Research News

Dr. Maunank Shah
September 24, 2021

A new Johns Hopkins Medicine mathematical model to predict how the human immunodeficiency virus (HIV) spreads in urban areas...

Clinical Research

Leadership
While we conduct research all over the world, the majority of our work is in India. Our Indo-JHU Clinical Research Partnership is located in Pune and is directed by Dr. Amita Gupta (Baltimore, MD), with onsite direction from Dr. Vidya Mave, Dr. Nishi Suryavanshi, and Dr. Nikhil Gupte (Pune). The Indo-JHU Partnership employs more than 200 people and in addition to our memberships in cosortia with many esteemed Indian research institutions, we have formal agreements with:

 
 

The Presentation and Disease Progression of HIV Infection Among Indian Children

Post Date: 
2008-09-22
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This study was terminated July 24, 2010.

Immunomodulatory Properties of BCG: Implications for MTCT

Post Date: 
2008-06-01
To evaluate the immune activating properties of BCG vaccination in neonatal CD4 cells and test the hypothesis that neonatal BCG vaccination leads to activation of immune response that may increase the susceptibility to HIV infection in breast-fed infants of HIV-positive mothers.

HIV Latino Outreach Program, Baltimore City Health Department

Post Date: 
2008-01-01
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Dr. Kathleen Page founded and directs the Baltimore City Health Department’s HIV Latino Outreach Program, which provides more than 1000 HIV tests per year to Baltimore's Latino community, and provides linkages to care services for those testing positive.

Peer Community-based Assistant in REtention: Effect of Peer Health Workers on People Living with HIV Not on Antiretroviral Therapy—A Randomized Operations Research Trial

Post Date: 
2007-03-29
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Countries: 
Human resource limitations, long travel times, and a weak health care infrastructure pose significant challenges to the delivery of anti-retroviral therapy (ART) in rural settings such as the Rakai District in southwestern Uganda. HIV increases demand for health services and also impacts the health...

Calibration and Application of a Simple Sensitive/Less Sensitive Assay Applicable to Resource-Limited Countries for Determination of Recent HIV Infection and Incidence Estimates

Post Date: 
2007-03-22
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Countries: 
This study was terminated March 31, 2007. Sensitive/Less Sensitive assays (S/LS) to distinguish between recent and established HIV infections have been successfully applied to identify recently infected persons and determine HIV incidence. However, all currently used S/LS assays require laboratory...

BWI CTU: Baltimore-Washington-India Clinical Trials Unit

Post Date: 
2007-02-02
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Comprising clinical trial sites at Johns Hopkins Medicine in Baltimore, Whitman Walker Health in Washington, DC, and the BJGMC-CCGHE collaboration in Pune, India, the Baltimore-Washington-India Clinical Trials Unit (BWI-CTU) is one of only 25 international HIV/TB clinical trial sites funded by the...

Integration of HIV and Other Prevalent Relevant Infectious Disease Care into Primary Medical Care

Post Date: 
2007-01-01
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Countries: 
According to the Pan American Health Organization (PAHO), HIV is rapidly expanding in Latin America, and among the Latin American countries with highest HIV prevalence, four are located in Central America. Notably, AIDS is among the 10 leading causes of death in three of the six countries in...

BJGMC-JHU Fogarty HIV-TB Training Program

Post Date: 
2007-01-01
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Funded by the Fogarty International Center at the National Institutes of Health, the JHU Fogarty program has nearly 20 years of success with providing training, professional development, and mentorship to clinicians and scientists in low and middle income countries. CCGHE's latest efforts in this...

P1060: Phase II, parallel, randomized, clinical trials comparing the responses to initiation of NNRTI-based antiretroviral therapy in HIV-infected infants who have not previously received Single dose Nevirapine for prevention of Mother-to-child HIV...

Post Date: 
2006-03-27
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This study ended June 28, 2015. This multi-country trial was conducted in India, Malawi, South Africa, Tanzania, Uganda, Zambia, and Zimbabwe under the International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) Network and funded by the U.S. National Institutes of Health...

A5207: Maintaining Options for Mothers Study (MOMS): A Phase II Randomized Comparison of Three Antiretroviral Strategies Administered for 7 or 21 Days to Reduce the Emergence of Nevirapine Resistant HIV-1 Following a Single Intrapartum Dose of Nevirapine

Post Date: 
2004-12-20
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This study was terminated January 16, 2014; it was conducted under the AIDS Clinical Trials Group (ACTG) and funded by the U.S. National Institutes of Health. A major disadvantage of giving SD NVP is the potential for maternal development of NVP resistance and additional resistance to other...

A5175: PEARLS Evaluation of the Efficacy of Once-Daily Protease Inhibitor and Once-Daily Non-Nucleoside Reverse Transcriptase Inhibitor- Containing Therapy Combinations for Initial Treatment of HIV-1 Infected Individuals

Post Date: 
2004-07-27
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Full Title: A Phase IV, Prospective, Randomized, Open-Label Evaluation of the Efficacy of Once-Daily Protease Inhibitor and Once Daily Non-Nucleoside Reverse Transcriptase Inhibitor Containing Therapy Combinations for Initial Treatment of HIV-1 Infected Individuals from Resource-Limited Settings (...

Evaluation of Provider, Patient and Pharmacy Knowledge, Attitudes and Practices Regarding HIV Care and Use of Antiretroviral Therapy in Pune, India

Post Date: 
2004-03-29
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Countries: 
This study ended in 2007. Antiretroviral therapy (ART) has dramatically affected morbidity and mortality among HIV-infected persons in industrialized countries. In India, where approximately 4.3 million persons are estimated to be HIV-infected (NACO), the use of ART has been limited because of the...

A Study to Validate New Assays for Measuring HIV Seroincidence in Indian HIV Subtype C Seroconverters

Post Date: 
2003-08-05
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Countries: 
This study ended in July 2006.

Mother-to-Child Transmission (MTCT) of HIV: India SWEN Study

Post Date: 
2002-06-07
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This study was officially terminated August 2018. Primary and secondary analyses of the India SWEN study, an NIH-funded phase III randomized controlled trial of an extended nevirapine prophylaxis regimen among 783 HIV-infected pregnant women and their breastfed infants in Pune, India.

Technology-enhanced Peer Navigation to Improve Injection Drug User (IDU) Engagement in HIV Care

Post Date: 
2000-01-01
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Countries: 
This study is evaluating an mHealth-enhanced peer navigation intervention for improving retention-in-care and adherence to antiretroviral therapy (ART) for out-of-care, HIV-infected injection drug users (IDUs). The CCGHE-developed emocha® is assisting peer navigators (former IDUs successfully...

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Risk factors for early mortality on antiretroviral therapy in advanced HIV-infected adults

Post Date: 
2017-10-23
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Publication: 
AIDS
Background: Many HIV-infected individuals present with advanced HIV disease. These patients are at high risk of death after antiretroviral therapy (ART) initiation, but risk factors for death in these patients are unclear. Methods: We used data from a multisite randomized trial...

Impact of a community health worker HIV treatment and prevention intervention in an HIV hotspot fishing community in Rakai, Uganda (mLAKE): study protocol for a randomized controlled trial

Post Date: 
2017-10-23
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Countries: 
Publication: 
Trials
Abstract Background: Effective yet practical strategies are needed to increase engagement in HIV treatment and prevention services, particularly in high-HIV-prevalence hotspots. We designed a community-based intervention called "Health Scouts" to promote uptake and adherence to...

Of testing and treatment: Implications of implementing new regimens for multidrug-resistant tuberculosis

Post Date: 
2017-10-01
Publication: 
Clinical Infectious Diseases
A novel, shorter-course regimen for treating multidrug-resistant (MDR) tuberculosis was recently recommended by the World Health Organization. However, the most appropriate use of drug susceptibility testing (DST) to support this regimen is less clear. Implementing countries must therefore...

Global, regional, and national under-5 mortality, adult mortality, age-specific mortality, and life expectancy, 1970-2016: a systematic analysis for the Global Burden of Disease Study 2016

Post Date: 
2017-09-16
Publication: 
The Lancet
Abstract Background: Detailed assessments of mortality patterns, particularly age-specific mortality, represent a crucial input that enables health systems to target interventions to specific populations. Understanding how all-cause mortality has changed with respect to...

Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016

Post Date: 
2017-09-16
Publication: 
The Lancet
Abstract Background: As mortality rates decline, life expectancy increases, and populations age, non-fatal outcomes of diseases and injuries are becoming a larger component of the global burden of disease. The Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD...

Measuring progress and projecting attainment on the basis of past trends of the health-related Sustainable Development Goals in 188 countries: an analysis from the Global Burden of Disease Study 2016

Post Date: 
2017-09-12
Publication: 
The Lancet
Abstract Background: The UN's Sustainable Development Goals (SDGs) are grounded in the global ambition of "leaving no one behind". Understanding today's gains and gaps for the health-related SDGs is essential for decision makers as they aim to improve the health of populations. As...

Healthcare Access and Quality Index based on mortality from causes amenable to personal health care in 195 countries and territories, 1990-2015: a novel analysis from the Global Burden of Disease Study 2015

Post Date: 
2017-07-15
Publication: 
The Lancet
Abstract Background: National levels of personal health-care access and quality can be approximated by measuring mortality rates from causes that should not be fatal in the presence of effective medical care (ie, amenable mortality). Previous analyses of mortality amenable to...

A qualitative study exploring factors influencing clinical decision-making for influenza-like illness in Solapur city, Maharashtra, India

Post Date: 
2017-07-03
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Countries: 
Publication: 
Anthropology and Medicine
Abstract The co-existence of different types of medical systems (medical pluralism) is a typical feature of India's healthcare system. For conditions such as influenza-like illness (ILI), where non-specific disease signs/symptoms exist, clinical reasoning in the context of medical...

Cardiovascular risk in an HIV-infected population in India

Post Date: 
2017-07-03
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Publication: 
Heart Asia
Findings: HIV+ Indian patients who had cardiovascular disease at a younger age appear to be at imminent risk for morbidity.

Household food insecurity is associated with low interferon-gamma levels in pregnant Indian women

Post Date: 
2017-07-01
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Publication: 
International Journal of Tuberculosis and Lung Disease
Objective: To determine the association between household food insecurity and interferon-gamma (IFN-γ) levels in pregnancy. Design: Pregnant women in India were administered the Household Food Insecurity Access Scale (HFIAS) questionnaire and underwent an IFN-γ release assay...

Vitamin A and D deficiencies associated with incident tuberculosis in HIV-infected patients initiating antiretroviral therapy in multinational case-cohort study

Post Date: 
2017-07-01
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Publication: 
Journal of Acquired Immune Deficiency Syndromes
Introduction: Numerous micronutrients have immunomodulatory roles that may influence risk of tuberculosis (TB), but the association between baseline micronutrient deficiencies and incident TB after antiretroviral therapy (ART) initiation in HIV-infected individuals is not well characterized...

Maternal syphilis: An independent risk factor for mother to infant human immunodeficiency virus transmission

Post Date: 
2017-06-15
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Publication: 
Sexually Transmitted Diseases
Abstract Syphilis is associated with increased human immunodeficiency virus acquisition and sexual transmission; we examined impact on human immunodeficiency virus mother-to-child transmission among mother-infant pairs enrolled in the India Six-Week Extended-Dose Nevirapine study...

Presence of human hepegivirus-1 in a cohort of people who inject drugs

Post Date: 
2017-06-07
Publication: 
Annals of Internal Medicine
Findings on the sensitivity of next-generation metagenomic sequencing for discovery of new viral infections.

Tuberculosis screening among persons with diabetes mellitus in Pune, India

Post Date: 
2017-06-02
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Clinical Sites: 
Publication: 
BMC Infectious Diseases
Background: Diabetes mellitus (DM) increases tuberculosis (TB) risk, and there is increasing concern over the public health implications of the convergence of these two epidemics. Screening for TB among people with DM is now recommended in India. Methods: People with DM seeking care at a large...

Pulmonary infections in pregnancy

Post Date: 
2017-06-01
Publication: 
Seminars in Respiratory and Critical Care Medicine
Clinical review from Drs. Amita Gupta & Jyoti Mathad on improving tuberculosis treatment outcomes for pregnant women.

The impact of preexposure prophylaxis among men who have sex with men: An individual-based model

Post Date: 
2017-06-01
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Countries: 
Publication: 
Journal of Acquired Immune Deficiency Syndromes
Objectives Preexposure prophylaxis (PrEP) is recommended for preventing HIV infection among individuals at high risk, including men who have sex with men (MSM). Although its individual-level efficacy is proven, questions remain regarding population-level impact of PrEP implementation...

Design and implementation of a community health worker HIV treatment and prevention intervention in an HIV hot spot fishing community in Rakai, Uganda

Post Date: 
2017-05-22
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Countries: 
Publication: 
Journal of the International Association of Providers of AIDS Care
Abstract Innovative approaches are needed to increase engagement in HIV treatment and prevention services, particularly in HIV hot spots. Here, we detail our design, training approach, and early implementation experiences of a community-based HIV intervention called "health scouts." The...

Treatment of pulmonary tuberculosis

Post Date: 
2017-04-27
Publication: 
Handbook of Tuberculosis
This chapter addresses the treatment of pulmonary tuberculosis highlighting drug classes, recommended regimens, adverse drug reactions, drug-drug interactions, and practical aspects of monitoring, The principles of treatment of latent tuberculosis are also addressed including whom to treat, what...

Clinical features and diagnosis of tuberculosis: primary infection and progressive pulmonary tuberculosis

Post Date: 
2017-04-27
Publication: 
Handbook of Tuberculosis
In this chapter, we will review the clinical manifestations of intrathoracic tuberculosis (TB), including pathophysiology and clinical features of primary and secondary or reactivation TB. Specific topics discussed are the physical examination, and microbiological, radiological, and immunological...

Extrapulmonary tuberculosis

Post Date: 
2017-04-27
Publication: 
Handbook of Tuberculosis
M. tuberculosis (MTB) can cause disease in almost any organ of the body. Extrapulmonary tuberculosis (EPTB) is defined as tuberculosis (TB) disease outside of the lung parenchyma [1]. Much like pulmonary TB, EPTB can occur as a primary infection or as reactivation of a latent focus with subsequent...

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Impact of Rifapentine Price Reduction on Utilization for TB Treatment in the United States

Post Date: 
2015-12-04
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Gupta, A. Impact of Rifapentine Price Reduction on Utilization for TB Treatment in the United States. The 46th Union World Conference on Lung Health. Cape Town, South Africa.

Characteristics Associated with Mobile Phone Access among TB Patients in Pune, India

Post Date: 
2015-12-04
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Countries: 
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Ogale YP, Elf J, Lokhande R, Mave V, Roy S, Gupta A, Golub J, Mathad J. Characteristics Associated with Mobile Phone Access among TB Patients in Pune, India. The 46th Union World Conference on Lung Health. Cape Town, South Africa.

Risk Factors for Unfavorable Treatment Outcomes in DOTs-treated Pediatric TB Patients

Post Date: 
2015-12-04
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Countries: 
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Clinical Sites: 
Shelke S, Bollinger R, Chandanwale A, DeLuca A, Gupta A, Gupte N, Adhav PS, Kadam DB. Risk Factors for Unfavorable Treatment Outcomes in DOTs-treated Pediatric TB Patients. The 46th Union World Conference on Lung Health. Cape Town, South Africa.

Utility of GeneXpert for Diagnosis of Rifampicin-resistant Extra-pulmonary TB—A Retrospective Review of 70 Cases, SGH, Pune, India

Post Date: 
2015-12-04
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Countries: 
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Clinical Sites: 
Girish S, Dharmashle S, Desai S, Kagal A, Bharadwaj R, Chandanwale A, Lokhande R, Kadam DB, DeLuca A, Gupte N, Jain D, Gupta A, Bollinger R, Mave V. Utility of GeneXpert for Diagnosis of Rifampicin-resistant Extra-pulmonary TB—A Retrospective Review of 70 Cases, SGH, Pune, India, The 46th Union...

Maternal and Infant TB: Advancing Our Understanding of Pathogenesis, Treatment and Prevention

Post Date: 
2015-12-04
Mathad J, Bekker A. Maternal and Infant TB: Advancing Our Understanding of Pathogenesis, Treatment and Prevention. The 46th Union World Conference on Lung Health. Cape Town, South Africa.

TB/HIV Treatment during Pregnancy: Does Drug Metabolism Change?

Post Date: 
2015-12-04
Dooley K, Savic R. TB/HIV Treatment during Pregnancy: Does Drug Metabolism Change? The 46th Union World Conference on Lung Health. Cape Town, South Africa.

Current Research on the Pathophysiology, Immunology, Prevention and Treatment of TB in Pregnant Women

Post Date: 
2015-12-04
Gupta A, Mathad J. Current Research on the Pathophysiology, Immunology, Prevention and Treatment of TB in Pregnant Women. The 46th Union World Conference on Lung Health. Cape Town, South Africa.

Current Research on the Pathophysiology, Immunology, Prevention and Treatment of TB in Pregnant Women

Post Date: 
2015-12-04
Gupta, A., Mathad, J. Current Research on the Pathophysiology, Immunology, Prevention and Treatment of TB in Pregnant Women. International Union for Tuberculosis and Lung Disease. 46th Union World Conference on Lung Health. Capetown, South Africa.

Applied HIV Epidemiology and Implementation Science: a multidisciplinary approach to understanding and controlling an evolving epidemic

Post Date: 
2015-11-20
Chang, L. Applied HIV Epidemiology and Implementation Science: a multidisciplinary approach to understanding and controlling an evolving epidemic. National Institutes of Health. Bethesda, MD.

Isoniazid Concentration in Hair among Children with Tuberculosis

Post Date: 
2015-11-15
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Clinical Sites: 
Mave, V. Isoniazid Concentration in Hair among Children with Tuberculosis. Annual Meeting, Center for AIDS Research. Seattle, WA.

BJMC-JHU Research Program

Post Date: 
2015-10-31
Mave, V. BJMC-JHU Research Program. TreatAsia Network Meeting. Bangkok, Thailand.

Rakai Health Sciences Program: Social, Behavioral, and Biomedical Research in HIV Dynamics, Prevention, and Care

Post Date: 
2015-10-30
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Chang, L. Rakai Health Sciences Program: Social, Behavioral, and Biomedical Research in HIV Dynamics, Prevention, and Care. CFAR National Social and Behavioral Sciences Research Network Annual Meeting. Baltimore, MD.

mHealth

Post Date: 
2015-10-29
Chang, L. mHealth. CFAR National Social and Behavioral Sciences Research Network Annual Meeting. Baltimore, MD.

Does Quality of Delivery Care Differ Between Public and Private Facilities in Madhya Pradesh, India?: An Exit Interview Study of Routine Delivery Care Practices

Post Date: 
2015-10-20
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Countries: 
Chaturvedi C, Randive B , Sabde Y, Diwan V, Raven J, De Costa A. Does Quality of Delivery Care Differ Between Public and Private Facilities in Madhya Pradesh, India?: An Exit Interview Study of Routine Delivery Care Practices. Global Maternal Newborn Health Conference 2015. Mexico City, Mexico. 2015

Operational Challenges Undermine WHO TB Symptom Screen in Pregnant Women

Post Date: 
2015-10-11
Vaidya A , Tambe S, Bhosale R, Mave V, Elf J, Pradhan N, Nevrekar N, Patil S, Kagal A, Joshi S, Chandanwale A, Gupta A, MathadJ. Operational Challenges Undermine WHO TB Symptom Screen in Pregnant Women. ID Week 2015. San Diego, CA. San Diego, CA. 2015

Developing a Validated Tool to Assess Internal Medicine and Infectious Disease Trainees’ Ability to Obtain and Interpret TB Diagnostics

Post Date: 
2015-10-11
Chida N, Gupta A, Bollinger B, Melia M. Developing a Validated Tool to Assess Internal Medicine and Infectious Disease Trainees’ Ability to Obtain and Interpret TB Diagnostics. ID Week 2015. San Diego, CA. 2015

Dengue and Malaria are Common Infections among Adults and Adolescents Hospitalized with Acute Febrile Illness in Western India

Post Date: 
2015-10-09
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Countries: 
Mave V, Kadam D, Bharadwaj R, Kagal A, Sachs J, Raichur P, Kanade S, Gupte N, Joshi S, Chandanwale A, Zenilman JM, Bollinger R, Gupta A. Dengue and Malaria are Common Infections among Adults and Adolescents Hospitalized with Acute Febrile Illness in Western India. Infectious Diseases Society of...

A Man from Central America with Progressive Shortness of Breath

Post Date: 
2015-10-07
Chida, N. A Man from Central America with Progressive Shortness of Breath. ID Week 2015. San Diego, CA. 2015.

TB and Women

Post Date: 
2015-09-29
Gupta, A. TB and Women. Mid Atlantic TB Intensive Workshop. Rehoboth, DE.

Conducting HIV and TB Research in India: Challenges and Opportunities

Post Date: 
2015-08-27
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Countries: 
Gupta, A. Conducting HIV and TB Research in India: Challenges and Opportunities. Emory University. Atlanta, GA.

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