Research News

Kathleen Page briefs UN Security Council on Venezuela humanitarian crisis, April 9, 2019
April 10, 2019

Calling for the declaration of a humanitarian crisis, Dr. Kathleen Page briefed the UN Security Council on Venezuela's Humanitarian Emergency, a recent report by Page and colleagues at Human Rights Watch

Clinical Research

Leadership
Dr. Amita Gupta of Johns Hopkins is Principal Investigator for the Indo-JHU Clinical Research Partnership based out of CCGHE. Research is directed locally in India out of the BJGMC-JHU Clinical Research Site by Dr. Vidya Mave, a Hopkins faculty member who lives in Pune. Dr. Nikhil Gupte is the Lead Biostatistician and Deputy Director and Dr. Nishi Suryavanshi is Clinical Site Coordinator and Deputy Director. Research is conducted in collaboration with the following institutions:
 
 

Contraceptive use and factors associated with postpartum surgical sterilization among HIV-infected women in Pune, India

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2015-08-21
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Journal of HIV/AIDS & Social Services
The authors desire to better understand contraceptive practices and factors associated with surgical tubal ligation (STL) among HIV-infected women. Secondary data were obtained from HIV-infected women enrolled in a National Institutes of Health–funded clinical trial assessing the efficacy of...

Effectiveness of peer support on care engagement and preventive care intervention utilization among pre-antiretroviral therapy, HIV-infected adults in Rakai, Uganda: a randomized trial

Post Date: 
2015-08-14
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AIDS and Behavior
442 pre-ART, HIV-infected adults were randomized to peer support consisting of structured home visits to promote clinic attendance and preventive care intervention use or standard of care. At baseline, 62 % reported previously visiting an HIV clinic, 45 % reported taking cotrimoxazole prophylaxis,...

Failure to use and sustain male condom usage: lessons learned from a prospective study among men attending STI clinic in Pune, India

Post Date: 
2015-08-13
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PLOS One
Background: Sustained or consistent use of condoms by men remains a challenge. A study was carried out to identify factors associated with failure to use condoms consistently by men attending STD clinics in Pune, India. Method: Among 14137 STI clinic attendees, 8360 HIV sero-negative men were...

Concurrent anemia and elevated CRP predicts HIV clinical treatment failure, including TB, post-antiretroviral therapy initiation

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2015-07-01
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Clinical Infectious Diseases
Background: Anemia is a known risk factor for clinical failure following antiretroviral therapy (ART). Notably, anemia and inflammation are interrelated, and recent studies have associated elevated C-reactive protein (CRP), an inflammation marker, with adverse human immunodeficiency virus (HIV)...

Policy Guidance: The Use of Lateral-Flow Urine LAM for Diagnosis and Screening of Active TB in People Living with HIV

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2015-06-30
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WHO: The Use of Lateral-Flow Urine LAM for Diagnosis and Screening of Active TB in People Living with HIV
Background : Tests based on the detection of mycobacterial lipoarabinomannan (LAM) antigen in urine have emerged as potential point-of-care tests for tuberculosis (TB). LAM antigen is a lipopolysaccharide present in mycobacterial cell walls, which is released from metabolically active or...

Feasibility and acceptability of smartphone-based ecological momentary assessment of alcohol use among African American men who have sex with men in Baltimore

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2015-06-17
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Journal of Medical Internet Research
Background: Alcohol use is a risk factor for the acquisition of human immunodeficiency virus (HIV) among African American men who havesex with men (MSM). Mobile phone-based ecological momentary assessments (EMA) could minimize bias due to retrospective recall and thus provide a better understanding...

Efavirenz pharmacokinetics in HIV-infected persons receiving rifapentine and isoniazid for tuberculosis prevention

Post Date: 
2015-06-16
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Clinical Infectious Diseases
Background: Concomitant use of rifamycins to treat or prevent tuberculosis can result in subtherapeutic concentrations of antiretroviral drugs. We studied the interaction of efavirenz with daily rifapentine and isoniazid in human immunodeficiency virus (HIV)-infected individuals receiving a 4-week...

Lyme carditis

Post Date: 
2015-06-15
Publication: 
Infectious Disease Clinics of North America
Lyme disease is a common disease that uncommonly affects the heart. Because of the rarity of this diagnosis and the frequent absence of other concurrent clinical manifestations of early Lyme disease, consideration of Lyme carditis demands a high level of suspicion when patients in endemic areas...

Impact of patient-selected care buddies on adherence to HIV care, disease progression and conduct of daily life among pre-antiretroviral HIV-infected patients in Rakai, Uganda: a randomized controlled trial

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2015-06-01
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Journal of Acquired Immune Deficiency Syndromes
Background: Data are limited on effects of household or community support persons ("care buddies") on enrollment into and adherence to pre-antiretroviral HIV care. We assessed the impact of care buddies on adherence to HIV clinic appointments, HIV progression, and conduct of daily life among pre-...

Utilizing mHealth methods to identify patterns of high risk illicit drug use

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2015-06-01
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Drug and Alcohol Dependence
Introduction: We assessed patterns of illicit drug use using mobile health (mHealth) methods and subsequent health care indicators among drug users in Baltimore, MD. Methods: Participants of the EXposure Assessment in Current Time (EXACT) study were provided a mobile device for assessment of their...

Durable suppression of HIV-1 after virologic monitoring-based antiretroviral adherence counseling in Rakai, Uganda

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2015-05-26
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PLOS One
Objectives: HIV viral load is recommended for monitoring antiretroviral treatment and identifying treatment failure. We assessed the durability of viral suppression after viral load-triggered adherence counseling among patients with HIV viremia 6 months after ART initiation. Design: Observational...

Neisseria gonorrhoeae and Chlamydia trachomatis among women reporting extragenital exposures

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2015-05-15
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Sexually Transmitted Diseases
Background: The Centers for Disease Control and Prevention recommends pharyngeal screening of Neisseria gonorrhoeae (GC) and rectal screening of GC and Chlamydia trachomatis (CT) in HIV-infected and at-risk men who have sex with men (MSM). There are currently no recommendations to routinely screen...

Dengue and chikungunya co-infection associated with more severe clinical disease than mono-infection

Post Date: 
2015-04-15
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International Journal of Healthcare and Biomedical Research
Background: Dengue and chikungunya infections appear to be increasing in India. While Aedies aegypti is the transmitting vector for both viruses and co-infection occurs in the same communities, studies on the clinical significance of co-infection are limited. Materials and Methods: We conducted a...

Availability and distribution of safe abortion services in rural areas: a facility assessment study in Madhya Pradesh, India

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2015-03-20
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Global Health Action
Abstract Background: Unsafe abortion contributes to a significant portion of maternal mortality in India. Access to safe abortion care is known to reduce maternal mortality. Availability and distribution of abortion care facilities can influence women's access to these services, especially in rural...

Vitamin D deficiency and risk of postpartum tuberculosis among HIV-infected breastfeeding mothers in India

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2015-03-15
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International Journal of Tuberculosis and Lung Disease
Some studies have associated low vitamin D levels with the risk of tuberculosis (TB), but its association in human immunodeficiency virus (HIV) infected mothers in a TB-endemic region has not been well studied. We conducted a nested 1:2 case-control study among HIV-infected mothers in western India...

What tuberculosis means for maternal health

Post Date: 
2015-03-04
Mrs. Kumar [not her real name] was diagnosed with TB 18 years ago, during her first pregnancy, which ended in miscarriage. She then became depressed and side effects from the TB medications caused her difficulty eating. Three years later, during her second pregnancy, she and her husband were...

Analysis of latent tuberculosis infection treatment adherence among refugees and other patient groups referred to the Baltimore City Health Department TB clinic

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2015-02-15
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Journal of Immigrant and Minority Health
We sought to determine the proportion of refugee patients at the Baltimore City Health Department Tuberculosis program (BCHD-TB) successfully completing latent tuberculosis infection (LTBI) treatment, as compared to other referral groups, and to identify factors associated with treatment completion...

Predictors and outcomes of mycobacteremia among HIV-infected smear- negative presumptive tuberculosis patients in Uganda

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2015-02-15
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BMC Infectious Diseases
Background : Sputum smear microscopy for tuberculosis (TB) diagnosis lacks sensitivity in HIV-infected symptomatic patients and increases the likelihood that mycobacterial infections particularly disseminated TB will be missed; delays in diagnosis can be fatal. Given the duration for MTB growth in...

Capturing illicit drug use where and when it happens: an ecologic momentary assessment of the social, physical and activity environment of using versus craving illicit drugs

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2015-02-15
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Addiction
Aim: To understand the environmental and contextual influences of illicit cocaine and heroin use and craving using mobile health (mHealth) methods. Design: Interactive mHealth methods of ecological momentary assessment (EMA) were utilized in the Exposure Assessment in Current Time (EXACT) study to...

Implementing a large scale systematic tuberculosis screening program in correctional facilities in South Africa

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2015-01-08
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Open Forum Infectious Diseases
Background : Tuberculosis (TB) prevalence is high in correctional facilities in southern Africa. With support from local South African nongovernmental organizations, the South African Department of Correctional Services initiated a program of systematically screening newly admitted and current...

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Prevalence and Risk Factors of Multiple Micronutrient Deficiencies Pre- and Post-ART

Post Date: 
2015-02-24
Shivakoti R, Christian P, Gupte N, Kanyama C, Berendes S, Lama JR, Semba RD, Campbell TB, Gupta A for the NWCS 319 and PEARLS Study Team. Prevalence and Risk Factors of Multiple Micronutrient Deficiencies Pre- and Post-ART. Conference on Retroviruses and Opportunistic Infections 2015. Seattle, WA...

Obesity and Inflammation in Resource-Driven Settings of ART Initiation

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2015-02-24
Erlandson KM, Gupte N, Lama JR, Patcharaphan S, Mwelase T, Balagopal A, Asmuth D, Campbell TB, Gupta A. Obesity and Inflammation in Resource-Driven Settings of ART Initiation. Conference on Retroviruses and Opportunistic Infections 2015. Seattle, WA. 2015.

Cost-effectiveness of Isonaizid Preventive Therapy for HIV-Infected Pregnant Women in India

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2015-02-24
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Kapoor S, Chida N, Gupta A, Shah M. Cost-effectiveness of Isonaizid Preventive Therapy for HIV-Infected Pregnant Women in India. Conference on Retroviruses and Opportunistic Infections 2015. Seattle, WA. 2015.

Persistently High IL-18 and sCD14 are Independently Associated with Clinical Failure

Post Date: 
2015-02-24
Balagopal A, Gupte N, Hakim J, Hosseinipour M, Nagalingeswaran K, Cox A, Sanne I, Asmuth D, Campbell T, Gupta A. Persistently High IL-18 and sCD14 are Independently Associated with Clinical Failure. Conference on Retroviruses and Opportunistic Infections 2015. Seattle, WA. 2015.

Empowering Women in Global Health: Lessons Learned and Strategies for Success

Post Date: 
2015-02-16
Gupta, A. Empowering Women in Global Health: Lessons Learned and Strategies for Success. Empowering Women in Global Health: Lessons Learned and Strategies for Success. New York, NY.

Conducting Infectious Diseases Research in India

Post Date: 
2015-02-16
Gupta, A. Conducting Infectious Diseases Research in India. Johns Hopkins University School of Medicine. Baltimore, MD.

PMTCT: Current Recommendations

Post Date: 
2015-01-31
Mave, V. PMTCT: Current Recommendations. 5th National Conference on HIV/AIDS Therapy. Mumbai, India.

Global Health Panel Discussion

Post Date: 
2015-01-22
Gupta, A. Global Health Panel Discussion. Johns Hopkins University School of Medicine Global Health Webinar. Baltimore, MD.

Metabolic Complications/Inflammation Lecture

Post Date: 
2015-01-10
Gupta A. Metabolic Complications/Inflammation Lecture. 5th National Conference on HIV/AIDS Therapy. Mumbai, India.

Metabolic Complications/Inflammation

Post Date: 
2015-01-10
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Gupta, A. Metabolic Complications/Inflammation. 5th National Conference on HIV/AIDS Therapy. Mumbai, India.

Intro to mHealth

Post Date: 
2014-12-17
Change, L. Intro to mHealth. JHU-GmI Seminar. Johns Hopkins School of Medicine. Baltimore, MD.

IMPAACT TB Scientific Committee 5 year Priorities and Plans

Post Date: 
2014-12-03
Gupta A. IMPAACT TB Scientific Committee 5 year Priorities and Plans. IMPAACT Network External Review. NIH. Washington, DC.

Conducting International Clinical Trials: Some Important Considerations

Post Date: 
2014-11-19
Gupta A. Conducting International Clinical Trials: Some Important Considerations. Johns Hopkins Clinical Investigation Course. Baltimore, MD.

Barriers and Delays in TB Diagnosis and Treatment: Does Gender Matter?

Post Date: 
2014-11-17
Gupta, A. Barriers and Delays in TB Diagnosis and Treatment: Does Gender Matter? PATH Gender & TB Experts Meeting. Washington, DC.

GETHealth Summit to Bridge Health Workforce Gap in Developing Countries

Post Date: 
2014-11-10
Bollinger, R. GETHealth Summit to Bridge Health Workforce Gap in Developing Countries. GETHealth Summit. Dublin, Ireland.

Developing a Roadmap for Integration of TB/HIV Activities in Maternal and Child Health Setting

Post Date: 
2014-10-26
Gupta, A. Developing a Roadmap for Integration of TB/HIV Activities in Maternal and Child Health Setting. International Union for Tuberculosis and Lung Disease. 45th Union World Conference on Lung Health. Barcelona, Spain.

Global Health Opportunities: Conducting International Health Work from the US

Post Date: 
2014-10-14
Gupta, A. Global Health Opportunities: Conducting International Health Work from the US. Johns Hopkins Medical Student Global Health Elective. Baltimore, MD.

Advancing Public Reporting and Surveillance of Healthcare-associated Infections

Post Date: 
2014-10-06
Bollinger, R. Advancing Public Reporting and Surveillance of Healthcare-associated Infections. ID Week 2014. Philadelphia, PA. 2014.

Metabolic Complications over a Lifetime

Post Date: 
2014-09-27
Gupta, A. Metabolic Complications over a Lifetime. 2014 Southern African HIV Clinician Society Conference. Cape Town, South Africa. 2014.

Complex Cases in HIV/Metabolic Complications Management

Post Date: 
2014-09-25
Gupta, A. Complex Cases in HIV/Metabolic Complications Management. 2014 Southern African HIV Clinician Society Conference. Cape Town, South Africa. 2014.

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