Presentations

Regional Prospective Observational Research in TB (RePORT) India: Biomarkers, Diagnostics, and Comorbidities

Post Date: 
2018-10-25
Christopher DJ, Kornfeld H, Ellner J, Mave V, Rustomjee R, Rodrigues C, Gupta A. Regional Prospective Observational Research in TB (RePORT) India: Biomarkers, Diagnostics, and Comorbidities. 49th Annual Union World Conference on Lung Health. The Hague, The Netherlands. October 24-27, 2018.

What Is the Right Dose of Pyrazinamide?

Post Date: 
2018-10-25
Dooley K. What Is the Right Dose of Pyrazinamide? Symposium: Optimisation of Standard Drugs in the Treatment of Tuberculosis, Finally?

BRIEF TB Treatment of Latent TB Infection With One Month of Isoniazid & Rifapentine in HIV-Infected People: Interaction of Treatment & CD4 Count

Post Date: 
2018-10-25
Swindells S, Ramchandami R, Gupta A, Sanchez J, Juste MAJ, Mwelase N, Chaisson R, BRIEF TB Study Team. BRIEF TB Treatment of Latent TB Infection With One Month of Isoniazid & Rifapentine in HIV-Infected People: Interaction of Treatment & CD4 Count. Session: TB Infection: From Latent to...

Impact of Maternal Isoniazid Preventive Therapy (IPT) Timing on Acquisition of Infant TB Infection (TBI) in the IMPAACT P1078/TB APPRISE Trial

Post Date: 
2018-10-25
Gupta A , Aaron L, Montepiedra G, Theron G, Chipato T, Onyango-Makumbi C, Stranix-Chibanda L, Weinberg A, for the IMPAACT P1078/TB APPRISE Study Team. Impact of Maternal Isoniazid Preventive Therapy (IPT) Timing on Acquisition of Infant TB Infection (TBI) in the IMPAACT P1078/TB APPRISE Trial. 49th...

Preventive Therapy for PLWH - 3HP. MTE HIV Meet the Expert Session

Post Date: 
2018-10-25
Dooley K. Preventive Therapy for PLWH - 3HP. MTE HIV Meet the Expert Session. 49th Annual Union World Conference on Lung Health. The Hague, The Netherlands. October 24-27, 2018.

Alcohol Use Disorder, Drinking Patterns, and Tuberculosis Treatment Failure in Indian Patients

Post Date: 
2018-10-25
Samyra R Cox, Andrea Deluca, Beena Thomas, Nishi Suryavanshi, Divyashri Jain, Mandar Paradkar, Nikhil Gupte, Akshay Gupte, Bob Bollinger, Shri Vijay Bala Yogendra Shivakumar, Kannan Thiruvengadam, Geetanjali Chander, Vidya Mave, Padmapriyadarshini Chandrasekaran, Amita Gupta for the CTRIUMPh Study...

Interleukin-6, Interleukin-13 and Interferon-γ as Potential Biomarkers for Treatment Failure in Pulmonary Tuberculosis

Post Date: 
2018-10-25
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Gupte A, Kumar P, Kulkarni V, Bharadwaj R, Andrade B, Mave V, Chandrasekaran P, Gupta A. Interleukin-6, Interleukin-13 and Interferon-γ as Potential Biomarkers for Treatment Failure in Pulmonary Tuberculosis. 49th Annual Union World Conference on Lung Health. The Hague, The Netherlands. October 24-...

Challenges in TB Diagnosis in Pregnant Women in India: Findings from a Cohort Study in Pune, India

Post Date: 
2018-10-25
Alexander M, Bhosale R, Gupte N, Deshpande P, Kulkarni V, Chandanwale A, Gupta A, Mathad J. Challenges in TB Diagnosis in Pregnant Women in India: Findings from a Cohort Study in Pune, India. Session: LTBI Screening: Challenges and Opportunities. 49th Annual Union World Conference on Lung Health...

Sub-therapeutic Rifampicin Concentration is Associated with Unfavourable Treatment Outcomes in Pulmonary Tuberculosis Patients on Thrice Weekly Regimens in India

Post Date: 
2018-10-25
Ramachandran G, Chandrasekaran P, Kumar AKH, Kannan T, Gomathi NS, Gaikwad S, Gupta A, Mave V, for C-TRIUMPh team. Sub-therapeutic Rifampicin Concentration is Associated with Unfavourable Treatment Outcomes in Pulmonary Tuberculosis Patients on Thrice Weekly Regimens in India. Session: Clinical...

Host Inflammation Markers IFN- γ, IL-6 and IL-15 Strongly Associated with Risk of Incident TB in Advanced HI

Post Date: 
2018-10-25
Manabe YC, Gupte N, Leong S, Kintali M, Bisson G, Hosseinipour M, Salgame P, Gupta A for the ACTG 5274 REMEMBER and NWCS 408 Study Team. Host Inflammation Markers IFN- γ, IL-6 and IL-15 Strongly Associated with Risk of Incident TB in Advanced HI. Session: Diagnosis, Screening, Prediction of Disease...

Time to culture conversion, identifying independent modifiable risk factors in Indian patients

Post Date: 
2018-10-25
Gupte N, Gupte A, Sivaramakrishnan GN, Pradhan N, Shivakumar SVBY, Gupta A, Mave V, Chandrasekaran P for the CTRIUMPh RePORT India team. Time to culture conversion, identifying independent modifiable risk factors in Indian patients. Presented at 49th Union World Conference on Lung Health. The Hague...

Pharmacokinetics/pharmacodynamics of tuberculosis medicines: outcomes of a WHO expert consultation

Post Date: 
2018-10-24
Dooley K. Pharmacokinetics/pharmacodynamics of tuberculosis medicines: outcomes of a WHO expert consultation. Post graduate course: Update on Clinical and Programmatic Management of Multi-drug- and Extensively Drug-resisant MB (MDR/XDR-TB). 49th Annual Union World Conference on Lung Health. The...

Pharmacokinetics, pharmacodynamics (PK/PD) and Critical Concentrations of Tuberculosis Medicines

Post Date: 
2018-10-24
Dooley K, Gilpin C. Pharmacokinetics, pharmacodynamics (PK/PD) and Critical Concentrations of Tuberculosis Medicines. Workshop: Updated World Health Organization Policies on the Management of Tuberculosis. 49th Annual Union World Conference on Lung Health. The Hague, The Netherlands. October 24-27...

How can we translate next generation sequencing data to shorten anti-tuberculosis treatment?

Post Date: 
2018-10-23
Tornheim J. How can we translate next generation sequencing data to shorten anti-tuberculosis treatment? TBScience 2 Parallel session on reducing transmission: what is the scientific basis behind for the reduction of transmission and the initiation of appropriate treatment? 49th Annual Union World...

Mobile Phone Access and Comfort: Implications for HIV and Tuberculosis Care in India and South Africa

Post Date: 
2018-10-04
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Cox SN , Elf J, Lokhande R, Ogale YP, DiAndreth L, Dupuis E, Milovanovic M, Mpongose N, Martinson N, Mave V, Suryavanshi N, Gupta A, Golub JE, Mathad JS. Mobile Phone Access and Comfort: Implications for HIV and Tuberculosis Care in India and South Africa. I DSA. IDWeek 2018. San Francisco, CA,...

Perinatal Depression among HIV and TB Infected and Uninfected Women in an Urban Slum in India: Prevalence and Associated Birth Outcomes

Post Date: 
2018-10-04
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Grossman TB , Bhosale R, Alexander M, Suryavanshi N, Mave V, Jain D, Patil NU, Gupta A, Mathad JS. Perinatal depression among HIV and TB infected and uninfected women in an urban slum in India: prevalence and associated birth outcomes. IDSA. ID Week 2018. San Francisco, CA. October 3-7, 2018.

Antibiotic Use and Drug-Resistant Late-Onset Infections Among Neonates Admitted to Neonatal Intensive Care Units in Pune, India

Post Date: 
2018-08-28
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Agarkhedkar S, Armstrong D, Bharadwaj R, Cox SR, Dohe V, Gupta A, Gupte N, Johnson J, Kadam A, Kinikar A, Malwade S, Manabe Y, Mave V, Milstone A, Parikh T, Rajput U, Randive B, Robinson M , Smith R, Suryavanshi N, Vaidya U, Westercamp M. Antibiotic Use and Drug-Resistant Late-Onset Infections...

High Prevalence of Dengue among Pregnant Women in India

Post Date: 
2018-08-27
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Alexander M, Naik S, Robinson M , Sapkal G, Deshpande P, Kulkarni V, Nimkar S, Sambarey P, Kinikar A, Mave V, Suryavanshi N, Gupte N, Bollinger R, Gupta A, Bharadwaj R, Mathad J. High Prevalence of Dengue among Pregnant Women in India. 2018 International Conference on Emerging Infectious Diseases...

Association of Maternal Viral Load and CD4 Count with Perinatal HIV-1 Transmission Risk during Breastfeeding in the PROMISE Postpartum Component

Post Date: 
2018-07-26
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Flynn P, Taha T, Cababasay M, Butler K, Fowler MG, Mofenson L, Owor M, Fiscus S, Stranix-Chibanda L, Coutsoudis A, Gnanshanmugam D, Chakhtoura N, McCarthy K, Mukuzunga C, Makanani B, Moodley D, Nematadzira T, Kusakara B, Patil S, Vhembo T, Bobat R, Mmbaga B, Masenya M, Nyati M, Theron G, Mulenga H...

Mobile Health and Behavioral PMTCT Intervention among Community Health Workers Improves Exclusive Breastfeeding and Early Infant Diagnosis in India: A Cluster Randomized Trial

Post Date: 
2018-07-24
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Suryavanshi N, Kadam A, Hegde A, Sivalenka S, Kumar VS, McKenzie-White J, Kanade S, Gupta A, Bollinger RC, Shankar A, Gupte N, Mave V. Mobile Health and Behavioral PMTCT Intervention among Community Health Workers Improves Exclusive Breastfeeding and Early Infant Diagnosis in India: A Cluster...

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Optimizing Treatment to Improve TBM Outcomes in Children

Post Date: 
2014-05-01
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This study, known as TBM Kids, is being conducted in India and Malawi. Primary Objectives To characterize the pharmacokinetics (PK) (plasma and cerebrospinal fluid (CSF)) of rifampicin given at model-derived optimal daily doses and levofloxacin in children ages 6 months to 12 years of age with TBM...

Feasibility and Acceptability of Smartphone-Based Ecological Momentary Assessment of Alcohol Use Among African American Men Who Have Sex With Men in Baltimore

Post Date: 
2013-01-01
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This study provides evidence to support the feasibility and acceptability of using Ecological Momentary Assessment (EMA ) methods for collecting data on alcohol use among African American men who have sex with men living in urban settings. These data provide the basis for future studies of EMA-...

Impact of Diabetes on TB Treatment Outcomes

Post Date: 
2013-02-01
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CCGHE, the JHU Center for TB Research and BJGMC have been awarded a $2.5 million dollar NIH grant (2013-2018) to conduct a study to evaluate treatment outcomes among Indian patients with both diabetes mellitus and active TB. This study is assessing the prevalence of impaired glucose or frank...

Editorial Commentary: Recruiting the next generation of infectious diseases physicians: how do we reignite the passion?

Post Date: 
2016-07-15
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Publication: 
Clinical Infectious Diseases
Introduction: Infectious diseases (ID) is the most exciting medical subspecialty. We may be biased, but we are not wrong. It is disheartening that applications to ID fellowships continue to decrease; in 2016, 61% of fellowship programs did not fill through the National Resident Matching Program, up...

Epidemiological impact of achieving UNAIDS 90-90-90 targets for HIV care in India: a modelling study

Post Date: 
2016-07-07
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BMJ Open
Objective: Recent UNAIDS ‘90-90-90’ targets propose that to end the HIV epidemic by 2030, 90% of persons living with HIV (PLWH) worldwide should know their diagnosis, 90% of diagnosed PLWH should be on antiretroviral therapy (ART) and 90% of PLWH on ART should be virally suppressed by 2020...

Lateral flow urine lipoarabinomannan assay for detecting active tuberculosis in HIV-positive adults

Post Date: 
2016-08-16
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Cochrane Database of Systematic Reviews
Background: Rapid detection of tuberculosis (TB) among people living with human immunodeficiency virus (HIV) is a global health priority. HIV-associated TB may have different clinical presentations and is challenging to diagnose. Conventional sputum tests have reduced sensitivity in HIV-positive...

Defining clinical excellence in adult infectious disease practice

Post Date: 
2016-06-16
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Open Forum Infectious Diseases
Clinical excellence should be recognized, particularly in the current climate that appropriately prioritizes relationship-centered care. In order to develop a recognition model, a definition of clinical excellence must be created and agreed upon. A paradigm recently suggested by C. Christmas...

Isoniazid hair concentrations in children with tuberculosis: a proof of concept study

Post Date: 
2016-06-01
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Publication: 
International Journal of Tuberculosis and Lung Disease
Assessing treatment adherence and quantifying exposure to anti-tuberculosis drugs among children is challenging. We undertook a 'proof of concept' study to assess the drug concentrations of isoniazid (INH) in hair as a therapeutic drug monitoring tool. Children aged <12 years initiated on...

Management and control of multidrug-resistant tuberculosis (MDR-TB): addressing policy needs for India

Post Date: 
2016-05-06
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Journal of Public Health Policy
Multidrug-resistant tuberculosis (MDR-TB) challenges TB control efforts because of delays in diagnosis plus its long-term treatment which has toxic effects. Of TB high-incidence countries, India carries the highest burden of MDR-TB cases. We describe policy issues in India concerning MDR-TB...

High proportion of extrapulmonary tuberculosis in a low prevalence setting: a retrospective cohort study

Post Date: 
2016-04-29
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Public Health
Objectives: The proportion of extrapulmonary tuberculosis (EPTB) cases in the United States (US) has been rising due to a slower rate of decline in EPTB compared to pulmonary tuberculosis (PTB). The purpose of this study was to characterise the clinical and treatment differences between EPTB and...

Empirical tuberculosis therapy versus isoniazid in adult outpatients with advanced HIV initiating antiretroviral therapy (REMEMBER): a multicountry open-label randomised controlled trial

Post Date: 
2016-03-19
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The Lancet
Background: Mortality within the first 6 months after initiating antiretroviral therapy is common in resource-limited settings and is often due to tuberculosis in patients with advanced HIV disease. Isoniazid preventive therapy is recommended in HIV-positive adults, but subclinical tuberculosis can...

Ecological momentary assessment of illicit drug use compared to biological and self-reported methods

Post Date: 
2016-03-15
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Journal of Medical Internet Research
Background: The use of mHealth methods for capturing illicit drug use and associated behaviors have become more widely used in research settings, yet there is little research as to how valid these methods are compared to known measures of capturing and quantifying drug use. Objective: We examined...

Infectious Diseases (ID) Learning Unit: How rapidly to evaluate for active tuberculosis disease in low-prevalence settings

Post Date: 
2016-03-11
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Open Forum Infectious Diseases
With declining tuberculosis (TB) incidence in low-prevalence settings, many clinicians are likely unaware that the approach to diagnosing active TB is evolving with newer technologies. Rapid molecular assays are commercially available, and more are likely to enter the market in the coming years...

Inflammation and change in body weight with antiretroviral therapy initiation in a multinational cohort of HIV-infected adults

Post Date: 
2016-04-01
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The Journal of Infectious Diseases
Background: Both wasting and obesity are associated with inflammation, but the extent to which body weight changes influence inflammation during human immunodeficiency virus infection is unknown. Methods: Among a random virologically suppressed participants of the Prospective Evaluation of...

Tuberculosis risk among medical trainees, Pune, India

Post Date: 
2016-03-22
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Emerging Infectious Diseases
During 2012–2013, at a public hospital in Pune, India, 26 (3.9%) cases of tuberculosis were reported among 662 medical trainees, representing an estimated incidence of 3,279 cases/100,000 person-years. Three of these infections were isoniazid-resistant, 1 was multidrug-resistant, and 1 occurred in...

Cohort for Tuberculosis Research by the Indo-US Medical Partnership (C-TRIUMPH): protocol for a multicentric prospective observational study

Post Date: 
2016-02-25
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BMJ Open
Introduction: Tuberculosis disease (TB) remains an important global health threat. An evidence-based response, tailored to local disease epidemiology in high-burden countries, is key to controlling the global TB epidemic. Reliable surrogate biomarkers that predict key active disease and latent TB...

Low Vitamin-D levels combined with PKP3-SIGIRR-TMEM16J host variants is strongly associated with tuberculosis and death in HIV-infected and -exposed infants

Post Date: 
2016-02-12
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PLOS One
Background: This study examined the associations of 25-hydroxyvitamin D and specific host genetic variants that affect vitamin D levels or its effects on immune function, with the risk of TB or mortality in children. Methods: A case-cohort sample of 466 South African infants enrolled in P1041 trial...

Quantitative IFN-y,IL-2 response and latent tuberculosis test discordance in HIV-infected pregnant women

Post Date: 
2016-06-15
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Publication: 
American Journal of Respiratory and Critical Care Medicine
Rationale: Pregnant women with latent tuberculosis infection (LTBI) are at high risk for development of TB, especially if infected with HIV. Objectives: To assess the performance of LTBI tests in pregnant and postpartum women infected with HIV, investigate the immunology behind discordance in...

Toward earlier inclusion of pregnant and postpartum women in TB drug trials: consensus statements from an International Expert Panel

Post Date: 
2016-01-04
Publication: 
Clinical Infectious Diseases
Tuberculosis is a major cause of morbidity and mortality in women of childbearing age (15–44 years). Despite increased tuberculosis risk during pregnancy, optimal clinical treatment remains unclear: safety, tolerability, and pharmacokinetic data for many tuberculosis drugs are lacking, and trials...

Rapid Diagnosis, Linkage and Treatment Initiation of Patients with Drug-resistant Tuberculosis in South Africa: The miLINC Solution to Improve Access to Care

Post Date: 
2016-07-20
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Farley JE , Seiguer S, Naicker M, McKenzie-White J, Greg C, Elmi M, Stevens W, Stewart-Isherwood L. Rapid Diagnosis, Linkage and Treatment Initiation of Patients with Drug-resistant Tuberculosis in South Africa: The miLINC Solution to Improve Access to Care. 21st International AIDS Conference...

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