Research News

Performers conduct a play to raise awareness about HIV and HPV

The BJGMC Clinical Research Site convened community awareness activities that focused on HIV and HPV

DNA molecule

New study launched in India & South Africa to identify functional relationships between genomics & metabolomics, & to characterize fundamental biological systems underlying resistance to Mtb infection.

Clinical Research

Leadership
Dr. Amita Gupta of Johns Hopkins is Principal Investigator for the Indo-JHU Clinical Research Partnership based out of CCGHE. Research is directed locally in India out of the BJGMC-JHU Clinical Research Site by Dr. Vidya Mave, a Hopkins faculty member who lives in Pune. Dr. Nikhil Gupte is the Lead Biostatistician and Deputy Director and Dr. Nishi Suryavanshi is Clinical Site Coordinator and Deputy Director. Research is conducted in collaboration with the following institutions:
 
 

Vitamin D deficiency and risk of postpartum tuberculosis among HIV-infected breastfeeding mothers in India

Post Date: 
2015-03-15
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Publication: 
International Journal of Tuberculosis and Lung Disease
Some studies have associated low vitamin D levels with the risk of tuberculosis (TB), but its association in human immunodeficiency virus (HIV) infected mothers in a TB-endemic region has not been well studied. We conducted a nested 1:2 case-control study among HIV-infected mothers in western India...

What tuberculosis means for maternal health

Post Date: 
2015-03-04
Mrs. Kumar [not her real name] was diagnosed with TB 18 years ago, during her first pregnancy, which ended in miscarriage. She then became depressed and side effects from the TB medications caused her difficulty eating. Three years later, during her second pregnancy, she and her husband were...

Predictors and outcomes of mycobacteremia among HIV-infected smear- negative presumptive tuberculosis patients in Uganda

Post Date: 
2015-02-15
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Publication: 
BMC Infectious Diseases
Background : Sputum smear microscopy for tuberculosis (TB) diagnosis lacks sensitivity in HIV-infected symptomatic patients and increases the likelihood that mycobacterial infections particularly disseminated TB will be missed; delays in diagnosis can be fatal. Given the duration for MTB growth in...

Capturing illicit drug use where and when it happens: an ecologic momentary assessment of the social, physical and activity environment of using versus craving illicit drugs

Post Date: 
2015-02-15
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Publication: 
Addiction
Aim: To understand the environmental and contextual influences of illicit cocaine and heroin use and craving using mobile health (mHealth) methods. Design: Interactive mHealth methods of ecological momentary assessment (EMA) were utilized in the Exposure Assessment in Current Time (EXACT) study to...

Analysis of latent tuberculosis infection treatment adherence among refugees and other patient groups referred to the Baltimore City Health Department TB clinic

Post Date: 
2015-02-15
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Publication: 
Journal of Immigrant and Minority Health
We sought to determine the proportion of refugee patients at the Baltimore City Health Department Tuberculosis program (BCHD-TB) successfully completing latent tuberculosis infection (LTBI) treatment, as compared to other referral groups, and to identify factors associated with treatment completion...

Implementing a large scale systematic tuberculosis screening program in correctional facilities in South Africa

Post Date: 
2015-01-08
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Publication: 
Open Forum Infectious Diseases
Background : Tuberculosis (TB) prevalence is high in correctional facilities in southern Africa. With support from local South African nongovernmental organizations, the South African Department of Correctional Services initiated a program of systematically screening newly admitted and current...

Activism on rifapentine pricing: removing cost barriers to improve the uptake of tuberculosis research innovations

Post Date: 
2014-12-21
Publication: 
Public Health Action
As recent advances have been made in developing tools to fight tuberculosis (TB), there is also a trend towards increasing advocacy by the civil society for TB research and access. One recent successful effort to increase access to treatment options for TB involved a collaborative effort to...

Inequalities in institutional delivery uptake and maternal mortality reduction in the context of cash incentive program, Janani Suraksha Yojana: Results from nine states in India

Post Date: 
2014-12-15
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Publication: 
Social Science and Medicine
Abstract Proportion of women giving birth in health institutions has increased sharply in India since the introduction of cash incentive program, Janani Suraksha Yojana (JSY) in 2005. JSY was intended to benefit disadvantaged population who had poor access to institutional care for childbirth and...

Is CD4 monitoring needed among Ugandan clients achieving a virologic and immunologic response to treatment?

Post Date: 
2014-11-15
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Publication: 
AIDS Patient Care and STDs
It is unclear whether ongoing CD4 monitoring is needed following immunologic and virologic response to antiretroviral therapy (ART). We investigated the proportion of clients who achieved a virologic and immunologic response and then had a subsequent CD4 count <200 cells/μL despite continued...

Pre-antiretroviral therapy selenium status predicts WHO stages 3, 4 or death but not virologic failure post-antiretroviral therapy

Post Date: 
2014-11-13
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Publication: 
Nutrients
A case-cohort study, within a multi-country trial of antiretroviral therapy (ART) efficacy (Prospective Evaluation of Antiretrovirals in Resource Limited Settings (PEARLS)), was conducted to determine if pre-ART serum selenium deficiency is independently associated with human immunodeficiency virus...

Complications of tuberculosis

Post Date: 
2014-10-15
Publication: 
Current Opinion in Infectious Diseases
Purpose of review : Diagnosis and management of tuberculosis (TB) remains challenging and complex because of the heterogeneity of disease presentations. Despite effective treatment, TB disease can lead to significant short-and long-term health consequences. We review potential acute and chronic...

High proportion of indeterminate QuantiFERON-TB Gold In-Tube results in an inpatient population are related to host factors and pre-analytical steps

Post Date: 
2014-09-19
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Publication: 
Open Forum Infectious Diseases
Background: QuantiFERON-TB Gold In-Tube test (QFT-GIT) can be used as an alternative to tuberculin skin testing (TST) for the targeted testing of latent tuberculosis. Due to many shortcomings with TST, QFT-GIT usage is increasing. QFT-GIT implementation in the inpatient setting remains unclear...

Source case investigation for children with TB disease in Pune, India

Post Date: 
2014-08-27
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Publication: 
Tuberculosis Research and Treatment
Setting. Contact tracing is broadly encouraged for tuberculosis (TB) control. In many high-burden countries, however, little effort is made to identify contacts of newly diagnosed TB patients. This failure puts children, many of whom live in poor crowded communities, at special risk. Objectives. To...

Economic challenges associated with tuberculosis diagnostic development

Post Date: 
2014-08-15
Publication: 
Expert Review of Pharmacoeconomics and Outcomes Research
Tuberculosis remains a global health crisis in part due to underdiagnosis. Technological innovations are needed to improve diagnostic test accuracy and reduce the reliance on expensive laboratory infrastructure. However, there are significant economic challenges impeding the development and...

Editorial commentary: Xpert MTB/RIF testing for individuals with presumed tuberculosis: implications for infection control and rapid tuberculosis detection in the United States.

Post Date: 
2014-08-04
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Publication: 
Clinical Infectious Diseases
Despite recent declines in incidence, tuberculosis remains a significant public health problem in the United States, with almost 10 000 new cases each year. As the disease becomes less common in the United States, diagnostic delays occur because of diverse clinical presentations and suboptimal...

Cell phone utilization among foreign-born latinos: a promising tool for dissemination of health and HIV information

Post Date: 
2014-08-01
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Publication: 
Journal of Immigrant and Minority Health
Latinos in the U.S. are disproportionately affected by HIV and are at risk for late presentation to care. Between June 2011 and January 2012, we conducted a cross-sectional survey of 209 Baltimore Latinos at community-based venues to evaluate the feasibility of using communication technology (ICT)-...

Impact of maternal hepatitis B virus coinfection on mother-to-child transmission of HIV

Post Date: 
2014-07-15
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Publication: 
HIV Medicine
Objectives: Despite high hepatitis B virus (HBV) endemicity in various resource-limited settings (RLSs), the impact of maternal HIV/HBV coinfection on infant health outcomes has not been defined. We aimed to assess the prevalence of HBV coinfection among HIV-infected pregnant women and its impact...

25-Hydroxyvitamin D insufficiency and deficiency is associated with HIV disease progression and virological failure post-antiretroviral therapy initiation in diverse multinational settings

Post Date: 
2014-07-15
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Publication: 
The Journal of Infectious Diseases
Background: Low 25-hydroxyvitamin D (25(OH)D) has been associated with increased HIV mortality, but prospective studies assessing treatment outcomes after combination antiretroviral therapy (cART) initiation in resource-limited settings are lacking. Methods: A case-cohort study (N = 411) was nested...

Diagnostic accuracy of a rapid urine lipoarabinomannan test for tuberculosis in HIV-infected adults

Post Date: 
2014-07-01
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Publication: 
Journal of Acquired Immune Deficiency Syndromes
Objective : In settings of high HIV prevalence, tuberculosis control and patient management are hindered by lack of accurate, rapid tuberculosis diagnostic tests that can be performed at point-of-care. The Determine TB LAM Ag (TB LAM) test is a lateral flow immunochromatographic test for detection...

Blood stream infections

Post Date: 
2014-07-01
Publication: 
BioMed Research International
Blood stream infection (BSI) is one of the most devastating preventable complications in Critical Care Units. It has far-reaching consequences resulting in prolonged length of hospital-stay, high costs to the individual and exchequer, and, in many instances, loss of life. Although exact rates of...

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Obesity and Inflammation in Resource-Driven Settings of ART Initiation

Post Date: 
2015-02-24
Erlandson KM, Gupte N, Lama JR, Patcharaphan S, Mwelase T, Balagopal A, Asmuth D, Campbell TB, Gupta A. Obesity and Inflammation in Resource-Driven Settings of ART Initiation. Conference on Retroviruses and Opportunistic Infections 2015. Seattle, WA. 2015.

Cost-effectiveness of Isonaizid Preventive Therapy for HIV-Infected Pregnant Women in India

Post Date: 
2015-02-24
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Kapoor S, Chida N, Gupta A, Shah M. Cost-effectiveness of Isonaizid Preventive Therapy for HIV-Infected Pregnant Women in India. Conference on Retroviruses and Opportunistic Infections 2015. Seattle, WA. 2015.

Persistently High IL-18 and sCD14 are Independently Associated with Clinical Failure

Post Date: 
2015-02-24
Balagopal A, Gupte N, Hakim J, Hosseinipour M, Nagalingeswaran K, Cox A, Sanne I, Asmuth D, Campbell T, Gupta A. Persistently High IL-18 and sCD14 are Independently Associated with Clinical Failure. Conference on Retroviruses and Opportunistic Infections 2015. Seattle, WA. 2015.

Conducting Infectious Diseases Research in India

Post Date: 
2015-02-16
Gupta, A. Conducting Infectious Diseases Research in India. Johns Hopkins University School of Medicine. Baltimore, MD.

Empowering Women in Global Health: Lessons Learned and Strategies for Success

Post Date: 
2015-02-16
Gupta, A. Empowering Women in Global Health: Lessons Learned and Strategies for Success. Empowering Women in Global Health: Lessons Learned and Strategies for Success. New York, NY.

PMTCT: Current Recommendations

Post Date: 
2015-01-31
Mave, V. PMTCT: Current Recommendations. 5th National Conference on HIV/AIDS Therapy. Mumbai, India.

Global Health Panel Discussion

Post Date: 
2015-01-22
Gupta, A. Global Health Panel Discussion. Johns Hopkins University School of Medicine Global Health Webinar. Baltimore, MD.

Metabolic Complications/Inflammation

Post Date: 
2015-01-10
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Gupta, A. Metabolic Complications/Inflammation. 5th National Conference on HIV/AIDS Therapy. Mumbai, India.

Metabolic Complications/Inflammation Lecture

Post Date: 
2015-01-10
Gupta A. Metabolic Complications/Inflammation Lecture. 5th National Conference on HIV/AIDS Therapy. Mumbai, India.

Intro to mHealth

Post Date: 
2014-12-17
Change, L. Intro to mHealth. JHU-GmI Seminar. Johns Hopkins School of Medicine. Baltimore, MD.

IMPAACT TB Scientific Committee 5 year Priorities and Plans

Post Date: 
2014-12-03
Gupta A. IMPAACT TB Scientific Committee 5 year Priorities and Plans. IMPAACT Network External Review. NIH. Washington, DC.

Conducting International Clinical Trials: Some Important Considerations

Post Date: 
2014-11-19
Gupta A. Conducting International Clinical Trials: Some Important Considerations. Johns Hopkins Clinical Investigation Course. Baltimore, MD.

Barriers and Delays in TB Diagnosis and Treatment: Does Gender Matter?

Post Date: 
2014-11-17
Gupta, A. Barriers and Delays in TB Diagnosis and Treatment: Does Gender Matter? PATH Gender & TB Experts Meeting. Washington, DC.

GETHealth Summit to Bridge Health Workforce Gap in Developing Countries

Post Date: 
2014-11-10
Bollinger, R. GETHealth Summit to Bridge Health Workforce Gap in Developing Countries. GETHealth Summit. Dublin, Ireland.

Developing a Roadmap for Integration of TB/HIV Activities in Maternal and Child Health Setting

Post Date: 
2014-10-26
Gupta, A. Developing a Roadmap for Integration of TB/HIV Activities in Maternal and Child Health Setting. International Union for Tuberculosis and Lung Disease. 45th Union World Conference on Lung Health. Barcelona, Spain.

Global Health Opportunities: Conducting International Health Work from the US

Post Date: 
2014-10-14
Gupta, A. Global Health Opportunities: Conducting International Health Work from the US. Johns Hopkins Medical Student Global Health Elective. Baltimore, MD.

Advancing Public Reporting and Surveillance of Healthcare-associated Infections

Post Date: 
2014-10-06
Bollinger, R. Advancing Public Reporting and Surveillance of Healthcare-associated Infections. ID Week 2014. Philadelphia, PA. 2014.

Metabolic Complications over a Lifetime

Post Date: 
2014-09-27
Gupta, A. Metabolic Complications over a Lifetime. 2014 Southern African HIV Clinician Society Conference. Cape Town, South Africa. 2014.

Complex Cases in HIV/Metabolic Complications Management

Post Date: 
2014-09-25
Gupta, A. Complex Cases in HIV/Metabolic Complications Management. 2014 Southern African HIV Clinician Society Conference. Cape Town, South Africa. 2014.

TB in Pregnancy

Post Date: 
2014-09-08
Gupta, A. TB in Pregnancy. Interscience Conference on Antimicrobial Agents and Chemotherapy. Washington, DC.

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