All Studies/Projects

Evaluation of Video-Based Directly Observed Therapy for Tuberculosis in India

Post Date: 
2018-05-14
This study was designed to evaluate Directly Observed Therapy conducted through miDOT, a secure mobile health interface, with traditional in-person Directly Observed Therapy.

Predictors of Resistance Emergence Evaluation in Multidrug Resistant-Tuberculosis Patients on Treatment (PREEMPT Pilot Study)

Post Date: 
2018-03-20
Country: 
Indo-JHU Clinical Resarch Partnership is participating with Brazilian colleagues in a 3-year effort led by Boston University to identify what contributes to TB drug resistance.

Assessing the Impact of the Fogarty HIV-TB Training Program at the Byramjee Jeejeebhoy Government Medical College, Pune, India

Post Date: 
2018-01-19
Country: 
Johns Hopkins University was funded in 2013 to establish a new post-doctoral training program in HIV-TB epidemiology, clinical and laboratory research, for junior faculty of the Byramjee Jeejeebhoy Government Medical College (BJGMC) in Pune, India, called the BJGMC-JHU Fogarty HIV-TB Training...

Perceptions of HCWs on Barriers and Opportunities to Airborne Infection Control Guideline Implementation

Post Date: 
2017-12-07
Country: 
Led by Dr. Nishi Suryavanshi, this qualitative, cross-sectional study is assessing healthcare worker (HCW) perceptions about barriers and facilitators to the uptake of airborne infection control (AIC) guidelines. Further, the study is assessing the potential barriers and opportunities to develop...

The Role of GeneXpert in Bacterial Diagnosis of Spinal Tuberculosis

Post Date: 
2017-10-26
Country: 
India has the maximum burden of tuberculosis (TB) in the world. In 2014, there were an estimated 9.6 million incident cases of TB (range, 9.1 million–10.0 million) globally, equivalent to 133 cases per 100000 population. Most of the estimated number of cases in 2014 occurred in Asia (58%) and the...

TREAT Asia: Substudy on Assessment of Cardiovascular Health Knowledge, Preventive Practices and Cardio-protective Behavior among HIV-infected Individuals in Pune, India

Post Date: 
2017-10-12
Cardiovascular Diseases (CVD) have become one of the leading causes of death among PLWH (People Living with HIV) across the globe. The burden that CVD will pose in the imminent future for the 2.1 million HIV-infected individuals in India is currently unclear. However given that Indians have a high...

Impact of Diabetes on TB Treatment Outcomes: Nested Study: Lipid Mediators of Inflammation in TB and TB-Diabetes

Post Date: 
2017-10-02
Studies have shown that individuals with Tuberculosis (TB) and diabetes (TB-DM) have a distinct immune profile compared to individuals with TB alone. Individuals with TB-DM have higher inflammation, a higher bacillary load, increased Th1 immune responses and a defective neutrophil and macrophage...

RePORT: C-TRIUMPH: Nested Study on Targeting Mycobacterium Tuberculosis Persisters by Enhancing Stringent Response-specific Cellular Immunity

Post Date: 
2017-09-11
Country: 
C-TRIUMPH nested study begins to see if stringent response antigen is enhanced while treating drug-susceptible TB using the first-line anti-TB regimen.

Zika Surveillance among Antenatal Clinic Outpatients in BJ Government Medical College and Sassoon General Hospitals, Pune, India

Post Date: 
2017-08-31
Country: 
CCGHE is keeping an eye on Zika among pregnant women, which is transmitted by mosquitoes & can cause devastating birth defects.

TB and Pregnancy Impact of Immune Changes of HIV and Stages of Pregnancy on Tuberculosis: Nested Study on Investigating Maternal Antibodies to Modify Infant Tuberculosis Acquisition

Post Date: 
2017-08-29
Country: 
New study in Pune, India, aims to identify the profile of TB antibodies between mothers and infants, and to see if the presence of antibodies lowers risk of infant infection.

The Role of Innate Immunity in the Acquisition of Sterile Protection against TB Infection

Post Date: 
2017-08-25
Country: 
Tuberculosis (TB) is a major global health problem. Vaccines are the most powerful instruments for limiting the morbidity and mortality of infectious diseases, so the development of highly protective TB vaccines is one of the highest priorities in public health. Bacille de Calmette et Guérin (BCG...

Validation of Transcriptional Signature to Predict Active TB Disease among Advanced HIV Patients

Post Date: 
2017-08-15
Country: 
There have been tremendous advances in the diagnosis of patients with tuberculosis (TB) based on nucleic acid amplification of bacteria in the sputum. The GenXpert MTB/RIF provides results in 2 hours. However, in HIV-infected sputum smear is often negative for AFB and the sensitivity of GenXpert...

Antimicrobial Use and Diagnosis among Hospitalized Febrile Patients in Pune, India

Post Date: 
2017-08-07
Country: 
Antimicrobial resistance, a leading threat to human health, is enabled by unnecessary antibiotic use. Strategies to reduce unnecessary antibiotic use in India, the world’s largest antibiotic consumer, are urgently needed. Although most patients hospitalized in India with acute febrile illness...

RePORT: C-TRIUMPH: Nested Study on Association of Lipid Mediators of Inflammation with TB Treatment Outcomes

Post Date: 
2017-08-03
Country: 
Purpose: Recent studies have shown the significant role that host lipids play in modulating immunity and disease outcomes. Prostaglandins and leukotrienes are lipids that have a pro-inflammatory role in the fight against infectious agents while Specialized Pro-resolving lipid Mediators (SPMs)...

Role of Specialized Pro-resolving Mediators (SPMs) on Markers of Inflammation in HIV-infected Adults

Post Date: 
2017-08-03
Country: 
Dr. Rupak Shivikoti is leading this study. There has been a surge of recent studies focusing on the role of novel lipid mediators of inflammation called specialized pro-resolving mediators (SPMs). They are produced during inflammation as a negative feedback to resolve inflammation. However, the...

Optimizing Treatment to Improve TBM Outcomes in Children: Substudy on Clinical Profile and CSF Biorepository of the Pediatric Suspected Meningitis Cases

Post Date: 
2017-07-18
Country: 
This sub-study is being led by PIs Dr. Kelly Dooley and Dr. Chhaya Valvi. Meningoencephalitis is associated with significant morbidity and mortality. Several viruses, bacteria, and fungal pathogens including Neisseria meningitidis, Streptococcus pneumoniae, Mycobacterium tuberculosis, Herpes...

Vaginal Microbiota in HIV Infected Pregnant Women

Post Date: 
2017-07-14
Country: 
Led by Dr. Rupak Shivakoti, this is a nested cross-sectional study of 30 HIV-infected and 60 non-HIV infected pregnant women. Pregnant women that are part of the parent study (“Impact of Immune Changes of HIV and Stages of Pregnancy on Tuberculosis” referred to as PRACHITI study from here on) will...

A5349: Rifapentine-containing Treatment Shortening Regimens for Pulmonary Tuberculosis: A Randomized, Open-label, Controlled Phase 3 Clinical Trial

Post Date: 
2017-06-05
Country: 
This is an international, multicenter, randomized, controlled, open-label, 3-arm, phase 3 non-inferiority trial. Primary Objectives: To evaluate the efficacy of a rifapentine-containing regimen to determine whether the single substitution of rifapentine for rifampin makes it possible to reduce to...

Understanding Quality of Life during and Loss to Follow-up from Drug-Resistant Tuberculosis Treatment in Pune, India

Post Date: 
2017-05-15
Country: 
This study will examine a) risk factors for loss to follow-up from DR-TB treatment, b) actively trace DR-TB patients lost to follow-up from treatment and c) establish a prospective observational cohort of MDR-TB, XDR-TB and DS-TB patients as well as healthy controls nested within ongoing RNTCP...

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