All Studies/Projects

Validation of Sputum as Direct DNA Source for Whole Genome Sequencing of Mycobacterium Tuberculosis

Post Date: 
2018-09-20
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Dr. Jeffrey Tornheim is Principal Investigator for this study. There are limited studies available from India on whole genome sequencing (WGS). This is a first-of-its-kind wherein WGS for MTB will be carried out utilizing direct sputum DNA and simultaneously look on the cultured DNA from the paired...

Health Professions Education and Training for Strengthening the Health System and Services in Uganda

Post Date: 
2018-09-19
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Led by Sarah Kiguli at the Makerere University College of Health Sciences, the goal of this effort is to improve service delivery of the Ugandan health system through strengthened health professional interdisciplinary education and research training to produce graduates with competencies to address...

Assessing Psychological Distress among Tuberculosis Patients and Their Household Members

Post Date: 
2018-07-17
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By assessing psychological distress, Indo-JHU researchers hope to better understand the correlation between depression and TB severity.

Evaluating the Source of Neonatal Bloodstream Infections due to Classically Hospital Acquired Pathogens in the Neonatal Intensive Care Unit in Pune, India

Post Date: 
2018-07-12
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This study is part of CDC's Safe healthcare, Epidemiology, and Prevention Research Development (SHEPheRD) Domain 7: International HAI and Other Adverse Healthcare Event Prevention. The PIs for this study are Dr. Julia Johnson of Johns Hopkins and Dr. Shilpa Naik of BJGMC. CoPIs are Dr. Aarti...

Assessing the Feasibility and Acceptability of a Computer-based Avatar-delivered Alcohol Reduction Intervention

Post Date: 
2018-07-05
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Study is assessing whether computer-delivered alcohol screening and intervention helps overcome barriers to treatment in India.

Molecular Signatures of Tuberculosis-Diabetes Interaction: Metabolomics Study

Post Date: 
2018-06-15
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Type 2 diabetes mellitus (DM) is an acquired host factor that increases the risk for and severity of pulmonary tuberculosis (PTB). A report published in 2007 estimated that, in India, DM accounted for 14.8% (range 7.1% to 23.8%) of PTB and 20.2% (8.3% to 41.9%) of smear-positive PTB. Emerging data...

Molecular Signatures of Tuberculosis-Diabetes Interaction: Transcriptomics Study

Post Date: 
2018-06-15
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Type 2 diabetes is an acquired host factor that increases the risk for and severity of pulmonary tuberculosis. A report published in 2007 estimated that, in India, diabetes accounted for 14.8% (range 7.1% to 23.8%) of pulmonary tuberculosis and 20.2% (8.3% to 41.9%) of smear-positive cases...

Gut Microbiota of HIV Infected Pregnant Women

Post Date: 
2018-06-14
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Birth Outcomes in HIV Both antiretroviral-therapy (ART)-naïve and ART-experienced HIV-infected pregnant women have higher incidences of pre-term birth (PTB) compared to HIV-uninfected women. For example, the global prevalence of PTB is around 8%, while the rates in in HIV-infected populations are...

Assessing Tuberculosis Transmission Dynamics, Drug Resistance and Recurrence Using Whole Genome Sequencing in Pune, India

Post Date: 
2018-06-12
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Indo-JHU researchers are using combined geospatial and genotyping methods to describe TB transmission dynamics in a hyperlocal region of Pune City in Western India.

Optimal Approach for TB Screening among HIV Infected Indian Children

Post Date: 
2018-06-11
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Determining TB status (ie, uninfected, latent, and active TB disease) is more difficult among children, particularly HIV-infected children. Diagnosis of TB disease is more difficult among HIV infected children because the signs and symptoms of the disease—such as weight loss, cough, and mild fever—...

Long-Acting/Extended Release Antiretroviral Resource Program (LEAP)

Post Date: 
2018-05-30
The Long-Acting/Extended Release Antiretroviral Resource Program (LEAP) is an effort to advance the development of long-lasting therapies for illnesses that require taking medications long-term. Life-long or long-term adherence to daily treatment regimens is challenging for patients who have...

Evaluation of Video-Based Directly Observed Therapy for Tuberculosis in India

Post Date: 
2018-05-14
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This study was designed to evaluate Directly Observed Therapy conducted through miDOT, a secure mobile health interface, with traditional in-person Directly Observed Therapy.

Multidisciplinary Research Training to Understand and Reduce HIV Incidence in Uganda

Post Date: 
2018-05-10
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Dr. Larry Chang is PI for this multi-year (2018-2023) training grant sponsored by the Fogarty International Center at the National Institute of Health. Abstract While substantial progress has been made in the global HIV response, impact has been uneven. Uganda provides a prime case study. Uganda...

Implementing the Comprehensive Unit-based Safety Program to Reduce Healthcare-Associated Sepsis in the Neonatal Intensive Care Unit in Pune, India

Post Date: 
2018-04-19
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This study is part of CDC's Safe healthcare, Epidemiology, and Prevention Research Development (SHEPheRD) Domain 7: International HAI and Other Adverse Healthcare Event Prevention. Dr. Aaron Milstone is the PI, and Dr. Amita Gupta and Yuka Manabe are Co-PIs. the Study Investigator is Dr. Julia...

Predictors of Resistance Emergence Evaluation in Multidrug Resistant-Tuberculosis Patients on Treatment (PREEMPT Pilot Study)

Post Date: 
2018-03-20
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Indo-JHU Clinical Resarch Partnership is participating with Brazilian colleagues in a 3-year effort led by Boston University to identify what contributes to TB drug resistance.

P2010: Phase III Study of the Virologic Efficacy and Safety of Dolutegravir-Containing versus Efavirenz-Containing Antiretroviral Therapy Regimens in HIV-1-Infected Pregnant Women and their Infants “VESTED”

Post Date: 
2018-01-30
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Title: P2010: Phase III Study of the Virologic Efficacy and Safety of Dolutegravir-Containing versus Efavirenz-Containing Antiretroviral Therapy Regimens in HIV-1-Infected Pregnant Women and their Infants “VESTED”: V irologic E fficacy and S afety of ART Combinations with T AF/TDF, E FV, and D TG...

A Multicenter Phase II/II Double-Blind, Randomized, Placebo Controlled Study to Evaluate the Efficacy and Safety of VPM1002 in the Prevention of Tuberculosis (TB) Recurrence in Pulmonary TB Patients After Successful TB Treatment in India

Post Date: 
2018-01-23
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Dr. Vidya Mave is leading this clinical trial evaluating the safety and efficacy of a new recombinant BCG vaccine.

Assessing the Impact of the Fogarty HIV-TB Training Program at the Byramjee Jeejeebhoy Government Medical College, Pune, India

Post Date: 
2018-01-19
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Johns Hopkins University was funded in 2013 to establish a new post-doctoral training program in HIV-TB epidemiology, clinical and laboratory research, for junior faculty of the Byramjee Jeejeebhoy Government Medical College (BJGMC) in Pune, India, called the BJGMC-JHU Fogarty HIV-TB Training...

Perceptions of HCWs on Barriers and Opportunities to Airborne Infection Control Guideline Implementation

Post Date: 
2017-12-07
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Led by Dr. Nishi Suryavanshi, this qualitative, cross-sectional study is assessing healthcare worker (HCW) perceptions about barriers and facilitators to the uptake of airborne infection control (AIC) guidelines. Further, the study is assessing the potential barriers and opportunities to develop...

A5302: BioBank for Surrogate Marker Research for TB (B-SMART)

Post Date: 
2017-11-21
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A5302 is a multi-center trial of the AIDS Clinical Trials Group (ACTG) in collaboration with the Tuberculosis Trials Consortium (TBTC).This study will be conducted at the BJ Government Medical College (BJGMC) in Pune, India. Study staff of the BJGMC will conduct the study and Johns Hopkins...

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