Research News

Annals of Internal Medicine
September 22, 2020

Risk factors for progression of coronavirus 2019 (COVID-19) to severe disease or death are underexplored in U.S. cohorts.

Clinical Research

Leadership
While we conduct research all over the world, the majority of our work is in India. Our Indo-JHU Clinical Research Partnership is located in Pune and is directed by Dr. Amita Gupta (Baltimore, MD), with onsite direction from Dr. Vidya Mave, Dr. Nishi Suryavanshi, and Dr. Nikhil Gupte (Pune). The Indo-JHU Partnership employs more than 200 people and in addition to our memberships in cosortia with many esteemed Indian research institutions, we have formal agreements with:

 
 

Vitamin A and D deficiencies associated with incident tuberculosis in HIV-infected patients initiating antiretroviral therapy in multinational case-cohort study

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2017-07-01
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Journal of Acquired Immune Deficiency Syndromes
Introduction: Numerous micronutrients have immunomodulatory roles that may influence risk of tuberculosis (TB), but the association between baseline micronutrient deficiencies and incident TB after antiretroviral therapy (ART) initiation in HIV-infected individuals is not well characterized...

Maternal syphilis: An independent risk factor for mother to infant human immunodeficiency virus transmission

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2017-06-15
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Sexually Transmitted Diseases
Abstract Syphilis is associated with increased human immunodeficiency virus acquisition and sexual transmission; we examined impact on human immunodeficiency virus mother-to-child transmission among mother-infant pairs enrolled in the India Six-Week Extended-Dose Nevirapine study...

Presence of human hepegivirus-1 in a cohort of people who inject drugs

Post Date: 
2017-06-07
Publication: 
Annals of Internal Medicine
Findings on the sensitivity of next-generation metagenomic sequencing for discovery of new viral infections.

Tuberculosis screening among persons with diabetes mellitus in Pune, India

Post Date: 
2017-06-02
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BMC Infectious Diseases
Background: Diabetes mellitus (DM) increases tuberculosis (TB) risk, and there is increasing concern over the public health implications of the convergence of these two epidemics. Screening for TB among people with DM is now recommended in India. Methods: People with DM seeking care at a large...

The impact of preexposure prophylaxis among men who have sex with men: An individual-based model

Post Date: 
2017-06-01
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Journal of Acquired Immune Deficiency Syndromes
Objectives Preexposure prophylaxis (PrEP) is recommended for preventing HIV infection among individuals at high risk, including men who have sex with men (MSM). Although its individual-level efficacy is proven, questions remain regarding population-level impact of PrEP implementation...

Pulmonary infections in pregnancy

Post Date: 
2017-06-01
Publication: 
Seminars in Respiratory and Critical Care Medicine
Clinical review from Drs. Amita Gupta & Jyoti Mathad on improving tuberculosis treatment outcomes for pregnant women.

Design and implementation of a community health worker HIV treatment and prevention intervention in an HIV hot spot fishing community in Rakai, Uganda

Post Date: 
2017-05-22
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Journal of the International Association of Providers of AIDS Care
Abstract Innovative approaches are needed to increase engagement in HIV treatment and prevention services, particularly in HIV hot spots. Here, we detail our design, training approach, and early implementation experiences of a community-based HIV intervention called "health scouts." The...

Treatment of pulmonary tuberculosis

Post Date: 
2017-04-27
Publication: 
Handbook of Tuberculosis
This chapter addresses the treatment of pulmonary tuberculosis highlighting drug classes, recommended regimens, adverse drug reactions, drug-drug interactions, and practical aspects of monitoring, The principles of treatment of latent tuberculosis are also addressed including whom to treat, what...

Clinical features and diagnosis of tuberculosis: primary infection and progressive pulmonary tuberculosis

Post Date: 
2017-04-27
Publication: 
Handbook of Tuberculosis
In this chapter, we will review the clinical manifestations of intrathoracic tuberculosis (TB), including pathophysiology and clinical features of primary and secondary or reactivation TB. Specific topics discussed are the physical examination, and microbiological, radiological, and immunological...

Extrapulmonary tuberculosis

Post Date: 
2017-04-27
Publication: 
Handbook of Tuberculosis
M. tuberculosis (MTB) can cause disease in almost any organ of the body. Extrapulmonary tuberculosis (EPTB) is defined as tuberculosis (TB) disease outside of the lung parenchyma [1]. Much like pulmonary TB, EPTB can occur as a primary infection or as reactivation of a latent focus with subsequent...

Resident doctors' attitudes toward tuberculosis patients

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2017-04-15
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Indian Journal of Tuberculosis
Background: The attitude of the resident doctors toward tuberculosis (TB) patients can affect their treatment seeking behavior, compliance to treatment as well as reinforce the stigma attached to the disease by the society at large. Aims: To assess the attitudes...

High burden of antimicrobial resistance and mortality among adults and children with community-onset bacterial infections in India

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2017-04-15
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Journal of Infectious Diseases
Of 133 isolates from 115 patients, 50% were multi-drug resistant; of 33 isolates tested for carbapenem susceptibility, 36% were resistant.

Novel interferon-gamma assays for diagnosing tuberculosis in young children in India

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2017-04-01
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International Journal of Tuberculosis and Lung Disease
Setting: The tuberculin skin test (TST) and interferon-gamma release assays (IGRAs) are used as supportive evidence to diagnose active tuberculosis (TB). Novel IGRAs could improve diagnosis, but data are lacking in young children. Design: Children (age 5 years or...

Prevalence of HIV testing provision at community organizations serving young people in a mid-Atlantic city, 2013-2014

Post Date: 
2017-03-31
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Public Health Reports
Objectives: Little is known about the prevalence of human immunodeficiency virus (HIV) testing at community organizations or the organizational characteristics associated with testing. The objective of this study was to describe (1) the prevalence of HIV testing at community organizations...

Reducing uncertainty for acute febrile illness in resource-limited settings: the current diagnostic landscape

Post Date: 
2017-03-27
Publication: 
The American Journal of Tropical Medicine and Hygiene
After decades of slow progress in diagnostics for acute febrile illness in resource-limited settings, a wave of converging advancements will enable clinicians in resource limited settings to reduce uncertainty for the diagnosis of acute febrile illness.

The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis

Post Date: 
2017-03-24
Publication: 
The Lancet Respiratory Medicine
Global tuberculosis incidence has declined marginally over the past decade, and tuberculosis remains out of control in several parts of the world including Africa and Asia. Although tuberculosis control has been effective in some regions of the world, these gains are threatened by the increasing...

High prevalence of cryptococcal antigenaemia amongst asymptomatic advanced HIV patients in Pune, India

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2017-03-21
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Indian Journal of Medical Microbiology
Methods : A prospective study was conducted in a large public sector ART centre and the inpatient wards of Sassoon Hospital, Pune, India. All consenting patients> 18 years of age with CD4 count <100 cells/mm3 were screened for CrAg by latex agglutination assay. Those with positive CrAg...

Drug-resistant tuberculosis in 2017: at a crossroads

Post Date: 
2017-03-15
Publication: 
Lancet Respiratory Medicine
In The Lancet Respiratory Medicine, Dheda and colleagues present one of the most comprehensive pictures to date of the global epidemic of drug-resistant tuberculosis. This comes at a time of increasing awareness of antimicrobial resistance as a global threat, and Mycobacterium tuberculosis...

Chilling effect? Post-election health care use by undocumented and mixed-status families

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2017-03-08
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New England Journal of Medicine
Perspective article from Dr. Kathleen Page in the New England Journal of Medicine

Vitamin A and D deficiencies associated with incident tuberculosis in HIV-infected patients initiating antiretroviral therapy in multinational case-cohort study

Post Date: 
2017-02-06
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Publication: 
Journal of Acquired Immune Deficiency Syndromes
Introduction: Numerous micronutrients have immunomodulatory roles that may influence risk of tuberculosis (TB), but the association between baseline micronutrient deficiencies and incident TB after antiretroviral (ART) initiation in HIV-infected individuals is not well characterized. ...

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TB/HIV Treatment during Pregnancy: Does Drug Metabolism Change?

Post Date: 
2015-12-04
Dooley K, Savic R. TB/HIV Treatment during Pregnancy: Does Drug Metabolism Change? The 46th Union World Conference on Lung Health. Cape Town, South Africa.

Current Research on the Pathophysiology, Immunology, Prevention and Treatment of TB in Pregnant Women

Post Date: 
2015-12-04
Gupta A, Mathad J. Current Research on the Pathophysiology, Immunology, Prevention and Treatment of TB in Pregnant Women. The 46th Union World Conference on Lung Health. Cape Town, South Africa.

Current Research on the Pathophysiology, Immunology, Prevention and Treatment of TB in Pregnant Women

Post Date: 
2015-12-04
Gupta, A., Mathad, J. Current Research on the Pathophysiology, Immunology, Prevention and Treatment of TB in Pregnant Women. International Union for Tuberculosis and Lung Disease. 46th Union World Conference on Lung Health. Capetown, South Africa.

Impact of Rifapentine Price Reduction on Utilization for TB Treatment in the United States

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2015-12-04
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Gupta, A. Impact of Rifapentine Price Reduction on Utilization for TB Treatment in the United States. The 46th Union World Conference on Lung Health. Cape Town, South Africa.

Characteristics Associated with Mobile Phone Access among TB Patients in Pune, India

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2015-12-04
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Ogale YP, Elf J, Lokhande R, Mave V, Roy S, Gupta A, Golub J, Mathad J. Characteristics Associated with Mobile Phone Access among TB Patients in Pune, India. The 46th Union World Conference on Lung Health. Cape Town, South Africa.

Risk Factors for Unfavorable Treatment Outcomes in DOTs-treated Pediatric TB Patients

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2015-12-04
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Shelke S, Bollinger R, Chandanwale A, DeLuca A, Gupta A, Gupte N, Adhav PS, Kadam DB. Risk Factors for Unfavorable Treatment Outcomes in DOTs-treated Pediatric TB Patients. The 46th Union World Conference on Lung Health. Cape Town, South Africa.

Utility of GeneXpert for Diagnosis of Rifampicin-resistant Extra-pulmonary TB—A Retrospective Review of 70 Cases, SGH, Pune, India

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2015-12-04
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Girish S, Dharmashle S, Desai S, Kagal A, Bharadwaj R, Chandanwale A, Lokhande R, Kadam DB, DeLuca A, Gupte N, Jain D, Gupta A, Bollinger R, Mave V. Utility of GeneXpert for Diagnosis of Rifampicin-resistant Extra-pulmonary TB—A Retrospective Review of 70 Cases, SGH, Pune, India, The 46th Union...

Applied HIV Epidemiology and Implementation Science: a multidisciplinary approach to understanding and controlling an evolving epidemic

Post Date: 
2015-11-20
Chang, L. Applied HIV Epidemiology and Implementation Science: a multidisciplinary approach to understanding and controlling an evolving epidemic. National Institutes of Health. Bethesda, MD.

Isoniazid Concentration in Hair among Children with Tuberculosis

Post Date: 
2015-11-15
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Mave, V. Isoniazid Concentration in Hair among Children with Tuberculosis. Annual Meeting, Center for AIDS Research. Seattle, WA.

BJMC-JHU Research Program

Post Date: 
2015-10-31
Mave, V. BJMC-JHU Research Program. TreatAsia Network Meeting. Bangkok, Thailand.

Rakai Health Sciences Program: Social, Behavioral, and Biomedical Research in HIV Dynamics, Prevention, and Care

Post Date: 
2015-10-30
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Chang, L. Rakai Health Sciences Program: Social, Behavioral, and Biomedical Research in HIV Dynamics, Prevention, and Care. CFAR National Social and Behavioral Sciences Research Network Annual Meeting. Baltimore, MD.

mHealth

Post Date: 
2015-10-29
Chang, L. mHealth. CFAR National Social and Behavioral Sciences Research Network Annual Meeting. Baltimore, MD.

Does Quality of Delivery Care Differ Between Public and Private Facilities in Madhya Pradesh, India?: An Exit Interview Study of Routine Delivery Care Practices

Post Date: 
2015-10-20
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Chaturvedi C, Randive B , Sabde Y, Diwan V, Raven J, De Costa A. Does Quality of Delivery Care Differ Between Public and Private Facilities in Madhya Pradesh, India?: An Exit Interview Study of Routine Delivery Care Practices. Global Maternal Newborn Health Conference 2015. Mexico City, Mexico. 2015

Operational Challenges Undermine WHO TB Symptom Screen in Pregnant Women

Post Date: 
2015-10-11
Vaidya A , Tambe S, Bhosale R, Mave V, Elf J, Pradhan N, Nevrekar N, Patil S, Kagal A, Joshi S, Chandanwale A, Gupta A, MathadJ. Operational Challenges Undermine WHO TB Symptom Screen in Pregnant Women. ID Week 2015. San Diego, CA. San Diego, CA. 2015

Developing a Validated Tool to Assess Internal Medicine and Infectious Disease Trainees’ Ability to Obtain and Interpret TB Diagnostics

Post Date: 
2015-10-11
Chida N, Gupta A, Bollinger B, Melia M. Developing a Validated Tool to Assess Internal Medicine and Infectious Disease Trainees’ Ability to Obtain and Interpret TB Diagnostics. ID Week 2015. San Diego, CA. 2015

Dengue and Malaria are Common Infections among Adults and Adolescents Hospitalized with Acute Febrile Illness in Western India

Post Date: 
2015-10-09
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Mave V, Kadam D, Bharadwaj R, Kagal A, Sachs J, Raichur P, Kanade S, Gupte N, Joshi S, Chandanwale A, Zenilman JM, Bollinger R, Gupta A. Dengue and Malaria are Common Infections among Adults and Adolescents Hospitalized with Acute Febrile Illness in Western India. Infectious Diseases Society of...

A Man from Central America with Progressive Shortness of Breath

Post Date: 
2015-10-07
Chida, N. A Man from Central America with Progressive Shortness of Breath. ID Week 2015. San Diego, CA. 2015.

TB and Women

Post Date: 
2015-09-29
Gupta, A. TB and Women. Mid Atlantic TB Intensive Workshop. Rehoboth, DE.

Conducting HIV and TB Research in India: Challenges and Opportunities

Post Date: 
2015-08-27
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Gupta, A. Conducting HIV and TB Research in India: Challenges and Opportunities. Emory University. Atlanta, GA.

Tuberculosis in Pregnant Women and Infants

Post Date: 
2015-08-26
Gupta, A. Tuberculosis in Pregnant Women and Infants. International Conference on Emerging Infectious Diseases. Atlanta, GA.

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