Research News

Remdesivir vials
March 24, 2021

Just Published in JAMA Network Open: In this retrospective analysis, remdesivir was associated with faster clinical improvement of COVID-19 in a cohort of predominantly non-White patients

Clinical Research

Leadership
While we conduct research all over the world, the majority of our work is in India. Our Indo-JHU Clinical Research Partnership is located in Pune and is directed by Dr. Amita Gupta (Baltimore, MD), with onsite direction from Dr. Vidya Mave, Dr. Nishi Suryavanshi, and Dr. Nikhil Gupte (Pune). The Indo-JHU Partnership employs more than 200 people and in addition to our memberships in cosortia with many esteemed Indian research institutions, we have formal agreements with:

 
 

P1060: Phase II, parallel, randomized, clinical trials comparing the responses to initiation of NNRTI-based antiretroviral therapy in HIV-infected infants who have not previously received Single dose Nevirapine for prevention of Mother-to-child HIV...

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2006-03-27
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This study ended June 28, 2015. This multi-country trial was conducted in India, Malawi, South Africa, Tanzania, Uganda, Zambia, and Zimbabwe under the International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) Network and funded by the U.S. National Institutes of Health...

A5207: Maintaining Options for Mothers Study (MOMS): A Phase II Randomized Comparison of Three Antiretroviral Strategies Administered for 7 or 21 Days to Reduce the Emergence of Nevirapine Resistant HIV-1 Following a Single Intrapartum Dose of Nevirapine

Post Date: 
2004-12-20
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This study was terminated January 16, 2014; it was conducted under the AIDS Clinical Trials Group (ACTG) and funded by the U.S. National Institutes of Health. A major disadvantage of giving SD NVP is the potential for maternal development of NVP resistance and additional resistance to other...

A5175: PEARLS Evaluation of the Efficacy of Once-Daily Protease Inhibitor and Once-Daily Non-Nucleoside Reverse Transcriptase Inhibitor- Containing Therapy Combinations for Initial Treatment of HIV-1 Infected Individuals

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2004-07-27
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Full Title: A Phase IV, Prospective, Randomized, Open-Label Evaluation of the Efficacy of Once-Daily Protease Inhibitor and Once Daily Non-Nucleoside Reverse Transcriptase Inhibitor Containing Therapy Combinations for Initial Treatment of HIV-1 Infected Individuals from Resource-Limited Settings (...

Evaluation of Provider, Patient and Pharmacy Knowledge, Attitudes and Practices Regarding HIV Care and Use of Antiretroviral Therapy in Pune, India

Post Date: 
2004-03-29
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This study ended in 2007. Antiretroviral therapy (ART) has dramatically affected morbidity and mortality among HIV-infected persons in industrialized countries. In India, where approximately 4.3 million persons are estimated to be HIV-infected (NACO), the use of ART has been limited because of the...

A Study to Validate New Assays for Measuring HIV Seroincidence in Indian HIV Subtype C Seroconverters

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2003-08-05
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This study ended in July 2006.

Mother-to-Child Transmission (MTCT) of HIV: India SWEN Study

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2002-06-07
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This study was officially terminated August 2018. Primary and secondary analyses of the India SWEN study, an NIH-funded phase III randomized controlled trial of an extended nevirapine prophylaxis regimen among 783 HIV-infected pregnant women and their breastfed infants in Pune, India.

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High prevalence of cryptococcal antigenaemia amongst asymptomatic advanced HIV patients in Pune, India

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2017-03-21
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Indian Journal of Medical Microbiology
Methods : A prospective study was conducted in a large public sector ART centre and the inpatient wards of Sassoon Hospital, Pune, India. All consenting patients> 18 years of age with CD4 count <100 cells/mm3 were screened for CrAg by latex agglutination assay. Those with positive CrAg...

Drug-resistant tuberculosis in 2017: at a crossroads

Post Date: 
2017-03-15
Publication: 
Lancet Respiratory Medicine
In The Lancet Respiratory Medicine, Dheda and colleagues present one of the most comprehensive pictures to date of the global epidemic of drug-resistant tuberculosis. This comes at a time of increasing awareness of antimicrobial resistance as a global threat, and Mycobacterium tuberculosis...

Vitamin A and D deficiencies associated with incident tuberculosis in HIV-infected patients initiating antiretroviral therapy in multinational case-cohort study

Post Date: 
2017-02-06
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Journal of Acquired Immune Deficiency Syndromes
Introduction: Numerous micronutrients have immunomodulatory roles that may influence risk of tuberculosis (TB), but the association between baseline micronutrient deficiencies and incident TB after antiretroviral (ART) initiation in HIV-infected individuals is not well characterized. ...

Tuberculosis associated with HIV infection

Post Date: 
2017-01-15
Publication: 
Microbiology Spectrum
Abstract Tuberculosis (TB) has recently surpassed HIV as the primary infectious disease killer worldwide, but the two diseases continue to display lethal synergy. The burden of TB is disproportionately borne by people living with HIV, particularly where HIV and poverty...

Bedaquiline

Post Date: 
2017-01-01
Publication: 
Kucers’ the Use of Antibiotics: A Clinical Review of Antibacterial, Antifungal, and Antiviral Drugs, 7th Edition
Section II, Antibiotics: Part 12 Anti-tuberculosis drugs.

Tuberculosis burden in India's private sector

Post Date: 
2016-11-15
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The Lancet Infectious Disease
Reply to author's reply

Mandatory tuberculosis case notification in high tuberculosis-incidence countries: policy and practice

Post Date: 
2016-10-20
Publication: 
European Respiratory Journal
Mandatory tuberculosis (TB) notification is an important policy under the End TB Strategy, but little is known about its enforcement especially in high TB incidence countries. We undertook a literature search for selected high-incidence countries, followed by a questionnaire-based survey...

Sex-related differences in inflammatory and immune activation markers before and after combined antiretroviral therapy initiation

Post Date: 
2016-10-01
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Journal of Acquired Immune Deficiency Syndromes
Background: Women progress to death at the same rate as men despite lower plasma HIV RNA (viral load). We investigated sex-specific differences in immune activation and inflammation as a potential explanation. Methods: Inflammatory and immune activation markers [...

Efficacy of six-week extended-dose nevirapine varies by infant birth weight with greatest relative efficacy in low birth weight infants

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2016-09-30
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PLOS One
Low birth weight (LBW), defined by the World Health Organization (WHO) as birth weight less than 2500 g, is a significant public health issue in resource-limited settings, particularly in Sub Saharan Africa and South Asia where the estimated annual incidence is 14% and 28–31%, respectively,...

Continued elevation of interleukin-18 and interferon-γ after initiation of antiretroviral therapy and clinical failure in a diverse multicountry human immunodeficiency virus cohort

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2016-07-27
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Open Forum Infectious Diseases
Background: We assessed immune activation after antiretroviral therapy (ART) initiation to understand clinical failure in diverse settings. Methods: We performed a case-control study in ACTG Prospective Evaluation of Antiretrovirals in Resource-Limited Settings (...

Epidemiological impact of achieving UNAIDS 90-90-90 targets for HIV care in India: a modelling study

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2016-07-07
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BMJ Open
Objective: Recent UNAIDS ‘90-90-90’ targets propose that to end the HIV epidemic by 2030, 90% of persons living with HIV (PLWH) worldwide should know their diagnosis, 90% of diagnosed PLWH should be on antiretroviral therapy (ART) and 90% of PLWH on ART should be virally suppressed by 2020...

Inflammation and change in body weight with antiretroviral therapy initiation in a multinational cohort of HIV-infected adults

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2016-07-01
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Journal of Infectious Diseases
Background: Both wasting and obesity are associated with inflammation, but the extent to which body weight changes influence inflammation during human immunodeficiency virus infection is unknown. Methods: Among a random virologically suppressed participants of the...

Quantitative IFN-y,IL-2 response and latent tuberculosis test discordance in HIV-infected pregnant women

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2016-06-15
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American Journal of Respiratory and Critical Care Medicine
Rationale: Pregnant women with latent tuberculosis infection (LTBI) are at high risk for development of TB, especially if infected with HIV. Objectives: To assess the performance of LTBI tests in pregnant and postpartum women infected with HIV, investigate the...

Next-generation sequencing in neuropathologic diagnosis of infections of the nervous system

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2016-06-13
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Neurology, Neuroimmunology and Neuroinflammation
OBJECTIVE: To determine the feasibility of next-generation sequencing (NGS) microbiome approaches in the diagnosis of infectious disorders in brain or spinal cord biopsies in patients with suspected CNS infections. METHODS: In a...

Isoniazid hair concentrations in children with tuberculosis: a proof of concept study

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2016-06-01
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International Journal of Tuberculosis and Lung Disease
Assessing treatment adherence and quantifying exposure to anti-tuberculosis drugs among children is challenging. We undertook a 'proof of concept' study to assess the drug concentrations of isoniazid (INH) in hair as a therapeutic drug monitoring tool. Children aged <12 years initiated on...

The availability of emergency obstetric care in the context of the JSY cash transfer programme in Madhya Pradesh, India

Post Date: 
2016-05-18
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BMC Pregnancy and Childbirth
Abstract Background: Since 2005, India has implemented a national cash transfer programme, the Janani Suraksha Yojana (JSY), which provides women a cash transfer upon giving birth in an existing public facility. This has resulted in a steep rise in facility births across the...

Applying ethical principles to international community-based research; a case study from the Consortium to Respond Effectively to the AIDS/TB Epidemic

Post Date: 
2016-05-15
This paper describes how one set of HIV-TB prevention research studies put procedures in place to be responsive to these foundational ethical principles when interacting with communities in large population-based, global public health research.

Management and control of multidrug-resistant tuberculosis (MDR-TB): addressing policy needs for India

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2016-05-06
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Journal of Public Health Policy
Multidrug-resistant tuberculosis (MDR-TB) challenges TB control efforts because of delays in diagnosis plus its long-term treatment which has toxic effects. Of TB high-incidence countries, India carries the highest burden of MDR-TB cases. We describe policy issues in India concerning MDR-TB...

Inflammation and change in body weight with antiretroviral therapy initiation in a multinational cohort of HIV-infected adults

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2016-04-01
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The Journal of Infectious Diseases
Background: Both wasting and obesity are associated with inflammation, but the extent to which body weight changes influence inflammation during human immunodeficiency virus infection is unknown. Methods: Among a random virologically suppressed participants of the...

Persistently elevated C-reactive protein level in the first year of antiretroviral therapy, despite virologic suppression, is associated with HIV disease progression in resource-constrained settings

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2016-04-01
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The Journal of Infectious Diseases
A case-cohort analysis of human immunodeficiency virus (HIV)-infected individuals receiving antiretroviral therapy (ART) was performed within a multicountry randomized trial (PEARLS) to assess the prevalence of persistently elevated C-reactive protein (CRP) levels, based on serial...

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Isoniazid Hair Concentrations in Children with TB

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2015-12-05
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Mave V, Kinikar AA, Gupte N, Nimkar S, Kagal A, Horng H, Ramachandran G, Dooley K, Gupta A. Isoniazid Hair Concentrations in Children with TB. 46th Union World Conference on Lung Health. International Union for Tuberculosis and Lung Disease. Cape Town, South Africa.

Novel Package of Integrated Mobile Applications Reduces Time to Treatment Initiation for Patients with MDR-TB

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2015-12-05
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Farley J, McKenzie-White J, Seiguer S, Naicker M, Peters A, Isherwood L, Olsen F, Stevens W. Novel Package of Integrated Mobile Applications Reduces Time to Treatment Initiation for Patients with MDR-TB. The 46th Union World Conference on Lung Health. Cape Town, South Africa.

Incidence and Risk Factors for TB among HIV+ Children in India

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2015-12-05
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Kinikar AA , DeLuca A, Gupte N, Kadam DB, Khadse S, Chandanwale A, Gupta A, Bollinger R. Incidence and Risk Factors for TB among HIV+ Children in India. The 46th Union World Conference on Lung Health. Cape Town, South Africa.

Risk Factors for Unfavorable Treatment Outcomes in DOTs-treated Pediatric TB Patients

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2015-12-04
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Shelke S, Bollinger R, Chandanwale A, DeLuca A, Gupta A, Gupte N, Adhav PS, Kadam DB. Risk Factors for Unfavorable Treatment Outcomes in DOTs-treated Pediatric TB Patients. The 46th Union World Conference on Lung Health. Cape Town, South Africa.

Utility of GeneXpert for Diagnosis of Rifampicin-resistant Extra-pulmonary TB—A Retrospective Review of 70 Cases, SGH, Pune, India

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2015-12-04
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Girish S, Dharmashle S, Desai S, Kagal A, Bharadwaj R, Chandanwale A, Lokhande R, Kadam DB, DeLuca A, Gupte N, Jain D, Gupta A, Bollinger R, Mave V. Utility of GeneXpert for Diagnosis of Rifampicin-resistant Extra-pulmonary TB—A Retrospective Review of 70 Cases, SGH, Pune, India, The 46th Union...

Maternal and Infant TB: Advancing Our Understanding of Pathogenesis, Treatment and Prevention

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2015-12-04
Mathad J, Bekker A. Maternal and Infant TB: Advancing Our Understanding of Pathogenesis, Treatment and Prevention. The 46th Union World Conference on Lung Health. Cape Town, South Africa.

TB/HIV Treatment during Pregnancy: Does Drug Metabolism Change?

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2015-12-04
Dooley K, Savic R. TB/HIV Treatment during Pregnancy: Does Drug Metabolism Change? The 46th Union World Conference on Lung Health. Cape Town, South Africa.

Current Research on the Pathophysiology, Immunology, Prevention and Treatment of TB in Pregnant Women

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2015-12-04
Gupta A, Mathad J. Current Research on the Pathophysiology, Immunology, Prevention and Treatment of TB in Pregnant Women. The 46th Union World Conference on Lung Health. Cape Town, South Africa.

Current Research on the Pathophysiology, Immunology, Prevention and Treatment of TB in Pregnant Women

Post Date: 
2015-12-04
Gupta, A., Mathad, J. Current Research on the Pathophysiology, Immunology, Prevention and Treatment of TB in Pregnant Women. International Union for Tuberculosis and Lung Disease. 46th Union World Conference on Lung Health. Capetown, South Africa.

Impact of Rifapentine Price Reduction on Utilization for TB Treatment in the United States

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2015-12-04
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Gupta, A. Impact of Rifapentine Price Reduction on Utilization for TB Treatment in the United States. The 46th Union World Conference on Lung Health. Cape Town, South Africa.

Characteristics Associated with Mobile Phone Access among TB Patients in Pune, India

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2015-12-04
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Ogale YP, Elf J, Lokhande R, Mave V, Roy S, Gupta A, Golub J, Mathad J. Characteristics Associated with Mobile Phone Access among TB Patients in Pune, India. The 46th Union World Conference on Lung Health. Cape Town, South Africa.

Isoniazid Concentration in Hair among Children with Tuberculosis

Post Date: 
2015-11-15
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Mave, V. Isoniazid Concentration in Hair among Children with Tuberculosis. Annual Meeting, Center for AIDS Research. Seattle, WA.

BJMC-JHU Research Program

Post Date: 
2015-10-31
Mave, V. BJMC-JHU Research Program. TreatAsia Network Meeting. Bangkok, Thailand.

Does Quality of Delivery Care Differ Between Public and Private Facilities in Madhya Pradesh, India?: An Exit Interview Study of Routine Delivery Care Practices

Post Date: 
2015-10-20
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Chaturvedi C, Randive B , Sabde Y, Diwan V, Raven J, De Costa A. Does Quality of Delivery Care Differ Between Public and Private Facilities in Madhya Pradesh, India?: An Exit Interview Study of Routine Delivery Care Practices. Global Maternal Newborn Health Conference 2015. Mexico City, Mexico. 2015

Operational Challenges Undermine WHO TB Symptom Screen in Pregnant Women

Post Date: 
2015-10-11
Vaidya A , Tambe S, Bhosale R, Mave V, Elf J, Pradhan N, Nevrekar N, Patil S, Kagal A, Joshi S, Chandanwale A, Gupta A, MathadJ. Operational Challenges Undermine WHO TB Symptom Screen in Pregnant Women. ID Week 2015. San Diego, CA. San Diego, CA. 2015

Dengue and Malaria are Common Infections among Adults and Adolescents Hospitalized with Acute Febrile Illness in Western India

Post Date: 
2015-10-09
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Mave V, Kadam D, Bharadwaj R, Kagal A, Sachs J, Raichur P, Kanade S, Gupte N, Joshi S, Chandanwale A, Zenilman JM, Bollinger R, Gupta A. Dengue and Malaria are Common Infections among Adults and Adolescents Hospitalized with Acute Febrile Illness in Western India. Infectious Diseases Society of...

TB and Women

Post Date: 
2015-09-29
Gupta, A. TB and Women. Mid Atlantic TB Intensive Workshop. Rehoboth, DE.

Conducting HIV and TB Research in India: Challenges and Opportunities

Post Date: 
2015-08-27
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Gupta, A. Conducting HIV and TB Research in India: Challenges and Opportunities. Emory University. Atlanta, GA.

Tuberculosis in Pregnant Women and Infants

Post Date: 
2015-08-26
Gupta, A. Tuberculosis in Pregnant Women and Infants. International Conference on Emerging Infectious Diseases. Atlanta, GA.

Tuberculosis in Peripartum Women and Infants

Post Date: 
2015-08-26
Gupta, A. Tuberculosis in Peripartum Women and Infants. International Conference on Emerging Infectious Diseases. Atlanta, GA.

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