All Studies/Projects

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This study was terminated May 7, 2018. P regnancy is a state of relative immunosuppression in order to protect the fetus from being rejected. It has also been shown that the Th-1 helper cell response, which is normally necessary for overcoming TB infection, is suppressed in pregnancy. Thus,...

Predictive Value of TB-symptom Screen in HIV-infected and HIV-uninfected Pregnant Women in Pune, India

Post Date:

2014-10-28

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This study was terminated July 17, 2017. This is a cross sectional observational study will be conducted at BJGMC to establish what the predictive value of the WHO TB symptom screen is in pregnant women in India. We hypothesize that the WHO TB symptom screen will have a higher positive predictive...

miLINC: MDR-TB South Africa - Patient Linkage to and Retention in Care

Post Date:

2014-10-06

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South Africa

Mycobacterium tuberculosis (TB) remains the leading cause of death among persons living with human immunodeficiency virus and acquired immunodeficiency syndrome (HIV/AIDS) in southern Africa. Drug-resistant TB remains a growing threat to public health despite advances made in diagnosis and...

Project S.O.A.R. (Supporting Operational AIDS Research): Positive Health Dignity and Prevention Sub-Project

Post Date:

2014-09-15

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Uganda

Dr. Larry Chang is a Co-Investigator for this effort. Purpose The goal of Project SOAR (Supporting Operational AIDS Research) is to improve the quality and impact of HIV and AIDS program outcomes by strengthening operations research and evaluation activities. Project SOAR supports the PEPFAR...

Diagnosis of Tuberculosis Infection and Th1 Immune Response in Pregnant Women in India

Post Date:

2014-09-01

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This study was terminated April 16, 2018. Tuberculosis (TB) disease is a major cause of mortality among Indian women of reproductive age; approximately 20-50% of women in India are latently infected with Mycobacterium tuberculosis (MTB). Due to immune changes of pregnancy, women are particularly at...

Impact of Immune Changes of HIV and Stages of Pregnancy on Tuberculosis

Post Date:

2014-09-01

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This is the Parent Study for CCGHE’s PRACHITI (PRegnancy And CHanges In TuberculosIs) effort. It's supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development at the U.S. National Institutes of Health. Purpose: TB is a leading cause of maternal mortality,...

TBM Kids Substudy: Assessment of Neurocognitive Functions in Children with Tuberculosis Meningitis and Healthy Control Children Using the Mullen Scale of Early Learning Attending a Tertiary Care Public Hospital in Pune, India

Post Date:

2014-09-01

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Objectives: The aim of the present study is to examine the neurological deficit in TBM kids and for that we need to assess, feasibility of the MSEL in our set up an Indian population of healthy children and children with meningitis in particular TB meningitis(TBM). The primary objective of the...

Evaluating Demand Generation (Stylish Man) for HIV/Family Planning Services, Rakai, Uganda

Post Date:

2014-08-01

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Uganda

Dr. Larry Chang is co-investigator of this effort to test a novel approach to promoting HIV services in Rakai, Uganda. The Stylish Man Program, attempts to “demedicalize” HIV prevention and care in a public health campaign designed to normalize HIV care as part of self care for African men. The...

A5279: Phase III Clinical Trial of Ultra-Short-Course Rifapentine/Isoniazid for the Prevention of Active Tuberculosis in HIV-infected Individuals with Latent Tuberculosis Infection

Post Date:

2014-06-30

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This study ended April 27, 2015; it was conducted under the AIDS Clinical Trials Group (ACTG) and funded by the U.S. National Institutes of Health. Dr. Amita Gupta was Protocol Co-Vice Chair for this multinational clinical trial being conducted in Botswana, Brazil, Haiti, Kenya, Malawi, Peru,...

Evaluation of Longitudinal Blood Culture Isolates from BJ Medical College in Pune, India, 2003-2013

Post Date:

2014-06-16

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This study was terminated July 31, 2014. Antibiotic resistance is a serious global problem and is caused by multiple factors which have led to difficulty in the management of life-threatening, multi-drug resistant (MDR) bacterial bloodstream infections. The knowledge of antibiotic resistance...

ART Study 1: Database: Epidemiology of HIV/AIDS and Associated Comorbidities in a Public Antiretroviral Treatment (ART) Clinic at BJGMC in Pune

Post Date:

2014-06-14

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Hinduja Hospital

Since 2004, the National AIDS Control Program of India has been rolling out free antiretroviral therapy. Byramjee Jeejeebhoy Government Medical College (BJGMC), located in Pune, India, is now the largest HIV clinic in India, with over 26,000 adult and pediatric patients registered since 2005. We...

Optimizing Treatment to Improve TBM Outcomes in Children

Post Date:

2014-05-01

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This study, known as TBM Kids, is being conducted in India and Malawi. Primary Objectives To characterize the pharmacokinetics (PK) (plasma and cerebrospinal fluid (CSF)) of rifampicin given at model-derived optimal daily doses and levofloxacin in children ages 6 months to 12 years of age with TBM...

P1078: A Phase IV Randomized Double-Blind Placebo-Controlled Trial to Evaluate the Safety of Immediate (Antepartum-Initiated) Versus Deferred (Postpartum-Initiated) Isoniazid Preventive Therapy Among HIV-Infected Women in High TB Incidence Settings

Post Date:

2014-04-01

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This is a clinical trial conducted under the International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) Network and funded by the U.S. National Institutes of Health. Dr. Amita Gupta is Protocol Chair for this multinational clinical trial being conducted in Botswana, Haiti, South...

Screening for Gender Based-violence (GBV) and Feasibility and Acceptability of mHealth GBV Screening and Support Tools

Post Date:

2014-03-26

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This study was terminated February 14, 2017. Gender-based violence (GBV) is a significant public health issue in India, with estimates that over a third of women and girls are impacted at some point in their lifetime. This pilot qualitative study examined the feasibility of enhancing GBV prevention...

Pulmonary and Functional Status of Patients with Pulmonary Mycobacterium Tuberculosis Post-treatment in Lima, Peru

Post Date:

2014-01-01

Countries:

Peru

To conduct a longitudinal study evaluating the hypothesis that pulmonary function and functional status (functional capacity and quality of life) is reduced among individuals previously treated for pulmonary tuberculosis compared to those without a history of tuberculosis.

Evaluation of HIV Disease Burden in Hospitalized Patients at Sassoon General Hospital in Pune, India

Post Date:

2013-11-18

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This study was terminated September 13, 2005. The goal of this project was to conduct both a retrospective and prospective epidemiological study of the burden of HIV disease at Sassoon General Hospital. The specific objectives of the study were to establish the proportion of HIV-infected...

Tuberculosis Noon Conference

Post Date:

2013-10-24

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This effort ended in 2015. As part of the BJGMC-Johns Hopkins India Fogarty Training Program, from 2013-2015 CCGHE hosted the live Tuberculosis Noon Conference webcast. Led by Drs. Maunank Shah, Jonathan Golub, and Richard Chaisson, these webcast meetings brought together Johns Hopkins TB...

Cohort for Tuberculosis Research by the Indo-US Medical Partnership (C-TRIUMPH)

Post Date:

2013-09-28

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