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BMC Infectious Diseases: Our survey among TB patients' household contacts with evidence of recent exposure found that knowledge is poor and families are confused about disease transmission.

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Study shows success with TB therapy observation conducted via video instead of via in-person clinic visits.

Clinical Research

Leadership
Dr. Amita Gupta of Johns Hopkins is Principal Investigator for the Indo-JHU Clinical Research Partnership based out of CCGHE. Research is directed locally in India out of the BJGMC-JHU Clinical Research Site by Dr. Vidya Mave, a Hopkins faculty member who lives in Pune. Dr. Nikhil Gupte is the Lead Biostatistician and Deputy Director and Dr. Nishi Suryavanshi is Clinical Site Coordinator and Deputy Director. Research is conducted in collaboration with the following institutions:
 
 

Correlates of lower comprehension of informed consent among participants enrolled in a cohort study in Pune, India

Post Date: 
2013-03-15
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Countries: 
Publication: 
International Health
Background: Optimum comprehension of informed consent by research participants is essential yet challenging. This study explored correlates of lower comprehension of informed consent among 1334 participants of a cohort study aimed at estimating HIV incidence in Pune, India. Methods: As part of the...

Availability of treatment for eclampsia in public health institutions in Maharashtra, India

Post Date: 
2013-03-15
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Countries: 
Publication: 
Journal of Health, Population, and Nutrition
Abstract Severe pre-eclampsia and eclampsia are common causes of maternal deaths worldwide and more so in developing countries. Magnesium sulphate (MgSO4) is now the most-recommended drug of choice to treat these conditions. Despite favourable policies for the use of MgSO4 treatment in India,...

Combination implementation for HIV prevention: moving from evidence to population-level impact

Post Date: 
2013-01-15
Publication: 
The Lancet Infectious Disease
The promise of combination HIV prevention-the application of multiple HIV prevention interventions to maximise population-level effects-has never been greater. However, to succeed in achieving significant reductions in HIV incidence, an additional concept needs to be considered: combination...

Assessing the evolving definition of underrepresented minority and its application in academic medicine

Post Date: 
2013-01-15
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Countries: 
Publication: 
Academic Medicine
Purpose: To assess how U.S. academic health centers (AHCs) define the term underrepresented minority (URM) and apply it to their diversity programs, following the 2003 revision of the Association of American Medical Colleges' (AAMC's) definition of URM. Method: In 2010, the authors developed and...

Tuberculosis in pregnant and postpartum women: Epidemiology, management, and research gaps

Post Date: 
2012-12-15
Publication: 
Clinical Infectious Diseases
Tuberculosis is most common during a woman's reproductive years and is a major cause of maternal-child mortality. National guidelines for screening and management vary widely owing to insufficient data. In this article, we review the available data on (1) the global burden of tuberculosis in women...

Household-based HIV counseling and testing as a platform for referral to HIV care and medical male circumcision in Uganda: a pilot evaluation

Post Date: 
2012-12-13
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Countries: 
Publication: 
PLOS One
Background: Combination HIV prevention initiatives incorporate evidence-based, biomedical and behavioral interventions appropriate and acceptable to specific populations, aiming to significantly reduce population-level HIV incidence. Knowledge of HIV serostatus is key to linkages to HIV care and...

Growth patterns among HIV-exposed infants receiving nevirapine prophylaxis in Pune, India

Post Date: 
2012-10-31
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Clinical Sites: 
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Countries: 
Publication: 
BMC Infectious Diseases
Background: India has among the highest rates of infant malnutrition. Few studies investigating the growth patterns of HIV-exposed infants in India or the impact of timing of HIV infection on growth in settings such as India exist. Methods: We used data from the Six Week Extended Nevirapine (SWEN)...

A novel educational strategy targeting health care workers in underserved communities in Central America to integrate HIV into primary medical care

Post Date: 
2012-10-24
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Publication: 
PLOS
Background: Current educational strategies to integrate HIV care into primary medical care in Central America have traditionally targeted managers or higher-level officials, rather than local health care workers (HCWs). We developed a complementary online and on-site interactive training program to...

Pooled individual data analysis of five randomized trials of infant nevirapine prophylaxis to prevent breast-milk HIV-1 transmission

Post Date: 
2012-10-19
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Clinical Sites: 
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Publication: 
Clinical Infectious Diseases
Background: In resource-limited settings, mothers infected with human immunodeficiency virus type 1 (HIV-1) face a difficult choice: breastfeed their infants but risk transmitting HIV-1 or not breastfeed their infants and risk the infants dying of other infectious diseases or malnutrition. Recent...

Vitamin D deficiency is common among HIV-infected breastfeeding mothers in Pune, India, but not associated with mother-to-child HIV transmission

Post Date: 
2012-10-01
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Clinical Sites: 
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Countries: 
Publication: 
HIV Clinical Trials
A recent report from Tanzania demonstrated an increased risk of being HIV infected or of dying at birth among children born to breastfeeding mothers with low baseline vitamin D levels. We conducted a nested case-control study among HIV-infected pregnant women in western India to confirm the...

Research capacity-building program for clinicians and staff at a community-based HIV clinic in Uganda: A pre/post evaluation

Post Date: 
2012-10-01
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Countries: 
Publication: 
Journal of the Association of Nurses in AIDS Care
Developing capacity for HIV research and clinical practice is critically needed in resource-limited countries. The purpose of this study was to evaluate a research capacity building program for community-based participants in preparation and conduct of mHealth interventions. A descriptive, cross-...

Evaluation of a multimodal, distance learning HIV management course for clinical care providers in India

Post Date: 
2012-10-01
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Countries: 
Publication: 
Journal of the International Association of Providers of AIDS Care
Distance learning is an important tool for training HIV health workers. However, there is limited evidence on design and evaluation of distance learning HIV curricula and tools. We therefore designed, implemented, and evaluated a distance learning course on HIV management for clinical care...

Cost analyses of peer health worker and mHealth support interventions for improving AIDS care in Rakai, Uganda

Post Date: 
2012-09-12
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Countries: 
Publication: 
AIDS Care
A cost analysis study calculates resources needed to deliver an intervention and can provide useful information on affordability for service providers and policy-makers. We conducted cost analyses of both a peer health worker (PHW) and a mHealth (mobile phone) support intervention. Excluding...

HIV testing behaviors among Latinos in Baltimore City

Post Date: 
2012-08-14
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Countries: 
Publication: 
Journal of Immigrant and Minority Health
In the US, HIV disproportionately affects Latinos who often present late in the disease. Baltimore has seen a recent rapid growth in its Latino population paralleled by an increasing impact of HIV/AIDS among Latinos. From 2009 to 2010, we performed a cross-sectional survey of Latinos accessing the...

Detection of microbial translocation in HIV and SIV infection using the limulus amebocyte lysate assay is masked by serum and plasma

Post Date: 
2012-08-01
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Publication: 
PLOS One
Objective: Microbial translocation (MT) is thought to be a major contributor to the pathogenesis of HIV-related immune activation, and circulating lipopolysaccharide (LPS) from Gram-negative bacteria is the principle measurement of this process. However, related research has been impeded by...

Mycobacterium tuberculosis complex enhances susceptibility of CD4 T Cells to HIV through a TLR2-mediated pathway

Post Date: 
2012-07-23
Publication: 
PLOS One
Among HIV-infected individuals, co-infection with Mycobacterium tuberculosis is associated with faster progression to AIDS. We investigated the hypothesis that M. bovis BCG and M. tuberculosis (Mtb complex) could enhance susceptibility of CD4+ cells to HIV infection. Peripheral blood mononuclear...

Guidelines for improving entry into and retention in care and antiretroviral adherence for persons with HIV: evidence-based recommendations from an International Association of Physicians in AIDS Care panel

Post Date: 
2012-06-05
Publication: 
Annals of Internal Medicine
Description: After HIV diagnosis, timely entry into HIV medical care and retention in that care are essential to the provision of effective antiretroviral therapy (ART). ART adherence is among the key determinants of successful HIV treatment outcome and is essential to minimize the emergence of...

Authors’ response to Hanrahan et al CID article

Post Date: 
2012-05-15
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Clinical Sites: 
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Publication: 
Clinical Infectious Diseases
Reply to letter

Programmatic impact of QuantiFERON-TB Gold In-Tube implementation on latent tuberculosis diagnosis and treatment in a public health clinic

Post Date: 
2012-05-07
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Countries: 
Publication: 
PLoS One
Background : QuantiFERON-TB Gold In-Tube (QFT-GIT) is considered an alternative to the tuberculin skin test (TST) for the diagnosis of tuberculosis (TB) infection, but the programmatic impact of QFT-GIT implementation is largely unknown. In March, 2010, the Baltimore City Health Department (BCHD)...

Safety, tolerability, and pharmacokinetic interactions between single-dose TMC207 and steady-state efavirenz in healthy volunteers: AIDS Clinical Trials Group (ACTG) Study.

Post Date: 
2012-04-15
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Countries: 
Publication: 
Journal of Acquired Immune Deficiency Syndromes
Background: Drug-drug interactions complicate management of coinfection with HIV-1 and Mycobacterium tuberculosis. Bedaquiline (formerly TMC207), an investigational agent for the treatment of tuberculosis, is metabolized by cytochrome P450 (CYP) 3A which may be induced by the antiretroviral drug...

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Update on TB and OIs

Post Date: 
2014-09-04
Presentation Location: 
Rio de Janeiro, Brazil
Event & Convener: 
Brazil-Hopkins AIDS Conference
Presentation

Body Mass Index (BMI) and Change in Levels of Immune Activation Post- ART Initiation in Diverse Low- and Middle-Income Settings

Post Date: 
2014-07-20
Presentation Location: 
Melbourne, Australia
Event & Convener: 
International AIDS Conference. AIDS 2014
Presentation.

Prevalence of Asymtpomatic Cryptococcemia and its Implications in Pune, India

Post Date: 
2014-07-20
Presentation Location: 
Melbourne, Australia
Event & Convener: 
International AIDS Conference. AIDS 2014
Presentation.

Vitamin D and TMEM16J Host Variants Associated with TB and Death in HIV Infected and Exposed Infants

Post Date: 
2014-06-13
Presentation Location: 
Baltimore, MD
Event & Convener: 
Johns Hopkins Center for TB Research Annual Scientific Meeting
Presentation

Conducting HIV Research through the US and India HIV Clinical Trials Units

Post Date: 
2014-06-11
Presentation Location: 
Baltimore, MD
Event & Convener: 
ICOHRTA-Fogarty Training Program
Presentation

Finding Your Passion to Do Your Best Work and Have Fun

Post Date: 
2014-05-31
Presentation Location: 
Baltimore, MD
Event & Convener: 
Research Initiatives for Student Enhancement. Kennedy Krieger Institute
Lecture

TB in Pregnancy

Post Date: 
2014-05-12
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Clinical Sites: 
Presentation Location: 
Mumbai, India
Event & Convener: 
Hinduja Hospital
Lecture

Grant Writing: The Clinician Researcher Perspective

Post Date: 
2014-05-10
Presentation Location: 
Pondicherry, India
Event & Convener: 
RePORT Meeting. Jawaharlal Institute of Postgraduate Medical Education & Research
Lecture

Integrating Engineering and Technology in to Prevention

Post Date: 
2014-05-07
Presentation Location: 
Baltimore, MD
Event & Convener: 
Centers for Intervention and Services Research Meeting
Panel participation

RePORT India: Objectives and Future Directions

Post Date: 
2014-04-30
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Countries: 
Presentation Location: 
Shanghai, China
Event & Convener: 
TB Vaccine 4th Global Forum
Presentation

Inflammatory Markers and Incident TB: An International Case-Control Study

Post Date: 
2014-04-24
Presentation Location: 
Baltimore, MD
Event & Convener: 
Center for TB Research. Johns Hopkins School of Medicine
Lecture

JHU Entrepreneurship Week

Post Date: 
2014-04-21
Presentation Location: 
Baltimore, MD
Event & Convener: 
Medical and Educational Perspectives, Inc. JHU Entrepreneurship Week
Opening ceremony speaker

Identifying Global Trends and Gaps

Post Date: 
2014-04-21
Presentation Location: 
Baltimore, MD
Event & Convener: 
Medical and Educational Perspectives, Inc., Johns Hopkins School of Medicine.
Panel participant

Epidemiology of HIV/AIDS in India

Post Date: 
2014-04-04
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Countries: 
Presentation Location: 
Baltimore, MD
Event & Convener: 
Mylan HIV Course Series. JHU Global mHealth
Lecture

Centro SOL: Salud and Opportunity for Latinos (and Beyond) A Case Study of How Passion and Diversity Drove Change at JHU

Post Date: 
2014-03-31
Presentation Location: 
Baltimore, MD
Event & Convener: 
Dr. James EK Hildreth Lecture: Johns Hopkins School of Medicine
Lecture

mHealth: Overview and Opportunities for Novel Cancer Research

Post Date: 
2014-03-19
Presentation Location: 
Bethesda, MD
Event & Convener: 
National Cancer Institute DCEG Fellows’ Training Symposium. National Institutes of Health
Lecture

Managing Opportunistic Illnesses in 2014

Post Date: 
2014-03-18
Presentation Location: 
Baltimore, MD
Event & Convener: 
24th Annual Clinical Care of the Patient with HIV Infection. Hopkins Center for AIDS Research
Presentation

An Equity Analysis of Institutional Delivery Uptake and Maternal Mortality Reduction in Context of Cash Transfer Programme (JSY): Results from Nine States of India

Post Date: 
2014-03-10
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Countries: 
Presentation Location: 
Cape Town, South Africa
Event & Convener: 
Third Global Symposium on Health Systems Research. Health Systems Global
Abstract Presenation. Randive B , San Sebastian M, De Costa A, Lindholm L.

Crucial Issues in Mother-to-Child Transmission (MTCT), Maternal Health, and HIV Treatment in Children

Post Date: 
2014-03-05
Presentation Location: 
Boston, MA
Event & Convener: 
21st Conference on Retroviruses and Opportunistic Infections (CROI)
Oral Abstract Moderator

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