Research News

Zika Surveillance Among Pregnant Women in India

India leads the world in dengue cases. CCGHE researchers are keeping an eye on Zika among pregnant women, which is transmitted by the same mosquito & can cause devastating birth defects.

Sepsis among newborns in the neonatal intensive care unit (NICU) is a big problem in India, and a complex one to untangle.

Clinical Research

We work with scientists and practitioners around the world to conduct clinical trials and observational studies that improve prevention and treatment of many grave health issues affecting resource-limited regions, including HIV and tuberculosis.
 
We have formal research partnerships with the following institutions:
 
 

Mortality in HIV infected individuals in Pune, India

Post Date: 
2011-04-15
Publication: 
Indian Journal of Medical Research
Country: 
Background & Objectives: With the presence of HIV epidemic for more than two decades in India, rise in the number of HIV related deaths is expected. Data on mortality in HIV infected individuals from prospective studies are scanty in India. We report here data on mortality in a systematically...

Twelve month follow-up of the SWEN randomized controlled trials: Differential impact of extended-dose nevirapine on mother-to-child transmission and infant death by maternal CD4 cell count

Post Date: 
2011-03-27
Publication: 
AIDS Care
Objectives: We previously reported combined analysis of 6-week and 6-month endpoints of three randomized controlled trials [Six Week Extended Dose Nevirapine (SWEN) trials] that compared extended-dose nevirapine through 6 weeks of age to single-dose nevirapine to prevent HIV transmission via...

Predictors of retention among men attending STI clinics in HIV prevention programs and research: A case control study in Pune, India

Post Date: 
2011-03-11
Publication: 
PLOS One
Country: 
Background: Retention is critical in HIV prevention programs and clinical research. We studied retention in the three modeled scenarios of primary prevention programs, cohort studies and clinical trials to identify predictors of retention. Methodology/Principal Findings: Men attending Sexually...

Maternal tuberculosis: a risk factor for mother-to-child transmission of human immunodeficiency virus

Post Date: 
2011-02-01
Publication: 
The Journal of Infectious Diseases
Country: 
Background: Maternal human immunodeficiency virus (HIV) RNA load, CD4 cell count, breast-feeding, antiretroviral use, and malaria are well-established factors associated with mother-to-child transmission (MTCT) of HIV; the role of maternal tuberculosis (TB), however, has not been well established...

Unstimulated primary CD4+ T cells from HIV-1-positive elite suppressors are fully susceptible to HIV-1 entry and productive infection

Post Date: 
2011-01-15
Publication: 
Journal of Virology
Elite controllers or suppressors (ES) are a group of HIV-1-infected individuals who maintain viral loads below the limit of detection of commercial assays for many years. The mechanisms responsible for this remarkable control are under intense study, with the hope of developing therapeutic vaccines...

Tuberculosis in women and children

Post Date: 
2010-12-15
Publication: 
The Lancet
Apart from improvement of tuberculosis control, innovative strategies to advance tuberculosis prevention and treatment in women and children would contribute to the attainment of Millennium Development Goals 4 and 5 by reduction of the mortality rate in young children and women of reproductive age...

Predictors of HIV testing among Latinos in Baltimore City

Post Date: 
2010-12-15
Publication: 
Journal of Immigrant and Minority Health
Country: 
To better understand access to HIV testing and prevention services experienced by Latinos, we evaluated data compiled through Baltimore City Health Department HIV outreach efforts in 2008. Of 6,443 clients served, Latinos were more likely male, young, and less-educated than non-Latinos. A greater...

Gonorrhoea and chlamydia testing rates of HIV-infected men: low despute guidelines

Post Date: 
2010-11-15
Publication: 
Sexually Transmitted Infections
Country: 
Objectives: Screening HIV-infected men for gonorrhea (GC) and Chlamydia (CT) may decrease HIV transmission and reduce the incidence of pelvic inflammatory disease in female partners. This study determined GC/CT testing rates in a clinical HIV cohort before and after 2003 when the U.S. Centers for...

Stigmatizing attitudes and low levels of knowledge but high willingness to participate in HIV management: A community based survey of pharmacies in Pune, India

Post Date: 
2010-08-27
Publication: 
BMC Public Health
Country: 
Background: The World Health Organization (WHO) recommends that the role of pharmacists in low-income settings be expanded to address the increasing complexity of HIV antiretroviral (ARV) and co-infection drug regimens. However, in many such settings including in India, many pharmacists and...

Unique aspects of the care of HIV-positive Latino patients living in the United States

Post Date: 
2010-08-15
Publication: 
Current HIV/AIDS Reports
Country: 
Latinos are disproportionately affected by HIV, with a higher risk of infection and a delayed presentation to care as compared to non-Hispanic whites. Over the last decade many Latinos, especially foreign-born migrants, have settled in regions of the country with historically low Latino...

Quantitative analysis of a urine-based assay for lipoarabinomannan in patients with tuberculosis

Post Date: 
2010-08-15
Publication: 
Journal of Clinical Microbiology
Abstract Urinary lipoarabinomannan (LAM) detection is a promising approach for rapid diagnosis of active tuberculosis (TB). In microbiologically confirmed TB patients, quantitative LAM detection results increased progressively with bacillary burden and immunosuppression. Patients with disseminated...

Antiretroviral regimens for patients with HIV who fail first-line antiretroviral therapy

Post Date: 
2010-06-16
Publication: 
Cochrane Database of Systematic Reviews
Background: Highly active antiretroviral therapy has reduced the morbidity and mortality of patients with HIV/AIDS. A common first-line ART regimen in low-resource settings includes a non-nucleoside reverse transcriptase inhibitor (NNRTI) and two nucleoside reverse transcriptase inhibitors (NRTIs...

Effect of peer health workers on AIDS care in Rakai, Uganda: a cluster-randomized trial

Post Date: 
2010-06-02
Publication: 
PLOS
Country: 
Background: Human resource limitations are a challenge to the delivery of antiretroviral therapy (ART) in low-resource settings. We conducted a cluster randomized trial to assess the effect of community-based peer health workers (PHW) on AIDS care of adults in Rakai, Uganda. Methodology/Principal...

Developing WHO guidelines with pragmatic, structured, evidence-based processes: a case study

Post Date: 
2010-05-15
Publication: 
Global Public Health
Many guidelines, including those produced by the World Health Organisation (WHO), have failed to adhere to rigorous methodological standards. Operational examples of guideline development processes may provide important lessons learned to improve the rigour and quality of future guidelines. To this...

Optimal monitoring strategies for guiding when to switch first-line antiretroviral therapy regimens for treatment failure among adults and adolescents living with HIV in low-resource settings

Post Date: 
2010-04-14
Publication: 
Cochrane Database of Systematic Reviews
Background: One of the critical clinical decisions made in antiretroviral therapy (ART) is when to switch from an initial regimen to another due to treatment failure. This complex process requires consideration of multiple factors including: (1) what type of monitoring (e.g. clinical, immunologic,...

Physician estimate of antiretroviral adherence: poor correlation with patient self-report and viral load

Post Date: 
2010-03-15
Publication: 
AIDS Patient Care and STDs
Country: 
Adherence to antiretroviral therapy (ART) is critical in maintaining viral suppression and minimizing resistance in HIV-infected patients. We compared physician estimates of their patients' ART adherence with participant's self-reported adherence to determine patient-provider agreement and identify...

Sexually transmitted infection prevalence and behavioral risk factors among Latino and non-Latino patients attending the Baltimore City STD clinics

Post Date: 
2010-03-15
Publication: 
Sexually Transmitted Diseases
Country: 
Background: Many studies have evaluated factors influencing STD/HIV disparities between African-American and white populations, but fewer have explicitly included Latinos for comparison. Methods: We analyzed demographic and behavioral data captured in electronic medical records of patients first...

One-, two-, and three-class resistance among HIV-infected patients on antiretroviral therapy in private care clinics: Mumbai, India

Post Date: 
2010-01-26
Publication: 
AIDS Research and Human Retroviruses
Country: 
HIV-infected patients receiving antiretroviral (ARV) therapy (ART) in India are not all adequately virally suppressed. We analyzed ARV drug resistance in adults receiving ART in three private clinics in Mumbai, India. HIV viral load was measured in 200 patients with the Roche AMPLICOR HIV-1 Monitor...

Diagnostic accuracy of a urine lipoarabinomannan test for tuberculosis in hospitalized patients in a high HIV prevalence setting

Post Date: 
2009-10-01
Publication: 
Journal of Acquired Immune Deficiency Syndromes
Country: 
We evaluated the accuracy of a urine lipoarabinomannan (LAM) test for TB diagnosis in South Africa.

Extended-dose nevirapine to 6 weeks of age for infants to prevent HIV transmission via breastfeeding in Ethiopia, India, and Uganda: an analysis of three randomized controlled trials

Post Date: 
2009-07-26
Publication: 
The Lancet
Background: UNICEF/WHO recommends that infants born to HIV-infected mothers who do not have access to acceptable, feasible, affordable, sustainable, and safe replacement feeding should be exclusively breastfed for at least 6 months. The aim of three trials in Ethiopia, India, and Uganda was to...

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Global Health Opportunities: Conducting International Health Work from the US

Post Date: 
2013-11-05
Presentation Location: 
Baltimore, MD
Event & Convener: 
Johns Hopkins Medical Student Global Health Elective
Lecture

Global Mobile Health

Post Date: 
2013-11-02
Presentation Location: 
Baltimore, MD
Event & Convener: 
Wireless Health 2013. Johns Hopkins Carey School of Business
Panelist

Risk Factors for Adult In-Patient Mortality for Tuberculosis in Pune, India

Post Date: 
2013-10-31
Presentation Location: 
Paris, France
Event & Convener: 
International Union for Tuberculosis and Lung Disease. 44th Union World Conference on Lung Health.
Presentation.

Vitamin D Insufficiency (VDI) is Common Among HIV-Infected Breastfeeding Mothers in Pune, India, but Not Associated with Risk of Postpartum TB

Post Date: 
2013-10-31
Presentation Location: 
Paris, France
Event & Convener: 
International Union for Tuberculosis and Lung Disease. 44th Union World Conference on Lung Health.
Presentation.

Recognizing the Need for HIV Prevention and Care in Emerging Latino Communities

Post Date: 
2013-10-09
Presentation Location: 
Baltimore, MD
Country: 
Event & Convener: 
Center for AIDS Research. Johns Hopkins Bloomberg School of Public Health
Presentation

Laboratory Capacity Building for International Clinical Research: The JHU-BJMC Pune, India Example

Post Date: 
2013-09-11
Presentation Location: 
Baltimore, MD
Country: 
Event & Convener: 
Inaugural Pathology Education Symposium. Johns Hopkins School of Medicine: Department of Pathology
Presentation

Medical Design Initiative: Low-Cost Solutions to Global Health Challenges

Post Date: 
2013-07-25
Presentation Location: 
Baltimore, MD
Event & Convener: 
Medical and Educational Perspectives (MEP) 2013. Johns Hopkins School of Medicine
Presentation

Towards Earlier Involvement of Children and Pregnant Women in Trials of New TB Drugs

Post Date: 
2013-05-23
Presentation Location: 
Baltimore, MD
Event & Convener: 
Expert Consensus Panel for Pregnant Women. National Institute of Allergy and Infectious Diseases, National Institutes of Health
Group leader

TB in Pregnant Women

Post Date: 
2013-05-22
Presentation Location: 
Bethesda, MD
Event & Convener: 
Towards Earlier Involvement of Children and Pregnant Women in Trials of New TB Drugs. National Institute of Allergy and Infectious Diseases, National Institutes of Health
Presentation

TB in Pregnant and Postpartum Women

Post Date: 
2013-05-16
Presentation Location: 
Baltimore, MD
Event & Convener: 
Seminar. Johns Hopkins Center for TB Research
Presentation

Update in TB Diagnosis, Treatment and Prevention

Post Date: 
2013-04-19
Presentation Location: 
Rio de Janeiro, Brazil
Event & Convener: 
Brazil-Hopkins AIDS Conference
Presentation

The Changing Face of the African Economy

Post Date: 
2013-04-16
Presentation Location: 
Baltimore, MD
Event & Convener: 
African Public Health Network (APHN). Johns Hopkins Bloomberg School of Public Health
Panelist

mHealth and HIV in 2013: Applying mHealth Interventions to HIV Prevention Research

Post Date: 
2013-01-08
Presentation Location: 
Baltimore, MD
Event & Convener: 
Prevention Core of the Johns Hopkins Center for AIDS Research. Johns Hopkins Bloomberg School of Public Health
Presentation

Conducting International Research

Post Date: 
2012-12-31
Presentation Location: 
Baltimore, MD
Event & Convener: 
Graduate Training Program in Clinical Research (GTCPI). Johns Hopkins Bloomberg School of Public Health
Lecture

Where in the World is eMOCHA?

Post Date: 
2012-12-11
Presentation Location: 
Baltimore, MD
Event & Convener: 
GmI Series – JHU Global mHealth Initiative. Johns Hopkins University
Presentation

The Use of IT to Support Global Health Research and Education

Post Date: 
2012-12-07
Presentation Location: 
Baltimore, MD
Event & Convener: 
JHU Region III Leadership Education in Adolescent Health (LEAH) Health Disparities Conference. Johns Hopkins University
Presentation

Building HIV Expertise through Tele-learning

Post Date: 
2012-10-20
Presentation Location: 
San Diego, CA
Event & Convener: 
ID Week 2012
Presentation

Hospitals and Health Care in India

Post Date: 
2012-07-31
Presentation Location: 
Baltimore, MD
Event & Convener: 
Medical and Educational Perspectives: Medical Design Initiative Seminar. Johns Hopkins School of Medicine
Presentation

Peer Navigators: Conscripting an Army of HIV-Positive Individuals to Supplement the Health Workforce

Post Date: 
2012-06-04
Presentation Location: 
Miami, FL
Event & Convener: 
7th International Conference on HIV Treatment and Prevention Adherence
Presentation

Fever in a Traveler

Post Date: 
2012-05-09
Presentation Location: 
Baltimore, MD
Event & Convener: 
Topics in Clinical Medicine. Johns Hopkins University
Lecture. Bollinger R, Philip A

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