All Studies/Projects

Bacterial Antimicrobial Resistance Patterns in Pune, India

Post Date: 
2013-01-10
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This study was terminated September 24, 2019. Evaluate etiology of acute fever and bacterial drug resistance patterns among adults and children in India.

ONCOGRID: An mHealth Approach to Prevention and Early Diagnosis of Oral Cancer in Rural South India

Post Date: 
2012-11-01
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This study ended February 7, 2017. The Indian sub-continent is burdened with 80% of the world’s patients with oral cancer, and delay in oral cancer diagnosis is one of the major problems that leads to poor treatment outcomes (V. Shanta, R. Swaminathan, R. Rama. Cancer Control 2013). Current...

Diagnosis of Active Tuberculosis in HIV-infected and Uninfected Young Children in India

Post Date: 
2012-07-24
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Tuberculosis (TB) is the most common cause of morbidity/mortality in HIV-infected individuals in India. India has the world's highest burden of HIV and TB, and since children acquire HIV/TB from their caregivers, active TB is highly prevalent (14-67.5%) among HIV-infected young children in India...

ACTG 5279: Phase III Clinical Trial of Ultra-Short-Course Rifapentine/Isoniazid for the Prevention of Active Tuberculosis in HIV-Infected Individuals with Latent Tuberculosis Infection

Post Date: 
2012-07-23
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This study was terminated April 27, 2015. Dr. Amita Gupta is Protocol Co-Vice Chair for this multinational clinical trial being conducted in Botswana, Brazil, Haiti, Kenya, Malawi, Peru, Puerto Rico, South Africa, Tanzania, Thailand, Uganda, United States, Zambia, Zimbabwe, and India by the...

A5288: MULTIOCTAVE, Management Using the Latest Technologies in Resource-limited Settings to Optimize Combination Therapy After Viral Failure

Post Date: 
2012-07-16
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This study was terminated in March 2020. It was a mult-country clinical trial conducted in Brazil, Haiti, India, Kenya, Malawi, Peru, South Africa, Thailand, Uganda, and Zambia under the AIDS Clinical Trials Group (ACTG) and funded by the U.S. National Institutes of Health. A5288 is a multi-step,...

RePORT India

Post Date: 
2012-06-30
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RePORT India is a joint venture between the Indian and US governments. The Indo-US Vaccine Action Program, a collaboration between the Indian Department of Biotechnology (DBT), the Indian Council of Medical Research (ICMR), and the US NIH, is co-funding six teams of India- and US-based...

C-TRIUMPH Pilot Study: Burden and Risk Factors for Drug-resistant Tuberculosis in Pune, India

Post Date: 
2012-05-29
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This pilot study ended in April 2015. Drug resistant TB (MDR-TB and XDR-TB) is increasing worldwide. Although 20% of all global TB cases occur in India, current estimates of the burden of MDR-TB in India are limited. A well-characterized TB clinical cohort, household cohort and control cohort would...

Tuberculosis (TB) Diagnosis, Treatment, and Prevention Course

Post Date: 
2012-01-01
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To strengthen tuberculosis (TB) clinical care and research in India and Pakistan, CCGHE collaborated with BJGMC, the National AIDS Research Institute (NARI) and Indus Hospital to develop and deploy the Tuberculosis (TB) Diagnosis, Treatment ,and Prevention course. Originally developed as a...

Understanding Challenges and Perspectives of Parents about HIV Disclosures to their Children and Develop a Structured HIV Disclosure Model for Pediatric Age Group

Post Date: 
2011-12-08
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This study is terminated. In 2008 an estimated 70,000 children in India were living with HIV, with 21,000 new children are infected each year through mother to child transmission (Singh et al 2008). Increasing availability of antiretroviral treatment (ART) to HIV infected children in India means...

A5274: Reducing Early Mortality and Early Morbidity by Empiric Tuberculosis Treatment Regimens

Post Date: 
2011-10-01
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This study was terminated in May 2017. Dr. Amita Gupta is Protocol Co-Vice Chair for this multinational clinical trial being conducted in Brazil, Haiti, Kenya, Malawi, Peru, South Africa, Uganda, Zambia, and Zimbabwe , and in India by the Baltimore-Washington-India Clinical Trials Unit, of which...

Characterization of Pulmonary and Extrapulmonary Tuberculosis Among Adult Patients Admitted to Sassoon General Hospital, Pune, India

Post Date: 
2011-09-27
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This study was terminated September 21, 2012. The diagnosis of pulmonary and extrapulmonary tuberculosis is usually made clinically. While confirmation from laboratory tests is sought, the sensitivity of such diagnostic tests is poor. TB diagnostics are still evolving and in resource poor settings...

Sexually Transmitted Infections among Women in the Reproductive Age Group in Shevgaon, Ahmednagar District, Maharashtra, India

Post Date: 
2011-05-15
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Countries: 
This study was conducted in 2011. Sexually transmitted infections (STIs) constitute a significant epidemiological burden all over the world especially in middle and low income countries. Women are more vulnerable to STIs due to several biological and socio-economic reasons. Although transmission of...

A5273: Multicenter Study of Options for Second-Line Effective Combination Therapy (SELECT)

Post Date: 
2011-05-12
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This study was terminated May 2, 2017; it was conducted under the AIDS Clinical Trials Group (ACTG) and funded by the U.S. National Institutes of Health. This was a multinational clinical trial conducted in Brazil, India, Kenya, Malawi, Peru, South Africa, Tanzania, Thailand, and Zimbabwe. The...

Predictors of Perinatal HBV Transmission in an HIV/HBV Infected Cohort

Post Date: 
2011-04-22
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This study ended in 2014. Hepatitis B virus (HBV) coinfection is common; affecting greater than 10% of HIV-infected individuals in resource-limited settings(1-3). Although the impact of HIV disease on HBV coinfection has been studied in non-pregnant adults, little is known about the effects of HIV...

A5282: A Randomized, Phase II Trial to Compare an HPV Test-and-Treat Strategy to a Cytology-Based Strategy for Prevention of CIN 2+ in HIV-Infected Women

Post Date: 
2011-03-15
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Countries: 
Indo-JHU partnership work on this trial was officially terminated September 10, 2018; it was conducted under the AIDS Clinical Trials Group (ACTG) and funded by the U.S. National Institutes of Health. This multi-country trial is being conducted in Botswana, Haiti, India, Malawi, Peru, South Africa...

A Prospective Study Evaluating the Burden of Cryptococcal Disease Among HIV-infected Population in Pune, India

Post Date: 
2011-01-06
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This study ended in December 2012. By 2008, 33.4 million people were living with HIV globally, with an estimated 2.3 million living in India, representing the third largest absolute burden of HIV globally. [1] The current statistics as summarized by National AIDS Control Organization (NACO) of...

A Prospective Study Evaluating the Role of Cryptococcal Antigen Screening among HIV-infected Adults with Low CD4 Counts

Post Date: 
2011-01-01
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This prospective observational study aimed to evaluate the burden of cryptococcal disease among approximately 200 HIV-infected adults with low CD4 cell counts in Pune, India to determine whether a Cryptococcal screening strategy should be the standard of care among patients with advanced HIV...

The Role of Vitamin D in the Development of Active Tuberculosis Disease in Young Children

Post Date: 
2010-12-09
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This study was terminated September 2014. Mycobacterium tuberculosis (MTB) results in significant morbidity and mortality worldwide, yet remains difficult to diagnose and manage, particularly in resource constrained settings. Deficiency in vitamin D, a recently recognized antimicrobial peptide, is...

P1073: Study of Immune Reconstitution Inflammatory Syndrome (IRIS) for International Sites Initiating Highly Active Antiretroviral Therapy (HAART) in Infants and Children < 72 Months of Age

Post Date: 
2010-11-15
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This study was terminated April 23, 2015. This was a multi-national study conducted in India, South Africa, and Tanzania under the International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) Network and funded by the U.S. National Institutes of Health...

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