Presentations

Sub-therapeutic Rifampicin Concentration is Associated with Unfavourable Treatment Outcomes in Pulmonary Tuberculosis Patients on Thrice Weekly Regimens in India

Post Date: 
2018-10-25
Ramachandran G, Chandrasekaran P, Kumar AKH, Kannan T, Gomathi NS, Gaikwad S, Gupta A, Mave V, for C-TRIUMPh team. Sub-therapeutic Rifampicin Concentration is Associated with Unfavourable Treatment Outcomes in Pulmonary Tuberculosis Patients on Thrice Weekly Regimens in India. Session: Clinical...

Host Inflammation Markers IFN- γ, IL-6 and IL-15 Strongly Associated with Risk of Incident TB in Advanced HI

Post Date: 
2018-10-24
Manabe YC, Gupte N, Leong S, Kintali M, Bisson G, Hosseinipour M, Salgame P, Gupta A for the ACTG 5274 REMEMBER and NWCS 408 Study Team. Host Inflammation Markers IFN- γ, IL-6 and IL-15 Strongly Associated with Risk of Incident TB in Advanced HI. Session: Diagnosis, Screening, Prediction of Disease...

Time to culture conversion, identifying independent modifiable risk factors in Indian patients

Post Date: 
2018-10-24
Gupte N, Gupte A, Sivaramakrishnan GN, Pradhan N, Shivakumar SVBY, Gupta A, Mave V, Chandrasekaran P for the CTRIUMPh RePORT India team. Time to culture conversion, identifying independent modifiable risk factors in Indian patients. Presented at 49th Union World Conference on Lung Health. The Hague...

Regional Prospective Observational Research in TB (RePORT) India: Biomarkers, Diagnostics, and Comorbidities

Post Date: 
2018-10-24
Christopher DJ, Kornfeld H, Ellner J, Mave V, Rustomjee R, Rodrigues C, Gupta A. Regional Prospective Observational Research in TB (RePORT) India: Biomarkers, Diagnostics, and Comorbidities. 49th Annual Union World Conference on Lung Health. The Hague, The Netherlands. October 24-27, 2018.

Pharmacokinetics/pharmacodynamics of tuberculosis medicines: outcomes of a WHO expert consultation

Post Date: 
2018-10-24
Dooley K. Pharmacokinetics/pharmacodynamics of tuberculosis medicines: outcomes of a WHO expert consultation. Post graduate course: Update on Clinical and Programmatic Management of Multi-drug- and Extensively Drug-resisant MB (MDR/XDR-TB). 49th Annual Union World Conference on Lung Health. The...

Pharmacokinetics, pharmacodynamics (PK/PD) and Critical Concentrations of Tuberculosis Medicines

Post Date: 
2018-10-24
Dooley K, Gilpin C. Pharmacokinetics, pharmacodynamics (PK/PD) and Critical Concentrations of Tuberculosis Medicines. Workshop: Updated World Health Organization Policies on the Management of Tuberculosis. 49th Annual Union World Conference on Lung Health. The Hague, The Netherlands. October 24-27...

How can we translate next generation sequencing data to shorten anti-tuberculosis treatment?

Post Date: 
2018-10-23
Tornheim J. How can we translate next generation sequencing data to shorten anti-tuberculosis treatment? TBScience 2 Parallel session on reducing transmission: what is the scientific basis behind for the reduction of transmission and the initiation of appropriate treatment? 49th Annual Union World...

Mobile Phone Access and Comfort: Implications for HIV and Tuberculosis Care in India and South Africa

Post Date: 
2018-10-04
   |   
Countries: 
   |   
Clinical Sites: 
Cox SN , Elf J, Lokhande R, Ogale YP, DiAndreth L, Dupuis E, Milovanovic M, Mpongose N, Martinson N, Mave V, Suryavanshi N, Gupta A, Golub JE, Mathad JS. Mobile Phone Access and Comfort: Implications for HIV and Tuberculosis Care in India and South Africa. I DSA. IDWeek 2018. San Francisco, CA,...

Perinatal Depression among HIV and TB Infected and Uninfected Women in an Urban Slum in India: Prevalence and Associated Birth Outcomes

Post Date: 
2018-10-04
   |   
Countries: 
   |   
Clinical Sites: 
Grossman TB , Bhosale R, Alexander M, Suryavanshi N, Mave V, Jain D, Patil NU, Gupta A, Mathad JS. Perinatal depression among HIV and TB infected and uninfected women in an urban slum in India: prevalence and associated birth outcomes. IDSA. ID Week 2018. San Francisco, CA. October 3-7, 2018.

Antibiotic Use and Drug-Resistant Late-Onset Infections Among Neonates Admitted to Neonatal Intensive Care Units in Pune, India

Post Date: 
2018-08-28
   |   
Countries: 
   |   
Clinical Sites: 
Agarkhedkar S, Armstrong D, Bharadwaj R, Cox SR, Dohe V, Gupta A, Gupte N, Johnson J, Kadam A, Kinikar A, Malwade S, Manabe Y, Mave V, Milstone A, Parikh T, Rajput U, Randive B, Robinson M , Smith R, Suryavanshi N, Vaidya U, Westercamp M. Antibiotic Use and Drug-Resistant Late-Onset Infections...

High Prevalence of Dengue among Pregnant Women in India

Post Date: 
2018-08-27
   |   
Countries: 
   |   
Clinical Sites: 
Alexander M, Naik S, Robinson M , Sapkal G, Deshpande P, Kulkarni V, Nimkar S, Sambarey P, Kinikar A, Mave V, Suryavanshi N, Gupte N, Bollinger R, Gupta A, Bharadwaj R, Mathad J. High Prevalence of Dengue among Pregnant Women in India. 2018 International Conference on Emerging Infectious Diseases...

Association of Maternal Viral Load and CD4 Count with Perinatal HIV-1 Transmission Risk during Breastfeeding in the PROMISE Postpartum Component

Post Date: 
2018-07-26
   |   
Countries: 
   |   
Clinical Sites: 
Flynn P, Taha T, Cababasay M, Butler K, Fowler MG, Mofenson L, Owor M, Fiscus S, Stranix-Chibanda L, Coutsoudis A, Gnanshanmugam D, Chakhtoura N, McCarthy K, Mukuzunga C, Makanani B, Moodley D, Nematadzira T, Kusakara B, Patil S, Vhembo T, Bobat R, Mmbaga B, Masenya M, Nyati M, Theron G, Mulenga H...

Mobile Health and Behavioral PMTCT Intervention among Community Health Workers Improves Exclusive Breastfeeding and Early Infant Diagnosis in India: A Cluster Randomized Trial

Post Date: 
2018-07-24
   |   
Countries: 
   |   
Clinical Sites: 
Suryavanshi N, Kadam A, Hegde A, Sivalenka S, Kumar VS, McKenzie-White J, Kanade S, Gupta A, Bollinger RC, Shankar A, Gupte N, Mave V. Mobile Health and Behavioral PMTCT Intervention among Community Health Workers Improves Exclusive Breastfeeding and Early Infant Diagnosis in India: A Cluster...

Opportunities, Challenges and Implications of m-Health Oral Cancer Screening for HIV-positive Individuals in India

Post Date: 
2018-07-23
   |   
Countries: 
   |   
Clinical Sites: 
Joshi S, Chandanwale A, Sangle S, Marbaniang I , Khaire S, Thakur R, Gupta A, Chigurupati R, Mave V. Opportunities, Challenges and Implications of m-Health Oral Cancer Screening for HIV-positive Individuals in India. AIDS 2018. Amsterdam, The Netherlands. July 23-27, 2018.

Health-related Quality of Life in the A5274 Trial of TB Therapy in Advanced HIV

Post Date: 
2018-07-22
   |   
Clinical Sites: 
Lando R, Sun X, Miyahara S, Hosseinpour MC, Bisson GP, Kumwenda J, Gupta A, Nyirenda M, Katendey K, Torres TS, Suryavanshi N, Beulah F, Opollo V, Shah NS on behalf of the A5274 study team. Health-related Quality of Life in the A5274 Trial of TB Therapy in Advanced HIV. TB 2018, Amsterdam, The...

Role of Maternal Viral Load and CD4 Count on Perinatal HIV-1 Transmission during Breastfeeding in the PROMISE Postpartum Component

Post Date: 
2018-07-20
   |   
Clinical Sites: 
Flynn P, Taha T, Cababasay M, Butler K, Fowler MG, Mofenson L, Owor M, Fiscus S, Stranix-Chibanda L, Coutsoudis A, Gnanshanmugam D, Chakhtoura N, McCarthy K, Mukuzunga C, Makanani B, Moodley D, Nematadzira T, Kusakara B, Patil S , Vhembo T, Bobat R, Mmbaga B, Masenya M, Nyati M, Theron G, Mulenga H...

Association between Dietary Intake and the Composition of the Vaginal Microbiota

Post Date: 
2018-06-20
   |   
Countries: 
   |   
Clinical Sites: 
Shivakoti R , Tuddenham S, Caulfield LE, Robinson C, Rave J, Ghanem K, Brotman R. Association between dietary intake and the composition of the vaginal microbiota. Society for Epidemiologic Research 51st Annual Meeting. Baltimore, MD. June 19-22, 2018.

Association between Dietary Intake and the Composition of the Vaginal Microbiota

Post Date: 
2018-06-09
   |   
Countries: 
   |   
Clinical Sites: 
Shivakoti R , Tuddenham S, Caulfield LE, Robinson C, Rave J, Ghanem K, Brotman R. Association between Dietary Intake and the Composition of the Vaginal Microbiota. Oral presentation at Nutrition 2018 Conference. American Society for Nutrition. Boston, MA. June 9, 2018.

Bloodstream Infections among Neonates Admitted to Neonatal Intensive Care Units in Pune, India

Post Date: 
2018-05-05
   |   
Countries: 
   |   
Clinical Sites: 
Johnson J , Rajput U, Valvi C, Bharadwaj R, Parikh T, Agarkhedkar S, Robinson M, Randive B, Gupte N, Smith R, Westercamp M, Mave V, Manabe Y, Milstone A, for the CDC SHEPheRD India Study Team. Bloodstream Infections among Neonates Admitted to Neonatal Intensive Care Units in Pune, India. Pediatric...

Importance of Diagnosis of TB Infection in Pregnant Women in India: Findings from a Cohort Study in Pune, India

Post Date: 
2018-04-24
   |   
Countries: 
   |   
Clinical Sites: 
Mathad J. Importance of Diagnosis of TB Infection in Pregnant Women in India: Findings from a Cohort Study in Pune, India. Oral Presentation. Presented at Global Health Research Initiative’s Scientific Conference, Weill Cornell Medical College, April 24, 2018.

Pages

Neisseria gonorrhoeae and Chlamydia trachomatis among women reporting extragenital exposures

Post Date: 
2015-05-15
   |   
Countries: 
Publication: 
Sexually Transmitted Diseases
Background: The Centers for Disease Control and Prevention recommends pharyngeal screening of Neisseria gonorrhoeae (GC) and rectal screening of GC and Chlamydia trachomatis (CT) in HIV-infected and at-risk men who have sex with men (MSM). There are currently no recommendations to routinely...

Feasibility and acceptability of smartphone-based ecological momentary assessment of alcohol use among African American men who have sex with men in Baltimore

Post Date: 
2015-06-17
   |   
Countries: 
Publication: 
Journal of Medical Internet Research
Background: Alcohol use is a risk factor for the acquisition of human immunodeficiency virus (HIV) among African American men who havesex with men (MSM). Mobile phone-based ecological momentary assessments (EMA) could minimize bias due to retrospective recall and thus provide a better...

Dengue and chikungunya co-infection associated with more severe clinical disease than mono-infection

Post Date: 
2015-04-15
   |   
Countries: 
Publication: 
International Journal of Healthcare and Biomedical Research
Background: Dengue and chikungunya infections appear to be increasing in India. While Aedies aegypti is the transmitting vector for both viruses and co-infection occurs in the same communities, studies on the clinical significance of co-infection are limited. Materials and Methods: We conducted a...

Concurrent anemia and elevated CRP predicts HIV clinical treatment failure, including TB, post-antiretroviral therapy initiation

Post Date: 
2015-07-01
   |      |   
Clinical Sites: 
Publication: 
Clinical Infectious Diseases
Background: Anemia is a known risk factor for clinical failure following antiretroviral therapy (ART). Notably, anemia and inflammation are interrelated, and recent studies have associated elevated C-reactive protein (CRP), an inflammation marker, with adverse human immunodeficiency virus (...

What tuberculosis means for maternal health

Post Date: 
2015-03-04
Mrs. Kumar [not her real name] was diagnosed with TB 18 years ago, during her first pregnancy, which ended in miscarriage. She then became depressed and side effects from the TB medications caused her difficulty eating. Three years later, during her second pregnancy, she and her husband were...

Vitamin D deficiency and risk of postpartum tuberculosis among HIV-infected breastfeeding mothers in India

Post Date: 
2015-03-15
   |   
Countries: 
   |   
Clinical Sites: 
Publication: 
International Journal of Tuberculosis and Lung Disease
Some studies have associated low vitamin D levels with the risk of tuberculosis (TB), but its association in human immunodeficiency virus (HIV) infected mothers in a TB-endemic region has not been well studied. We conducted a nested 1:2 case-control study among HIV-infected mothers in western...

C-reactive protein (CRP), interferon gamma-inducible protein 10 (IP-10), and lipopolysaccharide (LPS) are associated with risk of tuberculosis after initiation of antiretroviral therapy in resource-limited settings

Post Date: 
2015-02-26
   |   
Publication: 
PLOS One
Objective: The association between pre-antiretroviral (ART) inflammation and immune activation and risk for incident tuberculosis (TB) after ART initiation among adults is uncertain. Design: Nested case-control study (n = 332) within ACTG PEARLS trial of...

Capturing illicit drug use where and when it happens: an ecologic momentary assessment of the social, physical and activity environment of using versus craving illicit drugs

Post Date: 
2015-02-15
   |   
Countries: 
Publication: 
Addiction
Aim: To understand the environmental and contextual influences of illicit cocaine and heroin use and craving using mobile health (mHealth) methods. Design: Interactive mHealth methods of ecological momentary assessment (EMA) were utilized in the Exposure Assessment in...

Prevalence and risk factors of micronutrient deficiencies pre- and post-antiretroviral therapy (ART) among a diverse multicountry cohort of HIV-infected adults

Post Date: 
2016-02-10
   |   
Publication: 
Clinical Nutrition
Background & Aims: HIV-infected adults have increased risk of several individual micronutrient deficiencies. However, the prevalence and risk factors of concurrent and multiple micronutrient deficiencies and whether micronutrient concentrations change after antiretroviral therapy (ART)...

Activism on rifapentine pricing: removing cost barriers to improve the uptake of tuberculosis research innovations

Post Date: 
2014-12-21
Publication: 
Public Health Action
As recent advances have been made in developing tools to fight tuberculosis (TB), there is also a trend towards increasing advocacy by the civil society for TB research and access. One recent successful effort to increase access to treatment options for TB involved a collaborative effort to...

Pre-antiretroviral therapy selenium status predicts WHO stages 3, 4 or death but not virologic failure post-antiretroviral therapy

Post Date: 
2014-11-13
   |      |   
Clinical Sites: 
Publication: 
Nutrients
A case-cohort study, within a multi-country trial of antiretroviral therapy (ART) efficacy (Prospective Evaluation of Antiretrovirals in Resource Limited Settings (PEARLS)), was conducted to determine if pre-ART serum selenium deficiency is independently associated with human immunodeficiency...

Is CD4 monitoring needed among Ugandan clients achieving a virologic and immunologic response to treatment?

Post Date: 
2014-11-15
   |   
Countries: 
Publication: 
AIDS Patient Care and STDs
It is unclear whether ongoing CD4 monitoring is needed following immunologic and virologic response to antiretroviral therapy (ART). We investigated the proportion of clients who achieved a virologic and immunologic response and then had a subsequent CD4 count <200 cells/μL despite...

A consortium approach to competency-based undergraduate medical education in Uganda: process, opportunities and challenges

Post Date: 
2014-05-15
   |   
Countries: 
Publication: 
Education for Health
Background: Uganda, like the rest of Africa, is faced with serious health challenges including human immunodeficiency virus infection/acquired immunodeficiency syndrome (HIV/AIDS), other infectious diseases and increasing non-communicable diseases, yet it has a significant shortage of health...

High proportion of indeterminate QuantiFERON-TB Gold In-Tube results in an inpatient population are related to host factors and pre-analytical steps

Post Date: 
2014-09-19
   |   
Countries: 
Publication: 
Open Forum Infectious Diseases
Background: QuantiFERON-TB Gold In-Tube test (QFT-GIT) can be used as an alternative to tuberculin skin testing (TST) for the targeted testing of latent tuberculosis. Due to many shortcomings with TST, QFT-GIT usage is increasing. QFT-GIT implementation in the inpatient setting remains...

Source case investigation for children with TB disease in Pune, India

Post Date: 
2014-08-27
   |   
Countries: 
   |   
Clinical Sites: 
Publication: 
Tuberculosis Research and Treatment
Setting. Contact tracing is broadly encouraged for tuberculosis (TB) control. In many high-burden countries, however, little effort is made to identify contacts of newly diagnosed TB patients. This failure puts children, many of whom live in poor crowded communities, at special risk. ...

Blood stream infections

Post Date: 
2014-07-01
Publication: 
BioMed Research International
Blood stream infection (BSI) is one of the most devastating preventable complications in Critical Care Units. It has far-reaching consequences resulting in prolonged length of hospital-stay, high costs to the individual and exchequer, and, in many instances, loss of life. Although exact rates...

Applying ethical principles to international community-based research; a case study from the Consortium to Respond Effectively to the AIDS/TB Epidemic

Post Date: 
2016-05-15
This paper describes how one set of HIV-TB prevention research studies put procedures in place to be responsive to these foundational ethical principles when interacting with communities in large population-based, global public health research.

Taking the long view on CREATE studies' finding

Post Date: 
2014-05-15
   |   
Publication: 
The Lancet Infectious Disease
In the past 10 years, the Consortium to Respond Effectively to the AIDS TB Epidemic (CREATE) has done three large trials exploring new strategies to control HIV-related tuberculosis. Recognising that the global strategy for tuberculosis control of a decade ago (mainly directly observed short-...

Optimisation of the Medical Education Partnership Initiative to address African health-care challenges

Post Date: 
2014-06-25
   |   
Countries: 
Publication: 
The Lancet Global Health
The Medical Education Partnership Initiative (MEPI) is an innovative and potentially transformative 5-year programme, established by the US Government in 2010, to increase the number of doctors to meet crucial human resource needs in sub-Saharan Africa.1 MEPI allows African institutions that...

Gender-related barriers and delays in accessing tuberculosis diagnostic and treatment services - Part 2: a systematic review of qualitative studies

Post Date: 
2014-05-11
Publication: 
Tuberculosis Research and Treatment
Background: Tuberculosis (TB) remains a significant global public health problem with known gender-related (male versus female) disparities. We reviewed the qualitative evidence (written/spoken narrative) for gender-related differences limiting TB service access from symptom onset to treatment...

Pages