care

Post Date: 
2007-01-01
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Countries: 
According to the Pan American Health Organization (PAHO), HIV is rapidly expanding in Latin America, and among the Latin American countries with highest HIV prevalence, four are located in Central America. Notably, AIDS is among the 10 leading causes of death in three of the six countries in...

BJGMC-JHU Fogarty HIV-TB Training Program

Post Date: 
2007-01-01
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Funded by the Fogarty International Center at the National Institutes of Health, the JHU Fogarty program has nearly 20 years of success with providing training, professional development, and mentorship to clinicians and scientists in low and middle income countries. CCGHE's latest efforts in this...

P1060: Phase II, parallel, randomized, clinical trials comparing the responses to initiation of NNRTI-based antiretroviral therapy in HIV-infected infants who have not previously received Single dose Nevirapine for prevention of Mother-to-child HIV...

Post Date: 
2006-03-27
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This study ended June 28, 2015. This multi-country trial was conducted in India, Malawi, South Africa, Tanzania, Uganda, Zambia, and Zimbabwe under the International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) Network and funded by the U.S. National Institutes of Health. Full Title...

A5207: Maintaining Options for Mothers Study (MOMS): A Phase II Randomized Comparison of Three Antiretroviral Strategies Administered for 7 or 21 Days to Reduce the Emergence of Nevirapine Resistant HIV-1 Following a Single Intrapartum Dose of Nevirapine

Post Date: 
2004-12-20
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This study was terminated January 16, 2014; it was conducted under the AIDS Clinical Trials Group (ACTG) and funded by the U.S. National Institutes of Health. A major disadvantage of giving SD NVP is the potential for maternal development of NVP resistance and additional resistance to other...

A5175: PEARLS Evaluation of the Efficacy of Once-Daily Protease Inhibitor and Once-Daily Non-Nucleoside Reverse Transcriptase Inhibitor- Containing Therapy Combinations for Initial Treatment of HIV-1 Infected Individuals

Post Date: 
2004-07-27
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Full Title: A Phase IV, Prospective, Randomized, Open-Label Evaluation of the Efficacy of Once-Daily Protease Inhibitor and Once Daily Non-Nucleoside Reverse Transcriptase Inhibitor Containing Therapy Combinations for Initial Treatment of HIV-1 Infected Individuals from Resource-Limited Settings (...

Evaluation of Provider, Patient and Pharmacy Knowledge, Attitudes and Practices Regarding HIV Care and Use of Antiretroviral Therapy in Pune, India

Post Date: 
2004-03-29
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Countries: 
This study ended in 2007. Antiretroviral therapy (ART) has dramatically affected morbidity and mortality among HIV-infected persons in industrialized countries. In India, where approximately 4.3 million persons are estimated to be HIV-infected (NACO), the use of ART has been limited because of the...

A Study to Validate New Assays for Measuring HIV Seroincidence in Indian HIV Subtype C Seroconverters

Post Date: 
2003-08-05
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This study ended in July 2006.

Mother-to-Child Transmission (MTCT) of HIV: India SWEN Study

Post Date: 
2002-06-07
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This study was officially terminated August 2018. Primary and secondary analyses of the India SWEN study, an NIH-funded phase III randomized controlled trial of an extended nevirapine prophylaxis regimen among 783 HIV-infected pregnant women and their breastfed infants in Pune, India.

Technology-enhanced Peer Navigation to Improve Injection Drug User (IDU) Engagement in HIV Care

Post Date: 
2000-01-01
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Countries: 
This study is evaluating an mHealth-enhanced peer navigation intervention for improving retention-in-care and adherence to antiretroviral therapy (ART) for out-of-care, HIV-infected injection drug users (IDUs). The CCGHE-developed emocha® is assisting peer navigators (former IDUs successfully...

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HIV-related stigma among Spanish speaking Latinos in an emerging immigrant receiving city

Post Date: 
2016-09-27
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Publication: 
Journal of Immigrant and Minority Health
HIV-related stigma has been associated with a reluctance to test for HIV among Latinos . This study assessed community HIV-related stigma within an emerging Latino immigrant receiving city . We conducted a brief survey among a convenience sample of 312 Spanish - speaking Latinos in Baltimore,...

Continued importance of sexually transmitted disease clinics in the era of the Affordable Care Act

Post Date: 
2016-09-15
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Publication: 
American Journal of Preventive Medicine
Introduction: Following the 2014 expansions of Medicaid and private health insurance through the Affordable Care Act, municipal sexually transmitted disease (STD) clinics-which have historically served predominantly uninsured patients-have been threatened with budget cuts nationwide. This study was...

Lateral flow urine lipoarabinomannan assay for detecting active tuberculosis in HIV-positive adults

Post Date: 
2016-08-16
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Countries: 
Publication: 
Cochrane Database of Systematic Reviews
Background: Rapid detection of tuberculosis (TB) among people living with human immunodeficiency virus (HIV) is a global health priority. HIV-associated TB may have different clinical presentations and is challenging to diagnose. Conventional sputum tests have reduced sensitivity in HIV-positive...

Heterogeneity of the HIV epidemic in agrarian, trading, and fishing communities in Rakai, Uganda: an observational epidemiological study

Post Date: 
2016-08-15
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Countries: 
Publication: 
The Lancet HIV
Background : Understanding the extent to which HIV burden differs across communities and the drivers of local disparities is crucial for an effective and targeted HIV response. We assessed community-level variations in HIV prevalence, risk factors, and treatment and prevention service uptake in...

Community-based interventions to improve and sustain antiretroviral therapy adherence, retention in HIV care and clinical outcomes in low- and middle-income countries for achieving the UNAIDS 90-90-90 targets

Post Date: 
2016-07-30
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Countries: 
Publication: 
Current HIV/AIDS Reports
Little is known about the effect of community versus health facility-based interventions to improve and sustain antiretroviral therapy (ART) adherence, virologic suppression, and retention in care among HIV-infected individuals in low- and middle-income countries (LMICs). We systematically searched...

Continued elevation of interleukin-18 and interferon-γ after initiation of antiretroviral therapy and clinical failure in a diverse multicountry human immunodeficiency virus cohort

Post Date: 
2016-07-27
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Countries: 
Publication: 
Open Forum Infectious Diseases
Background: We assessed immune activation after antiretroviral therapy (ART) initiation to understand clinical failure in diverse settings. Methods: We performed a case-control study in ACTG Prospective Evaluation of Antiretrovirals in Resource-Limited Settings (PEARLS). Cases were defined as...

Association of medical male circumcision and antiretroviral therapy scale-up with community HIV incidence in Rakai, Uganda

Post Date: 
2016-07-12
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Publication: 
JAMA
Importance Medical male circumcision (MMC) and antiretroviral therapy (ART) are proven HIV prevention interventions, but there are limited data on the population-level effect of scale-up of these interventions in sub-Saharan Africa. Such evaluation is important for planning and resource allocation...

Epidemiological impact of achieving UNAIDS 90-90-90 targets for HIV care in India: a modelling study

Post Date: 
2016-07-07
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Publication: 
BMJ Open
Objective: Recent UNAIDS ‘90-90-90’ targets propose that to end the HIV epidemic by 2030, 90% of persons living with HIV (PLWH) worldwide should know their diagnosis, 90% of diagnosed PLWH should be on antiretroviral therapy (ART) and 90% of PLWH on ART should be virally suppressed by 2020...

Inflammation and change in body weight with antiretroviral therapy initiation in a multinational cohort of HIV-infected adults

Post Date: 
2016-07-01
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Countries: 
Publication: 
Journal of Infectious Diseases
Background: Both wasting and obesity are associated with inflammation, but the extent to which body weight changes influence inflammation during human immunodeficiency virus infection is unknown. Methods: Among a random virologically suppressed participants of the Prospective Evaluation of...

Defining clinical excellence in adult infectious disease practice

Post Date: 
2016-06-16
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Publication: 
Open Forum Infectious Diseases
Clinical excellence should be recognized, particularly in the current climate that appropriately prioritizes relationship-centered care. In order to develop a recognition model, a definition of clinical excellence must be created and agreed upon. A paradigm recently suggested by C. Christmas...

Quantitative IFN-y,IL-2 response and latent tuberculosis test discordance in HIV-infected pregnant women

Post Date: 
2016-06-15
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Publication: 
American Journal of Respiratory and Critical Care Medicine
Rationale: Pregnant women with latent tuberculosis infection (LTBI) are at high risk for development of TB, especially if infected with HIV. Objectives: To assess the performance of LTBI tests in pregnant and postpartum women infected with HIV, investigate the immunology behind discordance in...

Next-generation sequencing in neuropathologic diagnosis of infections of the nervous system

Post Date: 
2016-06-13
Publication: 
Neurology, Neuroimmunology and Neuroinflammation
OBJECTIVE: To determine the feasibility of next-generation sequencing (NGS) microbiome approaches in the diagnosis of infectious disorders in brain or spinal cord biopsies in patients with suspected CNS infections. METHODS: In a prospective pilot study, we applied NGS in combination with a new...

Isoniazid hair concentrations in children with tuberculosis: a proof of concept study

Post Date: 
2016-06-01
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Publication: 
International Journal of Tuberculosis and Lung Disease
Assessing treatment adherence and quantifying exposure to anti-tuberculosis drugs among children is challenging. We undertook a 'proof of concept' study to assess the drug concentrations of isoniazid (INH) in hair as a therapeutic drug monitoring tool. Children aged <12 years initiated on...

The availability of emergency obstetric care in the context of the JSY cash transfer programme in Madhya Pradesh, India

Post Date: 
2016-05-18
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Countries: 
Publication: 
BMC Pregnancy and Childbirth
Abstract Background: Since 2005, India has implemented a national cash transfer programme, the Janani Suraksha Yojana (JSY), which provides women a cash transfer upon giving birth in an existing public facility. This has resulted in a steep rise in facility births across the country. The early...

Applying ethical principles to international community-based research; a case study from the Consortium to Respond Effectively to the AIDS/TB Epidemic

Post Date: 
2016-05-15
This paper describes how one set of HIV-TB prevention research studies put procedures in place to be responsive to these foundational ethical principles when interacting with communities in large population-based, global public health research.

Public health clinic-based hepatitis C testing and linkage to care in Baltimore

Post Date: 
2016-05-15
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Countries: 
Publication: 
Journal of Viral Hepatitis
Testing and linkage to care are important determinants of hepatitis C virus (HCV) treatment effectiveness. Public health clinics serve populations at high risk of HCV. We investigated their potential to serve as sites for HCV testing, initiation of and linkage to HCV care. Cross-sectional study of...

Management and control of multidrug-resistant tuberculosis (MDR-TB): addressing policy needs for India

Post Date: 
2016-05-06
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Countries: 
Publication: 
Journal of Public Health Policy
Multidrug-resistant tuberculosis (MDR-TB) challenges TB control efforts because of delays in diagnosis plus its long-term treatment which has toxic effects. Of TB high-incidence countries, India carries the highest burden of MDR-TB cases. We describe policy issues in India concerning MDR-TB...

High proportion of extrapulmonary tuberculosis in a low prevalence setting: a retrospective cohort study

Post Date: 
2016-04-29
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Countries: 
Publication: 
Public Health
Objectives: The proportion of extrapulmonary tuberculosis (EPTB) cases in the United States (US) has been rising due to a slower rate of decline in EPTB compared to pulmonary tuberculosis (PTB). The purpose of this study was to characterise the clinical and treatment differences between EPTB and...

Inflammation and change in body weight with antiretroviral therapy initiation in a multinational cohort of HIV-infected adults

Post Date: 
2016-04-01
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Clinical Sites: 
Publication: 
The Journal of Infectious Diseases
Background: Both wasting and obesity are associated with inflammation, but the extent to which body weight changes influence inflammation during human immunodeficiency virus infection is unknown. Methods: Among a random virologically suppressed participants of the Prospective Evaluation of...

Persistently elevated C-reactive protein level in the first year of antiretroviral therapy, despite virologic suppression, is associated with HIV disease progression in resource-constrained settings

Post Date: 
2016-04-01
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Clinical Sites: 
Publication: 
The Journal of Infectious Diseases
A case-cohort analysis of human immunodeficiency virus (HIV)-infected individuals receiving antiretroviral therapy (ART) was performed within a multicountry randomized trial (PEARLS) to assess the prevalence of persistently elevated C-reactive protein (CRP) levels, based on serial measurements of...

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Characteristics Associated with Mobile Phone Access among TB Patients in Pune, India

Post Date: 
2015-12-04
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Clinical Sites: 
Ogale YP, Elf J, Lokhande R, Mave V, Roy S, Gupta A, Golub J, Mathad J. Characteristics Associated with Mobile Phone Access among TB Patients in Pune, India. The 46th Union World Conference on Lung Health. Cape Town, South Africa.

Risk Factors for Unfavorable Treatment Outcomes in DOTs-treated Pediatric TB Patients

Post Date: 
2015-12-04
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Countries: 
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Shelke S, Bollinger R, Chandanwale A, DeLuca A, Gupta A, Gupte N, Adhav PS, Kadam DB. Risk Factors for Unfavorable Treatment Outcomes in DOTs-treated Pediatric TB Patients. The 46th Union World Conference on Lung Health. Cape Town, South Africa.

Utility of GeneXpert for Diagnosis of Rifampicin-resistant Extra-pulmonary TB—A Retrospective Review of 70 Cases, SGH, Pune, India

Post Date: 
2015-12-04
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Countries: 
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Clinical Sites: 
Girish S, Dharmashle S, Desai S, Kagal A, Bharadwaj R, Chandanwale A, Lokhande R, Kadam DB, DeLuca A, Gupte N, Jain D, Gupta A, Bollinger R, Mave V. Utility of GeneXpert for Diagnosis of Rifampicin-resistant Extra-pulmonary TB—A Retrospective Review of 70 Cases, SGH, Pune, India, The 46th Union...

Maternal and Infant TB: Advancing Our Understanding of Pathogenesis, Treatment and Prevention

Post Date: 
2015-12-04
Mathad J, Bekker A. Maternal and Infant TB: Advancing Our Understanding of Pathogenesis, Treatment and Prevention. The 46th Union World Conference on Lung Health. Cape Town, South Africa.

TB/HIV Treatment during Pregnancy: Does Drug Metabolism Change?

Post Date: 
2015-12-04
Dooley K, Savic R. TB/HIV Treatment during Pregnancy: Does Drug Metabolism Change? The 46th Union World Conference on Lung Health. Cape Town, South Africa.

Applied HIV Epidemiology and Implementation Science: a multidisciplinary approach to understanding and controlling an evolving epidemic

Post Date: 
2015-11-20
Chang, L. Applied HIV Epidemiology and Implementation Science: a multidisciplinary approach to understanding and controlling an evolving epidemic. National Institutes of Health. Bethesda, MD.

Isoniazid Concentration in Hair among Children with Tuberculosis

Post Date: 
2015-11-15
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Clinical Sites: 
Mave, V. Isoniazid Concentration in Hair among Children with Tuberculosis. Annual Meeting, Center for AIDS Research. Seattle, WA.

BJMC-JHU Research Program

Post Date: 
2015-10-31
Mave, V. BJMC-JHU Research Program. TreatAsia Network Meeting. Bangkok, Thailand.

Rakai Health Sciences Program: Social, Behavioral, and Biomedical Research in HIV Dynamics, Prevention, and Care

Post Date: 
2015-10-30
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Countries: 
Chang, L. Rakai Health Sciences Program: Social, Behavioral, and Biomedical Research in HIV Dynamics, Prevention, and Care. CFAR National Social and Behavioral Sciences Research Network Annual Meeting. Baltimore, MD.

mHealth

Post Date: 
2015-10-29
Chang, L. mHealth. CFAR National Social and Behavioral Sciences Research Network Annual Meeting. Baltimore, MD.

Does Quality of Delivery Care Differ Between Public and Private Facilities in Madhya Pradesh, India?: An Exit Interview Study of Routine Delivery Care Practices

Post Date: 
2015-10-20
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Countries: 
Chaturvedi C, Randive B , Sabde Y, Diwan V, Raven J, De Costa A. Does Quality of Delivery Care Differ Between Public and Private Facilities in Madhya Pradesh, India?: An Exit Interview Study of Routine Delivery Care Practices. Global Maternal Newborn Health Conference 2015. Mexico City, Mexico. 2015

Operational Challenges Undermine WHO TB Symptom Screen in Pregnant Women

Post Date: 
2015-10-11
Vaidya A , Tambe S, Bhosale R, Mave V, Elf J, Pradhan N, Nevrekar N, Patil S, Kagal A, Joshi S, Chandanwale A, Gupta A, MathadJ. Operational Challenges Undermine WHO TB Symptom Screen in Pregnant Women. ID Week 2015. San Diego, CA. San Diego, CA. 2015

Developing a Validated Tool to Assess Internal Medicine and Infectious Disease Trainees’ Ability to Obtain and Interpret TB Diagnostics

Post Date: 
2015-10-11
Chida N, Gupta A, Bollinger B, Melia M. Developing a Validated Tool to Assess Internal Medicine and Infectious Disease Trainees’ Ability to Obtain and Interpret TB Diagnostics. ID Week 2015. San Diego, CA. 2015

Dengue and Malaria are Common Infections among Adults and Adolescents Hospitalized with Acute Febrile Illness in Western India

Post Date: 
2015-10-09
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Countries: 
Mave V, Kadam D, Bharadwaj R, Kagal A, Sachs J, Raichur P, Kanade S, Gupte N, Joshi S, Chandanwale A, Zenilman JM, Bollinger R, Gupta A. Dengue and Malaria are Common Infections among Adults and Adolescents Hospitalized with Acute Febrile Illness in Western India. Infectious Diseases Society of...

A Man from Central America with Progressive Shortness of Breath

Post Date: 
2015-10-07
Chida, N. A Man from Central America with Progressive Shortness of Breath. ID Week 2015. San Diego, CA. 2015.

TB and Women

Post Date: 
2015-09-29
Gupta, A. TB and Women. Mid Atlantic TB Intensive Workshop. Rehoboth, DE.

Conducting HIV and TB Research in India: Challenges and Opportunities

Post Date: 
2015-08-27
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Countries: 
Gupta, A. Conducting HIV and TB Research in India: Challenges and Opportunities. Emory University. Atlanta, GA.

Tuberculosis in Pregnant Women and Infants

Post Date: 
2015-08-26
Gupta, A. Tuberculosis in Pregnant Women and Infants. International Conference on Emerging Infectious Diseases. Atlanta, GA.

Tuberculosis in Peripartum Women and Infants

Post Date: 
2015-08-26
Gupta, A. Tuberculosis in Peripartum Women and Infants. International Conference on Emerging Infectious Diseases. Atlanta, GA.

Tuberculosis in Pregnant Women and Infants

Post Date: 
2015-08-25
Gupta, A. Tuberculosis in Pregnant Women and Infants. US Centers for Disease Control and Prevention. Atlanta, GA.

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