Presentations

Preventing tuberculosis in people with HIV infection

Post Date: 
2019-03-06
Gupta A. Choices and dilemmas: Preventing tuberculosis in people with HIV infection. Coinfections: Tuberculosis, Hepatitis B and C, and HIV Symposium. CROI 2019. Seattle, Washington. March 4-7, 2019.

The prevalence of perinatal depression and associated birth outcomes in Pune, India

Post Date: 
2019-02-11
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Grossman TB , Mathad JS, Suryavanshi N, Alexander M, Mave V, Bhosale R, Gupta A. The prevalence of perinatal depression and associated birth outcomes in Pune, India. Society for Maternal-Fetal Medicine 39th Annual Pregnancy Meeting. Las Vegas, NV. February 11-16, 2019.

Impact of Standard or Increased Moxifloxacin Dose Among MDR-TB Patients in Mumbai with Low-Level Resistance

Post Date: 
2019-02-04
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Tornheim JA , Udwadia ZF, Porwal S, Kishore G, Gajjar I, Karane M, Shivakumar SVBY, Rodrigues C, Gupta A. Impact of Standard or Increased Moxifloxacin Dose Among MDR-TB Patients in Mumbai with Low-Level Resistance. 8th Annual Regional Prospective Observational Research for Tuberculosis (RePORT)...

IL-6, TIMP-2 and TGFβ-2 Are Associated with Respiratory Impairment During and Following Successful Treatment of Pulmonary Tuberculosis

Post Date: 
2019-02-04
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Gupte A , Paradkar M, Selvaraju S, Kumar P, Lokhande R, Kulkarni V, Hanna LE, Thiruvengadam K, Sekar K, Momin A, Shivakumar SVBY, Gupte N, Babu S, Salvi S, Golub J, Checkley W, Bollinger RC, Andrade B, Mave V, Chandrasekaran P, Gupta A. IL-6, TIMP-2 and TGFβ-2 are associated with respiratory...

Linezolid Resistance in Mycobacterium Tuberculosis Isolates at a Tertiary Care Center in Mumbai, India, by Whole Genome Sequencing

Post Date: 
2019-02-04
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Tornheim JA , Diricks M, Katrien DB, Sadani M, Shetty A, Rodrigues C. Linezolid Resistance in Mycobacterium Tuberculosis Isolates at a Tertiary Care Center in Mumbai, India, by Whole Genome Sequencing. RePORT India 2019 Joint Leadership Meeting. Chennai, India. February 4-6, 2019.

Determination of Plasma Clofazimine Levels by Liquid Chromatography-Mass Spectrometry

Post Date: 
2019-02-04
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Chawla PK , Lokhande RV, Naik PR, Dherai AJ, Udwadia ZF, Mahashur AA, Pinto L, Soman R, Rodrigues C, Gupta A, Tornheim JA, Martinson N, Variava E, Weisner L, Joubert A, Ashavaid TF. Determination of Plasma Clofazimine Levels by Liquid Chromatography-Mass Spectrometry. 8th Annual Regional...

Determination of Serum Linezolid Levels by HPLC

Post Date: 
2019-02-04
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Chawla PK , Lokhande RV, NaiF PR, Dherai AJ, Udwadia ZF, Mahashur AA, Soman R, Rodrigues C, Gupta A, Tornheim JA, Ashavaid TK. Determination of Serum Linezolid Levels by HPLC. 8th Annual Regional Prospective Observational Research for Tuberculosis (RePORT) India Joint Leadership meeting – ‘’...

Mental Health and TB: High Prevalence of Depression among Drug-resistant TB Patients not Associated with Cycloserine

Post Date: 
2019-02-04
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Shivakumar SVBY , Tornheim JA, Gajjar I, Porwal S, Kishore G, Karane M, Sayed S, Chawla PK, Rodrigues C, Ashavaid TK, Gupta A, Udwadia ZF. Mental Health and TB: High prevalence of depression among drug-resistant TB patients not associated with cycloserine. 8th Annual Regional Prospective...

Quality of Life Among MDR-TB Patients from the Public Sector in Mumbai

Post Date: 
2019-02-04
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Gajjar IN , Udwadia ZF, Kishore G, Karane M, Sayed S, Sawant N, Chawla PK, Rodrigues C, Ashavaid TK, Shivakumar SVBY, Gupta A, Tornheim JA. Quality of Life Among MDR-TB Patients from the Public Sector in Mumbai. 8th Annual Regional Prospective Observational Research for Tuberculosis (RePORT) India...

Whole Genome Sequencing of Mycobacterium Tuberculosis Directly from Clinical Samples Accurately Identifies Drug Resistance

Post Date: 
2019-02-04
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Kambli P , Tornheim JA, Soundararajan L, Priyadarshini S, Gupta R, Ramprasad VL, Gupta A, Rodrigues C. Whole Genome Sequencing of Mycobacterium Tuberculosis Directly from Clinical Samples Accurately Identifies Drug Resistance. 8th Annual Regional Prospective Observational Research for Tuberculosis...

Host Lipidomic Profile Associated with Adverse Tuberculosis Treatment Outcomes

Post Date: 
2019-02-04
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Shivakoti R , Chandrasekaran P, Hannah LE, Thiruvengadam K, Saravanan N, Karunaianatham R, Gupta A, Mave V, Gupte N, Kulkarni V, Pradhan N, Gupte A, Paradkar M, Shivakumar SVBY, Bharadwaj, Kagal A, Gaikwad S, Sangle S, Borkowski K, Newman J, Fiehn O. Host Lipidomic Profile Associated with Adverse...

Does Smoking Have an Impact on TB Treatment Outcomes?

Post Date: 
2018-10-27
Thomas B, Kannan T, Rani V, Gupte N, Gupta A, Deluca A, Suryavanshi N, Kohli R, Chandrasekaran P for the CTRIUMPH RePORT India Study Team. Does Smoking Have an Impact on TB Treatment Outcomes? A Prospective Cohort Study from India. Session: Tobacco Use in Various Populations: Implications for...

Impact of Fogarty HIV-TB Training Program on ‘Institutional Research Capacity Building’ at the Byramjee Jeejeebhoy Government Medical College (BJGMC), Pune, India

Post Date: 
2018-10-27
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Dhumal G, DeLuca A, Chandanwale A, Kadam D, Joshi S, Kinikar A, Suryavanshi N, Mave V, Gupta A, Bollinger R. Impact of Fogarty HIV-TB Training Program on ‘Institutional Research Capacity Building’ at the Byramjee Jeejeebhoy Government Medical College (BJGMC), Pune, India. Session: Building...

Gestational Diabetes Suppresses the Inflammatory Response to M. tuberculosis in Pregnant Women in Pune, India. Session: Clinical Investigation for TB and Diabetes

Post Date: 
2018-10-27
Mathad J, Alexander M, Bhosale R, Shere D, Kulkarni V, Kumar P, Babu S, Gupta A for the PRACHITi Study team. Gestational Diabetes Suppresses the Inflammatory Response to M. tuberculosis in Pregnant Women in Pune, India. Session: Clinical Investigation for TB and Diabetes. 49th Annual Union World...

TB Stigma and Its Impact on Enrolling Household Contacts in Clinical Trials and Cohort Studies: An Indian Perspective

Post Date: 
2018-10-27
Suryavanshi N. TB Stigma and Its Impact on Enrolling Household Contacts in Clinical Trials and Cohort Studies: An Indian Perspective. Symposium: Tuberculosis Contact Investigation in High Tuberculosis Burden Settings. 49th Annual Union World Conference on Lung Health. The Hague, The Netherlands...

Managing Tuberculosis in Pregnancy. Meet the Expert Session

Post Date: 
2018-10-26
Gupta A. Managing Tuberculosis in Pregnancy. Meet the Expert Session. 49th Annual Union World Conference on Lung Health. The Hague, The Netherlands. October 24-27, 2018.

Factors Associated with Loss to Follow-up and Mortality in Public Sector MDR TB Treatment in Western Maharashtra, India from 2015-2016

Post Date: 
2018-10-26
Murrill M, More SW, Kamble S, Kulkarni V, Dowdy D, Gupta A. Factors Associated with Loss to Follow-up and Mortality in Public Sector MDR TB Treatment in Western Maharashtra, India from 2015-2016. 49th Annual Union World Conference on Lung Health. The Hague, The Netherlands. October 24,-27, 2018.

The TEKO trial: implementation of the QuantiFERON®-TB Gold In-Tube test at CD4 blood draw for diagnosing latent tuberculosis among newly diagnosed HIV-infected adults in South Africa

Post Date: 
2018-10-26
Golub J, Lebina L, Chon S, Cohn S, Jack T, Masonoke K, Variava E, Martinson N, TEKO team. The TEKO trial: implementation of the QuantiFERON®-TB Gold In-Tube test at CD4 blood draw for diagnosing latent tuberculosis among newly diagnosed HIV-infected adults in South Africa. 49th Annual Union World...

Utility of QGIT as an Adjunct to TST for Screening of Latent Tuberculosis Infection among Indian Healthcare Workers

Post Date: 
2018-10-26
Girish S, Kinikar A, Pardeshi G, Shelke S, Basavaraj A, Chandanwale A, Gupte N, Bollinger R. Utility of QGIT as an Adjunct to TST for Screening of Latent Tuberculosis Infection among Indian Healthcare Workers. 49th Annual Union World Conference on Lung Health. The Hague, The Netherlands. October 24...

Mortality Risk Doubled in Tuberculosis Patients with Diabetes Not Receiving Metformin

Post Date: 
2018-10-26
Mave V, Gupte N, Gaikwad S, Barthwal M, Chon S, Gupte A, Gupta A, Golub J. Mortality Risk Doubled in Tuberculosis Patients with Diabetes Not Receiving Metformin. Presented at 49th Union World Conference on Lung Health. The Hague, The Netherlands. October 24-27, 2018.

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Optimizing Treatment to Improve TBM Outcomes in Children

Post Date: 
2014-05-01
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This study, known as TBM Kids, is being conducted in India and Malawi. Primary Objectives To characterize the pharmacokinetics (PK) (plasma and cerebrospinal fluid (CSF)) of rifampicin given at model-derived optimal daily doses and levofloxacin in children ages 6 months to 12 years of age with TBM...

Feasibility and Acceptability of Smartphone-Based Ecological Momentary Assessment of Alcohol Use Among African American Men Who Have Sex With Men in Baltimore

Post Date: 
2013-01-01
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This study provides evidence to support the feasibility and acceptability of using Ecological Momentary Assessment (EMA ) methods for collecting data on alcohol use among African American men who have sex with men living in urban settings. These data provide the basis for future studies of EMA-...

Impact of Diabetes on TB Treatment Outcomes

Post Date: 
2013-02-01
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CCGHE, the JHU Center for TB Research and BJGMC have been awarded a $2.5 million dollar NIH grant (2013-2018) to conduct a study to evaluate treatment outcomes among Indian patients with both diabetes mellitus and active TB. This study is assessing the prevalence of impaired glucose or frank...

Editorial Commentary: Recruiting the next generation of infectious diseases physicians: how do we reignite the passion?

Post Date: 
2016-07-15
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Clinical Infectious Diseases
Introduction: Infectious diseases (ID) is the most exciting medical subspecialty. We may be biased, but we are not wrong. It is disheartening that applications to ID fellowships continue to decrease; in 2016, 61% of fellowship programs did not fill through the National Resident Matching Program, up...

Epidemiological impact of achieving UNAIDS 90-90-90 targets for HIV care in India: a modelling study

Post Date: 
2016-07-07
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BMJ Open
Objective: Recent UNAIDS ‘90-90-90’ targets propose that to end the HIV epidemic by 2030, 90% of persons living with HIV (PLWH) worldwide should know their diagnosis, 90% of diagnosed PLWH should be on antiretroviral therapy (ART) and 90% of PLWH on ART should be virally suppressed by 2020...

Lateral flow urine lipoarabinomannan assay for detecting active tuberculosis in HIV-positive adults

Post Date: 
2016-08-16
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Cochrane Database of Systematic Reviews
Background: Rapid detection of tuberculosis (TB) among people living with human immunodeficiency virus (HIV) is a global health priority. HIV-associated TB may have different clinical presentations and is challenging to diagnose. Conventional sputum tests have reduced sensitivity in HIV-positive...

Defining clinical excellence in adult infectious disease practice

Post Date: 
2016-06-16
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Open Forum Infectious Diseases
Clinical excellence should be recognized, particularly in the current climate that appropriately prioritizes relationship-centered care. In order to develop a recognition model, a definition of clinical excellence must be created and agreed upon. A paradigm recently suggested by C. Christmas...

Isoniazid hair concentrations in children with tuberculosis: a proof of concept study

Post Date: 
2016-06-01
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Publication: 
International Journal of Tuberculosis and Lung Disease
Assessing treatment adherence and quantifying exposure to anti-tuberculosis drugs among children is challenging. We undertook a 'proof of concept' study to assess the drug concentrations of isoniazid (INH) in hair as a therapeutic drug monitoring tool. Children aged <12 years initiated on...

Management and control of multidrug-resistant tuberculosis (MDR-TB): addressing policy needs for India

Post Date: 
2016-05-06
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Journal of Public Health Policy
Multidrug-resistant tuberculosis (MDR-TB) challenges TB control efforts because of delays in diagnosis plus its long-term treatment which has toxic effects. Of TB high-incidence countries, India carries the highest burden of MDR-TB cases. We describe policy issues in India concerning MDR-TB...

High proportion of extrapulmonary tuberculosis in a low prevalence setting: a retrospective cohort study

Post Date: 
2016-04-29
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Public Health
Objectives: The proportion of extrapulmonary tuberculosis (EPTB) cases in the United States (US) has been rising due to a slower rate of decline in EPTB compared to pulmonary tuberculosis (PTB). The purpose of this study was to characterise the clinical and treatment differences between EPTB and...

Empirical tuberculosis therapy versus isoniazid in adult outpatients with advanced HIV initiating antiretroviral therapy (REMEMBER): a multicountry open-label randomised controlled trial

Post Date: 
2016-03-19
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The Lancet
Background: Mortality within the first 6 months after initiating antiretroviral therapy is common in resource-limited settings and is often due to tuberculosis in patients with advanced HIV disease. Isoniazid preventive therapy is recommended in HIV-positive adults, but subclinical tuberculosis can...

Ecological momentary assessment of illicit drug use compared to biological and self-reported methods

Post Date: 
2016-03-15
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Journal of Medical Internet Research
Background: The use of mHealth methods for capturing illicit drug use and associated behaviors have become more widely used in research settings, yet there is little research as to how valid these methods are compared to known measures of capturing and quantifying drug use. Objective: We examined...

Infectious Diseases (ID) Learning Unit: How rapidly to evaluate for active tuberculosis disease in low-prevalence settings

Post Date: 
2016-03-11
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Open Forum Infectious Diseases
With declining tuberculosis (TB) incidence in low-prevalence settings, many clinicians are likely unaware that the approach to diagnosing active TB is evolving with newer technologies. Rapid molecular assays are commercially available, and more are likely to enter the market in the coming years...

Inflammation and change in body weight with antiretroviral therapy initiation in a multinational cohort of HIV-infected adults

Post Date: 
2016-04-01
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The Journal of Infectious Diseases
Background: Both wasting and obesity are associated with inflammation, but the extent to which body weight changes influence inflammation during human immunodeficiency virus infection is unknown. Methods: Among a random virologically suppressed participants of the Prospective Evaluation of...

Tuberculosis risk among medical trainees, Pune, India

Post Date: 
2016-03-22
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Emerging Infectious Diseases
During 2012–2013, at a public hospital in Pune, India, 26 (3.9%) cases of tuberculosis were reported among 662 medical trainees, representing an estimated incidence of 3,279 cases/100,000 person-years. Three of these infections were isoniazid-resistant, 1 was multidrug-resistant, and 1 occurred in...

Cohort for Tuberculosis Research by the Indo-US Medical Partnership (C-TRIUMPH): protocol for a multicentric prospective observational study

Post Date: 
2016-02-25
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BMJ Open
Introduction: Tuberculosis disease (TB) remains an important global health threat. An evidence-based response, tailored to local disease epidemiology in high-burden countries, is key to controlling the global TB epidemic. Reliable surrogate biomarkers that predict key active disease and latent TB...

Low Vitamin-D levels combined with PKP3-SIGIRR-TMEM16J host variants is strongly associated with tuberculosis and death in HIV-infected and -exposed infants

Post Date: 
2016-02-12
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PLOS One
Background: This study examined the associations of 25-hydroxyvitamin D and specific host genetic variants that affect vitamin D levels or its effects on immune function, with the risk of TB or mortality in children. Methods: A case-cohort sample of 466 South African infants enrolled in P1041 trial...

Quantitative IFN-y,IL-2 response and latent tuberculosis test discordance in HIV-infected pregnant women

Post Date: 
2016-06-15
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Publication: 
American Journal of Respiratory and Critical Care Medicine
Rationale: Pregnant women with latent tuberculosis infection (LTBI) are at high risk for development of TB, especially if infected with HIV. Objectives: To assess the performance of LTBI tests in pregnant and postpartum women infected with HIV, investigate the immunology behind discordance in...

Toward earlier inclusion of pregnant and postpartum women in TB drug trials: consensus statements from an International Expert Panel

Post Date: 
2016-01-04
Publication: 
Clinical Infectious Diseases
Tuberculosis is a major cause of morbidity and mortality in women of childbearing age (15–44 years). Despite increased tuberculosis risk during pregnancy, optimal clinical treatment remains unclear: safety, tolerability, and pharmacokinetic data for many tuberculosis drugs are lacking, and trials...

Rapid Diagnosis, Linkage and Treatment Initiation of Patients with Drug-resistant Tuberculosis in South Africa: The miLINC Solution to Improve Access to Care

Post Date: 
2016-07-20
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Farley JE , Seiguer S, Naicker M, McKenzie-White J, Greg C, Elmi M, Stevens W, Stewart-Isherwood L. Rapid Diagnosis, Linkage and Treatment Initiation of Patients with Drug-resistant Tuberculosis in South Africa: The miLINC Solution to Improve Access to Care. 21st International AIDS Conference...

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