All Studies/Projects

A5282: A Randomized, Phase II Trial to Compare an HPV Test-and-Treat Strategy to a Cytology-Based Strategy for Prevention of CIN 2+ in HIV-Infected Women

Post Date: 
2011-03-15
The investigators are looking for a better way to prevent cervical cancer. This study is comparing two different methods to prevent cancer of the cervix in women who have HIV. This study will also see if these methods are safe and tolerable in women who have HIV.

A Prospective Study Evaluating the Burden of Cryptococcal Disease Among HIV-infected Population in Pune, India

Post Date: 
2011-01-06
Country: 
By 2008, 33.4 million people were living with HIV globally, with an estimated 2.3 million living in India, representing the third largest absolute burden of HIV globally. [1] The current statistics as summarized by National AIDS Control Organization (NACO) of India show that of the estimated 750,...

A Prospective Study Evaluating the Role of Cryptococcal Antigen Screening among HIV-infected Adults with Low CD4 Counts

Post Date: 
2011-01-01
Country: 
This prospective observational study aimed to evaluate the burden of cryptococcal disease among approximately 200 HIV-infected adults with low CD4 cell counts in Pune, India to determine whether a Cryptococcal screening strategy should be the standard of care among patients with advanced HIV...

P1073: Study of Immune Reconstitution Inflammatory Syndrome (IRIS) for International Sites Initiating Highly Active Antiretroviral Therapy (HAART) in Infants and Children < 72 Months of Age

Post Date: 
2010-11-15
P1073 is a case controlled prospective, clinical, observational and pathogenesis study of HIV-infected infants and children (≥ 4 weeks to < 72 months of age) at international IMPAACT sites who are within 1 week of HAART initiation and if ≤ 12 months of age have had prior BCG immunization. The...

P1077BF: Breastfeeding Version of the PROMISE Study (Promoting Maternal and Infant Survival Everywhere)

Post Date: 
2010-02-02
1077BF is a randomized strategy trial, which is part of the PROMISE studies (1077BF, 1077FF, P1084s, and 1077HS). The Promoting Maternal and Infant Survival Everywhere (PROMISE) Protocol is a research protocol of the IMPAACT network designed to address in an integrated and comprehensive fashion...

P1077FF: Formula Feeding Version of the PROMISE Study (Promoting Maternal and Infant Survival Everywhere)

Post Date: 
2010-02-02
1077FF is a randomized strategy trial, which is part of the PROMISE studies (1077BF, 1077FF, P1084s, and 1077HS). The Promoting Maternal and Infant Survival Everywhere (PROMISE) Protocol is a research protocol of the IMPAACT network designed to address in an integrated and comprehensive fashion...

Impact of Malnutrition on HIV Treatment Failure in Resource-limited Settings

Post Date: 
2010-01-01
Country: 
Highly active antiretroviral therapy (HAART) has reduced morbidity and mortality among HIV-infected persons worldwide. However, early treatment failure (i.e. WHO stage 3 or 4 illnesses or death during the first 24 months of HAART) is more than 3-fold higher in resource limited settings (RLS) than...

A5225: Phase I/II Dose-Finding Study of High-Dose Fluconazole Treatment in AIDS-Associated Cryptococcal Meningitis

Post Date: 
2009-04-22
A5225/HiFLAC is a Phase I/II dose escalation and validation study of the safety, tolerability, and therapeutic effect of an induction-consolidation strategy of high-dose fluconazole alone for the treatment of cryptococcal meningitis (CM) in HIV-infected participants.

P1070: Dose-Finding and Pharmacogenetic Study of Efavirenz in HIV-Infected and HIV/TB Co-Infected Infants and Children ≥ 3 Months to < 36 Months of Age

Post Date: 
2008-12-05
Efavirenz (EFV) is an anti-HIV medicine that is commonly used to treat HIV infection in adults and children older than 3 years of age. This study is being conducted to look at the safety of EFV, blood levels of EFV, genetic factors that may affect blood levels of EFV, and how easy it is for infants...

EXposure Assessment in Current Time (EXACT) study

Post Date: 
2008-11-01
Country: 
Injection drug users (IDUs) are a marginalized population with substantial disparities in healthcare outcomes, especially among the HIV-infected IDU population. The EXACT study, which ended in 2013, was designed to optimize time to antiretroviral treatment (ART) initiation and retention-in-care...

Immunomodulatory Properties of BCG: Implications for MTCT

Post Date: 
2008-06-01
To evaluate the immune activating properties of BCG vaccination in neonatal CD4 cells and test the hypothesis that neonatal BCG vaccination leads to activation of immune response that may increase the susceptibility to HIV infection in breast-fed infants of HIV-positive mothers.

HIV Latino Outreach Program, Baltimore City Health Department

Post Date: 
2008-01-01
Country: 
Dr. Kathleen Page founded and directs the Baltimore City Health Department’s HIV Latino Outreach Program, which provides more than 1000 HIV tests per year to Baltimore's Latino community, and provides linkages to care services for those testing positive.

Peer Community-based Assistant in REtention: Effect of Peer Health Workers on People Living with HIV Not on Antiretroviral Therapy—A Randomized Operations Research Trial

Post Date: 
2007-03-29
Country: 
Human resource limitations, long travel times, and a weak health care infrastructure pose significant challenges to the delivery of anti-retroviral therapy (ART) in rural settings such as the Rakai District in southwestern Uganda. HIV increases demand for health services and also impacts the health...

BWI CTU: Baltimore-Washington-India Clinical Trials Unit

Post Date: 
2007-02-02
Comprising clinical trial sites at Johns Hopkins Medicine in Baltimore, Whitman Walker Health in Washington, DC, and the BJGMC-CCGHE collaboration in Pune, India, the Baltimore-Washington-India Clinical Trials Unit (BWI-CTU) is one of only 25 international HIV/TB clinical trial sites funded by the...

BJGMC-JHU Fogarty HIV-TB Training Program

Post Date: 
2007-01-01
Country: 
Funded by the Fogarty International Center at the National Institutes of Health, the JHU Fogarty program has nearly 20 years of success with providing training, professional development, and mentorship to clinicians and scientists in low and middle income countries. CCGHE's latest efforts in this...

Integration of HIV and Other Prevalent Relevant Infectious Disease Care into Primary Medical Care

Post Date: 
2007-01-01
Country: 
According to the Pan American Health Organization (PAHO), HIV is rapidly expanding in Latin America, and among the Latin American countries with highest HIV prevalence, four are located in Central America. Notably, AIDS is among the 10 leading causes of death in three of the six countries in...

P1060: Phase II, parallel, randomized, clinical trials comparing the responses to initiation of NNRTI-based antiretroviral therapy in HIV-infected infants who have not previously received Single dose Nevirapine for prevention of Mother-to-child HIV...

Post Date: 
2006-03-27
A single dose of nevirapine (SD NVP) given to an HIV infected pregnant woman followed by a single dose to her infant has been shown to be an effective way of reducing the risk of mother-to-child transmission (MTCT) of HIV. The purpose of this study was to compare the effectiveness of a non-...

Nursing Training Curriculum: HIV Practice and Reducing Stigma

Post Date: 
2004-01-01
Country: 
In 2004, CCGHE partnered with nursing leadership at Sassoon General Hospital, a 1500-bed public hospital in Pune, to develop a nursing training program to improve the care of patients with HIV. The program curriculum, developed by members of the Johns Hopkins (JH) AIDS Service (recognized worldwide...

Mother-to-Child Transmission (MTCT) of HIV: India SWEN Study

Post Date: 
2002-06-07
Country: 
Primary and secondary analyses of the India SWEN study, an NIH-funded phase III randomized controlled trial of an extended nevirapine prophylaxis regimen among 783 HIV-infected pregnant women and their breastfed infants in Pune, India.

Technology-enhanced Peer Navigation to Improve Injection Drug User (IDU) Engagement in HIV Care

Post Date: 
2000-01-01
Country: 
This study is evaluating an mHealth-enhanced peer navigation intervention for improving retention-in-care and adherence to antiretroviral therapy (ART) for out-of-care, HIV-infected injection drug users (IDUs). The CCGHE-developed emocha® is assisting peer navigators (former IDUs successfully...

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